{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:52:12Z","timestamp":1791611532421,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TTCRD 102-16"],"award-info":[{"award-number":["TTCRD 102-16"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 101-2320-B-039-042"],"award-info":[{"award-number":["NSC 101-2320-B-039-042"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["101-2320-B-039-043"],"award-info":[{"award-number":["101-2320-B-039-043"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007632","name":"Changhua Christian Hospital","doi-asserted-by":"publisher","award":["103-CCH-IRP-048"],"award-info":[{"award-number":["103-CCH-IRP-048"]}],"id":[{"id":"10.13039\/501100007632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.tox.2019.152245","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T11:28:22Z","timestamp":1563535702000},"page":"152245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Methylmercury exposure induces ROS\/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis"],"prefix":"10.1016","volume":"425","author":[{"given":"Yao-Pang","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chieh","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Cheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing-Hwa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Ching","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Shu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ying","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2019.152245_bib0005","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/toxsci\/kfy267","article-title":"Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology","volume":"167","author":"Ash","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2014.09.006","article-title":"Associations among exposure to methylmercury, reduced Reelin expression, and gender in the cerebellum of developing mice","volume":"45","author":"Biamonte","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0015","first-page":"1","article-title":"Mercury toxicity and neurodegenerative effects","volume":"229","author":"Carocci","year":"2014","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2010.04.007","article-title":"Methylmercury-induced neurotoxicity and apoptosis","volume":"188","author":"Ceccatelli","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2019.152245_bib0025","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2131\/jts.38.823","article-title":"Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells","volume":"38","author":"Chang","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fncel.2014.00213","article-title":"A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress","volume":"8","author":"Chaudhari","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tox.2019.152245_bib0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tox.2012.10.008","article-title":"Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals","volume":"303","author":"Chen","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0040","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2217\/fnl.12.72","article-title":"A critical kinase cascade in neurological disorders: PI 3-K, Akt, and mTOR","volume":"7","author":"Chong","year":"2012","journal-title":"Future Neurol."},{"key":"10.1016\/j.tox.2019.152245_bib0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1507\/endocrj.K10E-396","article-title":"Ghrelin suppresses tunicamycin- or thapsigargin-triggered endoplasmic reticulum stress-mediated apoptosis in primary cultured rat cortical neuronal cells","volume":"58","author":"Chung","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.tox.2019.152245_bib0050","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1677\/JOE-08-0160","article-title":"Phosphatidylinositol-3-kinase\/Akt\/glycogen synthase kinase-3 beta and ERK1\/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells","volume":"198","author":"Chung","year":"2008","journal-title":"J. Endocr."},{"key":"10.1016\/j.tox.2019.152245_bib0055","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra022471","article-title":"The toxicology of mercury--current exposures and clinical manifestations","volume":"349","author":"Clarkson","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2019.152245_bib0060","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.410350608","article-title":"Methylmercury poisoning: long-term clinical, radiological, toxicological, and pathological studies of an affected family","volume":"35","author":"Davis","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.tox.2019.152245_bib0065","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinson\u2019s Dis."},{"key":"10.1016\/j.tox.2019.152245_bib0070","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbrc.2012.01.037","article-title":"Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells","volume":"418","author":"Ding","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2019.152245_bib0075","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/019262339702500612","article-title":"Pathology of Minamata disease","volume":"25","author":"Eto","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2019.152245_bib0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.taap.2011.05.001","article-title":"Oxidative stress in MeHg-induced neurotoxicity","volume":"256","author":"Farina","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2019.152245_bib0085","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1242\/jcs.02724","article-title":"Protein kinase B\/Akt at a glance","volume":"118","author":"Fayard","year":"2005","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0090","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.taap.2014.12.008","article-title":"Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators","volume":"282","author":"Fujimura","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2019.152245_bib0095","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuro.2018.06.008","article-title":"Methylmercury induces oxidative stress and subsequent neural hyperactivity leading to cell death through the p38 MAPK-CREB pathway in differentiated SH-SY5Y cells","volume":"67","author":"Fujimura","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0100","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuro.2009.08.001","article-title":"Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain","volume":"30","author":"Fujimura","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0105","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1159\/000129365","article-title":"Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer\u2019s disease","volume":"25","author":"Gerhardsson","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.tox.2019.152245_bib0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/msj.20228","article-title":"Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans","volume":"78","author":"Grandjean","year":"2011","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.tox.2019.152245_bib0115","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10571-011-9671-8","article-title":"Akt as a victim, villain and potential hero in Parkinson\u2019s disease pathophysiology and treatment","volume":"31","author":"Greene","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.tox.2019.152245_bib0120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011189","article-title":"PI3K-PKB\/Akt pathway","volume":"4","author":"Hemmings","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tox.2019.152245_bib0125","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tox.2019.152245_bib0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tox.2019.152245_bib0135","first-page":"365","article-title":"Organomercurials. Their formation and pathways in the environment","volume":"7","author":"Hintelmann","year":"2010","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0140","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nm0410-396","article-title":"Endoplasmic reticulum stress and atherosclerosis","volume":"16","author":"Hotamisligil","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.tox.2019.152245_bib0145","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tox.2019.152245_bib0150","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxlet.2007.11.004","article-title":"Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+\/K(+)-ATPase involved","volume":"176","author":"Huang","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0155","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","article-title":"Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation","volume":"32","author":"Hybertson","year":"2011","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.tox.2019.152245_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.05.041","article-title":"2\u2032,4\u2032-Dihydroxy-6\u2032-methoxy-3\u2032,5\u2032-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K\/AKT pathway in BEL-7402\/5-FU cells","author":"Ji","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03033570","article-title":"Neurobehavioural and molecular changes induced by methylmercury exposure during development","volume":"11","author":"Johansson","year":"2007","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tox.2019.152245_bib0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/toxsci\/kfi028","article-title":"Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling","volume":"83","author":"Johnson","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tox.2019.152245_bib0180","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jprot.2018.06.020","article-title":"Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: deepening into the molecular mechanism of neurodegenerative diseases","volume":"187","author":"Karri","year":"2018","journal-title":"J. Proteomics"},{"key":"10.1016\/j.tox.2019.152245_bib0185","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tox.2019.152245_bib0190","first-page":"69A","article-title":"Neuroblastoma: cell culture analysis of a differentiating stem cell system","volume":"43","author":"Klebe","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tox.2019.152245_bib0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2011.01.030","article-title":"Akt\/GSK3beta signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SH-SY5Y cells","volume":"202","author":"Lee","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0200","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10495-013-0818-6","article-title":"New directions in ER stress-induced cell death","volume":"18","author":"Logue","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.tox.2019.152245_bib0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxlet.2010.11.019","article-title":"Arsenic induces pancreatic beta-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways","volume":"201","author":"Lu","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0210","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.toxlet.2013.10.013","article-title":"Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK\/ERK-mediated mitochondria-dependent and GRP 78\/CHOP-regulated pathways","volume":"224","author":"Lu","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0215","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1515\/REVEH.2006.21.2.105","article-title":"Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases","volume":"21","author":"Monnet-Tschudi","year":"2006","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.tox.2019.152245_bib0220","first-page":"331","article-title":"Alzheimer disease: mercury as pathogenetic factor and apolipoprotein E as a moderator","volume":"25","author":"Mutter","year":"2004","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0225","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.exger.2013.02.025","article-title":"PI3-kinase\/Akt\/mTOR signaling: impaired on\/off switches in aging, cognitive decline and Alzheimer\u2019s disease","volume":"48","author":"O\u2019Neill","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tox.2019.152245_bib0230","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/tx9003193","article-title":"Reactive oxygen species-activated Akt\/ASK1\/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells","volume":"23","author":"Pan","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0235","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1007\/s12035-016-0101-2","article-title":"Neurotoxicity of methylmercury in isolated astrocytes and neurons: the cytoskeleton as a main target","volume":"54","author":"Pierozan","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tox.2019.152245_bib0240","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s10495-009-0341-y","article-title":"Cellular responses to endoplasmic reticulum stress and apoptosis","volume":"14","author":"Rasheva","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.tox.2019.152245_bib0245","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3961\/jpmph.2014.47.2.74","article-title":"Environmental mercury and its toxic effects","volume":"47","author":"Rice","year":"2014","journal-title":"J. Prev. Med. Public Health"},{"key":"10.1016\/j.tox.2019.152245_bib0250","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","article-title":"Molecular mechanisms of caspase regulation during apoptosis","volume":"5","author":"Riedl","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tox.2019.152245_bib0255","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1474-4422(12)70238-7","article-title":"Endoplasmic reticulum dysfunction in neurological disease","volume":"12","author":"Roussel","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tox.2019.152245_bib0260","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tox.2005.05.013","article-title":"Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation","volume":"213","author":"Sakaue","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0265","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2131\/jts.40.817","article-title":"Methylmercury can induce Parkinson\u2019s-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells","volume":"40","author":"Shao","year":"2015","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2019.152245_bib0270","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: a key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2019.152245_bib0275","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1582-4934.2005.tb00337.x","article-title":"The activation of Akt\/PKB signaling pathway and cell survival","volume":"9","author":"Song","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2019.152245_bib0280","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.toxlet.2019.02.009","article-title":"Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts","volume":"306","author":"Takanezawa","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2019.152245_bib0285","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00204-004-0575-y","article-title":"Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin","volume":"78","author":"Toimela","year":"2004","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0290","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1038\/srep02346","article-title":"Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses","volume":"3","author":"Usuki","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2019.152245_bib0295","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuro.2007.08.011","article-title":"Methylmercury activates ASK1\/JNK signaling pathways, leading to apoptosis due to both mitochondria- and endoplasmic reticulum (ER)-generated processes in myogenic cell lines","volume":"29","author":"Usuki","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0300","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201110131","article-title":"The impact of the unfolded protein response on human disease","volume":"197","author":"Wang","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tox.2019.152245_bib0305","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1289\/ehp.0901510","article-title":"Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway","volume":"118","author":"Wang","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2019.152245_bib0310","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1471-4159.2010.07162.x","article-title":"Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons","volume":"117","author":"Xia","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2019.152245_bib0315","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tox.2012.06.006","article-title":"Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: involvement of oxidative stress and glutamate metabolism dysfunction","volume":"300","author":"Xu","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2019.152245_bib0320","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00204-011-0709-y","article-title":"Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway","volume":"85","author":"Yen","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0325","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00204-012-0864-9","article-title":"Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway","volume":"86","author":"Yen","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2019.152245_bib0330","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2010.10.017","article-title":"Ischemic postconditioning protects brain from ischemia\/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway","volume":"1367","author":"Yuan","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.tox.2019.152245_bib0335","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/mp400749f","article-title":"Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK\/AKT-p53 pathway","volume":"11","author":"Zhang","year":"2014","journal-title":"Mol. Pharm."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1930201X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X1930201X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:54:19Z","timestamp":1778540059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X1930201X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":67,"alternative-id":["S0300483X1930201X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2019.152245","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylmercury exposure induces ROS\/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2019.152245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152245"}}