{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:06:38Z","timestamp":1790705198589,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.tox.2010.12.009","type":"journal-article","created":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T04:30:10Z","timestamp":1294374610000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alterations of apparent diffusion coefficient (ADC) in the brain of rats chronically exposed to lead acetate"],"prefix":"10.1016","volume":"281","author":[{"given":"Pilar","family":"L\u00f3pez-Larrubia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Cauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2010.12.009_bib0005","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/j.1471-4159.1988.tb01113.x","article-title":"Recovery from oedema and of protein synthesis differs between the cortex and caudate following transient focal cerebral ischemia in rats","volume":"51","author":"Abe","year":"1988","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.tox.2010.12.009_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3940(96)12546-5","article-title":"Intracarotid tumor necrosis factor-alpha administration increases the blood\u2013brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis","volume":"208","author":"Abraham","year":"1996","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.tox.2010.12.009_bib0015","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nrn1252","article-title":"The molecular basis of water transport in the brain","volume":"4","author":"Amiry-Moghaddam","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.tox.2010.12.009_bib0020","first-page":"902","article-title":"Pre- and posttreatment MR imaging findings in lead encephalopathy","volume":"27","author":"Atre","year":"2006","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.tox.2010.12.009_bib0025","first-page":"125","article-title":"The permissive nature of blood brain barrier (BBB) opening in oedema formation following traumatic brain injury","volume":"76","author":"Beaumont","year":"2000","journal-title":"Acta Neurochir. Suppl."},{"issue":"2\u20133","key":"10.1016\/j.tox.2010.12.009_bib0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.eplepsyres.2008.03.012","article-title":"Cell swelling precedes seizures induced by inhibition of astrocytic metabolism","volume":"80","author":"Broberg","year":"2008","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.tox.2010.12.009_bib0035","doi-asserted-by":"crossref","unstructured":"Cauli, O., L\u00f3pez-Larrubia, P., Rodrigo, R., Agusti, A., Boix, J., Nieto-Charques, L., Cerd\u00e1n, S., Felipo, V. Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology, in press, doi:10.1053\/j.gastro.2010.10.043.","DOI":"10.1053\/j.gastro.2010.10.043"},{"issue":"4","key":"10.1016\/j.tox.2010.12.009_bib0040","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/j.1471-4159.2007.04878.x","article-title":"Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors","volume":"103","author":"Cauli","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2010.12.009_bib0045","first-page":"1133","article-title":"Blood lead levels in young children\u2014United States and selected states, 1996\u20131999","volume":"49","author":"CDC. Center for Disease Control and Prevention","year":"2000","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"10.1016\/j.tox.2010.12.009_bib0050","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1102\/1470-7330.2006.0021","article-title":"Diffusion-weighted magnetic resonance imaging and its application to cancer","volume":"6","author":"Charles-Edwards","year":"2006","journal-title":"Cancer Imaging"},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejrad.2007.01.005","article-title":"Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology","volume":"63","author":"Chen","year":"2007","journal-title":"Eur. J. Radiol."},{"issue":"3","key":"10.1016\/j.tox.2010.12.009_bib0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0892-0362(94)00085-R","article-title":"Bridging human and experimental animal studies of lead neurotoxicity: moving beyond IQ","volume":"17","author":"Cory-Slechta","year":"1995","journal-title":"Neurotoxicol. Teratol."},{"issue":"2\u20133","key":"10.1016\/j.tox.2010.12.009_bib0065","first-page":"15","article-title":"Current issues in human lead exposure and regulation of lead","volume":"14","author":"Davis","year":"1993","journal-title":"Neurotoxicology"},{"issue":"8331","key":"10.1016\/j.tox.2010.12.009_bib0070","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0140-6736(83)92099-8","article-title":"Choroid plexus as a protective sink for heavy metals?","volume":"1","author":"Friedheim","year":"1983","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.tox.2010.12.009_bib0075","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0022-510X(01)00487-7","article-title":"Acute and chronic changes of the apparent diffusion coefficient in neurological disorders\u2014biophysical mechanisms and possible underlying histopathology","volume":"186","author":"Gass","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.tox.2010.12.009_bib0080","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneur.1974.00490420048005","article-title":"Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries","volume":"31","author":"Goldstein","year":"1974","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.tox.2010.12.009_bib0085","first-page":"9","article-title":"International perspectives of lead exposure and lead toxicity","volume":"14","author":"Grandjean","year":"1993","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2010.12.009_bib0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood\u2013brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2010.12.009_bib0100","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jneumeth.2005.08.006","article-title":"Fluorescence imaging of blood\u2013brain barrier disruption","volume":"151","author":"Hawkins","year":"2006","journal-title":"J. Neurosci. Methods"},{"issue":"6","key":"10.1016\/j.tox.2010.12.009_bib0105","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00005072-198211000-00008","article-title":"Development of resistance to lead encephalopathy during maturation in the rat pup","volume":"41","author":"Holtzman","year":"1982","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"5","key":"10.1016\/j.tox.2010.12.009_bib0110","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ana.20065","article-title":"Vascular endothelial growth factor mediates vasogenic oedema in acute lead encephalopathy","volume":"55","author":"Hossain","year":"2004","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.tox.2010.12.009_bib0115","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1046\/j.1471-4159.1995.65041631.x","article-title":"Low level lead exposure decreases in vivo release of dopamine in the rat nucleus accumbens: a microdialysis study","volume":"65","author":"Kala","year":"1995","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005072-196701000-00001","article-title":"Neuropathological aspects of brain oedema","volume":"26","author":"Klatzo","year":"1967","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.tox.2010.12.009_bib0125","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/3-211-30714-1_55","article-title":"Effect of dimethyl sulfoxide on blood\u2013brain barrier integrity following middle cerebral artery occlusion in the rat","volume":"96","author":"Kleindienst","year":"2006","journal-title":"Acta Neurochir. Suppl."},{"issue":"4","key":"10.1016\/j.tox.2010.12.009_bib0130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/01.STR.29.4.859","article-title":"Different apparent diffusion coefficient: water content correlations of gray and white matter during early ischemia","volume":"29","author":"Kuroiwa","year":"1998","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.tox.2010.12.009_bib0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00005072-198303000-00007","article-title":"Regressive or lethal lead encephalopathy in the suckling rat. Correlation of lead levels and morphological findings","volume":"42","author":"Lefauconnier","year":"1983","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.tox.2010.12.009_bib0140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF00687421","article-title":"Congenital lead encephalopathy in monkeys","volume":"77","author":"L\u00f6gdberg","year":"1988","journal-title":"Acta Neuropathol."},{"issue":"8398","key":"10.1016\/j.tox.2010.12.009_bib0145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0140-6736(84)92719-3","article-title":"Does the choroid plexus really protect the brain from lead?","volume":"2","author":"Manton","year":"1984","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.tox.2010.12.009_bib0150","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1056\/NEJM199511093331906","article-title":"Regulation of cell volume in health and disease","volume":"333","author":"McManus","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/01616412.1989.11739857","article-title":"Relationship between oedema, blood pressure, and blood flow following local brain injury","volume":"11","author":"Milhorat","year":"1989","journal-title":"Neurol. Res."},{"key":"10.1016\/j.tox.2010.12.009_bib0160","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1996"},{"key":"10.1016\/j.tox.2010.12.009_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00686515","article-title":"Morphology and morphogenesis of lead encephalopathy","volume":"5","author":"Pentschew","year":"1965","journal-title":"Acta Neuropathol."},{"issue":"9350","key":"10.1016\/j.tox.2010.12.009_bib0175","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/S0140-6736(02)12026-5","article-title":"Cerebellar ooedema and sideroblastic anaemia","volume":"360","author":"Rojas-Marcos","year":"2002","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.tox.2010.12.009_bib0180","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/00004647-199611000-00033","article-title":"Experimental cerebral venous thrombosis: evaluation using magnetic resonance imaging","volume":"16","author":"R\u00f6ther","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"10.1016\/j.tox.2010.12.009_bib0185","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/01.wco.0000044771.39452.8d","article-title":"Magnetic resonance imaging measurement of brain oedema in patients with liver disease: resolution after transplantation","volume":"15","author":"Rovira","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.tox.2010.12.009_bib0190","series-title":"Occupational Medicine","first-page":"506","article-title":"Lead and its compounds","author":"Saryan","year":"1994"},{"issue":"5","key":"10.1016\/j.tox.2010.12.009_bib0195","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00002142-200010000-00006","article-title":"Diffusion-weighted imaging as a problem-solving tool in the evaluation of patients with acute strokelike syndromes","volume":"11","author":"Schaefer","year":"2000","journal-title":"Top. Magn. Reson. Imaging"},{"key":"10.1016\/j.tox.2010.12.009_bib0200","doi-asserted-by":"crossref","unstructured":"Shaban El-Neweshy, M., Said El-Sayed, Y., 2010. Influence of vitamin C supplementation on lead-induced histopathological alterations in male rats. Exp. Toxicol. Pathol., in press, doi:10.1016\/j.etp.2009.12.003.","DOI":"10.1016\/j.etp.2009.12.003"},{"issue":"3","key":"10.1016\/j.tox.2010.12.009_bib0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0960327107070560","article-title":"Early lead exposure increases the leakage of the blood\u2013cerebrospinal fluid barrier, in vitro","volume":"26","author":"Shi","year":"2007","journal-title":"Hum. Exp. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2010.12.009_bib0210","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00687071","article-title":"Extracellular oedema and glial response to it in the cerebellum of suckling rats with low-dose lead encephalopathy. An electron microscopic and immunohistochemical study","volume":"75","author":"Sundstr\u00f6m","year":"1987","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00688948","article-title":"Changes in the integrity of the blood\u2013brain barrier in suckling rats with low dose lead encephalopathy","volume":"68","author":"Sundstr\u00f6m","year":"1985","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.tox.2010.12.009_bib0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02815125","article-title":"Lead-induced abnormalities in blood\u2013brain barrier permeability in experimental chronic toxicity","volume":"31","author":"Struzy\u0144ska","year":"1997","journal-title":"Mol. Chem. Neuropathol."},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-8993(78)90777-1","article-title":"Experimental lead encephalopathy in the suckling rat: concentration of lead in cellular fractions enriched in brain capillaries","volume":"147","author":"Toews","year":"1978","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.tox.2010.12.009_bib0230","first-page":"609","article-title":"Morphometric analysis of brain lesions in rat fetuses prenatally exposed to low-level lead acetate: correlation with lipid peroxidation","volume":"21","author":"Villeda-Hern\u00e1ndez","year":"2006","journal-title":"Histol. Histopathol."},{"issue":"1","key":"10.1016\/j.tox.2010.12.009_bib0235","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.taap.2006.11.035","article-title":"Iron supplement prevents lead-induced disruption of the blood\u2013brain barrier during rat development","volume":"219","author":"Wang","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2010.12.009_bib0240","series-title":"The Developmental Neurotoxicity of lead","author":"Winder","year":"1984"},{"issue":"8","key":"10.1016\/j.tox.2010.12.009_bib0245","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1096\/fasebj.5.8.1850706","article-title":"Choroid plexus protects cerebrospinal fluid against toxic metals","volume":"5","author":"Zheng","year":"1991","journal-title":"FASEB J."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11000035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11000035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:12:54Z","timestamp":1759533174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X11000035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":47,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0300483X11000035"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2010.12.009","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations of apparent diffusion coefficient (ADC) in the brain of rats chronically exposed to lead acetate","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2010.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}