{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:38:08Z","timestamp":1759541888705,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.tox.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T01:00:20Z","timestamp":1342400420000},"page":"12-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population"],"prefix":"10.1016","volume":"307","author":[{"given":"Maria","family":"Kokouva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalis","family":"Koureas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavlina","family":"Almpanidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kalogeraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despoina","family":"Kyriakou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios M.","family":"Hadjigeorgiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Hadjichristodoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2012.07.003_bib0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.taap.2011.08.009","article-title":"Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases","volume":"256","author":"Androutsopoulos","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.07.003_bib0010","first-page":"9","article-title":"CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case\u2013control study","author":"Antognelli","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tox.2012.07.003_bib0015","first-page":"421","article-title":"Investigation of PON1192 and PON1 55 polymorphisms in ovarian cancer patients in Turkish population","volume":"23","author":"Arpaci","year":"2009","journal-title":"In Vivo"},{"key":"10.1016\/j.tox.2012.07.003_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1081\/CLT-120018269","article-title":"Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates","volume":"41","author":"Costa","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.tox.2012.07.003_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13547500210148315","article-title":"Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity","volume":"8","author":"Costa","year":"2003","journal-title":"Biomarkers"},{"key":"10.1016\/j.tox.2012.07.003_bib0030","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1158\/1055-9965.EPI-06-0193","article-title":"Metabolic gene variants and risk of non-Hodgkin's lymphoma","volume":"15","author":"De Roos","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.tox.2012.07.003_bib0035","first-page":"939","article-title":"Occupational exposures and haematological malignancies: overview on human recent data","volume":"16","author":"Descatha","year":"2005","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tox.2012.07.003_bib0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jbt.20181","article-title":"Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds","volume":"21","author":"Furlong","year":"2007","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2012.07.003_bib0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.fpc.0000189796.21770.d3","article-title":"PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity","volume":"16","author":"Furlong","year":"2006","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.tox.2012.07.003_bib0050","first-page":"230","article-title":"Role of genetic polymorphism of human plasma paraoxonase\/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon","volume":"43","author":"Furlong","year":"1988","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tox.2012.07.003_bib0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.canep.2009.08.005","article-title":"Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma","volume":"33","author":"Gold","year":"2009","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.tox.2012.07.003_bib0060","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/jor.20393","article-title":"Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions","volume":"25","author":"Hadjigeorgiou","year":"2007","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tox.2012.07.003_bib0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cbf.1284","article-title":"Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas","volume":"24","author":"Kafadar","year":"2006","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.tox.2012.07.003_bib0070","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2141.2002.03606.x","article-title":"Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk","volume":"118","author":"Kerridge","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tox.2012.07.003_bib0075","first-page":"11","article-title":"Pesticide exposure and lymphohaematopoietic cancers: a case\u2013control study in an agricultural region (Larissa, Thessaly, Greece)","author":"Kokouva","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.tox.2012.07.003_bib0080","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.clinbiochem.2008.03.012","article-title":"Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes \u2013 Connection with inflammation","volume":"41","author":"Krzystek-Korpacka","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.tox.2012.07.003_bib0085","first-page":"566","article-title":"Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals","volume":"29","author":"La Du","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2012.07.003_bib0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s00109-003-0481-4","article-title":"Paraoxonase gene polymorphisms, oxidative stress, and diseases","volume":"81","author":"Li","year":"2003","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.tox.2012.07.003_bib0095","first-page":"628","article-title":"Xenobiotic gene polymorphisms and susceptibility to multiple myeloma","volume":"89","author":"Lincz","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.tox.2012.07.003_bib0100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.toxlet.2007.05.004","article-title":"Changes in antioxidant enzymes in humans with long-term exposure to pesticides","volume":"171","author":"Lopez","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2012.07.003_bib0105","first-page":"1209","article-title":"Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case\u2013control studies","volume":"18","author":"Merhi","year":"2007","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tox.2012.07.003_bib0110","series-title":"SPSS 16. 0 Advanced Statistical Procedures","article-title":"Multinominal logistic regression analysis","author":"Norusis","year":"2007"},{"key":"10.1016\/j.tox.2012.07.003_bib0115","first-page":"4041","article-title":"192R allele of paraoxanase 1 (PON1) gene as a new marker for susceptibility to bladder cancer","volume":"29","author":"Ozturk","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.tox.2012.07.003_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2008.11.001","article-title":"Paraoxonase 1 (PON1) status and substrate hydrolysis","volume":"235","author":"Richter","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2012.07.003_bib0125","first-page":"26","article-title":"Metabolic susceptibility to agricultural pesticides and non-Hodgkin's lymphoma","volume":"31","author":"Schroeder","year":"2005","journal-title":"Scand. J. Work. Environ. Health"},{"key":"10.1016\/j.tox.2012.07.003_bib0130","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/pros.20796","article-title":"Paraoxonase I (PONI) polymorphisms and prostate cancer in the CPS-II nutrition cohort","volume":"68","author":"Stevens","year":"2008","journal-title":"Prostate"},{"key":"10.1016\/j.tox.2012.07.003_bib0135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-4274(02)00233-3","article-title":"Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK\/PD) model","volume":"135","author":"Timchalk","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2012.07.003_bib0140","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/toxsci\/kfm119","article-title":"An age-dependent physiologically based pharmacokinetic\/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat","volume":"98","author":"Timchalk","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2012.07.003_bib0145","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3109\/00498254.2011.590545","article-title":"Associations of xenobiotic-metabolizing enzyme genotypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece","volume":"41","author":"Tsatsakis","year":"2011","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tox.2012.07.003_bib0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2008.10.018","article-title":"Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides","volume":"186","author":"Tsatsakis","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2012.07.003_bib0155","first-page":"284","article-title":"Carboxylic esterase and its associations with long-term effects of organophosphorus pesticides","volume":"20","author":"Zhou","year":"2007","journal-title":"Biomed. Environ. Sci."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12002703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X12002703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:22:31Z","timestamp":1759533751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X12002703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":31,"alternative-id":["S0300483X12002703"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2012.07.003","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2012.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}