{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T13:25:13Z","timestamp":1794144313725,"version":"4.8.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.tox.2021.152697","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:04:29Z","timestamp":1611918269000},"page":"152697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos"],"prefix":"10.1016","volume":"452","author":[{"given":"Yujie","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Aniagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.152697_bib0005","series-title":"ATSDR\u2019s Substance Priority List","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2017"},{"key":"10.1016\/j.tox.2021.152697_bib0010","first-page":"1466","article-title":"Resveratrol causes WAF-1\/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells","volume":"7","author":"Ahmad","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tox.2021.152697_bib0015","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1139\/cjpp-2016-0512","article-title":"Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats","volume":"95","author":"Ahmet","year":"2017","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.tox.2021.152697_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22071122","article-title":"Protective effect of quercetin against oxidative stress-induced cytotoxicity in rat pheochromocytoma (PC-12) cells","volume":"22","author":"Bao","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2021.152697_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/toxsci\/53.1.109","article-title":"Trichloroethylene inhibits development of embryonic heart valve precursors in vitro","volume":"53","author":"Boyer","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152697_bib0030","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0026-895X(24)12541-2","article-title":"Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity","volume":"56","author":"Casper","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2021.152697_bib0035","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0022-3565(24)29205-3","article-title":"Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2","volume":"299","author":"Chang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2021.152697_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152532","article-title":"Resveratrol ameliorates disorders of mitochondrial biogenesis and mitophagy in rats continuously exposed to benzo(a)pyrene from embryonic development through adolescence","volume":"442","author":"Chen","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2021.152697_bib0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.1205879","article-title":"Human health effects of trichloroethylene: key findings and scientific issues","volume":"121","author":"Chiu","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152697_bib0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1021\/jm0498194","article-title":"Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators","volume":"48","author":"de Medina","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tox.2021.152697_bib0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrfmmm.2018.12.002","article-title":"Implication of GATA4 synonymous variants in congenital heart disease: a comprehensive in-silico approach","volume":"813","author":"Dixit","year":"2019","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2021.152697_bib0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/toxsci\/kfl083","article-title":"Cardiogenic effects of trichloroethylene and trichloroacetic acid following exposure during heart specification of avian development","volume":"94","author":"Drake","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152697_bib0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/ics.12036","article-title":"Beyond UV radiation: a skin under challenge","volume":"35","author":"Dupont","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.tox.2021.152697_bib0070","series-title":"Toxicological Review of Trichloroethylene","author":"EPA","year":"2011"},{"key":"10.1016\/j.tox.2021.152697_bib0075","first-page":"4340","article-title":"SOX9 modulates the expression of key transcription factors required for heart valve development","volume":"142","author":"Garside","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.tox.2021.152697_bib0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00794186","article-title":"Incidence of congenital heart disease: II. Prenatal incidence","volume":"16","author":"Hoffman","year":"1995","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.tox.2021.152697_bib0085","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ecoenv.2018.05.056","article-title":"Levels, characteristics and health risk assessment of VOCs in different functional zones of Hefei","volume":"160","author":"Hu","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2021.152697_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126610","article-title":"Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish","volume":"251","author":"Huang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2021.152697_bib0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.siny.2013.05.003","article-title":"Environmental origins of congenital heart disease: the heart-placenta connection","volume":"18","author":"Huhta","year":"2013","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.tox.2021.152697_bib0100","first-page":"9","article-title":"Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver","author":"Jiang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2021.152697_bib0105","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/tox.22142","article-title":"Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene","volume":"31","author":"Jiang","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2021.152697_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121521","article-title":"AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos","volume":"385","author":"Jin","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2021.152697_bib0115","first-page":"4","article-title":"Heart fields and cardiac morphogenesis","author":"Kelly","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.tox.2021.152697_bib0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.redox.2017.07.015","article-title":"Cellular adaptation to xenobiotics: interplay between xenosensors, reactive oxygen species and FOXO transcription factors","volume":"13","author":"Klotz","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2021.152697_bib0125","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bbrc.2003.08.105","article-title":"Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses","volume":"309","author":"Leonard","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2021.152697_bib0130","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.18632\/oncotarget.14056","article-title":"Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tox.2021.152697_bib0135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/bj20031123","volume":"377","author":"Ma","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2021.152697_bib0140","series-title":"List of Toxic and Harmful Water Pollutants","author":"Ministry of Ecology and Environment of the People\u2019s Republic of China","year":"2019"},{"key":"10.1016\/j.tox.2021.152697_bib0145","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.tox.2021.152697_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/carcin\/bgy158","article-title":"Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53\/TIGAR axis in colon cancer cells","volume":"40","author":"Norden","year":"2019","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tox.2021.152697_bib0155","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"Olson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.tox.2021.152697_bib0160","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/08880018.2012.762962","article-title":"Resveratrol and adipose-derived mesenchymal stem cells are effective in the prevention and treatment of doxorubicin cardiotoxicity in rats","volume":"30","author":"Pinarli","year":"2013","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.tox.2021.152697_bib0165","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1039\/C7FO01300K","article-title":"A comprehensive review of the health perspectives of resveratrol","volume":"8","author":"Rauf","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.tox.2021.152697_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115029","article-title":"Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist","volume":"398","author":"Ren","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152697_bib0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.14712\/fb2012058040166","article-title":"Resveratrol inhibits proliferation of primary rat hepatocytes in G0\/G1 by inhibiting DNA synthesis","volume":"58","author":"Rubiolo","year":"2012","journal-title":"Folia Biol. (Praha)"},{"key":"10.1016\/j.tox.2021.152697_bib0180","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ecoenv.2009.12.031","article-title":"Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide-induced oxidative stress in rat liver","volume":"73","author":"Sebai","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2021.152697_bib0185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/nyas.12839","article-title":"Therapeutic potential of resveratrol in heart failure","volume":"1348","author":"Sung","year":"2015","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.tox.2021.152697_bib0190","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/10715760802673008","article-title":"Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage","volume":"43","author":"Tatlidede","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.tox.2021.152697_bib0195","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2174\/1389202915666140716175634","article-title":"Congenital heart disease: the crossroads of genetics, epigenetics and environment","volume":"15","author":"Vecoli","year":"2014","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.tox.2021.152697_bib0200","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2013.06.001","article-title":"The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"537","author":"Wang","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2021.152697_bib0205","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/CM9.0000000000000194","article-title":"Protection role of resveratrol against alcohol-induced heart defect in zebrafish embryos","volume":"132","author":"Wang","year":"2019","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.tox.2021.152697_bib0210","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3892\/mmr.2014.2716","article-title":"Resveratrol inhibits the proliferation of human melanoma cells by inducing G1\/S cell cycle arrest and apoptosis","volume":"11","author":"Wu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tox.2021.152697_bib0215","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/tox.22448","article-title":"Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt\/beta-catenin signal pathways","volume":"32","author":"Yue","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2021.152697_bib0220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/bjp.2008.81","article-title":"Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo","volume":"154","author":"Zhao","year":"2008","journal-title":"Br. J. Pharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21000202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21000202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:44:37Z","timestamp":1759535077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21000202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":44,"alternative-id":["S0300483X21000202"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152697","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152697"}}