{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:29:36Z","timestamp":1789817376298,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Overall Study on the Health Effects of Heavy Metals (Overall Study on Minamata disease) Project of Ministry of the Environment (MOE)"},{"name":"JSPS KAKENHI","award":["JP15K21405"],"award-info":[{"award-number":["JP15K21405"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.tox.2017.09.013","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T14:32:19Z","timestamp":1506349939000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity"],"prefix":"10.1016","volume":"392","author":[{"given":"Eiko","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komyo","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2017.09.013_bib0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tox.2017.09.013_bib0010","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nsb1295-1043","article-title":"Protein tyrosine phosphatases take off","volume":"2","author":"Barford","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.tox.2017.09.013_bib0015","first-page":"H2520","article-title":"Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels","volume":"271","author":"Bates","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tox.2017.09.013_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2006.11.007","article-title":"What is the blood-brain barrier (not)?","volume":"28","author":"Bechmann","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2017.09.013_bib0025","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1039\/C4MT00086B","article-title":"Zinc ions modulate protein tyrosine phosphatase 1B activity","volume":"6","author":"Bellomo","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.tox.2017.09.013_bib0030","doi-asserted-by":"crossref","first-page":"29993","DOI":"10.1074\/jbc.M414530200","article-title":"Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2\/EP4 receptors and SP-1 transcription factor binding sites","volume":"280","author":"Bradbury","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2017.09.013_bib0035","doi-asserted-by":"crossref","first-page":"11660","DOI":"10.1074\/jbc.274.17.11660","article-title":"Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and Prostaglandin E2","volume":"274","author":"Brock","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2017.09.013_bib0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00688076","article-title":"Minamata disease: a case report and a comparative study","volume":"26","author":"Chang","year":"1973","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tox.2017.09.013_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcp.1041160108","article-title":"Regulation of prostaglandin production and ectoenzyme activities in cultured aortic endothelial cells","volume":"116","author":"Chesterman","year":"1983","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tox.2017.09.013_bib0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0090-6980(94)90084-1","article-title":"A novel inhibitory prostanoid receptor in piglet saphenous vein","volume":"47","author":"Coleman","year":"1994","journal-title":"Prostaglandins"},{"key":"10.1016\/j.tox.2017.09.013_bib0055","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/BJ20111052","article-title":"Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages","volume":"443","author":"D\u00edaz-Mu\u00f1oz","year":"2012","journal-title":"Biochem. J"},{"key":"10.1016\/j.tox.2017.09.013_bib0060","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0006-2952(02)01661-1","article-title":"Regulation of cyclooxygenase-2 expression by iloprost in human vascular smooth muscle cells. role of transcription factors CREB and ICER","volume":"65","author":"Debey","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2017.09.013_bib0065","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","article-title":"Cyclooxygenase in biology and disease","volume":"12","author":"Dubois","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2017.09.013_bib0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/ajplung.00044.2006","article-title":"IL-1\u03b2, BK, and TGF-\u03b21 attenuate PGI 2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA","volume":"294","author":"El-Haroun","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tox.2017.09.013_bib0075","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/019262339702500612","article-title":"Pathology of Minamata disease","volume":"25","author":"Eto","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2017.09.013_bib0080","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/019262301317226375","article-title":"Methylmercury poisoning in common marmosets\u2014 a study of selective vulnerability within the cerebral cortex","volume":"29","author":"Eto","year":"2001","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2017.09.013_bib0085","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/mvre.2001.2367","article-title":"Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1","volume":"63","author":"Fischer","year":"2002","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.tox.2017.09.013_bib0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0167-4889(89)90098-0","article-title":"Inhibition of endothelial secretion of tissue-type plasminogen activator and its rapid inhibitor by agents which increase intracellular cyclic AMP","volume":"1012","author":"Francis","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2017.09.013_bib0095","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1165\/ajrcmb.17.6.2888","article-title":"Prostaglandins induce vascular endothelial growth factor in a human monocytic cell line and rat lungs via cAMP","volume":"17","author":"H\u00f6per","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tox.2017.09.013_bib0100","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1248\/jhs.53.450","article-title":"Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage","volume":"53","author":"Hirooka","year":"2007","journal-title":"J. Health Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0105","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2131\/jts.34.433","article-title":"Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of repair of wounded monolayers of cultured human brain microvascular endothelial cells","volume":"34","author":"Hirooka","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2131\/jts.35.287","article-title":"Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms","volume":"35","author":"Hirooka","year":"2010","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0115","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.tiv.2009.12.009","article-title":"Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes","volume":"24","author":"Hirooka","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2017.09.013_bib0120","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2131\/jts.38.837","article-title":"Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury","volume":"38","author":"Hirooka","year":"2013","journal-title":"J. Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.tox.2017.09.013_bib0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2131\/jts.42.329","article-title":"Methylmercury induces hyaluronan synthesis in cultured human brain microvascular endothelial cells and pericytes via different mechanisms","volume":"42","author":"Hirooka","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0130","doi-asserted-by":"crossref","first-page":"33396","DOI":"10.1074\/jbc.M705224200","article-title":"Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor","volume":"282","author":"Iwamoto","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2017.09.013_bib0135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0049-3848(96)00088-6","article-title":"Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells","volume":"82","author":"Kaji","year":"1996","journal-title":"Thromb. Res."},{"key":"10.1016\/j.tox.2017.09.013_bib0140","doi-asserted-by":"crossref","first-page":"SP105","DOI":"10.2131\/jts.41.SP105","article-title":"Introduction to the concept of signal toxicity","volume":"41","author":"Kanno","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2131\/jts.40.321","article-title":"The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules","volume":"40","author":"Kohri","year":"2015","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2017.09.013_bib0150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mvr.2009.01.007","article-title":"The pericyte: cellular regulator of microvascular blood flow","volume":"77","author":"Kutcher","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.tox.2017.09.013_bib0155","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/cvr\/cvp069","article-title":"Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1\/2, p38 MAPK, and NF-kappaB","volume":"82","author":"Lin","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tox.2017.09.013_bib0160","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/S0021-9258(17)33534-2","article-title":"Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes","volume":"251","author":"Miyamoto","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2017.09.013_bib0165","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1096\/fj.11-0302ufm","article-title":"Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years","volume":"25","author":"Narumiya","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2017.09.013_bib0170","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2017.09.013_bib0175","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1083\/jcb.105.3.1455","article-title":"Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells","volume":"105","author":"Orlidge","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tox.2017.09.013_bib0180","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF03033386","article-title":"Neurotoxicity of organomercurial compounds","volume":"5","author":"Sanfeliu","year":"2003","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tox.2017.09.013_bib0185","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.91.25.12013","article-title":"Pharmacological and biochemical demonstration of the role of cyclooxygenase-2 in inflammation and pain","volume":"91","author":"Seibert","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2017.09.013_bib0190","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1021\/cr000236l","article-title":"Physiological substrates of cAMP-dependent protein kinase","volume":"101","author":"Shabb","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tox.2017.09.013_bib0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1152\/ajpcell.00024.2008","article-title":"PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling","volume":"296","author":"Steinert","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tox.2017.09.013_bib0200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/0271678X15617172","article-title":"Molecular pathophysiology of cerebral edema","volume":"36","author":"Stokum","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tox.2017.09.013_bib0205","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.biocel.2006.03.021","article-title":"Signalling networks regulating cyclooxygenase-2","volume":"38","author":"Tsatsanis","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.tox.2017.09.013_bib0210","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1620\/tjem.205.53","article-title":"The severity of Minamata disease declined in 25 years: temporal profile of the neurological findings analyzed by multiple logistic regression model","volume":"205","author":"Uchino","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.tox.2017.09.013_bib0215","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0929-7855(95)00022-I","article-title":"Molecular biology of prostanoid receptors; an overview","volume":"12","author":"Ushikubi","year":"1995","journal-title":"J. Lipid Mediat. Cell Signal."},{"key":"10.1016\/j.tox.2017.09.013_bib0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0005-2760(77)90008-X","article-title":"Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands","volume":"487","author":"Van der Ouderaa","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2017.09.013_bib0225","doi-asserted-by":"crossref","first-page":"H434","DOI":"10.1152\/ajpheart.2001.280.1.H434","article-title":"VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly","volume":"280","author":"Wang","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tox.2017.09.013_bib0230","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1476-5381.1979.tb07860.x","article-title":"Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation","volume":"65","author":"Williams","year":"1979","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2017.09.013_bib0235","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1172\/JCI8218","article-title":"VEGF antagonism reduces edema formation and tissue damage after ischemia\/reperfusion injury in the mouse brain","volume":"104","author":"van Bruggen","year":"1999","journal-title":"J. Clin. Invest."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17302937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17302937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:36:45Z","timestamp":1759534605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X17302937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":47,"alternative-id":["S0300483X17302937"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2017.09.013","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2017.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}