{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:16Z","timestamp":1790740516414,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.tox.2019.152250","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T11:24:45Z","timestamp":1563449085000},"page":"152250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Potential attenuation of early-life overfeeding-induced metabolic dysfunction by chronic maternal acetylcholinesterase inhibitor exposure"],"prefix":"10.1016","volume":"425","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-8219","authenticated-orcid":false,"given":"Kelly","family":"Val\u00e9rio Prates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Aparecida","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrei","family":"Pavanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Paulo","family":"Jacinto Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veridiana Mota","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"da Silva Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Peixoto","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Andrade","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Divino","family":"Ferreira Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vander Silva","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laize Peron","family":"T\u00f3folo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Previate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudin\u00e9ia Conationi","family":"da Silva Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Mello","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesia","family":"Palma-Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Malta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Cezar","family":"de Freitas Mathias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tox.2019.152250_bib0005","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.nut.2013.07.012","article-title":"Pancreatic islets and their roles in metabolic programming","author":"Barella","year":"2014","journal-title":"Nutrition."},{"issue":"2","key":"10.1016\/j.tox.2019.152250_bib0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/03009734.2016.1154906","article-title":"Dynamic development of the pancreas from birth to adulthood","volume":"121","author":"Bonner-Weir","year":"2016","journal-title":"Ups. J. Med. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.tox.2019.152250_bib0015","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/ijosup.2012.17","article-title":"Nutritional programming of hypothalamic development: critical periods and windows of opportunity","author":"Bouret","year":"2012","journal-title":"Int. J. Obes. Suppl."},{"key":"10.1016\/j.tox.2019.152250_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fendo.2013.00037","article-title":"Beta cell dysfunction and insulin resistance","volume":"4","author":"Cerf","year":"2013","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"1","key":"10.1016\/j.tox.2019.152250_bib0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ijo.2017.189","article-title":"Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life","volume":"42","author":"Chan","year":"2017","journal-title":"Int. J. Obes."},{"issue":"2","key":"10.1016\/j.tox.2019.152250_bib0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/JOE-12-0408","article-title":"Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation","volume":"216","author":"de Oliveira","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2019.152250_bib0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.envres.2016.01.005","article-title":"Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth","volume":"146","author":"Debost-Legrand","year":"2016","journal-title":"Environ. Res."},{"issue":"Suppl. 3","key":"10.1016\/j.tox.2019.152250_bib0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1289\/ehp.99107s3409","article-title":"Exposures of children to organophosphate pesticides and their potential adverse health effects","volume":"107","author":"Eskenazi","year":"1999","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.tox.2019.152250_bib0045","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1289\/ehp.6789","article-title":"Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population","volume":"112","author":"Eskenazi","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2019.152250_bib0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s10661-018-6647-x","article-title":"Potential risks of dietary exposure to chlorpyrifos and cypermethrin from their use in fruit\/vegetable crops and beef cattle productions","volume":"190","author":"Ferr\u00e9","year":"2018","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.tox.2019.152250_bib0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuro.2015.02.003","article-title":"Neurobehavioral effects of exposure to organophosphates and pyrethroid pesticides among Thai children","volume":"48","author":"Fiedler","year":"2015","journal-title":"Neurotoxicology"},{"issue":"21","key":"10.1016\/j.tox.2019.152250_bib0060","first-page":"5503","article-title":"Maternal high-fat diet induces obesity and adrenal and thyroid dysfunction in male rat offspring at weaning","volume":"590","author":"Franco","year":"2012","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.tox.2019.152250_bib0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1289\/ehp.9087245","article-title":"Mechanism of action of organophosphorus and carbamate insecticides","volume":"87","author":"Fukuto","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2019.152250_bib0070","volume":"Vol. 199","author":"Gee","year":"2008"},{"issue":"7","key":"10.1016\/j.tox.2019.152250_bib0075","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF00400248","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis","volume":"35","author":"Hales","year":"1992","journal-title":"Diabetologia."},{"issue":"6","key":"10.1016\/j.tox.2019.152250_bib0080","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00125-011-2109-5","article-title":"Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function","volume":"54","author":"Hectors","year":"2011","journal-title":"Diabetologia."},{"issue":"6","key":"10.1016\/j.tox.2019.152250_bib0085","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13238-010-0069-z","article-title":"Insulin: a small protein with a long journey","volume":"1","author":"Hua","year":"2010","journal-title":"Protein Cell"},{"issue":"34","key":"10.1016\/j.tox.2019.152250_bib0090","doi-asserted-by":"crossref","first-page":"13603","DOI":"10.1073\/pnas.0702756104","article-title":"Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning","volume":"104","author":"Huang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.tox.2019.152250_bib0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.5604\/12321966.1167718","article-title":"Cholinesterase activity in blood and pesticide presence in sweat as biomarkers of children`s environmental exposure to crop protection chemicals","author":"Kapka-Skrzypczak","year":"2015","journal-title":"Ann. Agric. Environ. Med."},{"issue":"1","key":"10.1016\/j.tox.2019.152250_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00139709-200625010-00001","article-title":"Organophosphate-induced intermediate syndrome: aetiology and relationships with myopathy","volume":"25","author":"Karalliedde","year":"2006","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.tox.2019.152250_bib0105","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.injms.2018.06.007","article-title":"Recent advances in management of organophosphate & carbamate poisoning","author":"Kumar","year":"2018","journal-title":"Indian J. Med. Spec."},{"issue":"4","key":"10.1016\/j.tox.2019.152250_bib0110","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0091-3057(03)00022-4","article-title":"Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice","volume":"74","author":"Li","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.tox.2019.152250_bib0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40168-019-0635-4","article-title":"Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota","volume":"11","author":"Liang","year":"2019","journal-title":"Microbiome."},{"key":"10.1016\/j.tox.2019.152250_bib0120","doi-asserted-by":"crossref","first-page":"30745","DOI":"10.1038\/srep30745","article-title":"Neonatal treatment with scopolamine butylbromide prevents metabolic dysfunction in male rats","volume":"6","author":"Malta","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.tox.2019.152250_bib0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2009.12.005","article-title":"Butyrylcholinesterase for protection from organophosphorus poisons; catalytic complexities and hysteretic behavior","volume":"494","author":"Massona","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.tox.2019.152250_bib0130","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1159\/000358677","article-title":"Insulin oversecretion in MSG-obese rats is related to alterations in cholinergic muscarinic receptor subtypes in pancreatic islets","volume":"33","author":"Miranda","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"3-4","key":"10.1016\/j.tox.2019.152250_bib0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0300-9629(91)90443-G","article-title":"Milk secretion in the rat: progressive changes in milk composition during lactation and weaning and the effect of diet","volume":"98","author":"Nicholas","year":"1991","journal-title":"Camp. Biochem. Physiol."},{"issue":"5","key":"10.1016\/j.tox.2019.152250_bib0140","doi-asserted-by":"crossref","first-page":"E978","DOI":"10.1152\/ajpendo.00304.2011","article-title":"Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain","volume":"301","author":"Paranjape","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.tox.2019.152250_bib0145","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.beem.2012.03.008","article-title":"Early postnatal life as a critical time window for determination of long-term metabolic health","author":"Plagemann","year":"2012","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2019.152250_bib0150","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12889-015-1463-5","article-title":"Assessing biomarkers and neuropsychological outcomes in rural populations exposed to organophosphate pesticides in Chile \u2013 study design and protocol","volume":"15","author":"Ram\u00edrez-Santana","year":"2015","journal-title":"BMC Public Health"},{"issue":"3","key":"10.1016\/j.tox.2019.152250_bib0155","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbadis.2013.05.028","article-title":"Adipocytes under assault: environmental disruption of adipose physiology","volume":"1842","author":"Regnier","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2019.152250_bib0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tox.2016.10.010","article-title":"Acephate exposure during a perinatal life program to type 2 diabetes","volume":"372","author":"Ribeiro","year":"2016","journal-title":"Toxicology."},{"key":"10.1016\/j.tox.2019.152250_bib0165","first-page":"43","article-title":"Recognition and management of pesticide poisonings: united states environmental protection agency","author":"Roberts","year":"2013","journal-title":"Organophosphate Insecticides"},{"key":"10.1016\/j.tox.2019.152250_bib0170","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.pharep.2016.07.010","article-title":"Animal models of insulin resistance: a review","volume":"68","author":"Sah","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"6","key":"10.1016\/j.tox.2019.152250_bib0175","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/15563650701837030","article-title":"Fetal effects of environmental exposure of pregnant women to organophosphorus compounds in a rural farming community in Sri Lanka","volume":"46","author":"Samarawickrema","year":"2008","journal-title":"Clin. Toxicol. Phila. (Phila)"},{"key":"10.1016\/j.tox.2019.152250_bib0180","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF00257788","article-title":"A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans","volume":"21","author":"Scott","year":"1981","journal-title":"Diabetologia."},{"key":"10.1016\/j.tox.2019.152250_bib0185","volume":"Vol. 670","author":"Solecki","year":"2018"},{"key":"10.1016\/j.tox.2019.152250_bib0190","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12940-015-0019-6","article-title":"Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study","volume":"14","author":"Venerosi","year":"2015","journal-title":"Environ. Health"},{"issue":"22","key":"10.1016\/j.tox.2019.152250_bib0195","doi-asserted-by":"crossref","first-page":"10638","DOI":"10.1021\/jf8018084","article-title":"Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment","volume":"56","author":"Zhang","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.tox.2019.152250_bib0200","article-title":"Prenatal Exposure to Organophosphate Pesticides and Neurobehavioral Development of Neonates: A Birth Cohort Study in Shenyang, China","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X19302069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X19302069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:41:40Z","timestamp":1759534900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X19302069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":40,"alternative-id":["S0300483X19302069"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2019.152250","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential attenuation of early-life overfeeding-induced metabolic dysfunction by chronic maternal acetylcholinesterase inhibitor exposure","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2019.152250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152250"}}