{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:59:44Z","timestamp":1761310784808,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007585","name":"Alberta Water Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007585","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002793","name":"Canadian Water Network","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.tox.2012.05.019","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T17:46:19Z","timestamp":1338572779000},"page":"155-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium"],"prefix":"10.1016","volume":"299","author":[{"given":"Shugo","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lora L.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Kakiuchi-Kiyota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.Chris","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2012.05.019_bib0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.pa.23.040183.001205","article-title":"DMSA and DMPS\u2014water soluble antidotes for heavy metal poisoning","volume":"23","author":"Aposhian","year":"1983","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0022-3565(24)36818-1","article-title":"DMPS\u2013arsenic challenge test. I. Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate","volume":"282","author":"Aposhian","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2012.05.019_bib0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/taap.2000.8922","article-title":"DMPS\u2013arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine","volume":"165","author":"Aposhian","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.019_bib0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/toxsci\/kfr199","article-title":"Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks","volume":"123","author":"Clewell","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0025","first-page":"1","article-title":"Pathology of experimental bladder cancer in rodents","volume":"vol. 2","author":"Cohen","year":"1983"},{"key":"10.1016\/j.tox.2012.05.019_bib0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/019262339802600114","article-title":"Urinary bladder carcinogenesis","volume":"26","author":"Cohen","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2012.05.019_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/10408440500534230","article-title":"Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment","volume":"36","author":"Cohen","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0035","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1021\/tx020026z","article-title":"Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat","volume":"15","author":"Cohen","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0040","first-page":"135","article-title":"Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography","volume":"4","author":"Cohen","year":"1990","journal-title":"Scanning Microsc."},{"key":"10.1016\/j.tox.2012.05.019_bib0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3835(95)03785-U","article-title":"Rodent bladder tumors do not always predict for humans","volume":"93","author":"Cohen","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tox.2012.05.019_bib0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/01926230701197115","article-title":"Investigations of rodent urinary bladder carcinogens: collection, processing, and evaluation of urine and bladders","volume":"35","author":"Cohen","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2012.05.019_bib0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/toxsci\/kfh265","article-title":"Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats","volume":"82","author":"Cui","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0060","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1021\/tx00035a002","article-title":"Transfer of arsenite from glutathione to dithiols: a model of interaction","volume":"6","author":"Delnomdedieu","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.20505","article-title":"Analysis of genomic dose\u2013response information on arsenic to inform key events in a mode of action for carcinogenicity","volume":"51","author":"Gentry","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.tox.2012.05.019_bib0070","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/tx020058m","article-title":"Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate","volume":"15","author":"Gong","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/taap.1997.8269","article-title":"In vitro methylation of inorganic arsenic in mouse intestinal cecum","volume":"147","author":"Hall","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.019_bib0080","doi-asserted-by":"crossref","first-page":"26A","DOI":"10.1021\/ac041492r","article-title":"Arsenic speciation","volume":"76","author":"Le","year":"2004","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2012.05.019_bib0085","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1021\/ac000527u","article-title":"Speciation of key arsenic metabolic intermediates in human urine","volume":"72","author":"Le","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2012.05.019_bib0090","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1021\/ac034868u","article-title":"Speciation of dimethylarsinous acid and trimethylarsine oxide in urine from rats fed with dimethylarsinic acid and dimercaptopropane sulfonate","volume":"75","author":"Lu","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2012.05.019_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10915818409009068","article-title":"Randomization of animals by computer program for toxicology studies","volume":"3","author":"Martin","year":"1984","journal-title":"J. Am. Coll. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0100","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1254\/jjp.40.188","article-title":"Arsenic excretion after treatment of arsenic poisoning with DMSA or DMPS in mice","volume":"40","author":"Maehashi","year":"1986","journal-title":"Jpn. J. Pharmacol."},{"year":"1999","series-title":"Arsenic in Drinking Water","author":"National Research Council Subcommittee on Arsenic in Drinking Water","key":"10.1016\/j.tox.2012.05.019_bib0105"},{"key":"10.1016\/j.tox.2012.05.019_bib0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/70.1.4","article-title":"Reduction of arsenate to arsenite in hepatic cytosol","volume":"70","author":"N\u00e9meti","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/toxsci\/kfg116","article-title":"Arsenate reduction in human erythrocytes and rats\u2014testing the role of purine nucleoside phosphorylase","volume":"74","author":"N\u00e9meti","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0120","first-page":"225","article-title":"Sulphur mustard induced oxidative stress and its prevention by sodium 2,3-dimercapto propane sulphonic acid (DMPS) in mice","volume":"13","author":"Pant","year":"2000","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0125","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s002040050237","article-title":"Effect of DMPS and various adsorbents on the arsenic excretion in guinea-pigs after injection with As2O3","volume":"69","author":"Reichl","year":"1995","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s002040050134","article-title":"Effect of various antidotes on the biliary and intestinal excretion of arsenic in situ and into the feces in vivo in guinea-pigs after injection of As2O3","volume":"69","author":"Reichl","year":"1994","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0135","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jat.2550010508","article-title":"In vitro metabolism of inorganic arsenic by the gastro-intestinal microflora of the rat","volume":"1","author":"Rowland","year":"1981","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2012.05.019_bib0140","first-page":"3445","article-title":"Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation","volume":"60","author":"Simeonova","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2012.05.019_bib0145","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/toxsci\/kfn184","article-title":"Effects of inorganic arsenic on the rat and mouse urinary bladder","volume":"106","author":"Suzuki","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.019_bib0150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.taap.2009.12.026","article-title":"Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium","volume":"244","author":"Suzuki","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.019_bib0155","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tox.2009.04.042","article-title":"Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium","volume":"261","author":"Suzuki","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2012.05.019_bib0165","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1373\/clinchem.2007.092189","article-title":"Arsenic speciation analysis in human saliva","volume":"54","author":"Yuan","year":"2008","journal-title":"Clin. Chem."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12001758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12001758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:19:30Z","timestamp":1759533570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X12001758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":33,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0300483X12001758"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2012.05.019","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2012.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}