{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:39:40Z","timestamp":1790185180300,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.tox.2019.03.008","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T11:24:37Z","timestamp":1553945077000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats"],"prefix":"10.1016","volume":"421","author":[{"given":"Amanda Caroline","family":"Venturelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katlyn Barp","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefani Val\u00e9ria","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Henrique","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Adams","family":"Philipsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-4371","authenticated-orcid":false,"given":"Rosana Nogueira","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Joel","family":"Martino Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2019.03.008_bib0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/faat.1997.2318","article-title":"The rationale for culling of rodent litters","volume":"6","author":"Agnish","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2019.03.008_bib0010","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1095\/biolreprod65.4.1252","article-title":"Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate","volume":"65","author":"Akingbemi","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2019.03.008_bib0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tox.2006.08.020","article-title":"A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats","volume":"228","author":"Andrade","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.03.008_bib0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tox.2006.05.007","article-title":"A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats","volume":"225","author":"Andrade","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.03.008_bib0025","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1098\/rstb.2008.0304","article-title":"Applications and societal benefits of plastics","volume":"364","author":"Andrady","year":"2009","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry ."},{"key":"10.1016\/j.tox.2019.03.008_bib0035","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1074\/jbc.M111272200","article-title":"Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion","volume":"277","author":"Brissova","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2019.03.008_bib0040","doi-asserted-by":"crossref","first-page":"E707","DOI":"10.1152\/ajpendo.00252.2004","article-title":"Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis","volume":"288","author":"Brissova","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2019.03.008_bib0045","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1038\/nutd.2014.13","article-title":"In utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate promotes local adipose and systemic inflammation in adult male offspring","volume":"4","author":"Campioli","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.tox.2019.03.008_bib0050","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.envres.2009.07.015","article-title":"Influence of litter size on the postnatal growth of rat pups: is there a rationale for litter-size standardization in toxicity studies?","volume":"109","author":"Chahoud","year":"2009","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2019.03.008_bib0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.etap.2015.12.016","article-title":"Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms","volume":"42","author":"Chen","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2019.03.008_bib0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.envpol.2017.03.037","article-title":"Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population","volume":"225","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2019.03.008_bib0065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfi011","article-title":"Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract?","volume":"83","author":"Corton","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13679-017-0240-4","article-title":"Endocrine disruptors and obesity","author":"Darbre","year":"2017","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.tox.2019.03.008_bib0075","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/01926230152500040","article-title":"Reversibility of the chronic effects of Di(2-ethylhexyl)phthalate","volume":"29","author":"David","year":"2001","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2019.03.008_bib0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","article-title":"PPAR-mediated activity of phthalates: a link to the obesity epidemic?","volume":"304","author":"Desvergne","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tox.2019.03.008_bib0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic \u03b2-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tox.2019.03.008_bib0090","doi-asserted-by":"crossref","first-page":"19152","DOI":"10.1074\/jbc.M702724200","article-title":"The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis","volume":"282","author":"Feige","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2019.03.008_bib0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","author":"Foster","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tox.2019.03.008_bib0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/bmb\/60.1.123","article-title":"Intra-uterine programming of the endocrine pancreas","volume":"60","author":"Fowden","year":"2001","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.tox.2019.03.008_bib0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0890-6238(99)00036-2","article-title":"Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights","volume":"13","author":"Gallavan","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2019.03.008_bib0110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/toxsci\/kfj128","article-title":"A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: effects on female rat reproductive development","volume":"91","author":"Grande","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1385\/ENDO:30:2:191","article-title":"Pancreatic islets from hypothalamic obese rats maintain K ATP channel-dependent but not - independent pathways on glucose induced insulin release process","volume":"30","author":"Grassiolli","year":"2006","journal-title":"Endocrine ."},{"key":"10.1016\/j.tox.2019.03.008_bib0120","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/en.2005-1129","article-title":"Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling","volume":"147","author":"Grun","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2019.03.008_bib0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2009.02.018","article-title":"Endocrine disrupters as obesogens","volume":"304","author":"Grun","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tox.2019.03.008_bib0130","first-page":"1323","article-title":"Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians","volume":"85","author":"Hansen","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2019.03.008_bib0135","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1365-2605.2009.01035.x","article-title":"Association of endocrine disruptors and obesity: perspectives from epidemiological studies","volume":"33","author":"Hatch","year":"2010","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tox.2019.03.008_bib0140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13111085","article-title":"Effects of Di-(2-ethylhexyl) phthalate on lipid metabolism by the JAK\/STAT pathway in rats","volume":"13","author":"Jia","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2019.03.008_bib0155","article-title":"NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate","author":"Kavlock","year":"2002","journal-title":"Reproductive toxicology (Elmsford, N.Y.)"},{"key":"10.1016\/j.tox.2019.03.008_bib0160","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1074\/jbc.M508510200","article-title":"The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation","volume":"281","author":"Kawamori","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2019.03.008_bib0165","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tox.2016.08.021","article-title":"Manipulation of pre and postnatal androgen environments and anogenital distance in rats","volume":"368\u2013369","author":"Kita","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.03.008_bib0170","first-page":"1","article-title":"Di- (2-Ethylhexyl) -phthalate (DEHP) causes impaired adipocyte function and alters serum metabolites","author":"Kl\u00f6ting","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2019.03.008_bib0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas","volume":"16","author":"Lacy","year":"1967","journal-title":"Diabetes ."},{"key":"10.1016\/j.tox.2019.03.008_bib0180","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00204-015-1539-0","article-title":"Maternal exposure to di\u2011(2\u2011ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring","volume":"90","author":"Lee","year":"2016","journal-title":"Arch Toxicol ."},{"key":"10.1016\/j.tox.2019.03.008_bib0185","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/toxsci\/kfh169","article-title":"Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate","volume":"81","author":"Lehmann","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0190","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPAR\u03b3","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.tox.2019.03.008_bib0195","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1152\/ajpendo.00233.2011","article-title":"Developmental exposure to Di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat","volume":"301","author":"Lin","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2019.03.008_bib0200","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2605.2005.00642.x","article-title":"Possible impact of phthalates on infant reproductive health","volume":"29","author":"Lottrup","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tox.2019.03.008_bib0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1289\/EHP464","article-title":"Monoethylhexyl phthalate elicits an inflammatory response in adipocytes characterized by alterations in lipid and cytokine pathways","volume":"125","author":"Manteiga","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2019.03.008_bib0210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jsbmb.2013.01.007","article-title":"Fetal origin of endocrine dysfunction in the adult: the phthalate model","volume":"137","author":"Martinez-Arguelles","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tox.2019.03.008_bib0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/mnfr.200800312","article-title":"Reproductive toxicity of phthalate esters","volume":"54","author":"Martino-Andrade","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.tox.2019.03.008_bib0220","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1098\/rstb.2008.0268","article-title":"Phthalates and other additives in plastics: human exposure and associated health outcomes","volume":"364","author":"Meeker","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0225","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/bcpt.12072","article-title":"Utero and lactational exposure to fluoxetine in wistar rats : pregnancy outcomes and sexual development","author":"Muller","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2019.03.008_bib0230","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-13-0616","article-title":"Nutrient regulation of insulin secretion and action","volume":"221","author":"Newsholme","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2019.03.008_bib0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1939-4640.2000.tb02114.x","article-title":"Genetic and cellular analysis of male germ cell development","volume":"21","author":"Olaso","year":"2000","journal-title":"J. Androl."},{"key":"10.1016\/j.tox.2019.03.008_bib0240","first-page":"20","article-title":"Signaling at the crossroads of gonad development","volume":"16","author":"Ross","year":"2005","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.tox.2019.03.008_bib0245","first-page":"1","article-title":"Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines","author":"Semache","year":"2014","journal-title":"Islets"},{"key":"10.1016\/j.tox.2019.03.008_bib0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018782","article-title":"Ages decrease insulin synthesis in pancreatic \u03b2-cell by repressing pdx-1 protein expression at the post-translational level","volume":"6","author":"Shu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2019.03.008_bib0255","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.jnutbio.2015.05.012","article-title":"In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge","volume":"26","author":"Strakovsky","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tox.2019.03.008_bib0260","first-page":"1819","article-title":"An improved method for the isolation of islets of Langerhans from the adult rat pancreas","volume":"18","author":"Sutton","year":"1986","journal-title":"Transplant Proc"},{"key":"10.1016\/j.tox.2019.03.008_bib0265","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/humrep\/deu363","article-title":"First trimester phthalate exposure and anogenital distance in newborns","volume":"30","author":"Swan","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tox.2019.03.008_bib0270","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1098\/rstb.2009.0053","article-title":"Plastics, the environment and human health: current consensus and future trends","volume":"364","author":"Thompson","year":"2009","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0275","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1098\/rstb.2009.0054","article-title":"Our plastic age","volume":"364","author":"Thompson","year":"2009","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.tox.2019.03.008_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-14-0290","article-title":"The role of transcription factors in the transdifferentiation of pancreatic islet cells","volume":"54","author":"Van Der Meulen","year":"2015","journal-title":"J. Mol. Endocrinol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18305572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X18305572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:40:43Z","timestamp":1759534843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X18305572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":56,"alternative-id":["S0300483X18305572"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2019.03.008","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2019.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}