{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:56:37Z","timestamp":1789376197772,"version":"build-2803163510"},"reference-count":93,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.tox.2013.08.002","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T22:42:05Z","timestamp":1376088125000},"page":"83-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Role of drug-independent stress factors in liver injury associated with diclofenac intake"],"prefix":"10.1016","volume":"312","author":[{"given":"Susanne","family":"Ramm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2013.08.002_bib0005","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cld.2007.06.004","article-title":"Nonsteroidal anti-inflammatory drug-induced hepatotoxicity","volume":"11","author":"Aithal","year":"2007","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.tox.2013.08.002_bib0010","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hep.20205","article-title":"Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity","volume":"39","author":"Aithal","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2013.08.002_bib0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.192.4.565","article-title":"High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes","volume":"192","author":"Andersson","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2013.08.002_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12192-009-0154-5","article-title":"Neutrophil gelatinase-associated lipocalin induces the expression of heme oxygenase-1 and superoxide dismutase 1, 2","volume":"15","author":"Bahmani","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.tox.2013.08.002_bib0025","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/gut.47.6.838","article-title":"Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury","volume":"47","author":"Bhatia","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.tox.2013.08.002_bib0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.dld.2005.06.004","article-title":"Suspected drug-induced liver fatalities reported to the WHO database","volume":"38","author":"Bjornsson","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.tox.2013.08.002_bib0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0041-008X(03)00368-5","article-title":"Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity","volume":"192","author":"Boelsterli","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0040","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/dmd.30.4.404","article-title":"Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin","volume":"30","author":"Bolze","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/00498250802517714","article-title":"Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains","volume":"39","author":"Bruyere","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tox.2013.08.002_bib0050","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1096\/fj.02-0757fje","article-title":"CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury","volume":"17","author":"Campbell","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2013.08.002_bib0055","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00441-007-0494-3","article-title":"Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10","volume":"330","author":"Cassio","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tox.2013.08.002_bib0060","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.0903816","article-title":"Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production","volume":"184","author":"Chan","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2013.08.002_bib0065","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1126\/science.1168988","article-title":"CD24 and Siglec-10 selectively repress tissue damage-induced immune responses","volume":"323","author":"Chen","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tox.2013.08.002_bib0070","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/hep.22585","article-title":"Effect of polyI:C cotreatment on halothane-induced liver injury in mice","volume":"49","author":"Cheng","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2013.08.002_bib0075","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.510230315","article-title":"The role of cytokine networks in the local liver injury following hepatic ischemia\/reperfusion in the rat","volume":"23","author":"Colletti","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2013.08.002_bib0080","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1074\/jbc.271.7.3355","article-title":"Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation","volume":"271","author":"Cotto","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2013.08.002_bib0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.gastro.2006.11.023","article-title":"Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes","volume":"132","author":"Daly","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2013.08.002_bib0090","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/hep.510240542","article-title":"Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes","volume":"24","author":"de Vera","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2013.08.002_bib0095","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1124\/pr.109.001727","article-title":"Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models","volume":"61","author":"Deng","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2013.08.002_bib0100","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1124\/jpet.106.110247","article-title":"Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation","volume":"319","author":"Deng","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1515\/BC.2004.029","article-title":"Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS","volume":"385","author":"Donner","year":"2004","journal-title":"Biol. Chem."},{"key":"10.1016\/j.tox.2013.08.002_bib0110","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/hep.24314","article-title":"Diclofenac inhibits tumor necrosis factor-alpha-induced nuclear factor-kappaB activation causing synergistic hepatocyte apoptosis","volume":"53","author":"Fredriksson","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2013.08.002_bib0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbi.2004.09.002","article-title":"Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor","volume":"150","author":"Ganey","year":"2004","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2013.08.002_bib0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/clpt.1985.136","article-title":"Nonsteroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa","volume":"38","author":"Graham","year":"1985","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0125","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1021\/tx034038b","article-title":"Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes","volume":"16","author":"Grillo","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0130","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.embor.7400759","article-title":"Alarmin(g) news about danger: workshop on innate danger signals and HMGB1","volume":"7","author":"Harris","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tox.2013.08.002_bib0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-4347(00)00041-4","article-title":"Gemfibrozil and its oxidative metabolites: quantification of aglycones, acyl glucuronides, and covalent adducts in samples from preclinical and clinical kinetic studies","volume":"741","author":"Hermening","year":"2000","journal-title":"J. Chromatogr. B: Biomed. Sci. Appl."},{"key":"10.1016\/j.tox.2013.08.002_bib0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2010.08.013","article-title":"Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity","volume":"277","author":"Hoffmann","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2013.08.002_bib0145","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/gut.34.6.742","article-title":"Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs","volume":"34","author":"Hudson","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.tox.2013.08.002_bib0150","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1546322","article-title":"Effect of sodium salicylate on the human heat shock response","volume":"255","author":"Jurivich","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.tox.2013.08.002_bib0155","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd1750","article-title":"Idiosyncratic drug hepatotoxicity","volume":"4","author":"Kaplowitz","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tox.2013.08.002_bib0160","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2131\/jts.37.1143","article-title":"Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity","volume":"37","author":"Kishida","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.08.002_bib0165","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/j.1552-4604.1997.tb04311.x","article-title":"Cyclosporine and nonsteroidal antiinflammatory drugs: exploring potential drug interactions and their implications for the treatment of rheumatoid arthritis","volume":"37","author":"Kovarik","year":"1997","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0170","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0090-9556(25)08441-7","article-title":"Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct","volume":"22","author":"Kretz-Rommel","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0175","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.102.038992","article-title":"Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide","volume":"303","author":"Kumar","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0180","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0006-291X(86)91224-6","article-title":"Regulation of macrophage tumor necrosis factor production by prostaglandin E2","volume":"137","author":"Kunkel","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2013.08.002_bib0185","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1124\/mol.109.062364","article-title":"Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters","volume":"77","author":"Lagas","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0009-2797(02)00051-0","article-title":"A review of the common properties of drugs with idiosyncratic hepatotoxicity and the \u201cmultiple determinant hypothesis\u201d for the manifestation of idiosyncratic drug toxicity","volume":"142","author":"Li","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2013.08.002_bib0195","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/978-3-642-00663-0_18","article-title":"The danger hypothesis applied to idiosyncratic drug reactions","author":"Li","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0200","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2013.08.002_bib0205","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1124\/jpet.105.087981","article-title":"Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine","volume":"314","author":"Luyendyk","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0210","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/rcm.2697","article-title":"Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography\/electrospray tandem mass spectrometry","volume":"20","author":"Masoodi","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.tox.2013.08.002_bib0215","first-page":"1190","article-title":"Mechanism-based inactivation of CYP2C11 by diclofenac","volume":"29","author":"Masubuchi","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0220","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tox.2013.08.002_bib0225","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tox.2013.08.002_bib0230","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1021\/tx960190k","article-title":"Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid","volume":"10","author":"Miyamoto","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0235","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/clpt.2008.302","article-title":"Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics","volume":"85","author":"Morgan","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0240","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.toxlet.2009.05.016","article-title":"Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat","volume":"189","author":"Morita","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2013.08.002_bib0245","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI6899","article-title":"Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2","volume":"105","author":"Morteau","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2013.08.002_bib0250","doi-asserted-by":"crossref","first-page":"17315","DOI":"10.1073\/pnas.1008209107","article-title":"PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury","volume":"107","author":"North","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2013.08.002_bib0255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/toxsci\/kfl180","article-title":"Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities","volume":"97","author":"Ong","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.08.002_bib0260","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1124\/dmd.110.034470","article-title":"Impact of polyinosinic\/polycytidylic acid on placental and hepatobiliary drug transporters in pregnant rats","volume":"38","author":"Petrovic","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0265","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003088-199631030-00005","article-title":"Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism","volume":"31","author":"Pirmohamed","year":"1996","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.tox.2013.08.002_bib0270","first-page":"1608","article-title":"Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans","volume":"29","author":"Poon","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0163-7258(93)90067-N","article-title":"Liver cytoprotection by prostaglandins","volume":"58","author":"Quiroga","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0280","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/tx0155505","article-title":"A protective role for cyclooxygenase-2 in drug-induced liver injury in mice","volume":"14","author":"Reilly","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0285","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2008.75","article-title":"Neutral red uptake assay for the estimation of cell viability\/cytotoxicity","volume":"3","author":"Repetto","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2013.08.002_bib0290","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1172\/JCI119013","article-title":"Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2","volume":"98","author":"Reuter","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2013.08.002_bib0295","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1073\/pnas.94.2.746","article-title":"Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation","volume":"94","author":"Rossi","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2013.08.002_bib0300","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s004240100718","article-title":"Influence of systemic treatment with cyclooxygenase inhibitors on lipopolysaccharide-induced fever and circulating levels of cytokines and cortisol in guinea-pigs","volume":"443","author":"Roth","year":"2002","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.tox.2013.08.002_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.041624","article-title":"Inflammation and drug idiosyncrasy\u2014is there a connection?","volume":"307","author":"Roth","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0310","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0300-483X(01)00385-7","article-title":"Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1\/Th2 paradigm","volume":"163","author":"Sayeh","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2013.08.002_bib0315","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tox.2013.08.002_bib0320","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.139.12.6366","article-title":"Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets","volume":"139","author":"Scarim","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2013.08.002_bib0325","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1172\/JCI2465","volume":"102","author":"Schett","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2013.08.002_bib0330","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1021\/tx050040m","article-title":"Gene expression profiling in a model of d-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger","volume":"18","author":"Seguin","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0335","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1021\/tx970203+","article-title":"Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)","volume":"11","author":"Seitz","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0340","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri1372","article-title":"Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses","volume":"4","author":"Seong","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2013.08.002_bib0345","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1124\/jpet.102.047977","article-title":"Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway","volume":"305","author":"Serrano","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2013.08.002_bib0350","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.taap.2009.01.018","article-title":"The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability","volume":"236","author":"Shaw","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0355","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1172\/JCI117582","article-title":"Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism","volume":"94","author":"Shedlofsky","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2013.08.002_bib0360","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/tx9802365","article-title":"Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac","volume":"12","author":"Shen","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0365","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tox.2013.08.002_bib0370","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/toxsci\/kfp070","article-title":"Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity","volume":"109","author":"Sieber","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.08.002_bib0375","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2337\/diab.43.4.518","article-title":"Poly I:C induction of alpha-interferon in the diabetes-prone BB and normal Wistar rats. Dose\u2013response relationships","volume":"43","author":"Sobel","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2013.08.002_bib0380","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jchromb.2008.07.012","article-title":"Liquid chromatography\u2013tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma","volume":"872","author":"Sparidans","year":"2008","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tox.2013.08.002_bib0385","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2007.11.091","article-title":"Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I","volume":"366","author":"Stafford","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2013.08.002_bib0390","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1600-0773.1991.tb01272.x","article-title":"Possible role of glutathione in chromium(VI) metabolism and toxicity in rats","volume":"68","author":"Standeven","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0395","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/00498257909042328","article-title":"Biotransformation of diclofenac sodium (Voltaren) in animals and in man. II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile","volume":"9","author":"Stierlin","year":"1979","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tox.2013.08.002_bib0400","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-10-43","article-title":"Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice","volume":"10","author":"Stowell","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.tox.2013.08.002_bib0405","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/(SICI)1097-4652(199606)167:3<477::AID-JCP12>3.0.CO;2-1","article-title":"Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation","volume":"167","author":"Sultana","year":"1996","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tox.2013.08.002_bib0410","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0041-008X(89)90182-8","article-title":"Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats","volume":"98","author":"Suzuki","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0415","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1081\/DMR-55227","article-title":"Oxidative stress mediated idiosyncratic drug toxicity","volume":"37","author":"Tafazoli","year":"2005","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.tox.2013.08.002_bib0420","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0090-9556(24)14912-4","article-title":"Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites","volume":"27","author":"Tang","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2013.08.002_bib0425","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/tx9802217","article-title":"Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac","volume":"12","author":"Tang","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0430","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/tx700186p","article-title":"Idiosyncratic drug reactions: past, present, and future","volume":"21","author":"Uetrecht","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2013.08.002_bib0435","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.med.58.072905.160823","article-title":"Idiosyncratic toxicity: a convergence of risk factors","volume":"58","author":"Ulrich","year":"2007","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.tox.2013.08.002_bib0440","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/art.1780400204","article-title":"Quantitative studies of the risk of serious hepatic injury in persons using nonsteroidal antiinflammatory drugs","volume":"40","author":"Walker","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tox.2013.08.002_bib0445","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-2999(97)89179-0","article-title":"Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors","volume":"329","author":"Yamazaki","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tox.2013.08.002_bib0450","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbagrm.2009.11.002","article-title":"The alarmin functions of high-mobility group proteins","volume":"1799","author":"Yang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2013.08.002_bib0455","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1210\/me.2007-0420","article-title":"The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages","volume":"22","author":"Zhang","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tox.2013.08.002_bib0460","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/toxsci\/kfn259","article-title":"Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system","volume":"108","author":"Zou","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2013.08.002_bib0465","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/0006-2952(90)90359-S","article-title":"Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase","volume":"40","author":"Zuurbier","year":"1990","journal-title":"Biochem. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.tox.2013.12.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000}}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X13002126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X13002126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T13:47:44Z","timestamp":1746020864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X13002126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":93,"alternative-id":["S0300483X13002126"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2013.08.002","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of drug-independent stress factors in liver injury associated with diclofenac intake","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2013.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}