{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:37:55Z","timestamp":1759541875741,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.tox.2013.01.018","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T17:16:54Z","timestamp":1359998214000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Northern contaminant mixtures induced morphological and functional changes in human coronary artery endothelial cells under culture conditions typifying high fat\/sugar diet and ethanol exposure"],"prefix":"10.1016","volume":"313","author":[{"given":"Maria","family":"Florian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Ulhaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Coughlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahemuti","family":"Laziyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Willmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2013.01.018_bib0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/oxfordjournals.aje.a113024","article-title":"Metabolic consequences of exposure to polychlorinated biphenyls (PCB) in sewage sludge","volume":"112","author":"Baker","year":"1980","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tox.2013.01.018_bib0010","doi-asserted-by":"crossref","first-page":"G265","DOI":"10.1152\/ajpgi.00055.2010","article-title":"Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH","volume":"299","author":"Chen","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2013.01.018_bib0015","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1021\/es9001604","article-title":"Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada)","volume":"43","author":"Dallaire","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2013.01.018_bib0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.physiol.66.032102.144149","article-title":"Molecular and integrative physiology of intestinal peptide transport","volume":"66","author":"Daniel","year":"2004","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tox.2013.01.018_bib0025","first-page":"93","article-title":"From bacteria to man: archaic proton-dependent peptide transporters at work","volume":"21","author":"Daniel","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.tox.2013.01.018_bib0030","series-title":"Synopsis of Research Conducted under the 2005\u20132006 Northern Contaminants Program","first-page":"44","article-title":"Exposure to heavy metals and persistent organic pollutants in Nunavik: the Nunavik health study (Human Health)","author":"Dewailly","year":"2006"},{"key":"10.1016\/j.tox.2013.01.018_bib0035","series-title":"Synopsis of Research Conducted under the 2008\u20132009 Northern Contaminants Program","first-page":"24","article-title":"Contaminant exposure and emergence of cardio-vascular diseases in Inuit","author":"Dewailly","year":"2009"},{"key":"10.1016\/j.tox.2013.01.018_bib0040","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1160\/TH08-08-0524","article-title":"The \u2018PAI-1 paradox\u2019 in vascular remodeling","volume":"100","author":"Diebold","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tox.2013.01.018_bib0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00202203","article-title":"Increase in number of Weibel\u2013Palade bodies and endothelin-1 release from endothelial cells in the cadmium-treated rat thoracic aorta","volume":"428","author":"Doi","year":"1996","journal-title":"Virchows Arch."},{"key":"10.1016\/j.tox.2013.01.018_bib0050","first-page":"179","article-title":"Induction of oxidative stress and apoptosis by pentachlorophenol in primary cultures of Carassius carassius hepatocytes","volume":"150","author":"Dong","year":"2009","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2013.01.018_bib0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1476-069X-5-29","article-title":"A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon","volume":"5","author":"Fillion","year":"2006","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2013.01.018_bib0060","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","article-title":"Nitric oxide and oxidative stress in vascular disease","volume":"459","author":"Forstermann","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.tox.2013.01.018_bib0065","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.2527\/jas.2007-0826","article-title":"Board-invited review: peptide absorption and utilization: implications for animal nutrition and health","volume":"86","author":"Gilbert","year":"2008","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.tox.2013.01.018_bib0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.envres.2007.10.006","article-title":"High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population","volume":"106","author":"Goncharov","year":"2008","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2013.01.018_bib0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.thromres.2009.11.034","article-title":"Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment","volume":"125","author":"Gramling","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.tox.2013.01.018_bib0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0887-2333(03)00039-0","article-title":"Flow cytometric assessment of changes in rat sperm mitochondrial function after treatment with pentachlorophenol","volume":"17","author":"Gravance","year":"2003","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2013.01.018_bib0085","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0002-9440(10)64013-8","article-title":"Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake","volume":"158","author":"Groneberg","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2013.01.018_bib0090","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1289\/ehp.10184","article-title":"Association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence: results from the National Health and Nutrition Examination Survey, 1999\u20132002","volume":"115","author":"Ha","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2013.01.018_bib0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbrc.2006.10.038","article-title":"Effects of perfluorooctane sulfonate on action potentials and currents in cultured rat cerebellar Purkinje cells","volume":"351","author":"Harada","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2013.01.018_bib0100","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.aquatox.2006.07.002","article-title":"The marine secondary metabolites 2,4-dibromophenol and 2,4,6-tribromophenol differentially modulate voltage dependent ion currents in neuroendocrine (PC12) cells","volume":"79","author":"Hassenklover","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2013.01.018_bib0105","first-page":"77","article-title":"Alterations in cell membrane properties caused by perfluorinated compounds","volume":"135","author":"Hu","year":"2003","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2013.01.018_bib0110","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1253\/circj.CJ-10-0195","article-title":"Prostacyclin in vascular diseases \u2013 recent insights and future perspectives","volume":"74","author":"Kawabe","year":"2010","journal-title":"Circ. J."},{"key":"10.1016\/j.tox.2013.01.018_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(95)99370-R","article-title":"Effect of methylmercury (CH3HgCl) injury on nitric oxide synthase (NOS) activity in cultured human umbilical vascular endothelial cells","volume":"103","author":"Kishimoto","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2013.01.018_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00060.2009","article-title":"Regulation of blood pressure and salt homeostasis by endothelin","volume":"91","author":"Kohan","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2013.01.018_bib0125","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1001\/jama.1981.03310490023017","article-title":"Association of blood pressure and polychlorinated biphenyl levels","volume":"245","author":"Kreiss","year":"1981","journal-title":"JAMA"},{"key":"10.1016\/j.tox.2013.01.018_bib0130","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1039\/b314085g","article-title":"A pilot study on the determination of perfluorooctanesulfonate and other perfluorinated compounds in blood of Canadians","volume":"6","author":"Kubwabo","year":"2004","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.tox.2013.01.018_bib0135","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1182\/blood.V64.3.679.679","article-title":"Ethanol raises prostacyclin in vivo and in vitro","volume":"64","author":"Landolfi","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.tox.2013.01.018_bib0140","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1160\/TH08-05-0294","article-title":"Transcriptional regulation of the plasminogen activator inhibitor type 1\u2014with an emphasis on negative regulation","volume":"100","author":"Nagamine","year":"2008","journal-title":"Thromb. Haemost."},{"issue":"Pt 1","key":"10.1016\/j.tox.2013.01.018_bib0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1996.sp021192","article-title":"Effect of pentachlorophenol on calcium accumulation in barnacle muscle cells","volume":"491","author":"Nwoga","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.tox.2013.01.018_bib0150","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/toxsci\/kfh244","article-title":"Mitochondrial permeability transition as the critical target of N-acetyl perfluorooctane sulfonamide toxicity in vitro","volume":"82","author":"O\u2019Brien","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.01.018_bib0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01305903","article-title":"The effect of methylmercury (CH3HgCl) on the production of endothelium-derived relaxing factor (EDRF) by cultured human umbilical vascular endothelial cells based on its anti-aggregatory effect on human platelets","volume":"11","author":"Ohno","year":"1995","journal-title":"Cell Biol. Toxicol."},{"issue":"Suppl. 2","key":"10.1016\/j.tox.2013.01.018_bib0160","first-page":"S59L S67","article-title":"Initial response of endothelial cells to acute stimulation with a lipid component: increase cyclooxygenase activity by induction of COX-2 through activation of tyrosine kinase","volume":"93","author":"Plasen","year":"2010","journal-title":"J. Med. Assoc. Thai."},{"key":"10.1016\/j.tox.2013.01.018_bib0165","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/15287391003689317","article-title":"Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability","volume":"73","author":"Qian","year":"2010","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tox.2013.01.018_bib0170","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.phrs.2011.01.014","article-title":"Role of endothelin in the cardiovascular system","volume":"63","author":"Rodriguez-Pascual","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tox.2013.01.018_bib0230","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3835(98)00082-2","article-title":"Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro","volume":"130","author":"Sai","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tox.2013.01.018_bib0175","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1289\/ehp.7595","article-title":"Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants","volume":"113","author":"Sergeev","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2013.01.018_bib0180","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.ATV.0000019734.89917.35","article-title":"Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro","volume":"22","author":"Smith","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tox.2013.01.018_bib0185","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00001648-199907000-00006","article-title":"Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age","volume":"10","author":"Sorensen","year":"1999","journal-title":"Epidemiology"},{"key":"10.1016\/j.tox.2013.01.018_bib0190","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/66.2.244","article-title":"Structural determinants of fluorochemical-induced mitochondrial dysfunction","volume":"66","author":"Starkov","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.01.018_bib0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.envres.2004.07.016","article-title":"A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment","volume":"98","author":"Stern","year":"2005","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2013.01.018_bib0200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1096\/fj.10-161612","article-title":"Endothelin-1 gene regulation","volume":"25","author":"Stow","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2013.01.018_bib0205","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00424-009-0763-y","article-title":"Endothelium-derived endothelin-1","volume":"459","author":"Thorin","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.tox.2013.01.018_bib0210","first-page":"1057","article-title":"Orthostatic hypotension and supine hypertension in primary autonomic failure. Pathophysiology diagnosis and treatment","volume":"68","author":"Tykocki","year":"2010","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.tox.2013.01.018_bib0215","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1476-069X-7-29","article-title":"Cardiac autonomic activity and blood pressure among Nunavik Inuit adults exposed to environmental mercury: a cross-sectional study","volume":"7","author":"Valera","year":"2008","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2013.01.018_bib0220","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2011.05.128","article-title":"Perfluorooctane sulfonate triggers tight junction opening in brain endothelial cells via phosphatidylinositol 3-kinase","volume":"410","author":"Wang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2013.01.018_bib0225","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0021-9258(18)97510-1","article-title":"The interaction of uncoupling phenols with mitochondria and with mitochondrial protein","volume":"240","author":"Weinbach","year":"1965","journal-title":"J. Biol. Chem."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X13000231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X13000231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:26:10Z","timestamp":1759533970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X13000231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":46,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0300483X13000231"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2013.01.018","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Northern contaminant mixtures induced morphological and functional changes in human coronary artery endothelial cells under culture conditions typifying high fat\/sugar diet and ethanol exposure","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2013.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2013 Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}