{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:48:02Z","timestamp":1792669682486,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.tox.2021.152685","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:16:37Z","timestamp":1611270997000},"page":"152685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS\/3-MPST-H2S pathway in its astrocytic toxicity"],"prefix":"10.1016","volume":"451","author":[{"given":"Bobo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongzhu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.tox.2021.152685_bib0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jbt.20406","article-title":"Hepatoprotective activity of quercetin against acrylonitrile-induced hepatotoxicity in rats","volume":"25","author":"Abo-Salem","year":"2011","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2021.152685_bib0015","series-title":"ATSDR\u2019s Substance Priority List\/The ATSDR","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2019"},{"issue":"10","key":"10.1016\/j.tox.2021.152685_bib0020","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s00204-005-0667-3","article-title":"Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile","volume":"79","author":"Benz","year":"2005","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/faat.1997.2294","article-title":"Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time","volume":"36","author":"Benz","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0278-6915(86)90347-9","article-title":"Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water","volume":"24","author":"Binger","year":"1986","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.tox.2021.152685_bib0035","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/jcmm.12829","article-title":"High homocysteine levels prevent via H2S the CoCl2-induced alteration of lymphocyte viability","volume":"20","author":"Bruzzese","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2021.152685_bib0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuro.2013.04.007","article-title":"Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia","volume":"37","author":"Caito","year":"2013","journal-title":"Neurotoxicology."},{"issue":"11","key":"10.1016\/j.tox.2021.152685_bib0045","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1089\/ars.2009.3074","article-title":"Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders","volume":"13","author":"Calabrese","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.tox.2021.152685_bib0050","first-page":"3789","article-title":"A new hope for a devastating disease: hydrogen sulfide in Parkinson\u2019s disease","volume":"55","author":"Cao","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.tox.2021.152685_bib0055","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/ars.2017.7157","article-title":"Renal protective effect of hydrogen sulfide in cisplatin-induced nephrotoxicity","volume":"29","author":"Cao","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tox.2021.152685_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/molmed.2015.00035","article-title":"Regulation of vascular tone, angiogenesis and cellular bioenergetics by the 3-mercaptopyruvate sulfurtransferase\/H2S pathway: functional impairment by hyperglycemia and restoration by DL-\u03b1-lipoic acid","volume":"21","author":"Coletta","year":"2015","journal-title":"Mol Med."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0065","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.toxlet.2014.09.009","article-title":"Acrylonitrile exposure in the general population following a major train accident in Belgium: a human biomonitoring study","volume":"231","author":"De Smedt","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0022-1759(88)90310-9","article-title":"A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity","volume":"115","author":"Decker","year":"1988","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0075","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1152\/ajpregu.00419.2003","article-title":"Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout","volume":"286","author":"Dombkowski","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbrc.2014.07.107","article-title":"Downregulation of cystathionine beta-synthase\/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type","volume":"451","author":"Du","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2021.152685_bib0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.redox.2016.01.008","article-title":"Low sulfide levels and a high degree of cystathionine \u03b2-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat","volume":"8","author":"Dziegelewska","year":"2016","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1074248409357743","article-title":"L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury","volume":"15","author":"Elsey","year":"2010","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00204-014-1425-1","article-title":"Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes","volume":"90","author":"Fang","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.tox.2021.152685_bib0100","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/tx00024a013","article-title":"Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy","volume":"4","author":"Fennell","year":"1991","journal-title":"Chem. Res. Toxicol."},{"issue":"37","key":"10.1016\/j.tox.2021.152685_bib0105","doi-asserted-by":"crossref","first-page":"13559","DOI":"10.1073\/pnas.1413390111","article-title":"Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis","volume":"111","author":"Flannigan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.tox.2021.152685_bib0110","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1124\/mol.112.081596","article-title":"Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation","volume":"83","author":"Gade","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2004.04.094","article-title":"Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol","volume":"318","author":"Geng","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2021.152685_bib0125","first-page":"4925","article-title":"In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids","volume":"41","author":"Guengerich","year":"1981","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.tox.2021.152685_bib0130","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/humu.22335","article-title":"Correction of cystathionine \u03b2-synthase deficiency in mice by treatment with proteasome inhibitors","volume":"34","author":"Gupta","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.tox.2021.152685_bib0135","first-page":"43","volume":"Vol. 71","author":"IARC","year":"1999"},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2010.09.080","article-title":"Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice","volume":"650","author":"Jensen","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0145","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-4274(02)00074-7","article-title":"Chronic toxicity and oncogenic dose-response effects of lifetime oral acrylonitrile exposure to Fischer 344 rats","volume":"132","author":"Johannsen","year":"2002","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-007-0471-2","article-title":"N-acetyl-L-cysteine as a source of sulfane sulfur in astrocytoma and astrocyte cultures: correlations with cell proliferation","volume":"34","author":"Jurkowska","year":"2008","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfp043","article-title":"Neurovestibular toxicities of acrylonitrile and iminodipropionitrile in rats: a comparative evaluation of putative mechanisms and target sites","volume":"109","author":"Khan","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/ars.2011.4345","article-title":"Hydrogen sulfide is a signaling molecule and a cytoprotectant","volume":"17","author":"Kimura","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tox.2021.152685_bib0165","series-title":"Hydrogen Sulfide and Its Therapeutic Applications","author":"Kimura","year":"2013"},{"key":"10.1016\/j.tox.2021.152685_bib0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","article-title":"Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?","volume":"29","author":"Li","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.tox.2021.152685_bib0175","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1136\/gutjnl-2017-313778","article-title":"Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway","volume":"67","author":"Li","year":"2018","journal-title":"Gut."},{"key":"10.1016\/j.tox.2021.152685_bib0180","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2735347","article-title":"Hydrogen sulfide regulates the [Ca2+]i level in the primary medullary neurons","volume":"2016","author":"Liu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neures.2009.09.1713","article-title":"Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells","volume":"66","author":"Lu","year":"2010","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22020295","article-title":"Exogenous and endogenous hydrogen sulfide protects gastric mucosa against the formation and time-dependent development of ischemia\/reperfusion-induced acute lesions progressing into deeper ulcerations","volume":"22","author":"Magierowski","year":"2017","journal-title":"Molecules."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/jnc.12698","article-title":"Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons","volume":"130","author":"Miyamoto","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2021.152685_bib0200","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neures.2015.03.003","article-title":"Neuronal regulation of expression of hydrogen sulfide-producing enzyme cystathionine beta-synthase in rat spinal cord astrocytes","volume":"97","author":"Miyamoto","year":"2015","journal-title":"Neurosci. Res."},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0205","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbrc.2013.02.131","article-title":"Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway","volume":"433","author":"M\u00f3dis","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2021.152685_bib0210","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.niox.2014.03.001","article-title":"Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-\u03b2-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro","volume":"41","author":"M\u00f3dis","year":"2014","journal-title":"Nitric Oxide"},{"issue":"12","key":"10.1016\/j.tox.2021.152685_bib0215","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2003.10.007","article-title":"Hydrogen sulfide: from the smell of the past to the mediator of the future?","volume":"24","author":"Moore","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.tox.2021.152685_bib0220","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.1096\/fj.201901304R","article-title":"Hydrogen sulfide signaling in mitochondria and disease","volume":"33","author":"Murphy","year":"2019","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0225","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/bph.14100","article-title":"Multiple role of 3-mercaptopyruvate sulfurtransferase: antioxidative function, H2S and polysulfide production and possible SOx production","volume":"175","author":"Nagahara","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0230","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1096\/fj.03-1052fje","article-title":"Hydrogen sulfide induces calcium waves in astrocytes","volume":"18","author":"Nagai","year":"2004","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13075-020-02147-6","article-title":"The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis","volume":"22","author":"Nasi","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.tox.2021.152685_bib0240","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41514-020-0044-8","article-title":"Lifespan and healthspan benefits of exogenous H2S in C. Elegans are independent from effects downstream of eat-2 mutation","volume":"6","author":"Ng","year":"2020","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.tox.2021.152685_bib0245","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cca.2014.10.037","article-title":"Hydrogen sulfide in signaling pathways","volume":"439","author":"Olas","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tox.2021.152685_bib0250","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2019.10.410","article-title":"Are the beneficial effects of\u2019 antioxidant\u2019 lipoic acid mediated through metabolism of reactive sulfur species?","volume":"146","author":"Olson","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0255","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/molecules22040530","article-title":"Hydrogen sulphide production in healthy and ulcerated gastric mucosa of rats","volume":"22","author":"Patrycja","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2021.152685_bib0260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2018.07.029","article-title":"Reversal of Sp1 transactivation and TGF\u03b21\/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation","volume":"35","author":"Racine","year":"2018","journal-title":"Toxicol App Pharmacol."},{"key":"10.1016\/j.tox.2021.152685_bib0265","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fct.2013.06.035","article-title":"Acute toxicity of some synthetic cyanogens in rats: time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication","volume":"259","author":"Rao","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.tox.2021.152685_bib0270","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1096\/fj.202000173R","article-title":"Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells","volume":"34","author":"Rao","year":"2020","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.tox.2021.152685_bib0275","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H(2)S biosynthesis and catabolism: new insights from molecular studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"31","key":"10.1016\/j.tox.2021.152685_bib0280","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1073\/pnas.1608264113","article-title":"Transcriptional control of amino acid homeostasis is disrupted in Huntington\u2019s disease","volume":"113","author":"Sbodio","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2021.152685_bib0285","series-title":"Chemical & Engineering News","article-title":"Acrylonitrile fumes kill one in Belgium","author":"Scott","year":"2013"},{"issue":"5","key":"10.1016\/j.tox.2021.152685_bib0290","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.3892\/mmr.2017.7363","article-title":"Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells","volume":"16","author":"Shan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tox.2021.152685_bib0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2018.05.004","article-title":"MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS\/H2S pathway","volume":"78","author":"Shen","year":"2018","journal-title":"Nitric Oxide"},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0300","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2008","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0305","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfz091","article-title":"Sulfane sulfur in toxicology: a novel defense system against electrophilic stress","volume":"170","author":"Shinkai","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152685_bib0310","unstructured":"Specia M., 2015. Thousands evacuated after train carrying toxic chemicals derails in Tennessee. https:\/\/mashable.com\/2015\/07\/02\/train-derailment-tennessee\/ (accessed 27 January 2021)."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0315","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2060267","article-title":"Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat","volume":"206","author":"Stipanuk","year":"1982","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0320","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0006-291X(77)90056-0","article-title":"Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions","volume":"79","author":"Szabo","year":"1977","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0325","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuint.2009.08.008","article-title":"Hydrogen sulfide: a novel signaling molecule in the central nervous system","volume":"56","author":"Tan","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.tox.2021.152685_bib0330","unstructured":"United States Environmental Protection Agency (US EPA), 2020. Initial List of Hazardous Air Pollutants with Modifications. https:\/\/www.epa.gov\/haps\/initial-list-hazardous-air-pollutants-modifications (accessed 9 September 2020)."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0003-9861(67)90273-1","article-title":"Effect of sulfhydryl reagents on peroxidation in microsomes","volume":"118","author":"Utley","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0340","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.tox.2021.152685_bib0345","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00204-010-0519-7","article-title":"Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence","volume":"84","author":"Wang","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.tox.2021.152685_bib0350","first-page":"277","article-title":"Effects of S-adenosyl-L-methionine pretreatment on acute toxicity of acrylonitrile in mice","volume":"21","author":"Wang","year":"2011","journal-title":"J. Jiangsu Univ. (Med. Ed.)."},{"key":"10.1016\/j.tox.2021.152685_bib0355","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuroscience.2012.12.057","article-title":"L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS\/H\u2082S pathway","volume":"237","author":"Wang","year":"2013","journal-title":"Neuroscience."},{"issue":"2","key":"10.1016\/j.tox.2021.152685_bib0360","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/jpet.107.133538","article-title":"Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery","volume":"324","author":"Webb","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2021.152685_bib0365","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2018.00779","article-title":"Vascular protection of hydrogen sulfide on cerebral ischemia\/reperfusion injury in rats","volume":"9","author":"Wen","year":"2018","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.tox.2021.152685_bib0370","first-page":"140","article-title":"Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats","volume":"267","author":"Xing","year":"2010","journal-title":"Toxicology."},{"key":"10.1016\/j.tox.2021.152685_bib0375","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bioorg.2018.10.002","article-title":"Hydrogen sulfide releasing enmein-type diterpenoid derivatives as apoptosis inducers through mitochondria-related pathways","volume":"82","author":"Xu","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"6","key":"10.1016\/j.tox.2021.152685_bib0380","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s00204-018-2208-x","article-title":"Activation of autophagic flux and the Nrf2\/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes","volume":"92","author":"Yang","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152685_bib0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152248","article-title":"Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2\/ARE pathway independently of PKC\u03b4","volume":"425","author":"Yang","year":"2019","journal-title":"Toxicology."},{"issue":"Pt A","key":"10.1016\/j.tox.2021.152685_bib0390","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.phrs.2016.08.015","article-title":"Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosum","volume":"113","author":"Yetik-Anacak","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0395","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuro.2011.01.004","article-title":"Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen","volume":"32","author":"Yin","year":"2011","journal-title":"Neurotoxicology."},{"issue":"3","key":"10.1016\/j.tox.2021.152685_bib0400","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.neuint.2009.12.011","article-title":"Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells","volume":"56","author":"Yong","year":"2010","journal-title":"Neurochem. Int."},{"issue":"10","key":"10.1016\/j.tox.2021.152685_bib0405","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1021\/tx200394g","article-title":"Detoxification of methylmercury by hydrogen sulfide-producing enzyme in mammalian cells","volume":"24","author":"Yoshida","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152685_bib0410","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbi.2017.07.156","article-title":"The cystathionine \u03b2-synthase\/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tox.2021.152685_bib0415","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ecoenv.2019.04.063","article-title":"Induction of cystathionine gamma-lyase expression and metallothionein-1 S-sulfhydration alleviate cadmium-induced cell death in myoblast cells","volume":"179","author":"Zhang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2021.152685_bib0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105697","article-title":"Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: involved of inactivation of the TLR4\/NF-\u03baB signaling pathway","volume":"75","author":"Zhao","year":"2019","journal-title":"Int. Immunopharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21000081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21000081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:44:48Z","timestamp":1759535088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21000081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":84,"alternative-id":["S0300483X21000081"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152685","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS\/3-MPST-H2S pathway in its astrocytic toxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152685","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152685"}}