{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:12:43Z","timestamp":1771009963708,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.tox.2010.09.018","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T04:35:21Z","timestamp":1286512521000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The respiratory allergen glutaraldehyde in the local lymph node assay: Sensitization by skin exposure, but not by inhalation"],"prefix":"10.1016","volume":"279","author":[{"given":"Jos J.","family":"van Triel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca W.J.","family":"van Bree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Muijser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert","family":"Duistermaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud A.","family":"Woutersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Frieke","family":"Kuper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/toxsci\/kfn199","article-title":"The respiratory local lymph node assay as a tool to study respiratory sensitizers","volume":"106","author":"Arts","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2010.09.018_bib0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-4274(02)00513-1","article-title":"Approaches to induce and elicit respiratory allergy: impact of route and intensity of exposure","volume":"140\u2013141","author":"Arts","year":"2003","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2004.01.017","article-title":"Divergent immunological responses following glutaraldehyde exposure","volume":"197","author":"Azadi","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.tox.2010.09.018_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/occmed\/kqn007","article-title":"Fifteen-year trends in occupational asthma: data from the Shield surveillance scheme","volume":"58","author":"Bakerly","year":"2008","journal-title":"Occup. Med."},{"issue":"4","key":"10.1016\/j.tox.2010.09.018_bib0025","first-page":"193","article-title":"The acute toxicity and primary irritancy of glutaraldehyde solutions","volume":"43","author":"Ballantyne","year":"2001","journal-title":"Vet. Hum. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0278-6915(92)90138-B","article-title":"Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens","volume":"30","author":"Basketter","year":"1992","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-4274(89)90083-0","article-title":"The induction of respiratory allergy in guinea-pigs following intradermal injection of trimellitic anhydride: a comparison with the response to 2,4-dinitrochlorobenzene","volume":"47","author":"Botham","year":"1989","journal-title":"Toxicol. Lett."},{"issue":"11","key":"10.1016\/j.tox.2010.09.018_bib0040","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1398-9995.1996.tb00029.x","article-title":"Clinical and immunologic evaluation of workers exposed to glutaraldehyde","volume":"51","author":"Curran","year":"1996","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.tox.2010.09.018_bib0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tox.2009.04.057","article-title":"Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure","volume":"261","author":"De Jong","year":"2009","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/toxsci\/66.2.226","article-title":"Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay","volume":"66","author":"De Jong","year":"2002","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1365-2222.1999.00437.x","article-title":"Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde","volume":"29","author":"Dearman","year":"1999","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.tox.2010.09.018_bib0060","first-page":"1","volume":"L396","author":"EC","year":"2006","journal-title":"Off. J. Eur. Commun."},{"issue":"8","key":"10.1016\/j.tox.2010.09.018_bib0065","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/tx9001463","article-title":"Electrophilic reaction chemistry of low molecular weight respiratory sensitizers","volume":"22","author":"Enoch","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0070","first-page":"29","article-title":"Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde","volume":"9","author":"Hilton","year":"1998","journal-title":"Am. J. Contact Dermatitis"},{"issue":"4","key":"10.1016\/j.tox.2010.09.018_bib0075","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/oem.2004.016402","article-title":"Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds","volume":"62","author":"Jarvis","year":"2005","journal-title":"Occup. Environ. Med."},{"issue":"4","key":"10.1016\/j.tox.2010.09.018_bib0080","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/10408448609037467","article-title":"Respiratory effects of inhaled isocyanates","volume":"16","author":"Karol","year":"1986","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0085","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/026119290703500212","article-title":"Chemical respiratory allergy: opportunities for hazard identification and characterisation the report and recommendations of ECVAM workshop 60","volume":"35","author":"Kimber","year":"2007","journal-title":"Altern. Lab. Anim."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0300-483X(94)90193-7","article-title":"The local lymph node assay: developments and applications","volume":"93","author":"Kimber","year":"1994","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.tox.2010.09.018_bib0095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00278640","article-title":"A murine local lymph node assay for the identification of contact allergens Assay development and results of an initial validation study","volume":"63","author":"Kimber","year":"1989","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.tox.2010.09.018_bib0100","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2144\/04375RV01","article-title":"Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking","volume":"37","author":"Migneault","year":"2004","journal-title":"Biotechniques"},{"issue":"3","key":"10.1016\/j.tox.2010.09.018_bib0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol. Today"},{"issue":"11","key":"10.1016\/j.tox.2010.09.018_bib0110","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.4049\/jimmunol.0901064","article-title":"The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics","volume":"183","author":"Pickard","year":"2009","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/ACI.0b013e3282f85a31","article-title":"Lung\/skin connections in occupational lung disease","volume":"8","author":"Redlich","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"9","key":"10.1016\/j.tox.2010.09.018_bib0120","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1021\/tx060102o","article-title":"Mechanistic applicability domains for non-animal based toxicological endpoints QSAR analysis of the Schiff base applicability domain for skin sensitization","volume":"19","author":"Roberts","year":"2006","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/074823378900500103","article-title":"Contact hypersensitivity response to glutaraldehyde in guinea pigs and mice","volume":"5","author":"Stern","year":"1989","journal-title":"Toxicol. Ind. Health"},{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1539\/joh.48.75","article-title":"Effects of glutaraldehyde exposure on human health","volume":"48","author":"Takigawa","year":"2006","journal-title":"J. Occup. Health"},{"issue":"2","key":"10.1016\/j.tox.2010.09.018_bib0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1999.8841","article-title":"Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4","volume":"162","author":"Vandebriel","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.tox.2010.09.018_bib0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/taap.2002.9473","article-title":"Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers","volume":"184","author":"Van Och","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"11","key":"10.1016\/j.tox.2010.09.018_bib0145","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/oem.57.11.752","article-title":"Survey of symptoms, respiratory function, and immunology and their relation to glutaraldehyde and other occupational exposures among endoscopy nursing staff","volume":"57","author":"Vyas","year":"2000","journal-title":"Occup. Environ. Med."},{"issue":"3","key":"10.1016\/j.tox.2010.09.018_bib0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0300-483X(01)00566-2","article-title":"IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: comparison of inhalation and topical exposure","volume":"172","author":"Warbrick","year":"2002","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.tox.2010.09.018_bib0155","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/074823379501100503","article-title":"Respiratory peripheral sensory irritation and hypersensitivity studies with glutaraldehyde vapor","volume":"11","author":"Werley","year":"1995","journal-title":"Toxicol. Ind. Health"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1000507X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1000507X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:14:30Z","timestamp":1759533270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X1000507X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":31,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0300483X1000507X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2010.09.018","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The respiratory allergen glutaraldehyde in the local lymph node assay: Sensitization by skin exposure, but not by inhalation","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2010.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}