{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:39:32Z","timestamp":1784569172951,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010450","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","award":["99\/UR\/0860"],"award-info":[{"award-number":["99\/UR\/0860"]}],"id":[{"id":"10.13039\/100010450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.tox.2020.152412","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T11:42:25Z","timestamp":1583322145000},"page":"152412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Sub-chronic exposure to Kalach 360 SL, Glyphosate-based Herbicide, induced bone rarefaction in female Wistar rats"],"prefix":"10.1016","volume":"436","author":[{"given":"Latifa","family":"Hamdaoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassane","family":"Oudadesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lefeuvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Naifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Badraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Rebai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2020.152412_bib0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1289\/ehp.6667","article-title":"Glyphosate biomonitoring for farmers and their families: results from the farm family exposure study","volume":"112","author":"Acquavella","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2020.152412_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tox.2020.152412_bib0015","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.crvi.2007.09.002","article-title":"Effect of subchronic exposure to tetradifon on bone remodeling and metabolism in female rat","volume":"330","author":"Badraoui","year":"2007","journal-title":"C. R. Biol."},{"key":"10.1016\/j.tox.2020.152412_bib0020","first-page":"24","article-title":"Assessing the clinical utility of serum CTX in postmenopausal osteoporosis and its use in predicting risk of osteonecerosis of the jaw","author":"Baim","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tox.2020.152412_bib0025","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0002-9343(99)00460-X","article-title":"Osteomalacia due to vitamin D depletion: a neglected consequence of intestinal malabsorption","volume":"108","author":"Basha","year":"2000","journal-title":"Am. J. Med."},{"issue":"8","key":"10.1016\/j.tox.2020.152412_bib0030","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1043-2760(03)00144-9","article-title":"The molecular actions of thyroid hormone in bone","volume":"14","author":"Bassett","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.tox.2020.152412_bib0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of thyroid hormones in skeletal development and bone maintenance","volume":"37","author":"Bassett","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2020.152412_bib0040","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2215\/CJN.09750913","article-title":"Renal control of calcium, phosphate, and magnesium homeostasis","volume":"10","author":"Blaine","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.tox.2020.152412_bib0045","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.jes.7500535","article-title":"Perchlorate exposure of the US population, 2001-2002","volume":"17","author":"Blount","year":"2007","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.tox.2020.152412_bib0050","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1530\/eje.1.02128","article-title":"Environmental chemicals and thyroid function","volume":"154","author":"Boas","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.tox.2020.152412_bib0055","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00223-005-0009-8","article-title":"Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence","volume":"78","author":"Boonen","year":"2006","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.tox.2020.152412_bib0060","first-page":"302","article-title":"Microsomal lipid peroxidation","volume":"105","author":"Buege","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tox.2020.152412_bib0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.etap.2007.08.011","article-title":"The effect of sub-acute and sub-chronic exposure of ratsto the glyphosate-based herbicide Roundup","volume":"25","author":"Caglar","year":"2008","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2020.152412_bib0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tiv.2011.12.009","article-title":"A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels","volume":"26","author":"Clair","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2020.152412_bib0075","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(99)04466-9","article-title":"Reduced bone formation after exposure to organophosphates","volume":"354","author":"Compston","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2020.152412_bib0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.envpol.2008.07.027","article-title":"Bioaccumulation of glyphosate and its formulation Roundup in lumbriculus variegates and its effects on bio- transformation and antioxidant enzymes","volume":"157","author":"Contardo-Jara","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2020.152412_bib0085","series-title":"Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, Office of Pesticide Programs","author":"Draft Human Health Risk Assessment in Support of Registration Review","year":"2017"},{"key":"10.1016\/j.tox.2020.152412_bib0090","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bone.2012.03.018","article-title":"Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women","volume":"50","author":"Engstr\u00f6m","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.tox.2020.152412_bib0095","series-title":"Toxicological evaluations; International Programme on Chemical Safety","article-title":"Pesticide residues in food","author":"FAO","year":"2004"},{"key":"10.1016\/j.tox.2020.152412_bib0100","series-title":"Toxicological evaluations; International Programme on Chemical Safety","first-page":"373","article-title":"Pesticide residues in food","author":"FAO","year":"2011"},{"key":"10.1016\/j.tox.2020.152412_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu. Rev. Pathol. Mech."},{"key":"10.1016\/j.tox.2020.152412_bib0110","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2020.152412_bib0115","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s002239900350","article-title":"Identification of metabolic bone disease in patients with endogenous hyperthyroidism: role of biological markers of bone turnover","volume":"61","author":"Gimeno","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.tox.2020.152412_bib0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/15376516.2016.1230918","article-title":"Nephrotoxicity of Kalach 360 SL: biochemical and histopathological findings","volume":"26","author":"Hamdaoui","year":"2016","journal-title":"Toxicol. Mech. Meths."},{"key":"10.1016\/j.tox.2020.152412_bib0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/13813455.2017.1352606","article-title":"Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats","volume":"124","author":"Hamdaoui","year":"2018","journal-title":"Arch. Int. Physiol. Biochim. Biophys."},{"key":"10.1016\/j.tox.2020.152412_bib0130","first-page":"1","article-title":"Sub-chronic exposure to Kalach 360 SL\u2013induced damage in rats\u2019 liver and hematological system","author":"Hamdaoui","year":"2019","journal-title":"Environ. Sci. Pollut. R"},{"key":"10.1016\/j.tox.2020.152412_bib0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/07315724.2003.10719287","article-title":"Calcium absorption varies within the reference range for serum 25-hydroxy vitamin D","volume":"22","author":"Heaney","year":"2003","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.tox.2020.152412_bib0140","series-title":"Glyphosate; U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs","author":"Human-Health Assessment Scoping Document in Support of Registration Review","year":"2009"},{"issue":"7","key":"10.1016\/j.tox.2020.152412_bib0145","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00590-012-1087-8","article-title":"The impact of orthopedic device associated with carbonated hydroxyapatite on the oxidative balance: experimental study of bone healing rabbit model","volume":"23","author":"Jebahi","year":"2013","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.tox.2020.152412_bib0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcp.20041","article-title":"Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction","volume":"201","author":"Kanatani","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tox.2020.152412_bib0155","first-page":"231","article-title":"Diazinon exposure reduces trabecular and cortical bone mineral density","volume":"8","author":"Lari","year":"2012","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.tox.2020.152412_bib0160","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jtbi.2004.03.023","article-title":"Modeling the interactions between osteoblast and osteoclast activities in bone remodeling","volume":"229","author":"Lemaire","year":"2004","journal-title":"J. Theoretical boil."},{"issue":"2","key":"10.1016\/j.tox.2020.152412_bib0165","first-page":"251","article-title":"Osteoarticular disorders of endocrine origin, Best Pract","volume":"14","author":"Liote","year":"2000","journal-title":"Res. Clin. Rheumatol."},{"issue":"13","key":"10.1016\/j.tox.2020.152412_bib0170","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1289\/ehp.5800","article-title":"An approach to assessment of endocrine disruption in thenational children\u2019s study","volume":"111","author":"Longnecker","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2020.152412_bib0175","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2020.152412_bib0180","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.4314\/jab.v80i1.16","article-title":"Test d\u2019efficacit\u00e9 d\u2019un herbicide en culture d\u2019ananas et de production d\u2019Angu\u00e9d\u00e9dou en C\u00f4te d\u2019 Ivoire","volume":"80","author":"Mangara","year":"2014","journal-title":"J. Appl. Biosci."},{"key":"10.1016\/j.tox.2020.152412_bib0185","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis","volume":"31","author":"Manolagas","year":"2010","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2020.152412_bib0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What old means to bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tox.2020.152412_bib0195","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/rp.57.1.385","article-title":"Sex steroids and bone","volume":"57","author":"Manolagas","year":"2002","journal-title":"Recent Prog. Horm. Res."},{"issue":"12","key":"10.1016\/j.tox.2020.152412_bib0200","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrendo.2013.179","article-title":"The role of estrogen and androgen receptors in bone health and disease","volume":"9","author":"Manolagas","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tox.2020.152412_bib0205","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the super-oxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1975","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"10.1016\/j.tox.2020.152412_bib0210","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.yrtph.2012.05.012","article-title":"Epidemiologic studies of glyphosate and cancer: a review","volume":"63","author":"Mink","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2020.152412_bib0215","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/15287398209530276","article-title":"Teratogenic effects of cholinergicinsecticides in chick embryos. III. Development of cartilage and bone","volume":"10","author":"Misawa","year":"1982","journal-title":"J. Toxicol. Environ. Health"},{"issue":"9","key":"10.1016\/j.tox.2020.152412_bib0220","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/jbmr.432","article-title":"Thyroid hormone receptor \u03b2 mediates thyroid hormone effects on bone remodeling and bone mass","volume":"26","author":"Monfoulet","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tox.2020.152412_bib0225","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2265.2004.02053.x","article-title":"The thyroid and the skeleton","volume":"61","author":"Murphy","year":"2004","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.tox.2020.152412_bib0230","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.biopha.2017.05.023","article-title":"Protective effect of ethanolic extract of Urticaurens L. against the toxicity of imidacloprid on bone remodeling in rats and antioxidant activities","volume":"91","author":"Mzid","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tox.2020.152412_bib0235","article-title":"Thyroid disruption: mechanisms and clinical implications in human health","volume":"14","author":"Patrick","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.tox.2020.152412_bib0240","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.aquatox.2007.11.016","article-title":"Longitudinal changes in microbial planktonic communities of a French river in relation to pesticide and nutrient inputs","volume":"86","author":"Pesce","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2020.152412_bib0245","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.envres.2009.08.008","article-title":"Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women","volume":"109","author":"Rignell-Hydbom","year":"2009","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2020.152412_bib0250","first-page":"1993","author":"Rodwell","year":"1980"},{"issue":"12","key":"10.1016\/j.tox.2020.152412_bib0255","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.2337\/db07-0767","article-title":"Adipocyte death, adipose tissue remodeling, and obesity complications","volume":"56","author":"Strissel","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2020.152412_bib0260","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3358\/shokueishi.42.304","article-title":"Analysis of glyphosate and its metabolite, aminomethylphosphonic acid, in agricultural products by HPLC","volume":"42","author":"Takahashi","year":"2001","journal-title":"Shokuhin. Eiseigaku. Zasshi."},{"key":"10.1016\/j.tox.2020.152412_bib0265","first-page":"545","article-title":"The pesticide manual: a world compendium","author":"Tomlin","year":"2006","journal-title":"14th Edn. British Crop Protection Council, Hampshire"},{"key":"10.1016\/j.tox.2020.152412_bib0270","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13044-014-0012-0","article-title":"The influence of thyroid dysfunction on bone metabolism","volume":"7","author":"Tuchendler","year":"2014","journal-title":"J. Thyroid Res."},{"issue":"585","key":"10.1016\/j.tox.2020.152412_bib0275","first-page":"18","article-title":"Les glandes surr\u00e9nales, r\u00f4le et dysfonctionnement","volume":"58","author":"Turquetil","year":"2019","journal-title":"Actual. Pharm."},{"key":"10.1016\/j.tox.2020.152412_bib0280","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/02652039609374401","article-title":"Detection of same organochlorine pesticides in cow\u2019s milk","volume":"13","author":"Waliszevski","year":"1996","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.tox.2020.152412_bib0285","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/clinchem\/45.8.1359","article-title":"Clinical utility of biochemical markers of bone remodeling","volume":"45","author":"Watts","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.tox.2020.152412_bib0290","series-title":"Foye\u2019s Principles of Medicinal Chemistry","author":"Williams","year":"2002"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20300512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20300512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:43:03Z","timestamp":1759534983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X20300512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":58,"alternative-id":["S0300483X20300512"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2020.152412","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sub-chronic exposure to Kalach 360 SL, Glyphosate-based Herbicide, induced bone rarefaction in female Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2020.152412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152412"}}