{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:37:39Z","timestamp":1780612659973,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.tox.2020.152475","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T07:01:32Z","timestamp":1587970892000},"page":"152475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells"],"prefix":"10.1016","volume":"440","author":[{"given":"Yan","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanzhong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-7843","authenticated-orcid":false,"given":"Shizhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2020.152475_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molimm.2014.10.021","article-title":"Synergistic effect of pro-inflammatory TNFalpha and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis","volume":"64","author":"Amara","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.tox.2020.152475_bib0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/15476286.2016.1203501","article-title":"ADAR1 deletion induces NF\u03baB and interferon signaling dependent liver inflammation and fibrosis","volume":"14","author":"Ben-Shoshan","year":"2016","journal-title":"RNA biology"},{"key":"10.1016\/j.tox.2020.152475_bib0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/0008-5472.CAN-15-2556","article-title":"Transcriptional induction of periostin by a sulfatase 2-TGFbeta1-SMAD signaling Axis mediates tumor angiogenesis in hepatocellular carcinoma","volume":"77","author":"Chen","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2020.152475_bib0020","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2020.152475_bib0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jep.2015.07.020","article-title":"Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway","volume":"173","author":"Gao","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tox.2020.152475_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.tox.2020.152475_bib0035","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/jcmm.12636","article-title":"Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-beta1","volume":"19","author":"Hong","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2020.152475_bib0040","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ajpath.2014.11.002","article-title":"Matricellular protein periostin contributes to hepatic inflammation and fibrosis","volume":"185","author":"Huang","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2020.152475_bib0045","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.redox.2018.09.007","article-title":"Curcumol induces RIPK1\/RIPK3 complex-dependent necroptosis via JNK1\/2-ROS signaling in hepatic stellate cells","volume":"19","author":"Jia","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2020.152475_bib0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lfs.2019.04.021","article-title":"Periostin in chronic liver diseases: current research and future perspectives","volume":"226","author":"Jia","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2020.152475_bib0055","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/hep.29652","article-title":"Beta-Catenin and interleukin-1beta-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis","volume":"67","author":"Kaffe","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2020.152475_bib0060","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.ajpath.2017.06.009","article-title":"Platelet-Derived Growth Factor Receptor alpha Contributes to Human Hepatic Stellate Cell Proliferation and Migration","volume":"187","author":"Kikuchi","year":"2017","journal-title":"Am. J. Pathol."},{"issue":"25","key":"10.1016\/j.tox.2020.152475_bib0065","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/hum.2013.106","article-title":"Inhibitory effect of nuclear factor-\u03baB decoy oligodeoxynucleotide on liver fibrosis through regulation of the epithelial-mesenchymal transition","volume":"2014","author":"Kim","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tox.2020.152475_bib0070","doi-asserted-by":"crossref","first-page":"e0149652","DOI":"10.1371\/journal.pone.0149652","article-title":"Matricellular protein periostin mediates intestinal inflammation through the activation of nuclear factor kappa B signaling","volume":"11","author":"Koh","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2020.152475_bib0075","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1158\/0008-5472.CAN-05-4540","article-title":"Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer","volume":"66","author":"Kudo","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2020.152475_bib0080","doi-asserted-by":"crossref","first-page":"12781","DOI":"10.1074\/jbc.RA117.001601","article-title":"Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells","volume":"293","author":"Kumar","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2020.152475_bib0085","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.matbio.2014.04.007","article-title":"Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments","volume":"37","author":"Liu","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.tox.2020.152475_bib0090","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.biopha.2017.01.052","article-title":"Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia","volume":"88","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tox.2020.152475_bib0095","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1172\/JCI74438","article-title":"Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARalpha","volume":"124","author":"Lu","year":"2014","journal-title":"J. Clin. Inves."},{"key":"10.1016\/j.tox.2020.152475_bib0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12032-012-0385-7","article-title":"High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma","volume":"30","author":"Lv","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.tox.2020.152475_bib0105","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2016.04.018","article-title":"Sinusoidal communication in liver fibrosis and regeneration","volume":"65","author":"Marrone","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2020.152475_bib0110","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/cbin.10219","article-title":"Periostin and transforming growth factor beta-induced protein (TGFbetaIp) are both expressed by osteoblasts and osteoclasts","volume":"38","author":"Merle","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.tox.2020.152475_bib0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/mol.65.2.342","article-title":"Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells","volume":"65","author":"Nemeth","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2020.152475_bib0120","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1681\/ASN.2016070709","article-title":"Nf\u03bab-induced periostin activates integrin-\u03b23 signaling to promote renal injury in GN","volume":"28","author":"Prakoura","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tox.2020.152475_bib0125","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/rheumatology\/keu425","article-title":"Circulating periostin levels in patients with AS: association with clinical and radiographic variables, inflammatory markers and molecules involved in bone formation","volume":"54","author":"Sakellariou","year":"2015","journal-title":"Rheumatol. Oxf. (Oxf.)"},{"key":"10.1016\/j.tox.2020.152475_bib0130","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00535-016-1206-0","article-title":"Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via alphav integrin interaction","volume":"51","author":"Sugiyama","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.tox.2020.152475_bib0135","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/hep.25711","article-title":"Hepatic activation of IKK\/NF\u03baB signaling induces liver fibrosis via macrophage-mediated chronic inflammation","volume":"56","author":"Sunami","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tox.2020.152475_bib0140","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12369","article-title":"Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions","volume":"50","author":"Tang","year":"2017","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tox.2020.152475_bib0145","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/jid.2013.500","article-title":"Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1alpha\/IL-6 loop","volume":"134","author":"Taniguchi","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tox.2020.152475_bib0150","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1165\/rcmb.2011-0115OC","article-title":"Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis","volume":"46","author":"Uchida","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tox.2020.152475_bib0155","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.gastro.2009.04.011","article-title":"Kupffer cells mediate leptin-induced liver fibrosis","volume":"137","author":"Wang","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2020.152475_bib0160","doi-asserted-by":"crossref","first-page":"e10920","DOI":"10.1097\/MD.0000000000010920","article-title":"Inhibition of NF-\u03baB signaling pathway induces apoptosis and suppresses proliferation and angiogenesis of human fibroblast-like synovial cells in rheumatoid arthritis","volume":"97","author":"Xia","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.tox.2020.152475_bib0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.14348\/molcells.2017.2299","article-title":"Hepatitis C virus nonstructural 5A protein (HCV-NS5A) inhibits hepatocyte apoptosis through the NF-kappab\/miR-503\/bcl-2 pathway","volume":"40","author":"Xie","year":"2017","journal-title":"Mol. Cells"},{"key":"10.1016\/j.tox.2020.152475_bib0170","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.2147\/DDDT.S93732","article-title":"Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 mapk, nf-\u03bab\/i\u03bab\u03b1, and bcl-2\/bax signaling","volume":"9","author":"Yuan","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.tox.2020.152475_bib0175","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7150\/thno.22237","article-title":"Ligand activation of PPARgamma by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1alpha","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.tox.2020.152475_bib0180","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/jcmm.12286","article-title":"Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells","volume":"18","author":"Zhang","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2020.152475_bib0185","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12967-018-1676-3","article-title":"Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition","volume":"16","author":"Zhang","year":"2018","journal-title":"J. Transl. Med."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20301141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X20301141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:43:06Z","timestamp":1759534986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X20301141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":37,"alternative-id":["S0300483X20301141"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2020.152475","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2020.152475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152475"}}