{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:06:25Z","timestamp":1782187585522,"version":"3.54.5"},"reference-count":91,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-PAR-03-12"],"award-info":[{"award-number":["R21-PAR-03-12"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.tox.2011.08.021","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T10:51:25Z","timestamp":1315392685000},"page":"156-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL\/6 mice"],"prefix":"10.1016","volume":"290","author":[{"given":"A.","family":"Mustafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.D.","family":"Holladay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Witonsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"Sponenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Karpuzoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"R.M.","family":"Gogal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2011.08.021_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.coi.2008.03.014","article-title":"Peripheral B cell subsets","volume":"20","author":"Allman","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.0300-9475.2004.01463.x","article-title":"Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage","volume":"60","author":"Bagavant","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0015","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0020","doi-asserted-by":"crossref","DOI":"10.3810\/pgm.2002.04.1154","article-title":"Inflammatory rheumatologic disorders in the elderly. Unusual presentations, altered outlooks","volume":"111","author":"Belostocki","year":"2002","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/1359-6101(96)00004-4","article-title":"Interferon-gamma in autoimmunity","volume":"7","author":"Billiau","year":"1996","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0041-008X(92)90189-Y","article-title":"Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation","volume":"112","author":"Blaylock","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0035","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.md.0000147737.57861.7c","article-title":"Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature","volume":"83","author":"Boddaert","year":"2004","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tox.2011.08.021_bib0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.autrev.2004.03.004","article-title":"Inflamm-aging: autoimmunity, and the immune-risk phenotype","volume":"3","author":"Boren","year":"2004","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4049\/jimmunol.175.1.90","article-title":"Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells","volume":"175","author":"Camacho","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0050","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI115055","article-title":"Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD\/Wehi mice","volume":"87","author":"Campbell","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2011.08.021_bib0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1385\/IR:27:2-3:141","article-title":"Peripheral B cell selection and homeostasis","volume":"27","author":"Cancro","year":"2003","journal-title":"Immunol. Res."},{"key":"10.1016\/j.tox.2011.08.021_bib0060","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/cmi.2011.2","article-title":"Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis","volume":"8","author":"Carnrot","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0065","first-page":"175","article-title":"Systemic lupus erythematosus in the elderly: clinical and serological characteristics","volume":"11","author":"Catoggio","year":"1984","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.tox.2011.08.021_bib0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00005792-199303000-00005","article-title":"Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus","volume":"72","author":"Cervera","year":"1993","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tox.2011.08.021_bib0075","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1191\/096120398678920479","article-title":"The clinical features and prognosis of male lupus in Taiwan","volume":"7","author":"Chang","year":"1998","journal-title":"Lupus"},{"key":"10.1016\/j.tox.2011.08.021_bib0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1191\/0961203302lu161oa","article-title":"Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States","volume":"11","author":"Cooper","year":"2002","journal-title":"Lupus"},{"key":"10.1016\/j.tox.2011.08.021_bib0085","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00296-009-1151-9","article-title":"Male gender results in more severe lupus nephritis","volume":"30","author":"de Carvalho","year":"2010","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.tox.2011.08.021_bib0090","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.coi.2010.04.009","article-title":"B cell repertoire and ageing","volume":"22","author":"Dunn-Walters","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0095","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000236719","article-title":"Dioxins and the immune system: mechanisms of interference. A meeting report","volume":"104","author":"Esser","year":"1994","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0100","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1126\/science.1092556","article-title":"Inflammatory exposure and historical changes in human life-spans","volume":"305","author":"Finch","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tox.2011.08.021_bib0105","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.144.4.1169","article-title":"Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"144","author":"Fine","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0110","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0022-3565(25)12730-4","article-title":"Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure","volume":"255","author":"Fine","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2011.08.021_bib0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/kfh058","article-title":"Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity","volume":"78","author":"Fisher","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2011.08.021_bib0120","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/096120339900800609","article-title":"Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI. SLE Disease Activity Index","volume":"8","author":"Formiga","year":"1999","journal-title":"Lupus"},{"key":"10.1016\/j.tox.2011.08.021_bib0125","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.tox.2011.08.021_bib0130","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1515\/BC.2006.151","article-title":"Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice","volume":"387","author":"Frericks","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.tox.2011.08.021_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2006.12.004","article-title":"B cell signaling and autoimmune diseases: CD19\/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity","volume":"46","author":"Fujimoto","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.tox.2011.08.021_bib0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0300-483X(97)00098-X","article-title":"Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin I [correction of II]. Effects on the fetus and the neonate","volume":"122","author":"Gehrs","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2011.08.021_bib0445","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0300-483X(99)00024-4","article-title":"Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"134","author":"Gehrs","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2011.08.021_bib0145","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0300-483X(00)00351-6","article-title":"Bilateral dissected spleens and thymuses in rodents exhibit homogeneity in leukocyte markers","volume":"157","author":"Gogal","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2011.08.021_bib0150","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.167.4.1886","article-title":"Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus","volume":"167","author":"Grimaldi","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0155","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.4049\/jimmunol.158.11.5484","article-title":"IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL\/Ipr mice","volume":"158","author":"Haas","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0160","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/art.1780390305","article-title":"Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood","volume":"39","author":"Hagiwara","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tox.2011.08.021_bib0450","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.4049\/jimmunol.150.12.5682","article-title":"Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation","volume":"150","author":"Hanawa","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0165","first-page":"497","article-title":"Differences in clinical and immunological findings of systemic lupus erythematosus related to age","volume":"14","author":"Hashimoto","year":"1987","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.tox.2011.08.021_bib0170","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/08916939608995349","article-title":"Cytokine gene expression and autoantibody production in Sjogren's syndrome of MRL\/lpr mice","volume":"23","author":"Hayashi","year":"1996","journal-title":"Autoimmunity"},{"key":"10.1016\/j.tox.2011.08.021_bib0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/ard.57.7.437","article-title":"Late onset systemic lupus erythematosus in southern Chinese","volume":"57","author":"Ho","year":"1998","journal-title":"Ann. Rheum. Dis."},{"issue":"Suppl. 3","key":"10.1016\/j.tox.2011.08.021_bib0180","first-page":"463","article-title":"Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure","volume":"108","author":"Holladay","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2011.08.021_bib0185","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/tera.1420440405","article-title":"Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD)","volume":"44","author":"Holladay","year":"1991","journal-title":"Teratology"},{"issue":"3","key":"10.1016\/j.tox.2011.08.021_bib0190","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.reprotox.2010.08.001","article-title":"Prenatal TCDD in mice increases adult autoimmunity","volume":"31","author":"Holladay","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2011.08.021_bib0195","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0300-483X(91)90184-3","article-title":"A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update","volume":"69","author":"Holsapple","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2011.08.021_bib0200","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/1529-0131(199805)41:5<838::AID-ART10>3.0.CO;2-S","article-title":"Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus","volume":"41","author":"Horwitz","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tox.2011.08.021_bib0205","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.4049\/jimmunol.168.10.5014","article-title":"Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire","volume":"168","author":"Johnson","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/taap.1996.8049","article-title":"Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo","volume":"142","author":"Kamath","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0215","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0049-0172(89)90061-9","article-title":"Male lupus: retrospective analysis of the clinical and laboratory features of 52 patients, with a review of the literature","volume":"18","author":"Kaufman","year":"1989","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.tox.2011.08.021_bib0220","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/15321810500403755","article-title":"Impact of different cell isolation techniques on lymphocyte viability and function","volume":"27","author":"Klein","year":"2006","journal-title":"J. Immunoassay Immunochem."},{"key":"10.1016\/j.tox.2011.08.021_bib0225","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.4049\/jimmunol.162.6.3342","article-title":"B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation","volume":"162","author":"Kline","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-065X.1997.tb01031.x","article-title":"The B-cell biology of aging","volume":"160","author":"Klinman","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0235","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tox.2011.08.021_bib0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2567.2004.02006.x","article-title":"Age-related loss of naive T cells and dysregulation of T-cell\/B-cell interactions in human lymph nodes","volume":"114","author":"Lazuardi","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.tox.2011.08.021_bib0245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-065X.1997.tb01032.x","article-title":"Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development","volume":"160","author":"LeMaoult","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0250","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"Loder","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0255","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0192-0561(92)90133-6","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits the activation of antigen-specific T-cells in mice","volume":"14","author":"Lundberg","year":"1992","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0260","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0192-0561(80)90030-2","article-title":"Examination of bone marrow, immunologic parameters and host susceptibility following pre- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"2","author":"Luster","year":"1980","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0265","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1289\/ehp.5860","article-title":"Consensus workshop on methods to evaluate developmental immunotoxicity","volume":"111","author":"Luster","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"Suppl. 13","key":"10.1016\/j.tox.2011.08.021_bib0270","first-page":"182","article-title":"Systemic lupus erythematosus in the elderly","volume":"14","author":"Maddison","year":"1987","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.tox.2011.08.021_bib0275","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.immunol.24.021605.090517","article-title":"B cell immunobiology in disease: evolving concepts from the clinic","volume":"24","author":"Martin","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0280","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-065X.2000.imr017515.x","article-title":"B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a \u201cnatural immune memory\u201d","volume":"175","author":"Martin","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0285","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/bbrc.1995.1931","article-title":"The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes","volume":"212","author":"Masten","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2011.08.021_bib0290","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1074\/jbc.M611446200","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induces premature activation of the KLF2 regulon during thymocyte development","volume":"282","author":"McMillan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2011.08.021_bib0295","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.273.5271.70","article-title":"The aging immune system: primer and prospectus","volume":"273","author":"Miller","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.tox.2011.08.021_bib0300","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1385\/IR:27:2-3:427","article-title":"Positive and negative selection during B lymphocyte development","volume":"27","author":"Monroe","year":"2003","journal-title":"Immunol. Res."},{"key":"10.1016\/j.tox.2011.08.021_bib0305","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.taap.2008.04.015","article-title":"An enhanced postnatal autoimmune profile in 24 week-old C57BL\/6 mice developmentally exposed to TCDD","volume":"232","author":"Mustafa","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0310","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/bdra.20603","article-title":"Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24-week-old SNF1 mice","volume":"85","author":"Mustafa","year":"2009","journal-title":"Birth Defects Res. A: Clin. Mol. Teratol."},{"key":"10.1016\/j.tox.2011.08.021_bib0315","doi-asserted-by":"crossref","first-page":"S393","DOI":"10.1016\/j.chemosphere.2006.05.134","article-title":"Immunologic effects of perinatal exposure to dioxins, PCBs and organochlorine pesticides in Japanese infants","volume":"67","author":"Nagayama","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2011.08.021_bib0320","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF01973455","article-title":"Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. Effects on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"64","author":"Neubert","year":"1990","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2011.08.021_bib0455","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.175.3.661","article-title":"Estrogen administration activates extrathymic T cell differentiation in the liver","volume":"175","author":"Okuyama","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/faat.1995.1040","article-title":"Phenotypic analysis of spleen, thymus, and peripheral blood cells in aged C57B1\/6 mice following long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"25","author":"Oughton","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2011.08.021_bib0330","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00296-006-0284-3","article-title":"Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages","volume":"27","author":"Padovan","year":"2007","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.tox.2011.08.021_bib0335","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri1085","article-title":"Negative selection\u2014clearing out the bad apples from the T-cell repertoire","volume":"3","author":"Palmer","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0340","first-page":"283","article-title":"Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus","volume":"16","author":"Park","year":"1998","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.tox.2011.08.021_bib0345","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0531-5565(03)00189-X","article-title":"The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism","volume":"38","author":"Pietschmann","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tox.2011.08.021_bib0350","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.autrev.2005.09.008","article-title":"Aging of the immune system: a risk factor for autoimmunity?","volume":"5","author":"Prelog","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.tox.2011.08.021_bib0355","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1191\/096120300678828109","article-title":"The clinical features and prognosis of lupus with disease onset at age 65 and older","volume":"9","author":"Pu","year":"2000","journal-title":"Lupus"},{"key":"10.1016\/j.tox.2011.08.021_bib0360","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0167-5699(92)90074-H","article-title":"The extrathymic T-cell development pathway","volume":"13","author":"Rocha","year":"1992","journal-title":"Immunol. Today"},{"key":"10.1016\/j.tox.2011.08.021_bib0365","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1074-7613(00)80029-1","article-title":"Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter","volume":"10","author":"Sandel","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.tox.2011.08.021_bib0370","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1146\/annurev.immunol.17.1.829","article-title":"Selection of the T cell repertoire","volume":"17","author":"Sebzda","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0375","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0047-6374(98)00051-7","article-title":"Age-associated modulation of apoptosis and activation in murine B lymphocytes","volume":"103","author":"Souvannavong","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.tox.2011.08.021_bib0380","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0047-6374(02)00035-0","article-title":"Immunological memory and late onset autoimmunity","volume":"123","author":"Stacy","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.tox.2011.08.021_bib0385","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2478\/v.10001-010-0006-7","article-title":"Perinatal exposure of mice to TCDD decreases allergic sensitisation through inhibition of IL-4 production rather than T regulatory cell-mediated suppression","volume":"23","author":"Tarkowski","year":"2010","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"10.1016\/j.tox.2011.08.021_bib0390","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1074\/jbc.274.1.510","article-title":"Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity","volume":"274","author":"Tian","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2011.08.021_bib0395","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.exger.2003.07.003","article-title":"Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis","volume":"38","author":"Van der Put","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tox.2011.08.021_bib0400","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/15287390500246985","article-title":"A dose\u2013response study of the effects of prenatal and lactational exposure to TCDD on the immune response to influenza a virus","volume":"69","author":"Vorderstrasse","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tox.2011.08.021_bib0405","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1191\/0961203302lu253oa","article-title":"Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature","volume":"11","author":"Voulgari","year":"2002","journal-title":"Lupus"},{"key":"10.1016\/j.tox.2011.08.021_bib0410","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00290880","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) in pregnant C57BL\/6N mice: distribution to the embryo and excretion","volume":"57","author":"Weber","year":"1985","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2011.08.021_bib0415","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-4274(85)90161-4","article-title":"Teratogenic potency of TCDD, TCDF and TCDD-TCDF combinations in C57BL\/6N mice","volume":"26","author":"Weber","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2011.08.021_bib0420","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1023\/A:1006659401385","article-title":"The effect of age on the B-cell repertoire","volume":"20","author":"Weksler","year":"2000","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.tox.2011.08.021_bib0425","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1006\/taap.2002.9396","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system","volume":"180","author":"Wyman","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2011.08.021_bib0430","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1084\/jem.183.3.959","article-title":"Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice","volume":"183","author":"Yang","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0435","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1084\/jem.157.4.1300","article-title":"Antigen responsiveness of the mature and generative B cell populations of aged mice","volume":"157","author":"Zharhary","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2011.08.021_bib0440","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-065X.1997.tb01028.x","article-title":"Immunosenescence and germinal center reaction","volume":"160","author":"Zheng","year":"1997","journal-title":"Immunol. Rev."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11003258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X11003258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:45:26Z","timestamp":1761777926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X11003258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":91,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0300483X11003258"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2011.08.021","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2011.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}