{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:43:33Z","timestamp":1759538613387,"version":"build-2065373602"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.tox.2020.152411","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:56:29Z","timestamp":1581940589000},"page":"152411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury"],"prefix":"10.1016","volume":"433-434","author":[{"given":"Xiaohua","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-653X","authenticated-orcid":false,"given":"Hongshan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2020.152411_bib0005","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12917-018-1684-9","article-title":"Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice","volume":"14","author":"An","year":"2018","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.tox.2020.152411_bib0010","article-title":"Animal NLRs provide structural insights into plant NLR function","volume":"119","author":"Bentham","year":"2017","journal-title":"Ann. Bot."},{"key":"10.1016\/j.tox.2020.152411_bib0015","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.lpm.2017.08.012","article-title":"Autoimmune hepatitis: immunological diagnosis","volume":"46","author":"Brahim","year":"2017","journal-title":"Presse Med."},{"key":"10.1016\/j.tox.2020.152411_bib0020","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/08916930601061470","article-title":"Carbohydrate recognition systems in autoimmunity","volume":"39","author":"Buzas","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1016\/j.tox.2020.152411_bib0025","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3389\/fimmu.2017.00987","article-title":"Distinctive surface glycosylation patterns associated with mouse and human CD4(+) regulatory T Cells and their suppressive function","volume":"8","author":"Cabral","year":"2017","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.tox.2020.152411_bib0030","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.psyneuen.2012.05.008","article-title":"Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--curt Richter Award winner","volume":"37","author":"Dhabhar","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.tox.2020.152411_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/biom6030033","article-title":"Mucin-type O-glycosylation in gastric carcinogenesis","volume":"6","author":"Duarte","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.tox.2020.152411_bib0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-019-00741-8","article-title":"Treg cells in autoimmunity: from identification to Treg-based therapies","volume":"41","author":"Goschl","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.tox.2020.152411_bib0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7150\/ijms.29134","article-title":"Bilirubin attenuates ER stress-mediated inflammation, escalates apoptosis and reduces proliferation in the LS174T colonic epithelial cell line","volume":"16","author":"Gundamaraju","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.tox.2020.152411_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4049\/jimmunol.182.1.111","article-title":"CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1","volume":"182","author":"Han","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0055","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.3389\/fimmu.2018.02089","article-title":"Deficient O-GlcNAc glycosylation impairs regulatory t cell differentiation and notch signaling in autoimmune hepatitis","volume":"9","author":"Hao","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0060","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(12)62163-1","article-title":"Autoimmune hepatitis","volume":"382","author":"Heneghan","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2020.152411_bib0065","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2019.02.147","article-title":"Adoptive transfer of regulatory T cells stimulated by allogeneic hepatic stellate cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis","volume":"512","author":"Huang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2020.152411_bib0070","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bpg.2011.10.006","article-title":"The benefit of animal models for autoimmune hepatitis","volume":"25","author":"Jaeckel","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"10","key":"10.1016\/j.tox.2020.152411_bib0075","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1111\/jcmm.13752","article-title":"Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer","volume":"22","author":"Jiang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2020.152411_bib0080","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.it.2013.01.006","article-title":"The regulatory power of glycans and their binding partners in immunity","volume":"34","author":"Johnson","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0085","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/4371252a","article-title":"Protein glycosylation: chaperone mutation in Tn syndrome","volume":"437","author":"Ju","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tox.2020.152411_bib0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.molimm.2013.11.001","article-title":"The Tim-3\/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis","volume":"58","author":"Ju","year":"2014","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.tox.2020.152411_bib0095","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000487903","article-title":"Glucocorticoids reduce aberrant O-Glycosylation of IgA1 in IgA nephropathy patients","volume":"43","author":"Kosztyu","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.tox.2020.152411_bib0100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.it.2017.01.001","article-title":"NLRP6: a multifaceted innate immune sensor","volume":"38","author":"Levy","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3753081","article-title":"The imbalance between Foxp3(+)Tregs and Th1\/Th17\/Th22 cells in patients with newly diagnosed autoimmune hepatitis","volume":"2018","author":"Liang","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.tox.2020.152411_bib0110","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/hep.29307","article-title":"Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis\/autoimmune sclerosing cholangitis","volume":"66","author":"Liberal","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2020.152411_bib0115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0092-8674(01)00277-X","article-title":"Glycosylation, immunity, and autoimmunity","volume":"104","author":"Lowe","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.tox.2020.152411_bib0120","doi-asserted-by":"crossref","first-page":"20119","DOI":"10.1073\/pnas.1218059109","article-title":"Conservation of NLR-triggered immunity across plant lineages","volume":"109","author":"Maekawa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2020.152411_bib0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/0929866526666181208170027","article-title":"Leucine rich repeat proteins: sequences, mutations, structures and diseases","volume":"26","author":"Matsushima","year":"2019","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.tox.2020.152411_bib0130","article-title":"Serum cytokine profiles and Mac-2 binding protein glycosylation isomer (M2BPGi) level in patients with autoimmune hepatitis","volume":"97","author":"Migita","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tox.2020.152411_bib0135","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2020.152411_bib0140","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.celrep.2017.07.027","article-title":"Blockage of core fucosylation reduces cell-surface expression of PD-1 and promotes anti-tumor immune responses of t cells","volume":"20","author":"Okada","year":"2017","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.tox.2020.152411_bib0145","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22071104","article-title":"L1210 cells overexpressing ABCB1 drug transporters are resistant to inhibitors of the N- and O-glycosylation of proteins","volume":"22","author":"Pavlikova","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2020.152411_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06492.x","article-title":"Glycobiology of immune responses","volume":"1253","author":"Rabinovich","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2020.152411_bib0155","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/497056","article-title":"CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?","volume":"2015","author":"Radulovic","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.tox.2020.152411_bib0160","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1134\/S0006297908040032","article-title":"Mammalian galectins: structure, carbohydrate specificity, and functions","volume":"73","author":"Rapoport","year":"2008","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.tox.2020.152411_bib0165","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep4.1202","article-title":"Immune alterations in patients with type 1 autoimmune hepatitis persist upon standard immunosuppressive treatment","volume":"2","author":"Renand","year":"2018","journal-title":"Hepatol. Commun."},{"issue":"7","key":"10.1016\/j.tox.2020.152411_bib0170","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1007\/s12035-016-0075-0","article-title":"High-resolution expression profiling of peripheral blood CD8+ cells in patients with multiple sclerosis displays fingolimod-induced immune cell redistribution","volume":"54","author":"Roch","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.tox.2020.152411_bib0175","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment","volume":"13","author":"Scheuer","year":"1991","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2020.152411_bib0180","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jaci.2014.10.057","article-title":"Glycans and glycan-binding proteins in immune regulation: a concise introduction to glycobiology for the allergist","volume":"135","author":"Schnaar","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0185","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrrheum.2017.146","article-title":"Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?","volume":"13","author":"Seeling","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7670","key":"10.1016\/j.tox.2020.152411_bib0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature23875","article-title":"Discovery of stimulation-responsive immune enhancers with CRISPR activation","volume":"549","author":"Simeonov","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.tox.2020.152411_bib0195","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1080\/19420862.2019.1630218","article-title":"Site-specific N- and O-glycosylation analysis of atacicept","volume":"11","author":"Stavenhagen","year":"2019","journal-title":"MAbs"},{"issue":"1","key":"10.1016\/j.tox.2020.152411_bib0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1167\/iovs.07-1038","article-title":"Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells","volume":"49","author":"Sumiyoshi","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tox.2020.152411_bib0205","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.180.3.1655","article-title":"Suppression of Th2 cell development by Notch ligands Delta1 and Delta4","volume":"180","author":"Sun","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ni.f.203","article-title":"Protein-glycan interactions in the control of innate and adaptive immune responses","volume":"9","author":"Van Kooyk","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tox.2020.152411_bib0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sbi.2018.12.006","article-title":"O-glycosylation disorders pave the road for understanding the complex human O-glycosylation machinery","volume":"56","author":"Van Tol","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"6","key":"10.1016\/j.tox.2020.152411_bib0220","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005462","article-title":"Evolutionary forces shaping the Golgi glycosylation machinery: why cell surface glycans are universal to living cells","volume":"3","author":"Varki","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tox.2020.152411_bib0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/glycob\/cww086","article-title":"Biological roles of glycans","volume":"27","author":"Varki","year":"2017","journal-title":"Glycobiology"},{"key":"10.1016\/j.tox.2020.152411_bib0230","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3748\/wjg.v18.i2.119","article-title":"Immune mechanisms of Concanavalin A model of autoimmune hepatitis","volume":"18","author":"Wang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tox.2020.152411_bib0235","doi-asserted-by":"crossref","first-page":"48","DOI":"10.14218\/JCTH.2017.00032","article-title":"Autoimmune hepatitis in the Asia-Pacific Area","volume":"6","author":"Wang","year":"2018","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.tox.2020.152411_bib0240","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pharep.2017.07.017","article-title":"Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen","volume":"70","author":"Wongsena","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tox.2020.152411_bib0245","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2020.152411_bib0250","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1073\/pnas.1702041114","article-title":"NLR network mediates immunity to diverse plant pathogens","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2020.152411_bib0255","first-page":"1","article-title":"New insights into Nod-like receptors (NLRs) in liver diseases","volume":"10","author":"Xu","year":"2020","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.tox.2020.152411_bib0260","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1159\/000489074","article-title":"Comparison of concanavalin a-Induced murine autoimmune hepatitis models","volume":"46","author":"Ye","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tox.2020.152411_bib0265","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.5604\/01.3001.0012.7202","article-title":"Association of Interleukin-6 and Interleukin-1 family gene polymorphisms in autoimmune hepatitis","volume":"17","author":"Yousefi","year":"2020","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.tox.2020.152411_bib0270","first-page":"129","article-title":"The role of protein glycosylation in immune system","volume":"61","author":"Zabczynska","year":"2015","journal-title":"Postepy Biochem."},{"key":"10.1016\/j.tox.2020.152411_bib0275","first-page":"237","article-title":"O-GlcNAc glycosylation influences the biological behaviors and etoposide-induced apoptosis of Nalm-6 cells","volume":"38","author":"Zhang","year":"2017","journal-title":"Zhonghua Xue Ye Xue Za Zhi"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20300500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20300500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:42:51Z","timestamp":1759534971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X20300500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":55,"alternative-id":["S0300483X20300500"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2020.152411","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2020.152411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152411"}}