{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:58:37Z","timestamp":1768287517642,"version":"3.49.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"S\u00e3o Paulo State Research Foundation","award":["2013\/12154-2"],"award-info":[{"award-number":["2013\/12154-2"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.tox.2018.08.001","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T13:06:49Z","timestamp":1533647209000},"page":"112-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD"],"prefix":"10.1016","volume":"409","author":[{"given":"Mariana A.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly S.","family":"Estill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geysson J.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo N.","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Krawetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-2934","authenticated-orcid":false,"given":"Wellerson R.","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2018.08.001_bib0005","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.fertnstert.2012.11.054","article-title":"Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments","volume":"99","author":"Abu-Halima","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2018.08.001_bib0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.taap.2011.02.019","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytotoxicity accompanied by oxidative stress in rat Sertoli cells: Possible role of mitochondrial fractions of Sertoli cells","volume":"252","author":"Aly","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.08.001_bib0015","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.tox.2018.08.001_bib0020","doi-asserted-by":"crossref","first-page":"D180","DOI":"10.1093\/nar\/gkr1007","article-title":"doRiNA: a database of RNA interactions in post-transcriptional regulation","volume":"40","author":"Anders","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0025","first-page":"2824","article-title":"HTSeq A Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2014","journal-title":"bioRxiv"},{"key":"10.1016\/j.tox.2018.08.001_bib0030","series-title":"FastQC A Quality Control Tool for High Throughput Sequence Data","author":"Andrews","year":"2010"},{"key":"10.1016\/j.tox.2018.08.001_bib0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs : Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.tox.2018.08.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc."},{"key":"10.1016\/j.tox.2018.08.001_bib0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/aje\/153.11.1031","article-title":"Health effects of dioxin exposure: a 20-year mortality study","volume":"153","author":"Bertazzi","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tox.2018.08.001_bib0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/nar\/gkm995","article-title":"The microRNA.org resource: targets and expression","volume":"36","author":"Betel","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jncimonographs\/lgi006","article-title":"Mechanisms of toxic damage to spermatogenesis","author":"Boekelheide","year":"2005","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"10.1016\/j.tox.2018.08.001_bib0060","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/REP-14-0481","article-title":"Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling","volume":"149","author":"Chen","year":"2015","journal-title":"Reproduction"},{"issue":"8","key":"10.1016\/j.tox.2018.08.001_bib0065","article-title":"Software for pre-processing Illumina next-generation sequencing short read sequences","volume":"9","author":"Chen","year":"2014","journal-title":"Source Code Biol. Med."},{"key":"10.1016\/j.tox.2018.08.001_bib0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12282-013-0476-0","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression","volume":"22","author":"Chen","year":"2015","journal-title":"Breast Cancer"},{"key":"10.1016\/j.tox.2018.08.001_bib0075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3945\/jn.110.131318","article-title":"Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice","volume":"141","author":"Croxford","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2018.08.001_bib0080","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1096\/fj.06-7852com","article-title":"LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop","volume":"21","author":"Davey","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2018.08.001_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2016.02.017","article-title":"Regulatory and junctional proteins of the blood-testis barrier in human sertoli cells are modified by monobutyl phthalate (MBP) and bisphenol A (BPA) exposure","volume":"34","author":"de Freitas","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2018.08.001_bib0090","doi-asserted-by":"crossref","first-page":"G475","DOI":"10.1152\/ajpgi.00408.2014","article-title":"The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment","volume":"309","author":"de Valli\u00e8re","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2018.08.001_bib0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2018.08.001_bib0100","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk--database: prediction of possible miRNA binding sites by &quot;walking&quot; the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.tox.2018.08.001_bib0105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk-database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.tox.2018.08.001_bib0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/toxsci\/kft028","article-title":"Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes","volume":"133","author":"Forgacs","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2018.08.001_bib0115","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0120","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1517\/14728222.2015.1039513","article-title":"Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight","volume":"19","author":"Gao","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.tox.2018.08.001_bib0125","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.tox.2018.08.001_bib0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1095\/biolreprod.113.108845","article-title":"The aryl hydrocarbon receptor is important for proper seminiferous tubule architecture and sperm development in mice","volume":"90","author":"Hansen","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2018.08.001_bib0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1039\/b211406b","article-title":"Human dietary intake and excretion of dioxin-like compounds","volume":"5","author":"Harrad","year":"2003","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.tox.2018.08.001_bib0140","doi-asserted-by":"crossref","first-page":"9776","DOI":"10.1073\/pnas.93.18.9776","article-title":"17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1","volume":"93","author":"Hayes","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2018.08.001_bib0145","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tox.2014.12.016","article-title":"Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo- \u03c1-dioxin","volume":"328","author":"Houlahan","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2018.08.001_bib0150","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkm1012","article-title":"miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes","volume":"36","author":"Hsu","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0155","series-title":"Ah Receptor \u2013 Mediated Suppression of Liver Regeneration Through NC- XRE \u2013 Driven p21 Cip1 Expression","author":"Jackson","year":"2011"},{"key":"10.1016\/j.tox.2018.08.001_bib0160","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0165","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tox.2018.08.001_bib0170","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.tox.2018.08.001_bib0175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tox.2004.07.002","article-title":"Effects of TCDD in modulating the expression of Sertoli cell secretory products and markers for cell-cell interaction","volume":"206","author":"Lai","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2018.08.001_bib0180","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.tox.2018.08.001_bib0185","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1093\/bioinformatics\/btv193","article-title":"EBSeq-HMM: a Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments","volume":"31","author":"Leng","year":"2015","journal-title":"Bioinformatics"},{"issue":"323","key":"10.1016\/j.tox.2018.08.001_bib0190","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.tox.2018.08.001_bib0195","first-page":"7","article-title":"Altered microRNA expression in patients with non-obstructive azoospermia","volume":"11","author":"Lian","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tox.2018.08.001_bib0200","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.92.20.9220","article-title":"4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis","volume":"92","author":"Liehr","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2018.08.001_bib0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tox.2018.08.001_bib0210","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/bioinformatics\/bts615","article-title":"Interactive exploration of RNA22 microRNA target predictions","volume":"28","author":"Loher","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tox.2018.08.001_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tox.2018.08.001_bib0220","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1210\/en.2002-0211","article-title":"TGF-\u03b23 regulates the blood-testis barrier dynamics via the p38 Mitogen Activated Protein (MAP) kinase pathway: an in Vivo study","volume":"144","author":"Lui","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2018.08.001_bib0225","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/bioinformatics\/btr336","article-title":"PathVisio-MIM: PathVisio plugin for creating and editing Molecular Interaction Maps (MIMs)","volume":"27","author":"Luna","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tox.2018.08.001_bib0230","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/nar\/gks1337","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation","volume":"41","author":"MacPherson","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0235","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/nar\/gks1337","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation","volume":"41","author":"MacPherson","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0240","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.3390\/ijms15057939","article-title":"Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling","volume":"15","author":"MacPherson","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2018.08.001_bib0245","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.scitotenv.2014.03.022","article-title":"Dioxins and PCBs in feed and food--review from European perspective","volume":"491\u2013492","author":"Malisch","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"175","key":"10.1016\/j.tox.2018.08.001_bib0250","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/taap.2001.9241","article-title":"7,12-Dimethylbenz[a]anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1","author":"Mandal","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.08.001_bib0255","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/nar\/gkp292","article-title":"DIANA-microT web server: elucidating microRNA functions through target prediction","volume":"37","author":"Maragkakis","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0260","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0304-4165(02)00485-3","article-title":"Functional role of AhR in the expression of toxic effects by TCDD","volume":"1619","author":"Mimura","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2018.08.001_bib0265","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1439-0272.2010.01135.x","article-title":"Effects of basic fibroblast growth factor and leukaemia inhibitory factor on proliferation and short-term culture of human spermatogonial stem cells","volume":"44","author":"Mirzapour","year":"2012","journal-title":"Andrologia"},{"key":"10.1016\/j.tox.2018.08.001_bib0270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.tox.2018.08.001_bib0275","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","article-title":"Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis","volume":"25","author":"Mruk","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2018.08.001_bib0280","doi-asserted-by":"crossref","first-page":"26029","DOI":"10.18632\/oncotarget.4347","article-title":"Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy","volume":"6","author":"O\u2019Neill","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.tox.2018.08.001_bib0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajhg.2016.08.020","article-title":"Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta","author":"Parry","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tox.2018.08.001_bib0290","series-title":"HHS Public Access","first-page":"229","author":"Pio","year":"2015"},{"issue":"Suppl. 1","key":"10.1016\/j.tox.2018.08.001_bib0295","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1023\/B:VERC.0000014134.23782.10","article-title":"Dioxin and PCB contamination of fish and shellfish: assessment of human exposure. Review of the international situation","volume":"27","author":"Pompa","year":"2003","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.tox.2018.08.001_bib0300","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cca.2004.08.002","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3","volume":"138","author":"Puebla-Osorio","year":"2004","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2018.08.001_bib0305","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/toxsci\/kft129","article-title":"Sertoli cell is a potential target for perfluorooctane sulfonate-induced reproductive dysfunction in male mice","volume":"135","author":"Qiu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2018.08.001_bib0310","first-page":"679","article-title":"The interaction between sertoli cells and luekemia inhibitory factor on the propagation and differentiation of spermatogonial stem cells in vitro","volume":"13","author":"Rastegar","year":"2015","journal-title":"Iran. J. Reprod. Med."},{"key":"10.1016\/j.tox.2018.08.001_bib0315","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1261\/rna.5248604","article-title":"Fast and effective prediction of microRNA\/target duplexes","volume":"10","author":"Rehmsmeier","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.tox.2018.08.001_bib0320","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.tox.2018.08.001_bib0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tox.2018.08.001_bib0330","doi-asserted-by":"crossref","first-page":"W467","DOI":"10.1093\/nar\/gkv555","article-title":"sRNAtoolbox: an integrated collection of small RNA research tools","volume":"43","author":"Rueda","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0335","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0045-6535(01)00197-7","article-title":"Characterization of dioxin exposure in firefighters, residents, and chemical workers in the Irkutsk Region of Russian Siberia","volume":"47","author":"Schecter","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2018.08.001_bib0340","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.tox.2018.08.001_bib0345","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1745-7262.2008.00370.x","article-title":"Endocrine disruptors and estrogenic effects on male reproductive axis","volume":"10","author":"Sikka","year":"2008","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.tox.2018.08.001_bib0350","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1158\/1055-9965.EPI-04-0749","article-title":"Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism","volume":"14","author":"Starr","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.tox.2018.08.001_bib0355","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1021\/acs.est.5b00385","article-title":"The aryl hydrocarbon receptor: a key bridging molecule of external and internal chemical signals","volume":"49","author":"Tian","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2018.08.001_bib0360","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molcel.2010.03.007","article-title":"Targeting networks using gene-set signatures","volume":"38","author":"Tsang","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tox.2018.08.001_bib0365","doi-asserted-by":"crossref","first-page":"W165","DOI":"10.1093\/nar\/gkt430","article-title":"miRmap web: Comprehensive microRNA target prediction online","volume":"41","author":"Vejnar","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0370","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1289\/ehp.1206113","article-title":"Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso women\u2019s health study","volume":"121","author":"Warner","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2018.08.001_bib0375","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/aja.1001670203","article-title":"Three-dimensional reconstruction of a rat stage V Sertoli cell: II. Morphometry of Sertoli--Sertoli and Sertoli--germ-cell relationships","volume":"167","author":"Weber","year":"1983","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.tox.2018.08.001_bib0380","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/toxsci\/51.2.259","article-title":"Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring","volume":"51","author":"Wolf","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2018.08.001_bib0385","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gku1104","article-title":"miRDB: an online resource for microRNA target prediction and functional annotations","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2018.08.001_bib0390","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1095\/biolreprod.103.025387","article-title":"Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2","volume":"70","author":"Wu","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2018.08.001_bib0395","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/humrep\/deu011","article-title":"Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins","volume":"29","author":"Xiao","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tox.2018.08.001_bib0400","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/cr.2012.17","article-title":"Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18302178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18302178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:40:15Z","timestamp":1759534815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X18302178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":80,"alternative-id":["S0300483X18302178"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2018.08.001","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2018.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}