{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:25:37Z","timestamp":1789593937122,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274146"],"award-info":[{"award-number":["81274146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81320108029"],"award-info":[{"award-number":["81320108029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573514"],"award-info":[{"award-number":["81573514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key development projects of Xinjiang Uygur Autonomous Region","award":["2016B03044-3"],"award-info":[{"award-number":["2016B03044-3"]}]},{"name":"Tianjin Research Program of Application Foundation and Advanced Technology","award":["14JCQNJC13000"],"award-info":[{"award-number":["14JCQNJC13000"]}]},{"name":"Public Interest Research of Traditional Chinese Medicine","award":["201507004-002"],"award-info":[{"award-number":["201507004-002"]}]},{"name":"National \u201cMajor Scientific and Technological Special Project for Significant New Drugs Creation\u201d project","award":["2015ZX09501004-002-004"],"award-info":[{"award-number":["2015ZX09501004-002-004"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.tox.2017.05.011","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T14:16:03Z","timestamp":1495635363000},"page":"40-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity"],"prefix":"10.1016","volume":"386","author":[{"given":"Guolin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengqiu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2017.05.011_bib0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0923-1811(98)00064-4","article-title":"Psoralen photobiology and photochemotherapy: 50 years of science and medicine","volume":"19","author":"Bethea","year":"1999","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.tox.2017.05.011_bib0010","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2340\/0001555559371372","article-title":"Liver injury following administration of 8-methoxypsoralen during PUVA therapy","volume":"59","author":"Bjellerup","year":"1979","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.tox.2017.05.011_bib0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0076-6879(90)92090-Z","article-title":"Preparation and specific applications of isolated hepatocyte couplets","volume":"192","author":"Boyer","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tox.2017.05.011_bib0020","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1093\/nar\/21.16.3885","article-title":"Cloning and regulation of the rat mdr2 gene","volume":"21","author":"Brown","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2017.05.011_bib0025","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1517\/14728222.2011.607163","article-title":"Targeting the ABCB4 gene to control cholesterol homeostasis","volume":"15","author":"Elferink","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.tox.2017.05.011_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbamcr.2006.04.014","article-title":"Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration","volume":"1773","author":"Geier","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.tox.2017.05.011_bib0035","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hep.26894","article-title":"Peroxisome proliferator-activated receptor alpha activates human multidrug resistance transporter 3\/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion","volume":"59","author":"Ghonem","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2017.05.011_bib0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jhep.2012.08.002","article-title":"Bile acid transporters and regulatory nuclear receptors in the liver and beyond","volume":"58","author":"Halilbasic","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2017.05.011_bib0045","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1021\/acs.chemrestox.5b00201","article-title":"Inhibition of MDR3 activity in human hepatocytes by drugs associated with liver injury","volume":"28","author":"He","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2017.05.011_bib0050","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1055\/s-2001-19033","article-title":"Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases","volume":"21","author":"Jacquemin","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.tox.2017.05.011_bib0055","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jhep.2008.10.034","article-title":"HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H(2)O(2) levels: a novel mechanism for NAFLD","volume":"50","author":"Jin","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2017.05.011_bib0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR alpha","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tox.2017.05.011_bib0065","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj20020981","article-title":"Peroxisome proliferator-activated receptor alpha (PPAR alpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice","volume":"369","author":"Kok","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2017.05.011_bib0070","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/MCB.15.6.3012","article-title":"Targeted disruption of the alpha-isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators","volume":"15","author":"Lee","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tox.2017.05.011_bib0075","series-title":"Sax\u2019s Dangerous Properties of Industrial Materials","author":"Lewis","year":"2004"},{"key":"10.1016\/j.tox.2017.05.011_bib0080","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0022-3565(25)38914-7","article-title":"Disposition of 8-methoxypsoralen in the rat: methodology for measurement, dose-dependent pharmacokinetics, tissue distribution and identification of metabolites","volume":"236","author":"Mays","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2017.05.011_bib0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0090-9556(25)06703-0","article-title":"Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry","volume":"15","author":"Mays","year":"1987","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2017.05.011_bib0090","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR alpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.tox.2017.05.011_bib0095","series-title":"Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts","author":"Morita","year":"2014"},{"key":"10.1016\/j.tox.2017.05.011_bib0100","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1081\/CLT-200068863","article-title":"A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia (Boh-Gol-Zhee)","volume":"43","author":"Nam","year":"2005","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.tox.2017.05.011_bib0105","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0190-9622(80)80187-3","article-title":"Toxic hepatitis from oral methoxsalen photochemotherapy (PUVA)","volume":"3","author":"Pariser","year":"1980","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.tox.2017.05.011_bib0110","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/archderm.1976.01630350007002","article-title":"Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system","volume":"112","author":"Parrish","year":"1976","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.tox.2017.05.011_bib0115","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3748\/wjg.15.1677","article-title":"Bile-acid-induced cell injury and protection","volume":"15","author":"Perez","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tox.2017.05.011_bib0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/tx3003824","article-title":"Reactive metabolites in the biotransformation of molecules containing a furan ring","volume":"26","author":"Peterson","year":"2013","journal-title":"Chemical Res. Toxicol."},{"key":"10.1016\/j.tox.2017.05.011_bib0125","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/liv.12456","article-title":"Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal","volume":"35","author":"Schmitt","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.tox.2017.05.011_bib0130","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1194\/jlr.M400132-JLR200","article-title":"Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPAR alpha-mediated redistribution of ABCB4","volume":"45","author":"Shoda","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tox.2017.05.011_bib0135","first-page":"638","article-title":"Tissue distribution of the human MDR3 P-glycoprotein","volume":"71","author":"Smit","year":"1994","journal-title":"Lab. Invest."},{"key":"10.1016\/j.tox.2017.05.011_bib0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2012.03.003","article-title":"Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells","volume":"296","author":"Tian","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2017.05.011_bib0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0092-8674(00)81370-7","article-title":"MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine","volume":"87","author":"vanHelvoort","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.tox.2017.05.011_bib0150","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1002\/j.1460-2075.1987.tb02653.x","article-title":"The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver","volume":"6","author":"Van der Bliek","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/j.tox.2017.05.011_bib0155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2012.08.028","article-title":"Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tox.2017.05.011_bib0160","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/aps.2014.119","article-title":"Resveratrol effectively attenuates alpha-naphthylisothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tox.2017.05.011_bib0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpba.2015.03.026","article-title":"Identification of metabolites of PSORALEAE FRUCTUS in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis","volume":"112","author":"Wang","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.tox.2017.05.011_bib0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1124\/mol.110.067256","article-title":"Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3\/ABCB4","volume":"79","author":"Yoshikado","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2017.05.011_bib0175","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1124\/mol.112.081752","article-title":"Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolitess","volume":"83","author":"Yoshikado","year":"2013","journal-title":"Mol. Pharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17301518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17301518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:35:46Z","timestamp":1759534546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X17301518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":35,"alternative-id":["S0300483X17301518"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2017.05.011","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2017.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}