{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:11:02Z","timestamp":1777032662365,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.tox.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T16:33:57Z","timestamp":1305909237000},"page":"8-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["An OGG1 polymorphism is associated with mitochondrial DNA content in pesticide-exposed fruit growers"],"prefix":"10.1016","volume":"287","author":[{"given":"Pei-Lin","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Fuu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Shen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiuan-Chih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim-Shoung","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruey-Hong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2011.05.001_bib0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mrfmmm.2004.08.002","article-title":"Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?","volume":"556","author":"Aka","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0010","first-page":"602","article-title":"Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer","volume":"59","author":"Ambrosone","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0015","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.febslet.2005.03.027","article-title":"Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide","volume":"579","author":"Banmeyer","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2011.05.001_bib0020","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tox.2011.05.001_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-1119(01)00813-7","article-title":"Mitochondrial DNA repair of oxidative damage in mammalian cells","volume":"286","author":"Bohr","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.tox.2011.05.001_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-4598-1-9","article-title":"Mitochondrial defects in cancer","volume":"1","author":"Carew","year":"2002","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tox.2011.05.001_bib0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ijc.20630","article-title":"Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes, a multigenic study on cancer susceptibility","volume":"113","author":"Cheng","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2011.05.001_bib0040","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.exer.2005.04.017","article-title":"Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria","volume":"81","author":"Cortina","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0045","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0891-5849(01)00483-X","article-title":"DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increases in mitochondrial but not in nuclear extracts","volume":"30","author":"de Souza-Pinto","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2011.05.001_bib0050","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1128\/MCB.25.12.5196-5204.2005","article-title":"Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae","volume":"25","author":"Doudican","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tox.2011.05.001_bib0055","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1365-2125.2009.03533.x","article-title":"Relationship between blood alcohol concentration on admission and outcome in dimethoate organophosphorus self-poisoning","volume":"68","author":"Eddleston","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.tox.2011.05.001_bib0060","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/nar\/gkf392","article-title":"The mitochondrial DNA polymerase as a target of oxidative damage","volume":"30","author":"Graziewicz","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0065","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/aje\/kwk024","article-title":"Pesticide exposure and self-reported Parkinson's disease in the agricultural health study","volume":"165","author":"Kamel","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tox.2011.05.001_bib0070","doi-asserted-by":"crossref","first-page":"14659","DOI":"10.1074\/jbc.270.24.14659","article-title":"Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria","volume":"270","author":"Kang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2011.05.001_bib0075","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3748\/wjg.v9.i5.956","article-title":"hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer","volume":"9","author":"Kim","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tox.2011.05.001_bib0080","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1038\/sj.onc.1201872","article-title":"Genetic polymorphisms and alternative splicing of the hOGG1 gene that is involved in the repair of 8-hydroxyguanine in damaged DNA","volume":"16","author":"Kohno","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.tox.2011.05.001_bib0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0014-5793(98)01564-6","article-title":"Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung","volume":"441","author":"Lee","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2011.05.001_bib0090","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/10715760310001621342","article-title":"Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes","volume":"37","author":"Liu","year":"2003","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0095","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1158\/1055-9965.EPI-05-0617","article-title":"GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers","volume":"15","author":"Liu","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.tox.2011.05.001_bib0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1158\/1055-9965.EPI-05-0210","article-title":"Mitochondrial DNA content increase in response to cigarette smoking","volume":"15","author":"Masayesva","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.tox.2011.05.001_bib0105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.exger.2003.10.011","article-title":"Detection of the 4977bp deletion of mitochondrial DNA in different human blood cells","volume":"39","author":"Mohamed","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tox.2011.05.001_bib0110","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/exmp.2002.2442","article-title":"Increase in DNA polymerase gamma in the hearts of adriamycin-administered rats","volume":"73","author":"Ogihara","year":"2002","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tox.2011.05.001_bib0115","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.emboj.7601975","article-title":"Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs","volume":"27","author":"Oka","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.tox.2011.05.001_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/ajmg.1425","article-title":"Mitochondria and degenerative disorders","volume":"106","author":"Orth","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.tox.2011.05.001_bib0125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.1993.tb39148.x","article-title":"Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite","volume":"686","author":"Pryor","year":"1993","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.tox.2011.05.001_bib0215","article-title":"Association between mitochondrial DNA content in leukocytes and colorectal cancer risk","author":"Qu","year":"2011","journal-title":"A case-control analysis Cancer"},{"key":"10.1016\/j.tox.2011.05.001_bib0135","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1023\/A:1005427323835","article-title":"The role of manganese superoxide dismutase in health and disease","volume":"21","author":"Robinson","year":"1998","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.tox.2011.05.001_bib0140","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.93.9.4471","article-title":"On signal sequence polymorphisms and diseases of distribution","volume":"93","author":"Rosenblum","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2011.05.001_bib0145","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1098-2280(1996)27:4<263::AID-EM3>3.0.CO;2-E","article-title":"Cytogenetic monitoring of occupational exposure to pesticides, characterization of GSTM1, GSTT1, and NAT2 genotypes","volume":"27","author":"Scarpato","year":"1996","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.tox.2011.05.001_bib0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1096\/fasebj.10.7.8635688","article-title":"Antioxidant and redox regulation of gene transcription","volume":"10","author":"Sen","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2011.05.001_bib0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/exnr.2002.8072","article-title":"Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation","volume":"179","author":"Sherer","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.tox.2011.05.001_bib0160","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/bbrc.1996.1394","article-title":"Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease","volume":"226","author":"Shimoda-Matsubayashi","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2011.05.001_bib0165","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/nar\/gkp100","article-title":"Oxidative stress induces degradation of mitochondrial DNA","volume":"37","author":"Shokolenko","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0170","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1471-4159.1980.tb11189.x","article-title":"Effect of organophosphorus insecticides on the oxidative processes in rat brain synaptosomes","volume":"34","author":"Sitkiewicz","year":"1980","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2011.05.001_bib0175","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.1998.9181","article-title":"Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells","volume":"249","author":"Suzuki","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2011.05.001_bib0180","unstructured":"Taichung County Government, Taiwan, 2009. The Statistical Abstract of Taichung County."},{"key":"10.1016\/j.tox.2011.05.001_bib0185","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1681\/ASN.V12112338","article-title":"Effect of human OGG1 1245C\u2192G gene polymorphism on 8-hydroxy-2\u2032-deoxyguanosine levels of leukocyte DNA among patients undergoing chronic hemodialysis","volume":"12","author":"Tarng","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tox.2011.05.001_bib0190","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","article-title":"Mitochondrial diseases in man and mouse","volume":"283","author":"Wallace","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.tox.2011.05.001_bib0195","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mrgentox.2008.06.005","article-title":"Polymorphisms in metabolic GSTP1 and DNA-repair XRCC1 genes with an increased risk of DNA damage in pesticide-exposed fruit growers","volume":"654","author":"Wong","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2011.05.001_bib0200","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2011.05.001_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00213961","article-title":"Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes II","volume":"28","author":"Yamano","year":"1995","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tox.2011.05.001_bib0210","first-page":"269","article-title":"Pesticides and cancer","volume":"12","author":"Zahm","year":"1997","journal-title":"Occup. Med."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1100165X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1100165X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:18:45Z","timestamp":1759533525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X1100165X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":42,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0300483X1100165X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2011.05.001","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An OGG1 polymorphism is associated with mitochondrial DNA content in pesticide-exposed fruit growers","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2011.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}