{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:35:57Z","timestamp":1790105757921,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.tox.2015.03.005","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T13:37:00Z","timestamp":1426167420000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury"],"prefix":"10.1016","volume":"331","author":[{"given":"M.","family":"V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-0208","authenticated-orcid":false,"given":"V.","family":"Devesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2015.03.005_bib0005","doi-asserted-by":"crossref","first-page":"C1525","DOI":"10.1152\/ajpcell.00480.2002","article-title":"DMT1: a physiologically relevant apical Cu1+ transporter of intestinal cells","volume":"284","author":"Arredondo","year":"2003","journal-title":"Am. J. Physiol. \u2013 Cell Physiol."},{"key":"10.1016\/j.tox.2015.03.005_bib0010","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0006-291X(02)00756-8","article-title":"Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells","volume":"295","author":"Bannon","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2015.03.005_bib0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1196\/annals.1306.011","article-title":"Divalent metal transporter 1 in lead and cadmium transport","volume":"1012","author":"Bressler","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2015.03.005_bib0020","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/j.gastro.2010.12.037","article-title":"Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation","volume":"140","author":"Brasse-Lagnel","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2015.03.005_bib0025","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0002-9440(10)63396-2","article-title":"Homocysteine system b0,+ and the renal epithelial transport and toxicity of inorganic mercury","volume":"165","author":"Bridges","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2015.03.005_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.ASN.0000113553.62380.F5","article-title":"Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry","volume":"15","author":"Bridges","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tox.2015.03.005_bib0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.taap.2007.03.004","article-title":"Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells","volume":"221","author":"Bridges","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2015.03.005_bib0040","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1182\/blood.V93.12.4406","article-title":"Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron","volume":"93","author":"Canonne-Hergaux","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.tox.2015.03.005_bib0045","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2015.03.005_bib0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"2005","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.tox.2015.03.005_bib0055","doi-asserted-by":"crossref","unstructured":"EFSA, European Food Safety Authority 2012. Scientific opinion on the risk for public health related to the presence of mercury and methylmercury in food, EFSA J., 10(12), 2985.","DOI":"10.2903\/j.efsa.2012.2985"},{"key":"10.1016\/j.tox.2015.03.005_bib0060","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/02652030400004259","article-title":"Methylmercury levels in predatory fish species marketed in Canada","volume":"21","author":"Forsyth","year":"2004","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.tox.2015.03.005_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0076-6879(02)50957-5","article-title":"Transformation of yeast by lithium acetate\/single-stranded carrier DNA\/polyethylene glycol method","volume":"350","author":"Gietz","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tox.2015.03.005_bib0070","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton\u2013coupled metal-ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.tox.2015.03.005_bib0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jtemb.2007.12.001","article-title":"Gastrointestinal uptake of trace elements are changed during the course of a common human viral (Coxsackievirus B3) infection in mice","volume":"22","author":"Ilback","year":"2008","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tox.2015.03.005_bib0080","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives), 2011. Safety evaluation of certain contaminants in food. WHO Food Additives Series No. 63. (http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241660631_eng.pdf)."},{"key":"10.1016\/j.tox.2015.03.005_bib0085","doi-asserted-by":"crossref","first-page":"G192","DOI":"10.1152\/ajpgi.00122.2007","article-title":"Hepcidin inhibits apical iron uptake in intestinal cells","volume":"294","author":"Mena","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2015.03.005_bib0090","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-1119(95)00037-7","article-title":"Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds","volume":"156","author":"Mumberg","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.tox.2015.03.005_bib0095","series-title":"Toxicological Effects of Methylmercury","first-page":"147","article-title":"Board on environmental studies and toxicology","author":"National Research Council Commission on Life Sciences","year":"2000"},{"key":"10.1016\/j.tox.2015.03.005_bib0100","unstructured":"NTP (National Toxicology Program) (1993) Toxicology and carcinogenesis studies of mercuric chloride (CAS No. 7487\u201394\u20137) in F344\/N rats and B6C3F1 mice (gavage studies) (as modified based on peer review), NTP TR 408, NIH publication no. 91\u20133139, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC."},{"key":"10.1016\/j.tox.2015.03.005_bib0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0041-008X(02)00078-9","article-title":"Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes","volume":"187","author":"Okubo","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2015.03.005_bib0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijpharm.2009.08.044","article-title":"Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol","volume":"383","author":"Siissalo","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.tox.2015.03.005_bib0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tiv.2014.09.013","article-title":"Characterization of the intestinal absorption of inorganic mercury in Caco-2 cells","volume":"29","author":"V\u00e1zquez","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2015.03.005_bib0120","doi-asserted-by":"crossref","DOI":"10.1039\/C4TX00205A","article-title":"Participation of b0,+ and B0,+ systems in the intestinal transport of inorganic mercury and methylmercury","author":"V\u00e1zquez","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tox.2015.03.005_bib0125","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2004-03-0829","article-title":"Inhibition of iron transport across human intestinal epithelial cells by hepcidin","volume":"104","author":"Yamaji","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.tox.2015.03.005_bib0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0031-6997(24)01438-8","article-title":"Molecular interactions with mercury in the kidney","volume":"52","author":"Zalups","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2015.03.005_bib0135","series-title":"Cellular and Molecular Biology of Metals","first-page":"127","article-title":"Essential and toxic metal transport in the liver","author":"Zalups","year":"2010"},{"key":"10.1016\/j.tox.2015.03.005_bib0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-12-394390-3.00003-3","article-title":"Iron transport machinery of human cells: players and their interactions","volume":"69","author":"Zhao","year":"2012","journal-title":"Curr. Top Membr."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X15000566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X15000566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:29:50Z","timestamp":1759534190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X15000566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":28,"alternative-id":["S0300483X15000566"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2015.03.005","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2015.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}