{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:27:50Z","timestamp":1791404870416,"version":"4.3.3"},"reference-count":82,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.tox.2012.05.023","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T22:17:52Z","timestamp":1338502672000},"page":"31-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action"],"prefix":"10.1016","volume":"300","author":[{"given":"Katie B.","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Hedge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Thomas","family":"Zoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"DeVito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Crofton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2012.05.023_bib0005","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0045-6535(01)00255-7","article-title":"Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden","volume":"46","author":"Adolfsson-Erici","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2012.05.023_bib0010","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1021\/ac060666x","article-title":"Determination of triclosan as its pentafluorobenzoyl ester in human plasma and milk using electron capture negative ionization mass spectrometry","volume":"78","author":"Allmyr","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2012.05.023_bib0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2006.08.007","article-title":"Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products","volume":"372","author":"Allmyr","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2012.05.023_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.scitotenv.2007.12.006","article-title":"The influence of age and gender on triclosan concentrations in Australian human blood serum","volume":"393","author":"Allmyr","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2012.05.023_bib0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1742-7843.2009.00455.x","article-title":"Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones","volume":"105","author":"Allmyr","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2008.05.020","article-title":"Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes","volume":"232","author":"Axelstad","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.tox.2012.05.023_bib0375","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/toxsci\/kfn206","article-title":"A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures","volume":"107","author":"Baldwin","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.devbrainres.2005.01.007","article-title":"Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs)","volume":"156","author":"Bansal","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.tox.2012.05.023_bib0380","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/taap.1994.1174","article-title":"Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats","volume":"128","author":"Barter","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0045","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/endo-128-2-741","article-title":"Thyroxine and 3,3\u2032,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases","volume":"128","author":"Beetstra","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0050","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/0020-711X(93)90525-J","article-title":"Expression of P450 isoenzymes during rat liver organogenesis","volume":"25","author":"Borlakoglu","year":"1993","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.tox.2012.05.023_bib0385","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1124\/dmd.108.024190","volume":"37","author":"Buckley","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2012.05.023_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3476(84)80990-7","article-title":"Human milk intake and growth in exclusively breast-fed infants","volume":"104","author":"Butte","year":"1984","journal-title":"J. Pediatr."},{"key":"10.1016\/j.tox.2012.05.023_bib0060","first-page":"1","article-title":"Nutrient adequacy of exclusive breast feeding for the term infant during the first 6 months of life","author":"Butte","year":"2002","journal-title":"WHO Geneva"},{"key":"10.1016\/j.tox.2012.05.023_bib0065","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.10768","article-title":"Urinary concentrations of triclosan in the U.S. population: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2012.05.023_bib0070","first-page":"173","article-title":"Mechanisms of chemical injury of thyroid gland","volume":"387","author":"Capen","year":"1994","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.tox.2012.05.023_bib0075","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.tox.2007.10.014","article-title":"Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)","volume":"243","author":"Chang","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2012.05.023_bib0390","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1124\/dmd.105.003988","article-title":"Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways","volume":"33","author":"Cheng","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2012.05.023_bib0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0041-008X(82)90032-1","article-title":"Effects of perinatal methimazole exposure on a developmental test battery for neurobehavioral toxicity in rats","volume":"63","author":"Comer","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0085","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/68.2.372","article-title":"Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL\/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners","volume":"68","author":"Craft","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/57.1.131","article-title":"PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure","volume":"57","author":"Crofton","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.etap.2007.04.008","article-title":"Short-term in vivo exposure to the water contaminant triclosan: evidence for disruption of thyroxine","volume":"24","author":"Crofton","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.fct.2006.08.009","article-title":"Risk assessment of triclosan [Irgasan((R))] in human breast milk","volume":"45","author":"Dayan","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.reprotox.2008.09.010","article-title":"The ontogeny of drug metabolizing enzymes and transporters in the rat","volume":"26","author":"de Zwart","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0110","first-page":"185","article-title":"Triclosan: a safety profile","volume":"2 Spec No","author":"DeSalva","year":"1989","journal-title":"Am. J. Dent."},{"key":"10.1016\/j.tox.2012.05.023_bib0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/faat.1993.1015","article-title":"Comparative ability of various PCBs, PCDFs, and TCDD to INduce Cytochrome P450 1A1 and 1a2 activity following 4 weeks of treatment","volume":"20","author":"DeVito","year":"1993","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0120","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0163-7258(79)90099-8","article-title":"The rat as model for the study of drug effects on thyroid function: consideration of methodological problems","volume":"5","author":"Dohler","year":"1979","journal-title":"Pharmacol. Ther. B"},{"key":"10.1016\/j.tox.2012.05.023_bib0125","first-page":"598","article-title":"Tissue-specific expression of rat sulfotransferase messenger RNAs","volume":"26","author":"Dunn","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2012.05.023_bib0130","series-title":"Exposure Factors Handbook Vol II Food Ingestion Factors","author":"US EPA.","year":"1997"},{"key":"10.1016\/j.tox.2012.05.023_bib0135","series-title":"Benchmark Dose Technical Guidance Document External Review Draft. Risk Assessment Forum","author":"US EPA","year":"2000"},{"key":"10.1016\/j.tox.2012.05.023_bib0140","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/toxsci\/kfp280","article-title":"Triclosan and anuran metamorphosis: no effect on thyroid-mediated metamorphosis in Xenopus laevis","volume":"113","author":"Fort","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0145","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1289\/ehp.6672","article-title":"Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors","volume":"112","author":"Gauger","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2012.05.023_bib0150","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1289\/ehp.10328","article-title":"Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells","volume":"115","author":"Gauger","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2012.05.023_bib0155","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1210\/en.2010-1490","article-title":"Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development","volume":"152","author":"Giera","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/en.2006-0164","article-title":"Thyroid hormone insufficiency during brain development reduces parvalbumin immunoreactivity and inhibitory function in the hippocampus","volume":"148","author":"Gilbert","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0165","first-page":"94","article-title":"Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats","volume":"45","author":"Goldey","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1995.1210","article-title":"Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats","volume":"135","author":"Goldey","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/taap.1995.1209","article-title":"Effects of developmental hypothyroidism on auditory and motor function in the rat","volume":"135","author":"Goldey","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0180","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1042\/bj0890114","article-title":"The preparation of I-131-labelled human growth hormone of high specific radioactivity","volume":"89","author":"Greenwood","year":"1963","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2012.05.023_bib0185","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0026-895X(24)12334-6","article-title":"Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor","volume":"61","author":"Guo","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199908193410801","article-title":"Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child","volume":"341","author":"Haddow","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2012.05.023_bib0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.yexmp.2005.08.009","article-title":"Changes in cytochrome P450 isozymes (CYPs) protein levels during lactation in rat liver","volume":"79","author":"He","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tox.2012.05.023_bib0200","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yexmp.2004.08.011","article-title":"Effects of pregnancy on CYPs protein expression in rat liver","volume":"78","author":"He","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tox.2012.05.023_bib0205","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/toxsci\/55.1.78","article-title":"Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation","volume":"55","author":"Hood","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s002440010298","article-title":"Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma","volume":"42","author":"Hovander","year":"2002","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0215","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1172\/JCI115894","article-title":"Adult rat brain is sensitive to thyroid hormone. Regulation of RC3\/neurogranin mRNA","volume":"90","author":"Iniguez","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2012.05.023_bib0220","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.taap.2005.03.015","article-title":"Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)","volume":"209","author":"Jacobs","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0225","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/toxsci\/67.2.182","article-title":"Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways","volume":"67","author":"Johnson","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0230","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/endo-107-4-1245","article-title":"Evidence for circadian variations in serum thyrotropin, 3,5,3\u2032-triiodothyronine, and thyroxine in the rat","volume":"107","author":"Jordan","year":"1980","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0235","first-page":"E592","article-title":"Characterization of rat iodothyronine sulfotransferases","volume":"285","author":"Kester","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tox.2012.05.023_bib0395","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1081\/DCT-100100114","article-title":"Effects of TCDD on thyroid hormone homeostasis in the rat","volume":"23","author":"Kohn","year":"2000","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0240","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbi.2005.06.003","article-title":"CAR and PXR: xenosensors of endocrine disrupters?","volume":"155","author":"Kretschmer","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2012.05.023_bib0245","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kfg122","article-title":"Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: Postnatal evaluation","volume":"74","author":"Lau","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0400","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/toxsci\/kfp026","article-title":"Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism","volume":"108","author":"Lecureux","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0250","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.tox.2012.05.023_bib0255","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1289\/ehp.0800247","article-title":"Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes","volume":"117","author":"Miller","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"Suppl. 1","key":"10.1016\/j.tox.2012.05.023_bib0260","first-page":"66","article-title":"Maternal-fetal thyroid hormone relationships and the fetal brain","volume":"15","author":"Morreale de Escobar","year":"1988","journal-title":"Acta Med. Austriaca"},{"key":"10.1016\/j.tox.2012.05.023_bib0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.1993.1168","article-title":"Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats","volume":"122","author":"Morse","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.47.120505.105349","article-title":"The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences","volume":"48","author":"Pascussi","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0275","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1002\/etc.339","article-title":"Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats","volume":"29","author":"Paul","year":"2010","journal-title":"Environ. Toxicol. Chem.\/SETAC"},{"key":"10.1016\/j.tox.2012.05.023_bib0280","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/toxsci\/kfp271","article-title":"Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats","volume":"113","author":"Paul","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0285","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cbi.2006.01.001","article-title":"Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats","volume":"160","author":"Pohjanvirta","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2012.05.023_bib0290","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1365-2265.1999.00639.x","article-title":"Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy","volume":"50","author":"Pop","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.tox.2012.05.023_bib0295","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1365-2265.2003.01822.x","article-title":"Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study","volume":"59","author":"Pop","year":"2003","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.tox.2012.05.023_bib0300","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1210\/en.2004-1350","article-title":"Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism","volume":"146","author":"Qatanani","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0305","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.taap.2010.07.010","article-title":"Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation","volume":"248","author":"Richardson","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0310","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/15287390600631706","article-title":"Pharmacokinetics of triclosan following oral ingestion in humans","volume":"69","author":"Sandborgh-Englund","year":"2006","journal-title":"J. Toxicol. Environ. Health"},{"issue":"Suppl. 1","key":"10.1016\/j.tox.2012.05.023_bib0315","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1289\/ehp.9369","article-title":"Endocrine disruptors and the thyroid gland \u2013 a combined in vitro and in vivo analysis of potential new biomarkers","volume":"115","author":"Schmutzler","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2012.05.023_bib0405","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1210\/endo.138.9.5386","article-title":"Extrathyroidal effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats","volume":"138","author":"Schuur","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0320","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/toxsci\/kfn230","article-title":"Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups","volume":"107","author":"Szabo","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0325","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1124\/jpet.106.112706","article-title":"The nuclear receptor constitutively active\/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver","volume":"320","author":"Tien","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2012.05.023_bib0330","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/taap.1995.1130","article-title":"Developmental stage-associated differences in the transplacental distribution of 13-cis- and all-trans-retinoic acid as well as their glucuronides in rats and mice","volume":"133","author":"Tzimas","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0410","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/taap.2001.9278","article-title":"Increased biliary excretion of thyroxine by microsomal enzyme inducers","volume":"176","author":"Vansell","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.05.023_bib0335","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/dmd.30.3.240","article-title":"Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation","volume":"30","author":"Vansell","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2012.05.023_bib0415","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1210\/endo.133.5.8404669","article-title":"Glucuronidation of thyroid hormone in rat liver: effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions","volume":"133","author":"Visser","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2012.05.023_bib0340","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0022-3565(25)25014-5","article-title":"Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit","volume":"238","author":"Wang","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2012.05.023_bib0345","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1289\/ehp.9488","article-title":"Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls","volume":"115","author":"Wolff","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2012.05.023_bib0350","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/toxsci\/kfi094","article-title":"Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats","volume":"84","author":"Wong","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0355","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/10915810490475835","article-title":"A rat neurodevelopmental evaluation of offspring, including evaluation of adult and neonatal thyroid, from mothers treated with ammonium perchlorate in drinking water","volume":"23","author":"York","year":"2004","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.tox.2012.05.023_bib0360","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/toxsci\/61.1.76","article-title":"Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats","volume":"61","author":"Zhou","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0365","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/toxsci\/66.1.105","article-title":"Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption","volume":"66","author":"Zhou","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.05.023_bib0370","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/kfn225","article-title":"The effects of triclosan on puberty and thyroid hormones in male Wistar rats","volume":"107","author":"Zorrilla","year":"2009","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12001795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12001795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:21:35Z","timestamp":1759533695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X12001795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":82,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0300483X12001795"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2012.05.023","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2012.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}