{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:42:05Z","timestamp":1781199725969,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.tox.2017.11.012","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T01:01:34Z","timestamp":1510275694000},"page":"102-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice"],"prefix":"10.1016","volume":"393","author":[{"given":"Tomoka","family":"Ozaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2017.11.012_bib0005","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.4049\/jimmunol.1301261","article-title":"Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions","volume":"191","author":"Brieger","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2017.11.012_bib0010","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1113\/jphysiol.2007.143941","article-title":"Zinc inhibition of rat NR1\/NR2A N-methyl-D-aspartate receptors","volume":"586","author":"Erreger","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.tox.2017.11.012_bib0015","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","article-title":"Zinc homeostasis and signaling in health and diseases: Zinc signaling","volume":"16","author":"Fukada","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.tox.2017.11.012_bib0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bcp.2015.08.005","article-title":"Functional upregulation of the H2S\/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells","volume":"97","author":"Fukami","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2017.11.012_bib0025","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.neuron.2014.07.036","article-title":"The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity","volume":"83","author":"Garcia-Caballero","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tox.2017.11.012_bib0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nchembio.146","article-title":"Zinc activates damage-sensing TRPA1 ion channels","volume":"5","author":"Hu","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tox.2017.11.012_bib0035","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1523\/JNEUROSCI.22-19-08352.2002","article-title":"Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS\/PN3)-null mice","volume":"22","author":"Laird","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2017.11.012_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pain.2008.12.021","article-title":"Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels","volume":"142","author":"Maeda","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.tox.2017.11.012_bib0045","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/gut.2007.144543","article-title":"Luminal hydrogen sulfide plays a pronociceptive role in mouse colon","volume":"58","author":"Matsunami","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.tox.2017.11.012_bib0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuroscience.2011.02.044","article-title":"Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels","volume":"181","author":"Matsunami","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.tox.2017.11.012_bib0055","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1476-5381.2012.02060.x","article-title":"Involvement of the endogenous hydrogen sulfide\/Cav 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice","volume":"167","author":"Matsunami","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2017.11.012_bib0060","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.pain.2011.02.019","article-title":"ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis","volume":"152","author":"Miki","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.tox.2017.11.012_bib0065","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/j.1349-7006.2008.00854.x","article-title":"Intracellular zinc homeostasis and zinc signaling","volume":"99","author":"Murakami","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.tox.2017.11.012_bib0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jphs.2015.01.004","article-title":"Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice","volume":"127","author":"Murakami-Nakayama","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tox.2017.11.012_bib0075","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1523\/JNEUROSCI.1800-07.2007","article-title":"Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels","volume":"27","author":"Nelson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2017.11.012_bib0080","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.2008.151910","article-title":"Hydrogen sulfide as a novel mediator for pancreatic pain in rodents","volume":"58","author":"Nishimura","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.tox.2017.11.012_bib0085","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nn.2844","article-title":"Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit","volume":"14","author":"Nozaki","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tox.2017.11.012_bib0090","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/j.1476-5381.2012.01886.x","article-title":"Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice","volume":"166","author":"Okubo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2017.11.012_bib0095","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1476-5381.2012.01835.x","article-title":"Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats","volume":"166","author":"Okubo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2017.11.012_bib0100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/eujp.1998.0105","article-title":"Cyclophosphamide cystitis in mice: behavioural characterisation and correlation with bladder inflammation","volume":"3","author":"Olivar","year":"1999","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.tox.2017.11.012_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.it.2006.11.005","article-title":"Zinc homeostasis and immunity","volume":"28","author":"Rink","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2017.11.012_bib0110","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1254\/jphs.13R05CP","article-title":"T-type calcium channels: functional regulation and implication in pain signaling","volume":"122","author":"Sekiguchi","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tox.2017.11.012_bib0115","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/j.pain.0000000000000565","article-title":"Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain","volume":"157","author":"Sekiguchi","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.tox.2017.11.012_bib0120","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.celrep.2016.11.047","article-title":"TRPV1 nociceptor activity initiates USP5\/T-type channel-mediated plasticity","volume":"17","author":"Stemkowski","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.tox.2017.11.012_bib0125","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917724698","article-title":"Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway","volume":"13","author":"Stemkowski","year":"2017","journal-title":"Mol. Pain"},{"key":"10.1016\/j.tox.2017.11.012_bib0130","doi-asserted-by":"crossref","first-page":"e1040","DOI":"10.1038\/cddis.2013.547","article-title":"Zinc depletion regulates the processing and secretion of IL-1beta","volume":"5","author":"Summersgill","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tox.2017.11.012_bib0135","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.brainresbull.2012.02.003","article-title":"Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice","volume":"87","author":"Takeda","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.tox.2017.11.012_bib0140","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jnr.23490","article-title":"Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis","volume":"93","author":"Terada","year":"2015","journal-title":"J. Neurosci. Res."},{"issue":"Suppl","key":"10.1016\/j.tox.2017.11.012_bib0145","first-page":"S103","article-title":"Cav3.2 T-type Ca2+ channels in sensory neruons of rats with neuropathic pain","volume":"128","author":"Tomita","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tox.2017.11.012_bib0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1254\/jphs.12086SC","article-title":"Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Cav3.2 and TRPA1 channels in mice","volume":"119","author":"Tsubota-Matsunami","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tox.2017.11.012_bib0155","doi-asserted-by":"crossref","first-page":"15489","DOI":"10.1074\/jbc.M111.310763","article-title":"Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)","volume":"287","author":"van Loo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2017.11.012_bib0160","doi-asserted-by":"crossref","first-page":"760.e1","DOI":"10.1016\/j.ajog.2016.07.023","article-title":"Multifactorial contributors to the severity of chronic pelvic pain in women","volume":"215","author":"Yosef","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.tox.2017.11.012_bib0165","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2017.11.012_bib0170","doi-asserted-by":"crossref","first-page":"e49257","DOI":"10.1371\/journal.pone.0049257","article-title":"Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2017.11.012_bib0175","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2010.11.001","article-title":"Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice","volume":"200","author":"Zhao","year":"2011","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17303426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X17303426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:37:25Z","timestamp":1759534645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X17303426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":35,"alternative-id":["S0300483X17303426"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2017.11.012","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2017.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}