{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:18:47Z","timestamp":1787498327219,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"UGC"},{"name":"DST"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.tox.2018.11.010","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T13:43:29Z","timestamp":1543499009000},"page":"63-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Sulphur dioxide ameliorates colitis related pathophysiology and inflammation"],"prefix":"10.1016","volume":"412","author":[{"given":"Sharmistha","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayantani","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2018.11.010_bib0005","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/gast.2003.50141","article-title":"Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn`s disease","volume":"124","author":"Abad","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2018.11.010_bib0010","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.20101330","article-title":"An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer","volume":"207","author":"Asquith","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2018.11.010_bib0015","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1128\/MCB.05164-11","article-title":"PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment","volume":"31","author":"Avivar-Valderas","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tox.2018.11.010_bib0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cbi.2017.11.019","article-title":"Unfolding the mechanism of cisplatin induced pathophysiology in spleen and its amelioration by carnosine","volume":"279","author":"Banerjee","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2018.11.010_bib0025","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/gut.2009.197822","article-title":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","volume":"59","author":"Bauer","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.tox.2018.11.010_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2018.01.004","article-title":"Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: implications for the pathogenesis and treatment of diabetes mellitus","author":"Be\u0142towski","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2018.11.010_bib0040","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tox.2018.11.010_bib0045","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"Cassel","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tox.2018.11.010_bib0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/labinvest.2014.147","article-title":"Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats","volume":"95","author":"Chen","year":"2015","journal-title":"Lab. Investig."},{"key":"10.1016\/j.tox.2018.11.010_bib0055","first-page":"469","article-title":"Curcumin attenuates the expression of IL-1\u03b2, IL-6, and TNF-\u03b1 as well as cyclin E in TNF-\u03b1-treated HaCaT cells; NF-\u03baB and MAPKs as potential upstream targets","volume":"19","author":"Cho","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tox.2018.11.010_bib0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/biof.1301","article-title":"Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses","volume":"42","author":"Chowdhury","year":"2016","journal-title":"Biofactors"},{"key":"10.1016\/j.tox.2018.11.010_bib0065","doi-asserted-by":"crossref","first-page":"84338","DOI":"10.18632\/oncotarget.12609","article-title":"H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair","volume":"7","author":"Ciocci","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.tox.2018.11.010_bib0070","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/nprot.2006.273","article-title":"Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics","volume":"1","author":"Cox","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2018.11.010_bib0075","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bcp.2011.01.008","article-title":"Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K\/Akt and inhibition of p53, p38-JNK","volume":"81","author":"Das","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0080","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s00726-011-0904-4","article-title":"Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis","volume":"42","author":"Das","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.tox.2018.11.010_bib0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2017.00065","article-title":"The hydrogen sulfide releasing molecule acetyl deacylasadisulfide inhibits metastatic melanoma","volume":"8","author":"De Cicco","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1191\/1358863x02vm424ra","article-title":"Carbon monoxide and bile pigments: surprising mediators of vascular function","volume":"7","author":"Durante","year":"2002","journal-title":"Vasc. Med."},{"key":"10.1016\/j.tox.2018.11.010_bib0095","doi-asserted-by":"crossref","first-page":"13559","DOI":"10.1073\/pnas.1413390111","article-title":"Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis","volume":"111","author":"Flannigan","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tox.2018.11.010_bib0100","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biochi.2013.01.016","article-title":"Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine","volume":"95","author":"Ghosh","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.tox.2018.11.010_bib0105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.taap.2009.07.008","article-title":"Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-\u03baB, p38 and JNK MAPK pathway","volume":"240","author":"Ghosh","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0110","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.freeradbiomed.2010.09.011","article-title":"Hepatotoxicity of di-(2-ethylhexyl) phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK\/NF-\u03baB pathway activation","volume":"49","author":"Ghosh","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2018.11.010_bib0115","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.biomaterials.2011.03.048","article-title":"The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis","volume":"32","author":"Ghosh","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.tox.2018.11.010_bib0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0041-008X(76)90165-4","article-title":"A model for the metabolism of sulfite in mammals","volume":"38","author":"Gunnison","year":"1976","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fphys.2016.00156","article-title":"Emerging roles of hydrogen sulfide in inflammatory and neoplastic colonic diseases","volume":"7","author":"Guo","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tox.2018.11.010_bib0130","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.2000.80.4.1337","article-title":"Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension","volume":"80","author":"Hampl","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2018.11.010_bib0135","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress\u2013mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"Hart","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2018.11.010_bib0140","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.tox.2018.11.010_bib0145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0278-6915(89)90140-3","article-title":"Comparative subchronic oral toxicity of sulphite and acetaldehyde hydroxysulphonate in rats","volume":"27","author":"Hui","year":"1989","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2018.11.010_bib0150","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/clinchem\/41.6.897","article-title":"Determination of total serum sulfite by HPLC with fluorescence detection","volume":"41","author":"Ji","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1016\/j.tox.2018.11.010_bib0155","doi-asserted-by":"crossref","first-page":"C451","DOI":"10.1152\/ajpcell.2000.278.3.C451","article-title":"The I\u03baB\/NF-\u03baB system: a key determinant of mucosal inflammation and protection","volume":"278","author":"Jobin","year":"2000","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"10.1016\/j.tox.2018.11.010_bib0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2009.122","article-title":"Endoplasmic reticulum stress and intestinal inflammation","volume":"3","author":"Kaser","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.tox.2018.11.010_bib0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0009-2797(89)90069-0","article-title":"Effects of sulfite on glutathione S-sulfonate and the glutathione status of lung cells","volume":"70","author":"Keller","year":"1989","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2018.11.010_bib0170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrm4007","article-title":"p53 in survival, death and metabolic health: a lifeguard with a licence to kill","volume":"16","author":"Kruiswijk","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tox.2018.11.010_bib0175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2018.11.010_bib0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature07687","article-title":"Dynamic expression of epidermal caspase 8 simulates a wound healing response","volume":"458","author":"Lee","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tox.2018.11.010_bib0185","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biomaterials.2015.06.014","article-title":"Direct imaging of biological sulfur dioxide derivatives in vivo using a two-photon phosphorescent probe","volume":"63","author":"Li","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.tox.2018.11.010_bib0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxlet.2017.02.004","article-title":"Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension","volume":"270","author":"Liang","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2018.11.010_bib0195","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1089\/ars.2013.5312","article-title":"Hydrogen sulfide signaling in the gastrointestinal tract","volume":"20","author":"Linden","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tox.2018.11.010_bib0200","doi-asserted-by":"crossref","first-page":"e1251","DOI":"10.1038\/cddis.2014.229","article-title":"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tox.2018.11.010_bib0205","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4529060","article-title":"Role of endogenous sulfur dioxide in regulating vascular structural remodeling in hypertension","volume":"2016","author":"Liu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tox.2018.11.010_bib0210","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2013.03.014","article-title":"Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"433","author":"Luo","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2018.11.010_bib0215","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1038\/srep09048","article-title":"TALEN mediated targeted editing of GM2\/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells","volume":"5","author":"Mahata","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2018.11.010_bib0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2009.12.024","article-title":"Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid","volume":"244","author":"Manna","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0225","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/ibd.21528","article-title":"Emerging role of hydrogen sulfide in colonic physiology and pathophysiology","volume":"17","author":"Medani","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.tox.2018.11.010_bib0230","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00535.2016","article-title":"Tumor necrosis factor-\u03b1, kidney function, and hypertension","volume":"313","author":"Mehaffey","year":"2017","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"10.1016\/j.tox.2018.11.010_bib0235","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.abb.2007.08.028","article-title":"Vasodilatation of sulfur dioxide derivatives and signal transduction","volume":"467","author":"Meng","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2018.11.010_bib0240","doi-asserted-by":"crossref","first-page":"32804","DOI":"10.1074\/jbc.272.52.32804","article-title":"Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells","volume":"272","author":"Morita","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2018.11.010_bib0245","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress: an immunologist\u2019s guide to reactive oxygen species","volume":"13","author":"Nathan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2018.11.010_bib0250","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/654963","article-title":"Inflammasome in intestinal inflammation and cancer","volume":"2013","author":"Nunes","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.tox.2018.11.010_bib0255","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2016.12.048","article-title":"Redox signaling in the gastrointestinal tract","volume":"104","author":"P\u00e9rez","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2018.11.010_bib0260","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tox.2011.03.006","article-title":"Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro","volume":"283","author":"Pal","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2018.11.010_bib0265","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00726-011-0869-3","article-title":"Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes","volume":"42","author":"Pal","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.tox.2018.11.010_bib0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107220","article-title":"Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNF\u03b1 related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats","volume":"9","author":"Pal","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2018.11.010_bib0275","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0140-6736(91)92033-X","article-title":"Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension","volume":"338","author":"Pepke-Zaba","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2018.11.010_bib0280","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbadis.2014.11.007","article-title":"Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death","volume":"1852","author":"Rashid","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"10.1016\/j.tox.2018.11.010_bib0285","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.taap.2014.12.003","article-title":"Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats","volume":"282","author":"Rashid","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0290","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bcp.2017.07.009","article-title":"Curcumin attenuates oxidative stress induced NF\u03baB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes","volume":"143","author":"Rashid","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2018.11.010_bib0295","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1038\/ncomms7201","article-title":"Mitochondrial Ca 2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis","volume":"6","author":"Rimessi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2018.11.010_bib0300","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn\u2019s disease and ulcerative colitis","volume":"3","author":"Sartor","year":"2006","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tox.2018.11.010_bib0305","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tox.2018.11.010_bib0310","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2018.11.010_bib0315","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/labinvest.2009.102","article-title":"Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling","volume":"90","author":"Sun","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.tox.2018.11.010_bib0320","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10753-016-0466-4","article-title":"Effects of CCK-8 and cystathionine \u03b3-Lyase\/Hydrogen sulfide system on acute lung injury in rats","volume":"40","author":"Tian","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.tox.2018.11.010_bib0325","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity","volume":"8","author":"Todd","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2018.11.010_bib0330","first-page":"55","article-title":"Formation of sulfate from L-cysteine in rat liver mitochondria","volume":"44","author":"Ubuka","year":"1990","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.tox.2018.11.010_bib0335","article-title":"Hydrogen sulfide and glucose homeostasis: a tale of sweet and the stink","author":"Untereiner","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tox.2018.11.010_bib0340","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tox.2018.11.010_bib0345","doi-asserted-by":"crossref","first-page":"521","DOI":"10.33549\/physiolres.931456","article-title":"Sulfur dioxide relaxes rat aorta by endothelium-dependent and-independent mechanisms","volume":"58","author":"Wang","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.tox.2018.11.010_bib0350","article-title":"Distinct roles of intracellular heat shock protein 70 (Hsp70) in maintaining gastrointestinal homeostasis","author":"Wang","year":"2017","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.tox.2018.11.010_bib0355","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.febslet.2007.04.082","article-title":"Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti\u2010inflammatory immuno\u2010modulators?","volume":"581","author":"Wieten","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2018.11.010_bib0360","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nprot.2007.41","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2018.11.010_bib0365","doi-asserted-by":"crossref","first-page":"12529","DOI":"10.18632\/oncotarget.3725","article-title":"Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-\u03baB signaling","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.tox.2018.11.010_bib0370","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.it.2011.02.002","article-title":"The Nlrp3 inflammasome: contributions to intestinal homeostasis","volume":"32","author":"Zaki","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2018.11.010_bib0375","article-title":"Precision editing of the gut microbiota ameliorates colitis","author":"Zhu","year":"2018","journal-title":"Nature"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18306310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18306310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:39:17Z","timestamp":1759534757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X18306310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":75,"alternative-id":["S0300483X18306310"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2018.11.010","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulphur dioxide ameliorates colitis related pathophysiology and inflammation","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2018.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}