{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:56:04Z","timestamp":1790499364823,"version":"4.1.0"},"reference-count":209,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.tox.2021.152803","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T11:11:23Z","timestamp":1619262683000},"page":"152803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Nutrition, one-carbon metabolism and arsenic methylation"],"prefix":"10.1016","volume":"457","author":[{"given":"Ahlam","family":"Abuawad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-5767","authenticated-orcid":false,"given":"Anne K.","family":"Bozack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-6252","authenticated-orcid":false,"given":"Roheeni","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V.","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.152803_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106401","article-title":"Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents","volume":"149","author":"Abuawad","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0010","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1158\/1055-9965.EPI-06-0676","article-title":"Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh","volume":"16","author":"Ahsan","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0015","series-title":"Known and Probable Human Carcinogens","author":"American Cancer Society","year":"2016"},{"key":"10.1016\/j.tox.2021.152803_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40572-015-0052-1","article-title":"Arsenic Exposure and Epigenetic Alterations: Recent Findings Based on the Illumina 450K DNA Methylation Array","volume":"2","author":"Argos","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.tox.2021.152803_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1289\/ehp.1307884","article-title":"Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh","volume":"123","author":"Argos","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0030","series-title":"National Water-quality Assessment Program Trace Elements and Radon in Groundwater Across the United States","author":"Ayotte","year":"2011"},{"key":"10.1016\/j.tox.2021.152803_bib0035","doi-asserted-by":"crossref","first-page":"12443","DOI":"10.1021\/acs.est.7b02881","article-title":"Estimating the high-arsenic domestic-well population in the Conterminous United States","volume":"51","author":"Ayotte","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2021.152803_bib0040","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1289\/ehp.1003393","article-title":"Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India","volume":"119","author":"Basu","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ijheh.2014.03.004","article-title":"Maternal arsenic exposure and birth outcomes: a comprehensive review of the epidemiologic literature focused on drinking water","volume":"217","author":"Bloom","year":"2014","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.envint.2018.12.004","article-title":"One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort","volume":"123","author":"Bommarito","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0055","article-title":"Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation trial in Bangladesh","author":"Bozack","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0060","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-nutr-082117-051757","article-title":"Nutritional influences on one-carbon metabolism: effects on arsenic methylation and toxicity","volume":"38","author":"Bozack","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0065","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/15592294.2018.1516453","article-title":"DNA methylation in cord blood as mediator of the association between prenatal arsenic exposure and gestational age","volume":"13","author":"Bozack","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.tox.2021.152803_bib0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.EE9.0000606056.51832.73","article-title":"Folic acid effects blood arsenic metabolites: results from the Folic Acid and Creatine Trial in Bangladesh","volume":"3","author":"Bozack","year":"2019","journal-title":"Environ. Epidemiol."},{"key":"10.1016\/j.tox.2021.152803_bib0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/ajcn\/nqy148","article-title":"Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh","volume":"109","author":"Bozack","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0080","article-title":"Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults","author":"Bozack","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0085","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6263","article-title":"Locus-specific differential DNA methylation and urinary arsenic: an epigenome-wide association study in blood among adults with low-to-Moderate arsenic exposure","volume":"128","author":"Bozack","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1017\/S2040174414000221","article-title":"Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys","volume":"5","author":"Broberg","year":"2014","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.tox.2021.152803_bib0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.18388\/abp.2004_3580","article-title":"Methylation demand: a key determinant of homocysteine metabolism","volume":"51","author":"Brosnan","year":"2004","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.tox.2021.152803_bib0100","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00726-011-0853-y","article-title":"The metabolic burden of creatine synthesis","volume":"40","author":"Brosnan","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.tox.2021.152803_bib0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0303-8467(92)90179-7","article-title":"Increased neurotoxicity of arsenic in methylenetetrahydrofolate reductase deficiency","volume":"94","author":"Brouwer","year":"1992","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.tox.2021.152803_bib0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00405933","article-title":"Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man","volume":"48","author":"Buchet","year":"1981","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0115","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.bi.64.070195.003445","article-title":"The catalytic mechanism and structure of thymidylate synthase","volume":"64","author":"Carreras","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tox.2021.152803_bib0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/cr60115a003","article-title":"Biological methylation","volume":"36","author":"Challenger","year":"1945","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tox.2021.152803_bib0125","first-page":"303","article-title":"Arsenic methylation and bladder cancer risk in Taiwan","volume":"14","author":"Chen","year":"2003","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tox.2021.152803_bib0130","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.chemosphere.2012.02.059","article-title":"Arsenic methylation, GSTO1 polymorphisms, and metabolic syndrome in an arseniasis endemic area of southwestern Taiwan","volume":"88","author":"Chen","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2021.152803_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108681","article-title":"Early life and adolescent arsenic exposure from drinking water and blood pressure in adolescence","volume":"178","author":"Chen","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00204-018-2332-7","article-title":"Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice","volume":"93","author":"Chi","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0145","first-page":"87","article-title":"Pattern of excretion of arsenic compounds [arsenite, arsenate, MMA(V), DMA(V)] in urine of children compared to adults from an arsenic exposed area in Bangladesh","volume":"38","author":"Chowdhury","year":"2003","journal-title":"J. Environ. Sci. Health A. Tox. Subst. Environ. Eng."},{"key":"10.1016\/j.tox.2021.152803_bib0150","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1289\/ehp.02110729","article-title":"Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water","volume":"110","author":"Chung","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.envres.2012.11.007","article-title":"Urinary arsenic profiles and the risks of cancer mortality: a population-based 20-year follow-up study in arseniasis-endemic areas in Taiwan","volume":"122","author":"Chung","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0160","series-title":"The Vitamins","author":"Combs","year":"2012"},{"key":"10.1016\/j.tox.2021.152803_bib0165","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/toxsci\/44.2.185","article-title":"Exposure to inorganic arsenic metabolites during early human development","volume":"44","author":"Concha","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152803_bib0170","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s004200050248","article-title":"Low-level arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water","volume":"71","author":"Concha","year":"1998","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0175","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1038\/s41467-018-07803-9","article-title":"The gut microbiome is required for full protection against acute arsenic toxicity in mouse models","volume":"9","author":"Coryell","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2021.152803_bib0180","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1074\/jbc.271.5.2839","article-title":"Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats","volume":"271","author":"Cui","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2021.152803_bib0185","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfj159","article-title":"Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung Cancer in A\/J mice","volume":"91","author":"Cui","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152803_bib0190","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/dc07-2417","article-title":"Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study","volume":"31","author":"Dabelea","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tox.2021.152803_bib0195","series-title":"Fortification of Wheat Flour: Biological, Behavioural and Contextual Rationale","author":"Darnton-Hill","year":"2017"},{"key":"10.1016\/j.tox.2021.152803_bib0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108098","article-title":"Dietary sources of methylated arsenic species in urine of the United States Population, NHANES 2003\u20132010","volume":"9","author":"deCastro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2021.152803_bib0205","doi-asserted-by":"crossref","DOI":"10.1289\/EHP3849","article-title":"Association of arsenic exposure with whole blood DNA methylation: an epigenome-wide study of bangladeshi adults","volume":"127","author":"Demanelis","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0210","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1017\/S0007114508162985","article-title":"Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats","volume":"102","author":"Deminice","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0215","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1021\/tx900179r","article-title":"Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate","volume":"22","author":"Drobna","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-Carbon Metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tox.2021.152803_bib0225","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mrfmmm.2008.07.003","article-title":"Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions","volume":"667","author":"Engstr\u00f6m","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/em.21896","article-title":"Genetic variation in arsenic (+3 oxidation state) methyltransferase (AS3MT), arsenic metabolism and risk of basal cell carcinoma in a European population","volume":"56","author":"Engstr\u00f6m","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.tox.2021.152803_bib0235","series-title":"Technical Fact Sheet: Final Rule for Arsenic in Drinking Water. Report No. EPA-815-F-00-016","author":"Environmental Protection Agency (EPA)","year":"2001"},{"key":"10.1016\/j.tox.2021.152803_bib0240","article-title":"National primary drinking water regulations; arsenic and clarifications to compliance and new cource contaminants","volume":"66","author":"Environmental Protection Agency (EPA)","year":"2001","journal-title":"Final rule."},{"key":"10.1016\/j.tox.2021.152803_bib0245","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3945\/ajcn.113.079038","article-title":"Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women: a large population-based, prospective cohort study","volume":"100","author":"Eshak","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0250","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1289\/ehp.11094","article-title":"Breast-feeding protects against arsenic exposure in bangladeshi infants","volume":"116","author":"F\u00e4ngstr\u00f6m","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0255","first-page":"106","article-title":"Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study","volume":"15","author":"Farzan","year":"2016","journal-title":"Environ. Health A Glob. Access Sci. Source"},{"key":"10.1016\/j.tox.2021.152803_bib0260","series-title":"Arsenic in Rice and Rice Products: Risk Assessment Report","author":"Food & Drug Administration (FDA)","year":"2016"},{"key":"10.1016\/j.tox.2021.152803_bib0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12940-017-0350-1","article-title":"Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. Adolescents and adults: an association modified by race\/ethnicity, NHANES 2005\u20132014","volume":"17","author":"Frediani","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0270","doi-asserted-by":"crossref","first-page":"a145","DOI":"10.1289\/ehp.1104807","article-title":"Relationship of creatinine and nutrition with arsenic metabolism","volume":"120","author":"Gamble","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0275","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/ajcn\/81.6.1372","article-title":"Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh","volume":"81","author":"Gamble","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0280","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1289\/ehp.8084","article-title":"Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh","volume":"113","author":"Gamble","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0285","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ajcn\/84.5.1093","article-title":"Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh","volume":"84","author":"Gamble","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0290","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/ajcn\/86.4.1202","article-title":"Folic acid supplementation lowers blood arsenic","volume":"86","author":"Gamble","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0295","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.envres.2017.04.016","article-title":"Arsenic metabolism and cancer risk: a meta-analysis","volume":"156","author":"Gamboa-Loira","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0300","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.envres.2018.01.050","article-title":"Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism","volume":"164","author":"Gamboa-Loira","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0305","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1289\/ehp.1408909","article-title":"The genetic architecture of arsenic metabolism efficiency: a SNP-based heritability study of Bangladeshi adults","volume":"123","author":"Gao","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0310","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1158\/1055-9965.EPI-13-0234-T","article-title":"Arsenic exposure and cancer mortality in a US-based prospective cohort: the Strong Heart Study","volume":"22","author":"Garc\u00eda-Esquinas","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0315","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.reprotox.2010.11.002","article-title":"Arsenic methylation efficiency increases during the first trimester of pregnancy independent of folate status","volume":"31","author":"Gardner","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0320","doi-asserted-by":"crossref","first-page":"20656","DOI":"10.1073\/pnas.1109127108","article-title":"Rice consumption contributes to arsenic exposure in US women","volume":"108","author":"Gilbert-Diamond","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2021.152803_bib0325","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1289\/ehp.1206178","article-title":"A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA","volume":"121","author":"Gilbert-Diamond","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0330","doi-asserted-by":"crossref","DOI":"10.1002\/jat.1492","article-title":"Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10","volume":"30","author":"Gomez-Rubio","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0335","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.taap.2011.02.007","article-title":"Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. And northwest Mexico","volume":"252","author":"Gomez-Rubio","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0340","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144832","article-title":"As3MT and GST polymorphisms influencing arsenic metabolism in human exposure to drinking groundwater","volume":"21","author":"Gonz\u00e1lez-Mart\u00ednez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2021.152803_bib0345","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jat.2898","article-title":"Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations","volume":"34","author":"Gosse","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0350","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2566","article-title":"Association of low-moderate arsenic exposure and arsenic metabolism with incident diabetes and insulin resistance in the strong heart family study","volume":"125","author":"Grau-Perez","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0355","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1289\/ehp.9906","article-title":"Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs","volume":"115","author":"Hall","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0360","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1289\/ehp.0800164","article-title":"Folate, cobalamin, cysteine, homocysteine, and arsenic metabolism among children in Bangladesh","volume":"117","author":"Hall","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0365","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1289\/ehp.0900734","article-title":"Influence of cobalamin on arsenic metabolism in Bangladesh","volume":"117","author":"Hall","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0370","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.scitotenv.2009.12.043","article-title":"Assessment of in vivo bioaccessibility of arsenic in dietary rice by a mass balance approach","volume":"408","author":"He","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2021.152803_bib0375","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/ajcn\/85.5.1367","article-title":"Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh","volume":"85","author":"Heck","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0380","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40572-016-0104-1","article-title":"Influence of arsenic on global levels of histone posttranslational modifications: a review of the literature and challenges in the field","volume":"3","author":"Howe","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.tox.2021.152803_bib0385","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1289\/ehp.1510412","article-title":"Associations between blood and urine arsenic concentrations and global levels of post-translational histone modifications in Bangladeshi men and women","volume":"124","author":"Howe","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0390","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/1055-9965.EPI-16-0202","article-title":"Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed bangladeshi adults","volume":"26","author":"Howe","year":"2017","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0395","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.taap.2006.10.022","article-title":"Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan","volume":"218","author":"Huang","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0400","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.fct.2007.10.017","article-title":"Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility","volume":"46","author":"Huang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0405","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00204-018-2206-z","article-title":"Prenatal arsenic exposure and dietary folate and methylcobalamin supplementation alter the metabolic phenotype of C57BL\/6J mice in a sex-specific manner","volume":"92","author":"Huang","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0410","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.taap.2010.09.017","article-title":"Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice","volume":"249","author":"Hughes","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0415","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/1055-9965.EPI-15-0718","article-title":"Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity","volume":"25","author":"Jansen","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0420","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/jes.2013.14","article-title":"Occurrence of trivalent monomethyl arsenic and other urinary arsenic species in a highly exposed juvenile population in Bangladesh","volume":"24","author":"Kalman","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.tox.2021.152803_bib0425","doi-asserted-by":"crossref","first-page":"E2319","DOI":"10.1073\/pnas.1619745114","article-title":"Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis","volume":"114","author":"Kamynina","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2021.152803_bib0430","doi-asserted-by":"crossref","DOI":"10.5620\/eaht.2020006","article-title":"Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic","volume":"35","author":"Kazemifar","year":"2020","journal-title":"Environ Anal Health Toxicol"},{"key":"10.1016\/j.tox.2021.152803_bib0435","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1210\/jc.2013-1536","article-title":"Insulin resistance and impaired pancreatic \u03b2-cell function in adult offspring of women with diabetes in pregnancy","volume":"98","author":"Kelstrup","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2021.152803_bib0440","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.bi.26.070157.001003","article-title":"Metabolism of Lipides","volume":"26","author":"Kennedy","year":"1957","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tox.2021.152803_bib0445","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1289\/ehp.11251","article-title":"Variability in biomarkers of arsenic exposure and metabolism in adults over time","volume":"117","author":"Kile","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0450","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1289\/ehp.1104173","article-title":"Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes","volume":"120","author":"Kile","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0455","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4161\/epi.28153","article-title":"Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood","volume":"9","author":"Kile","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.tox.2021.152803_bib0460","doi-asserted-by":"crossref","first-page":"87003","DOI":"10.1289\/EHP6943","article-title":"Arsenic metabolism in mice carrying a BORCS7\/AS3MT locus humanized by syntenic replacement","volume":"128","author":"Koller","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0465","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/ijc.31720","article-title":"Potential effect modifiers of the arsenic-bladder cancer risk relationship","volume":"143","author":"Koutros","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2021.152803_bib0470","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2337\/dc14-1641","article-title":"Arsenic exposure, arsenic metabolism, and incident diabetes in the strong heart study","volume":"38","author":"Kuo","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tox.2021.152803_bib0475","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.envint.2018.05.033","article-title":"Early-life arsenic exposure promotes atherogenic lipid metabolism in adolescence: a 15-year birth cohort follow-up study in central Taiwan","volume":"118","author":"Kuo","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0480","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.scitotenv.2017.07.019","article-title":"Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003-2004","volume":"607-608","author":"Kurzius-Spencer","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2021.152803_bib0485","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41370-018-0041-1","article-title":"Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico","volume":"28","author":"Laine","year":"2018","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.tox.2021.152803_bib0490","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1742-4682-8-31","article-title":"Mathematical model insights into arsenic detoxification","volume":"8","author":"Lawley","year":"2011","journal-title":"Theor. Biol. Med. Model."},{"key":"10.1016\/j.tox.2021.152803_bib0495","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1289\/ehp.10639","article-title":"Nutritional status has marginal influence on the metabolism of inorganic arsenic in pregnant Bangladeshi women","volume":"116","author":"Li","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0500","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1007\/s11356-013-1768-9","article-title":"Prolonged environmental exposure of arsenic through drinking water on the risk of hypertension and type 2 diabetes","volume":"20","author":"Li","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0505","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-069X-12-37","article-title":"Association of urinary monomethylated arsenic concentration and risk of hypertension: a cross-sectional study from arsenic contaminated areas in northwestern China","volume":"12","author":"Li","year":"2013","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0510","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.3390\/ijerph120403615","article-title":"A potential synergy between incomplete arsenic methylation capacity and demographic characteristics on the risk of hypertension: Findings from a cross-sectional study in an arsenic-endemic area of inner Mongolia, China","volume":"12","author":"Li","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2021.152803_bib0515","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15102191","article-title":"A comprehensive review of arsenic exposure and risk from Rice and a risk assessment among a cohort of adolescents in Kunming, China","volume":"15","author":"Liao","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2021.152803_bib0520","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.1074\/jbc.M110246200","article-title":"A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2021.152803_bib0525","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1289\/ehp.10026","article-title":"Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms","volume":"115","author":"Lindberg","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0530","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2008.02.001","article-title":"The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure","volume":"230","author":"Lindberg","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0535","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2014.07.013","article-title":"Arsenic methylation capacity is associated with breast cancer in northern Mexico","volume":"280","author":"L\u00f3pez-Carrillo","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0540","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.envres.2016.08.015","article-title":"Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women","volume":"151","author":"L\u00f3pez-Carrillo","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109361","article-title":"Inorganic arsenic methylation capacity and breast cancer by immunohistochemical subtypes in northern Mexican women","volume":"184","author":"L\u00f3pez-Carrillo","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0550","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/tx4002868","article-title":"Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation","volume":"26","author":"Lu","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0555","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/tx400454z","article-title":"Gut microbiome phenotypes driven by host genetics affect arsenic metabolism","volume":"27","author":"Lu","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0560","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/em.21987","article-title":"Dysregulation of DNA methylation induced by past arsenic treatment causes persistent genomic instability in mammalian cells","volume":"57","author":"Mauro","year":"2016","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.tox.2021.152803_bib0565","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12940-015-0020-0","article-title":"Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh","volume":"14","author":"Mazumdar","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0570","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.envpol.2014.07.031","article-title":"Urinary excretion of arsenic following rice consumption","volume":"194","author":"Meharg","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2021.152803_bib0575","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.taap.2013.11.014","article-title":"Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile","volume":"274","author":"Melak","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0580","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1289\/ehp.1408742","article-title":"Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico","volume":"124","author":"Mendez","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0585","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14060556","article-title":"A review of the effects of chronic arsenic exposure on adverse pregnancy outcomes","volume":"14","author":"Milton","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2021.152803_bib0590","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1289\/ehp.6841","article-title":"Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India","volume":"112","author":"Mitra","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0595","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jes.2016.10.004","article-title":"Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing","volume":"49","author":"Moe","year":"2016","journal-title":"J. Environ. Sci. China (China)"},{"key":"10.1016\/j.tox.2021.152803_bib0600","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0026-0495(75)90040-2","article-title":"Labile methyl balances for normal humans on various dietary regimens","volume":"24","author":"Mudd","year":"1975","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.tox.2021.152803_bib0605","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.3390\/biom5042184","article-title":"Arsenic disruption of DNA damage responses-potential role in carcinogenesis and chemotherapy","volume":"5","author":"Muenyi","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.tox.2021.152803_bib0610","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3945\/ajcn.114.087551","article-title":"Rice consumption and risk of cardiovascular disease: results from a pooled analysis of 3 U.S. Cohorts","volume":"101","author":"Muraki","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0615","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1289\/ehp.1205875","article-title":"The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem","volume":"121","author":"Naujokas","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0620","doi-asserted-by":"crossref","DOI":"10.1001\/jama.300.7.814","article-title":"Arsenic exposure and prevalence of type 2 diabetes in US adults","volume":"300","author":"Navas-Acien","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.tox.2021.152803_bib0625","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11892-019-1272-9","article-title":"Early-life arsenic exposure, nutritional status, and adult diabetes risk","volume":"19","author":"Navas-Acien","year":"2019","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.tox.2021.152803_bib0630","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/dme.12286","article-title":"Gestational diabetes predicts the risk of childhood overweight and abdominal circumference independent of maternal obesity","volume":"30","author":"Nehring","year":"2013","journal-title":"Diabet. Med."},{"key":"10.1016\/j.tox.2021.152803_bib0635","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/aje\/kww002","article-title":"Peripheral arterial disease and its association with arsenic exposure and metabolism in the strong heart study","volume":"184","author":"Newman","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tox.2021.152803_bib0640","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1289\/ehp.1206421","article-title":"A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults","volume":"121","author":"Niedzwiecki","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0645","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1158\/1055-9965.EPI-15-0432","article-title":"Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh","volume":"24","author":"Niedzwiecki","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0650","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.envint.2018.01.015","article-title":"Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: a one-carbon metabolism candidate gene study","volume":"113","author":"Niedzwiecki","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0655","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7313","article-title":"Inequalities in public water arsenic concentrations in counties and community water systems across the United States, 2006\u20132011","volume":"128","author":"Nigra","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0660","series-title":"Arsenic in the Environment. Part I. Cycling and Characterization","first-page":"1","author":"Nriagu","year":"1990"},{"key":"10.1016\/j.tox.2021.152803_bib0665","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1039\/b709339j","article-title":"Additional danger of arsenic exposure through inhalation from burning of cow dung cakes laced with arsenic as a fuel in arsenic affected villages in Ganga\u2013Meghna\u2013Brahmaputra plain","volume":"9","author":"Pal","year":"2007","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.tox.2021.152803_bib0670","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.taap.2015.04.011","article-title":"Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium","volume":"286","author":"Pelch","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0675","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1289\/ehp.1409396","article-title":"Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial","volume":"123","author":"Peters","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0680","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.3945\/jn.115.216739","article-title":"Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo-controlled trial","volume":"145","author":"Peters","year":"2015","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0685","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1999.8872","article-title":"Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes","volume":"163","author":"Petrick","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0690","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/tx000264z","article-title":"Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase","volume":"14","author":"Petrick","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0695","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.000976","article-title":"Uncovering the human methyltransferasome","volume":"10","author":"Petrossian","year":"2011","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.tox.2021.152803_bib0700","article-title":"A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh","volume":"15","author":"Pierce","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tox.2021.152803_bib0705","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/ajcn\/86.4.1179","article-title":"Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults","volume":"86","author":"Pilsner","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0710","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1289\/ehp.11872","article-title":"Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions","volume":"117","author":"Pilsner","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0715","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037147","article-title":"Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA","volume":"7","author":"Pilsner","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2021.152803_bib0720","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.envres.2010.05.001","article-title":"Association of genetic variation in cystathionine-\u03b2-synthase and arsenic metabolism","volume":"110","author":"Porter","year":"2010","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0725","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.taap.2006.09.021","article-title":"Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure","volume":"218","author":"Pu","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0730","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/EDE.0b013e3181f56a0d","article-title":"Arsenic exposure and risk of spontaneous abortion, stillbirth, and infant mortality","volume":"21","author":"Rahman","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.tox.2021.152803_bib0735","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.toxlet.2009.01.001","article-title":"Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh","volume":"185","author":"Raqib","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2021.152803_bib0740","series-title":"Arsenic Pollution: a Global Synthesis","author":"Ravenscroft","year":"2009"},{"key":"10.1016\/j.tox.2021.152803_bib0745","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12918-015-0215-6","article-title":"Mathematical analysis of the regulation of competing methyltransferases","volume":"9","author":"Reed","year":"2015","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.tox.2021.152803_bib0750","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2217\/epi.09.45","article-title":"Effects of arsenic exposure on DNA methylation and epigenetic gene regulation","volume":"2","author":"Reichard","year":"2010","journal-title":"Epigenomics"},{"key":"10.1016\/j.tox.2021.152803_bib0755","doi-asserted-by":"crossref","DOI":"10.1111\/1440-1681.13353","article-title":"Assessment of heavy metals by ICP-OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes","author":"Saba","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tox.2021.152803_bib0760","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12918-018-0621-7","article-title":"Sex differences in hepatic one-carbon metabolism","volume":"12","author":"Sadre-Marandi","year":"2018","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.tox.2021.152803_bib0765","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1124\/jpet.107.120758","article-title":"NAD+ and vitamin B3: from metabolism to therapies","volume":"324","author":"Sauve","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2021.152803_bib0770","doi-asserted-by":"crossref","first-page":"110750","DOI":"10.1016\/j.envres.2021.110750","article-title":"Nutrition, one-carbon metabolism and arsenic methylation in Bangladeshi adolescents","volume":"195","author":"Saxena","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0775","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0003-9861(89)90254-3","article-title":"Quantitation of carbon flow through the hepatic folate-dependent one-carbon pool in rats","volume":"271","author":"Schalinske","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2021.152803_bib0780","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2337\/diacare.18.5.611","article-title":"Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism","volume":"18","author":"Silverman","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tox.2021.152803_bib0785","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0971-6580.84258","article-title":"Mechanisms pertaining to arsenic toxicity","volume":"18","author":"Singh","year":"2011","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0790","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/toxsci\/kfw060","article-title":"Arsenic metabolism in children differs from that in adults","volume":"152","author":"Skr\u00f6der L\u00f6veborn","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152803_bib0795","first-page":"1093","article-title":"Contamination of drinking-water by arsenic in Bangladesh: a public health emergency","volume":"78","author":"Smith","year":"2000","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tox.2021.152803_bib0800","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1289\/ehp.8832","article-title":"Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood","volume":"114","author":"Smith","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0805","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1289\/ehp.1104867","article-title":"Mortality in young adults following in utero and childhood exposure to arsenic in drinking water","volume":"120","author":"Smith","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0810","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jnci\/djx201","article-title":"Lung, bladder, and kidney Cancer mortality 40 years after arsenic exposure reduction","volume":"110","author":"Smith","year":"2017","journal-title":"JNCI"},{"key":"10.1016\/j.tox.2021.152803_bib0815","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-4274(03)00307-2","article-title":"Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice","volume":"145","author":"Spiegelstein","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2021.152803_bib0820","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2004.07.006","article-title":"Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies","volume":"203","author":"Spiegelstein","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0825","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.etap.2004.01.007","article-title":"Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice","volume":"19","author":"Spiegelstein","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0830","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.fct.2017.05.004","article-title":"Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: evidence from the Strong Heart Study","volume":"105","author":"Spratlen","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0835","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/aje\/kwy048","article-title":"The association of arsenic exposure and arsenic metabolism with the metabolic syndrome and its individual components: prospective evidence from the strong heart family study","volume":"187","author":"Spratlen","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tox.2021.152803_bib0840","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.envint.2018.09.048","article-title":"Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study","volume":"121","author":"Spratlen","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152803_bib0845","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.envres.2018.09.034","article-title":"Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: preliminary evidence from the Strong Heart Family Study","volume":"168","author":"Spratlen","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0850","doi-asserted-by":"crossref","first-page":"E1095","DOI":"10.1152\/ajpendo.2001.281.5.E1095","article-title":"Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate","volume":"281","author":"Stead","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2021.152803_bib0855","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/ajcn\/83.1.5","article-title":"Is it time to reevaluate methyl balance in humans?","volume":"83","author":"Stead","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0860","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1289\/ehp.7907","article-title":"Dietary intake and arsenic methylation in a U.S. Population","volume":"113","author":"Steinmaus","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0865","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/01.jom.0000200982.28276.70","article-title":"Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States","volume":"48","author":"Steinmaus","year":"2006","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.tox.2021.152803_bib0870","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.taap.2010.06.006","article-title":"Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina","volume":"247","author":"Steinmaus","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0875","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1158\/1055-9965.EPI-12-1190","article-title":"Drinking water arsenic in Northern Chile: high cancer risks 40 years after exposure cessation","volume":"22","author":"Steinmaus","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0880","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1158\/1055-9965.EPI-14-0059","article-title":"Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure","volume":"23","author":"Steinmaus","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib0885","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s002040000134","article-title":"Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells","volume":"74","author":"Styblo","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0890","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1289\/ehp.9271","article-title":"Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China","volume":"115","author":"Sun","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0895","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1046\/j.1523-1755.2003.00206.x","article-title":"Creatine supplementation decreases homocysteine in an animal model of uremia","volume":"64","author":"Taes","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.tox.2021.152803_bib0900","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2021.152803_bib0905","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/15592294.2017.1312238","article-title":"Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh","volume":"12","author":"Tauheed","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.tox.2021.152803_bib0910","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.taap.2003.10.020","article-title":"Elucidating the pathway for arsenic methylation","volume":"198","author":"Thomas","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0915","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1383-5742(97)00004-5","article-title":"Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite","volume":"386","author":"Tice","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0920","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1289\/ehp.7719109","article-title":"Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic","volume":"19","author":"Tseng","year":"1977","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152803_bib0925","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.taap.2004.11.022","article-title":"Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan","volume":"206","author":"Tseng","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0930","first-page":"182","article-title":"Association between chronic exposure to arsenic and slow nerve conduction velocity among adolescents in Taiwan","volume":"24","author":"Tseng","year":"2006","journal-title":"J. Health Popul. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0935","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-nutr-080508-141102","article-title":"Effects of arsenic on maternal and fetal health","volume":"29","author":"Vahter","year":"2009","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib0940","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0378-4274(87)90165-2","article-title":"Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit","volume":"37","author":"Vahter","year":"1987","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2021.152803_bib0945","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s00204-014-1351-2","article-title":"Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis","volume":"89","author":"van Breda","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib0950","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0140-6736(65)92956-9","article-title":"Folic-acid deficiency in chronic arsenic poisoning","volume":"1","author":"van Tongeren","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2021.152803_bib0955","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1139\/o03-073","article-title":"Phospholipid biosynthesis in mammalian cells","volume":"82","author":"Vance","year":"2004","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.tox.2021.152803_bib0960","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.envres.2014.12.001","article-title":"Neurobehavioral effects of arsenic exposure among secondary school children in the Kandal Province, Cambodia","volume":"137","author":"Vibol","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib0965","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-069X-13-23","article-title":"A cross-sectional study of well water arsenic and child IQ in Maine schoolchildren","volume":"13","author":"Wasserman","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0970","series-title":"Arsenic in Groundwater: Geochemistry and Occurence","author":"Welch","year":"2002"},{"key":"10.1016\/j.tox.2021.152803_bib0975","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1021\/es0502324","article-title":"Variation in arsenic speciation and concentration in paddy rice related to dietary exposure","volume":"39","author":"Williams","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2021.152803_bib0980","first-page":"16","article-title":"Arsenic content in american wine","volume":"78","author":"Wilson","year":"2015","journal-title":"J. Environ. Health"},{"issue":"quiz 44","key":"10.1016\/j.tox.2021.152803_bib0985","first-page":"14","article-title":"Arsenic and lead in juice: Apple, citrus, and apple-base","volume":"75","author":"Wilson","year":"2012","journal-title":"J. Environ. Health"},{"key":"10.1016\/j.tox.2021.152803_bib0990","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/taap.2001.9303","article-title":"Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice","volume":"177","author":"Wlodarczyk","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib0995","series-title":"Guidelines for Drinking-water Quality: Incorporating First and Second Addenda to Third Edition","author":"World Health Organization (WHO)","year":"2008"},{"key":"10.1016\/j.tox.2021.152803_bib1000","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.taap.2006.05.005","article-title":"Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk of arsenic-associated carotid atherosclerosis","volume":"216","author":"Wu","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib1005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00204-013-1131-4","article-title":"Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation","volume":"88","author":"Xu","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2021.152803_bib1010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2010.04.013","article-title":"Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report","volume":"246","author":"Yokohira","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152803_bib1015","first-page":"1259","article-title":"Arsenic methylation capacity and skin cancer","volume":"9","author":"Yu","year":"2000","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152803_bib1020","doi-asserted-by":"crossref","first-page":"673S","DOI":"10.3945\/ajcn.2008.26811D","article-title":"Importance of methyl donors during reproduction","volume":"89","author":"Zeisel","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib1025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-nutr-071816-064732","article-title":"Trimethylamine N-Oxide, the microbiome, and heart and kidney disease","volume":"37","author":"Zeisel","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tox.2021.152803_bib1030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.envres.2014.04.036","article-title":"Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China","volume":"132","author":"Zhang","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2021.152803_bib1035","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ijc.29704","article-title":"Rice consumption and cancer incidence in US men and women","volume":"138","author":"Zhang","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2021.152803_bib1040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114968","article-title":"Interactions of arsenic metabolism with arsenic exposure and individual factors on diabetes occurrence: baseline findings from Arsenic and Non-Communicable disease cohort (AsNCD) in China","volume":"265","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2021.152803_bib1045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.etap.2019.04.007","article-title":"Association of maternal arsenic exposure with birth size: a systematic review and meta-analysis","volume":"69","author":"Zhong","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21001268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21001268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:47:19Z","timestamp":1759535239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21001268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":209,"alternative-id":["S0300483X21001268"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152803","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutrition, one-carbon metabolism and arsenic methylation","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152803"}}