{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:56:10Z","timestamp":1790430970973,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.tox.2014.04.006","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:15:49Z","timestamp":1398298549000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Effects of tamoxifen on the sex determination gene and the activation of sex reversal in the developing gonad of mice"],"prefix":"10.1016","volume":"321","author":[{"given":"Mingxi","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2014.04.006_bib0005","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0015-0282(03)01123-3","article-title":"Effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in men with idiopathic oligozoospermia","volume":"80","author":"Adamopoulos","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2014.04.006_bib0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.scitotenv.2004.04.062","article-title":"Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom","volume":"333","author":"Ashton","year":"2004","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.tox.2014.04.006_bib0015","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1101\/gad.1052503","article-title":"Pdgfr-\u03b1 mediates testis cord organization and fetal Leydig cell development in the XY gonad","volume":"17","author":"Brennan","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.tox.2014.04.006_bib0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/toxsci\/kft035","article-title":"Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala","volume":"133","author":"Cao","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2014.04.006_bib0025","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/jez.b.21291","article-title":"SOX9 is not required for the cellular events of testicular organogenesis in XX mole ovotestes","volume":"12B","author":"Carmona","year":"2009","journal-title":"J. Exp. Zool. B: Mol. Dev. Evol."},{"key":"10.1016\/j.tox.2014.04.006_bib0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.envint.2009.01.008","article-title":"Discharge of pharmaceutical products (PPs) through a conventional biological sewage treatment plant: MECs vs PECs?","volume":"35","author":"Coetsier","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2014.04.006_bib0035","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0092-8674(01)00284-7","article-title":"Male-to-female sex reversal in mice lacking fibroblast growth factor 9","volume":"104","author":"Colvin","year":"2001","journal-title":"Cell"},{"issue":"1323\u20131326","key":"10.1016\/j.tox.2014.04.006_bib0040","first-page":"S1","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"24","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tox.2014.04.006_bib0045","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.envint.2006.12.002","article-title":"Assessment of environmental estrogens and the intersex\/sex reversal capacity for chinook salmon (Oncorhynchus tshawytscha) in primary and final municipal wastewater effluents","volume":"33","author":"Fernandez","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2014.04.006_bib0050","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study","volume":"90","author":"Fisher","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tox.2014.04.006_bib0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1677\/joe.0.0700421","article-title":"Effect of the anti-oestrogen tamoxifen on plasma levels of luteinizing hormone, follicle-stimulating hormone, prolactin, oestradiol and progesterone in normal pre-menopausal women","volume":"70","author":"Groom","year":"1976","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2014.04.006_bib0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfn030","article-title":"Fifteen years after \u201cWingspread\u201d \u2013 environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go","volume":"105","author":"Hotchkiss","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2014.04.006_bib0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tox.2008.10.001","article-title":"Tamoxifen-induced [Ca2+]i rise and apoptosis in corneal epithelial cells","volume":"255","author":"Huang","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2014.04.006_bib0070","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0039-128X(75)90058-6","article-title":"Biological activity of some steroidal compounds in the adult and larval frogs","volume":"26","author":"Iela","year":"1975","journal-title":"Steroids"},{"key":"10.1016\/j.tox.2014.04.006_bib0075","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1242\/dev.00591","article-title":"Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad","volume":"130","author":"Jeays-Ward","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.tox.2014.04.006_bib0080","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1021\/es400329t","article-title":"Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish","volume":"47","author":"Ji","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2014.04.006_bib0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2013.07.014","article-title":"Evaluation of the genotoxicity of tamoxifen in the liver and kidney of F344 gpt delta transgenic rat in 3-week and 13-week repeated dose studies","volume":"312","author":"Kawamura","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2014.04.006_bib0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.breast.2003.10.005","article-title":"Management of physiological gynaecomastia with tamoxifen","volume":"13","author":"Khan","year":"2004","journal-title":"Breast."},{"key":"10.1016\/j.tox.2014.04.006_bib0095","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1371\/journal.pbio.0040187","article-title":"Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination","volume":"4","author":"Kim","year":"2006","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.tox.2014.04.006_bib0100","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1210\/en.2009-0313","article-title":"Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-\u03b1","volume":"150","author":"Kim","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2014.04.006_bib0105","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.biochi.2006.09.022","article-title":"A new method for toxicity assays on human and mouse fetal testis","volume":"88","author":"Lambrot","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.tox.2014.04.006_bib0110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01958155","article-title":"Tamoxifen \u2018sex reverses\u2019 alligator embryos at male producing temperature, but is an antiestrogen in female hatchlings","volume":"47","author":"Lance","year":"1991","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tox.2014.04.006_bib0115","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/es802661p","article-title":"Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol","volume":"43","author":"Lange","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2014.04.006_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0200001","article-title":"Origin, proliferation and differentiation of Leydig cells","volume":"20","author":"Lejeune","year":"1998","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tox.2014.04.006_bib0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real\u2013time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livaka","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tox.2014.04.006_bib0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2011.11.006","article-title":"Disruption of endocrine function in in vitro H295R cell\u2013based and in in vivo assay in zebrafish by 2,4-dichlorophenol","volume":"106\u2013107","author":"Ma","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2014.04.006_bib0135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1056\/NEJMra022784","article-title":"Sex determination and differentiation","volume":"350","author":"MacLaughlin","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2014.04.006_bib0140","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jemt.1060190205","article-title":"Sertoli cells and testicular differentiation in the rat fetus","volume":"19","author":"Magre","year":"1991","journal-title":"J. Electron. Microsc. Tech."},{"key":"10.1016\/j.tox.2014.04.006_bib0145","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0996-62","article-title":"Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds","volume":"14","author":"Morais da Silva","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tox.2014.04.006_bib0150","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1677\/jme.1.01947","article-title":"FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development","volume":"36","author":"Pannetier","year":"2006","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tox.2014.04.006_bib0155","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1741-7007-8-113","article-title":"Oestrogen blocks the nuclear entry of SOX9 in the developing gonad of a marsupial mammal","volume":"8","author":"Pask","year":"2010","journal-title":"BMC Biol."},{"key":"10.1016\/j.tox.2014.04.006_bib0160","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.scitotenv.2005.04.031","article-title":"The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment","volume":"356","author":"Roberts","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2014.04.006_bib0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0168-9525(93)90162-B","article-title":"Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions","volume":"9","author":"Rosen","year":"1993","journal-title":"Trends Genet."},{"key":"10.1016\/j.tox.2014.04.006_bib0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/mrd.20208","article-title":"Expression of Sox8, Sf1, Gata4, Wt1, Dax1, and Fog2 in the mouse ovarian follicle: implications for the regulation of Amh expression","volume":"70","author":"Salmon","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.tox.2014.04.006_bib0175","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","article-title":"Endocrine disrupting chemicals and disease susceptibility","volume":"127","author":"Schug","year":"2011","journal-title":"J. Steroid Bichem."},{"key":"10.1016\/j.tox.2014.04.006_bib0180","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.thromres.2011.08.010","article-title":"Tamoxifen promotes superoxide production in platelets by activation of PI3-kinase and NADPH oxidase pathways","volume":"129","author":"Shah","year":"2012","journal-title":"Thromb. Res."},{"key":"10.1016\/j.tox.2014.04.006_bib0185","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ygcen.2012.08.027","article-title":"Introduction of modern endocrine techniques for the production of monosex population of fishes","volume":"181","author":"Singh","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.tox.2014.04.006_bib0190","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/267434a0","article-title":"Tamoxifen is a potent \u2018pure\u2019 anti-oestrogen in chick oviduct","volume":"267","author":"Sutherland","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.tox.2014.04.006_bib0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ymgme.2006.03.005","article-title":"Foxl2 function in ovarian development","volume":"88","author":"Uhlenhaut","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.tox.2014.04.006_bib0200","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2009.11.021","article-title":"Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation","volume":"139","author":"Uhlenhaut","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.tox.2014.04.006_bib0205","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/etc.1892","article-title":"Development of a molecular biomarker for detecting intersex after exposure of male medaka fish to synthetic estrogen","volume":"31","author":"Zhao","year":"2012","journal-title":"Environ. Toxicol. Chem."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X14000833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X14000833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:28:43Z","timestamp":1759534123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X14000833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":41,"alternative-id":["S0300483X14000833"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2014.04.006","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of tamoxifen on the sex determination gene and the activation of sex reversal in the developing gonad of mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2014.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}