{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:15:37Z","timestamp":1788862537185,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.tox.2011.01.017","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T04:45:40Z","timestamp":1296621940000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":149,"title":["Ferulic acid protects against carbon tetrachloride-induced liver injury in mice"],"prefix":"10.1016","volume":"282","author":[{"given":"Hyo-Yeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Hoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hwan","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Shik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Mee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2011.01.017_bib0005","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.01.017_bib0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.01.017_bib0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods. Enzymol."},{"key":"10.1016\/j.tox.2011.01.017_bib0020","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.510260619","article-title":"Interleukin-6 protects liver against warm ischemia\/reperfusion injury and promotes hepatocyte proliferation in the rodent","volume":"26","author":"Camargo","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0025","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2011.01.017_bib0030","doi-asserted-by":"crossref","first-page":"G875","DOI":"10.1152\/ajpgi.00549.2002","article-title":"The future of GI and liver research: editorial perspectives. III. JNK\/AP-1 regulation of hepatocyte death","volume":"284","author":"Czaja","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2011.01.017_bib0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/taap.1993.1069","article-title":"The involvement of Kupffer cells in carbon tetrachloride toxicity","volume":"119","author":"Edwards","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0040","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0045","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0891-5849(92)90184-I","article-title":"Antioxidant potential of ferulic acid","volume":"13","author":"Graf","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2011.01.017_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","article-title":"Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine","volume":"106","author":"Griffith","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2011.01.017_bib0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.tox.2011.01.017_bib0060","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1440-1746.2007.04896.x","article-title":"Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury","volume":"22","author":"Hua","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tox.2011.01.017_bib0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00204-007-0181-x","article-title":"Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver","volume":"81","author":"Iida","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2011.01.017_bib0070","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1745-7254.2005.00158.x","article-title":"Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1\/2 and Akt\/protein kinase B in rat hippocampus","volume":"26","author":"Jin","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tox.2011.01.017_bib0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sc.2008.101","article-title":"Low-echoic lesions underneath the skin in subjects with spinal-cord injury","volume":"47","author":"Kanno","year":"2009","journal-title":"Spinal Cord"},{"key":"10.1016\/j.tox.2011.01.017_bib0080","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.1074\/jbc.270.28.16483","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"270","author":"Karin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2011.01.017_bib0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0031-9422(00)00110-2","article-title":"Neuroprotective phenylpropanoid esters of rhamnose isolated from roots of Scrophularia buergeriana","volume":"54","author":"Kim","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tox.2011.01.017_bib0090","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.bjp.0704576","article-title":"E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate","volume":"135","author":"Kim","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0095","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bjoms.2008.07.205","article-title":"Stent repair of an anastomotic pseudoaneurysm of the carotid artery after free fibula transplantation","volume":"47","author":"Kreeft","year":"2009","journal-title":"Br. J. Oral. Maxillofac. Surg."},{"key":"10.1016\/j.tox.2011.01.017_bib0100","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.20153","article-title":"Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver","volume":"39","author":"Kuniyasu","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-2002-32081","article-title":"Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl(4)-induced toxicity: action mechanism and structure\u2013activity relationship","volume":"68","author":"Lee","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.tox.2011.01.017_bib0110","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1248\/bpb.33.752","article-title":"Ferulic acid attenuates adhesion molecule expression in gamma-radiated human umbilical vascular endothelial cells","volume":"33","author":"Ma","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tox.2011.01.017_bib0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11010-005-0170-4","article-title":"Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions","volume":"280","author":"Maurya","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tox.2011.01.017_bib0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10493-008-9213-3","article-title":"A qualitative model of mortality in honey bee (Apis mellifera) colonies infested with tracheal mites (Acarapis woodi)","volume":"47","author":"McMullan","year":"2009","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.tox.2011.01.017_bib0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/taap.2000.9133","article-title":"Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice","volume":"172","author":"Morio","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0130","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1471-4892(03)00080-8","article-title":"Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases","volume":"3","author":"O\u2019Neill","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0135","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1096\/fj.04-2753fje","article-title":"The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation","volume":"19","author":"Planaguma","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2011.01.017_bib0140","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0891-5849(94)00215-6","article-title":"Simultaneous generation of nitric oxide and superoxide by inflammatory cells in rats","volume":"18","author":"Rodenas","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2011.01.017_bib0145","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1476-5381.2009.00324.x","article-title":"NCX 2057, a novel NO-releasing derivative of ferulic acid, suppresses inflammatory and nociceptive responses in in vitro and in vivo models","volume":"158","author":"Ronchetti","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0150","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/jhep.2001.27445","article-title":"Complementary and alternative medicine in chronic liver disease","volume":"34","author":"Seeff","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0155","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hep.21925","article-title":"Peroxisome proliferator-activated receptor-beta\/delta protects against chemically induced liver toxicity in mice","volume":"47","author":"Shan","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cyto.2008.07.003","article-title":"The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models","volume":"44","author":"Shibata","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.tox.2011.01.017_bib0170","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0024-3205(77)90446-5","article-title":"Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450","volume":"20","author":"Sipes","year":"1977","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2011.01.017_bib0175","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1472-8206.2005.00332.x","article-title":"Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity","volume":"19","author":"Srinivasan","year":"2005","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.tox.2011.01.017_bib0180","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3164\/jcbn.40.92","article-title":"Ferulic acid: therapeutic potential through its antioxidant property","volume":"40","author":"Srinivasan","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.tox.2011.01.017_bib0185","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1023\/B:DDAS.0000030097.52476.aa","article-title":"Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice","volume":"49","author":"Su","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.tox.2011.01.017_bib0190","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/onc.2008.300","article-title":"NF-kappaB signaling, liver disease and hepatoprotective agents","volume":"27","author":"Sun","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.tox.2011.01.017_bib0195","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/hep.20759","article-title":"Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity","volume":"42","author":"Taieb","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2011.01.017_bib0200","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.01.017_bib0205","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.lfs.2004.02.030","article-title":"Molecular process in acute liver injury and regeneration induced by carbon tetrachloride","volume":"75","author":"Taniguchi","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2011.01.017_bib0210","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jcp.20860","article-title":"The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage","volume":"210","author":"Thobe","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tox.2011.01.017_bib0215","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2011.01.017_bib0220","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.4049\/jimmunol.174.5.2825","article-title":"Involvement of TNF and NF-kappa B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages","volume":"174","author":"Vila-del Sol","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.01.017_bib0225","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tox.2011.01.017_bib0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-2008-1040483","article-title":"Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury","volume":"10","author":"Williams","year":"1990","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.tox.2011.01.017_bib0235","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3748\/wjg.v16.i22.2771","article-title":"Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice","volume":"16","author":"Zhu","year":"2010","journal-title":"World. J. Gastroenterol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11000369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11000369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:14:26Z","timestamp":1759533266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X11000369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0300483X11000369"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2011.01.017","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferulic acid protects against carbon tetrachloride-induced liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2011.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}