{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:21:03Z","timestamp":1792290063468,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.tox.2016.08.014","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T20:13:19Z","timestamp":1473365599000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat"],"prefix":"10.1016","volume":"368-369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-0100","authenticated-orcid":false,"given":"Audrey","family":"Legendre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Elie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Ramambason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Manens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamar","family":"Souidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Froment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Tack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2016.08.014_bib0005","series-title":"(Agency for Toxic Substances and Diseases Registry) Toxicological Profile for Uranium (an Update)","author":"ATSDR","year":"1999"},{"key":"10.1016\/j.tox.2016.08.014_bib0010","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.reprotox.2010.12.058","article-title":"In vitro effects of Uranium on human fetal germ cells","volume":"31","author":"Angenard","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2016.08.014_bib0015","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.fertnstert.2007.12.035","article-title":"Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model","volume":"89","author":"Benoff","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2016.08.014_bib0020","first-page":"258","article-title":"Uranium levels in the fetus and placenta of female rats implanted with depleted uranium pellets prior to breeding","volume":"36","author":"Benson","year":"1997","journal-title":"Toxicologist"},{"key":"10.1016\/j.tox.2016.08.014_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF02783169","article-title":"Embryotoxicity and teratogenicity of uranium in mice following subcutaneous administration of uranyl acetate","volume":"36","author":"Bosque","year":"1993","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2016.08.014_bib0030","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1048291115610344","article-title":"Why has it taken so long to address the problems created by uranium mining in the navajo nation?","volume":"25","author":"Brugge","year":"2016","journal-title":"New Solutions"},{"key":"10.1016\/j.tox.2016.08.014_bib0035","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuro.2005.11.003","article-title":"Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain","volume":"27","author":"Bussy","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2016.08.014_bib0040","first-page":"315","article-title":"Male reprotoxicity and endocrine disruption","volume":"101","author":"Campion","year":"2012","journal-title":"EXS"},{"key":"10.1016\/j.tox.2016.08.014_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2478\/v10039-008-0022-z","article-title":"Aromatase and estrogens in man reproduction: a review and latest advances","volume":"53","author":"Carreau","year":"2008","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.tox.2016.08.014_bib0050","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0891-5849(00)00302-6","article-title":"Triggering and modulation of apoptosis by oxidative stress","volume":"29","author":"Chandra","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2016.08.014_bib0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/spmg.1.1.13971","article-title":"Environmental toxicants and male reproductive function","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.tox.2016.08.014_bib0060","first-page":"451","article-title":"The stages of the cycle of the seminiferous epithelium of the rat: practical definitions in PA-Schiff-hematoxylin and hematoxylin-eosin stained sections","volume":"16","author":"Clermont","year":"1957","journal-title":"Rev. Can. Biol."},{"key":"10.1016\/j.tox.2016.08.014_bib0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tox.2015.08.004","article-title":"The neurotoxicology of uranium","volume":"337","author":"Dinocourt","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2016.08.014_bib0070","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1210\/endo.143.5.8815","article-title":"Reproductive abnormalities in human IGF binding protein-1 transgenic female mice","volume":"143","author":"Froment","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2016.08.014_bib0075","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1517\/14728222.2015.1039513","article-title":"Sertoli cells are the target of environmental toxicants in the testis \u2013 a mechanistic and therapeutic insight","volume":"19","author":"Gao","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.tox.2016.08.014_bib0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/10915810802367057","article-title":"Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat","volume":"27","author":"Grignard","year":"2008","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.tox.2016.08.014_bib0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1269\/jrr.11192","article-title":"The reproductive effects in rats after chronic oral exposure to low-dose depleted uranium","volume":"53","author":"Hao","year":"2012","journal-title":"J. Radiat. Res. (Tokyo)"},{"key":"10.1016\/j.tox.2016.08.014_bib0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0739-7240(90)90055-5","article-title":"Comparisons of endocrinological and testis parameters in 18-month-old Ile de France and Romanov rams","volume":"7","author":"Hochereau-de Reviers","year":"1990","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.tox.2016.08.014_bib0095","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuro.2005.05.005","article-title":"Enriched but not depleted uranium affects central nervous system in long-term exposed rat","volume":"26","author":"Houpert","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2016.08.014_bib0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2011.05.233","article-title":"Effects of maternal cadmium exposure during late pregnant period on testicular steroidogenesis in male offspring","volume":"205","author":"Ji","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2016.08.014_bib0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/toxics2010050","article-title":"The chemistry and toxicology of depleted uranium","volume":"2","author":"Katz","year":"2013","journal-title":"Toxics"},{"key":"10.1016\/j.tox.2016.08.014_bib0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1385\/BTER:75:1-3:235","article-title":"Effects of uranium poisoning on cultured preimplantation embryos","volume":"75","author":"Kundt","year":"2000","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2016.08.014_bib0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0946-672X(02)80053-0","article-title":"Oral cadmium exposure throughout puberty does not inhibit secretion of prolactin, GH and ACTH through dopamine metabolism changes in male rat","volume":"16","author":"Lafuente","year":"2002","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tox.2016.08.014_bib0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.fct.2013.06.024","article-title":"The hypothalamic-pituitary-gonadal axis is target of cadmium toxicity: an update of recent studies and potential therapeutic approaches","volume":"59","author":"Lafuente","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2016.08.014_bib0125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4067\/S0716-97602012000100001","article-title":"Contribution of environmental pollutants to male infertily: a working model of germ cell apoptosis induced by plasticizers","volume":"45","author":"Lagos-Cabre","year":"2012","journal-title":"Biol. Res."},{"key":"10.1016\/j.tox.2016.08.014_bib0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuro.2015.10.007","article-title":"Cell proliferation and cell death are disturbed during prenatal and postnatal brain development after uranium exposure","volume":"52","author":"Legrand","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2016.08.014_bib0135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.toxlet.2005.03.015","article-title":"Combined action of uranium and stress in the rat: II. Effects on male reproduction","volume":"158","author":"Linares","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2016.08.014_bib0140","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0272-0590(91)90167-3","article-title":"Influence of chronic exposure to uranium on male reproduction in mice","volume":"16","author":"Llobet","year":"1991","journal-title":"Fundament. Appl. Toxicol."},{"key":"10.1016\/j.tox.2016.08.014_bib0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-4274(98)80496-7","article-title":"Chronic alternate or daily cadmium exposure differentially affect its accumulation within the tissues. Effects of age","volume":"95","author":"M\u00e1rquez","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2016.08.014_bib0150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2605.2009.01005.x","article-title":"Androgen action in the masculinization programming window and development of male reproductive organs","volume":"33","author":"Macleod","year":"2009","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tox.2016.08.014_bib0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/toxsci\/kfh140","article-title":"2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules","volume":"80","author":"Markelewicz","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2016.08.014_bib0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/milmed\/167.suppl_1.117","article-title":"Health effects of embedded depleted uranium","volume":"167","author":"McClain","year":"2002","journal-title":"Mil. Med."},{"key":"10.1016\/j.tox.2016.08.014_bib0165","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.pbb.2005.01.008","article-title":"Dietary cadmium exposure attenuates D-amphetamine-evoked [3H]dopamine release from striatal slices and methamphetamine-induced hyperactivity","volume":"80","author":"Miller","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tox.2016.08.014_bib0170","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod.110.087452","article-title":"The blood-testis and blood-epididymis barriers are more than just their tight junctions","volume":"84","author":"Mital","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2016.08.014_bib0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00004032-197611000-00001","article-title":"Absorption, distribution and milk secretion of radionuclides by the dairy cow\u2013V. Radiotungsten","volume":"31","author":"Mullen","year":"1976","journal-title":"Health Phys."},{"key":"10.1016\/j.tox.2016.08.014_bib0180","first-page":"599","article-title":"The sex ratio in the offsprings of uranium miners","volume":"13","author":"Muller","year":"1967","journal-title":"Acta Univ. Carol. [Med.] (Praha)"},{"key":"10.1016\/j.tox.2016.08.014_bib0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.HP.0000174527.66111.83","article-title":"Accumulation and distribution of uranium in rats after chronic exposure by ingestion","volume":"90","author":"Paquet","year":"2006","journal-title":"Health Phys."},{"key":"10.1016\/j.tox.2016.08.014_bib0190","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0147-6513(89)90049-3","article-title":"The effects of uranium on reproduction, gestation, and postnatal survival in mice","volume":"17","author":"Paternain","year":"1989","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2016.08.014_bib0195","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1095\/biolreprod52.2.217","article-title":"Regulation of expression of steroidogenic enzymes in Leydig cells","volume":"52","author":"Payne","year":"1995","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2016.08.014_bib0200","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2016.08.014_bib0205","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3109\/10715762.2014.945441","article-title":"Chronic uranium exposure dose-dependently induces glutathione in rats without any nephrotoxicity","volume":"48","author":"Poisson","year":"2014","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.tox.2016.08.014_bib0210","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1289\/ehp.9910","article-title":"Drinking water with uranium below the U.S. EPA water standard causes estrogen receptor-dependent responses in female mice","volume":"115","author":"Raymond-Whish","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2016.08.014_bib0215","series-title":"Histological and Histopathological Evalution of the Testis","author":"Russel","year":"1990"},{"key":"10.1016\/j.tox.2016.08.014_bib0220","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00004032-199211000-00005","article-title":"Navajo birth outcomes in the Shiprock uranium mining area","volume":"63","author":"Shields","year":"1992","journal-title":"Health Phys."},{"key":"10.1016\/j.tox.2016.08.014_bib0225","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1098\/rstb.2006.1823","article-title":"Depleted uranium exposure and health effects in Gulf War veterans. Philosophical transactions of the Royal Society of London. Series B","volume":"361","author":"Squibb","year":"2006","journal-title":"Biol. Sci."},{"key":"10.1016\/j.tox.2016.08.014_bib0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jtemb.2012.07.004","article-title":"Uranium quantification in semen by inductively coupled plasma mass spectrometry","volume":"27","author":"Todorov","year":"2013","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tox.2016.08.014_bib0235","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/j.1939-4640.2001.tb02197.x","article-title":"Neonatally administered diethylstilbestrol retards the development of the blood-testis barrier in the rat","volume":"22","author":"Toyama","year":"2001","journal-title":"J. Androl."},{"key":"10.1016\/j.tox.2016.08.014_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.tox.2016.08.014_bib0245","series-title":"Guidelines for Drinking Water Quality","article-title":"Uranium in drinking-water","author":"WHO","year":"2011"},{"key":"10.1016\/j.tox.2016.08.014_bib0250","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbagen.2012.04.019","article-title":"Chronic exposure to natural uranium via drinking water affects bone in growing rats","volume":"1820","author":"Wade-Gueye","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2016.08.014_bib0255","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2016.08.014_bib0260","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2016.08.014_bib0265","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2307\/3579624","article-title":"Unexpected rates of chromosomal instabilities and alterations of hormone levels in Namibian uranium miners","volume":"147","author":"Zaire","year":"1997","journal-title":"Radiat. Res."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X16301895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X16301895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:34:17Z","timestamp":1759534457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X16301895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":53,"alternative-id":["S0300483X16301895"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2016.08.014","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2016.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}