{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:24:37Z","timestamp":1789129477271,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010629","name":"Fulbright Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["IIE- 15120279"],"award-info":[{"award-number":["IIE- 15120279"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.tox.2021.152823","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T19:50:11Z","timestamp":1622058611000},"page":"152823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones"],"prefix":"10.1016","volume":"458","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-4153","authenticated-orcid":false,"given":"Andres R.","family":"Henriquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1812-8582","authenticated-orcid":false,"given":"Samantha J.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette C.","family":"Schladweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie M.","family":"Hargrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Alewel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Colonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Gavett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette N.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-1024","authenticated-orcid":false,"given":"Urmila P.","family":"Kodavanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.152823_bib0005","first-page":"dxaa025","article-title":"Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation [published online ahead of print, 2020 Apr 10]","author":"Ao","year":"2020","journal-title":"Int. Immunol."},{"key":"10.1016\/j.tox.2021.152823_bib0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.immunol.18.1.309","article-title":"Glucocorticoids in T cell development and function*","volume":"18","author":"Ashwell","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0015","doi-asserted-by":"crossref","first-page":"e0142520","DOI":"10.1371\/journal.pone.0142520","article-title":"A single 9-Colour flow cytometric method to characterise major leukocyte populations in the rat: validation in a model of LPS-induced pulmonary inflammation","volume":"11","author":"Barnett-Vanes","year":"2016","journal-title":"PLoS One"},{"issue":"2\u20133","key":"10.1016\/j.tox.2021.152823_bib0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jsbmb.2010.03.058","article-title":"The role of the glucocorticoid receptor in inflammation and immunity","volume":"120","author":"Baschant","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.tox.2021.152823_bib0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.taap.2013.09.029","article-title":"Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats","volume":"273","author":"Bass","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152823_bib0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nyas.12786","article-title":"Neuroendocrine and viral correlates of premature immunosenescence","volume":"1351","author":"Bauer","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2021.152823_bib0035","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fphar.2019.00308","article-title":"Glucocorticoid-induced leucine zipper: a novel anti-inflammatory molecule","volume":"10","author":"Bereshchenko","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0041-008X(90)90361-W","article-title":"An immunofluorescence study of T and B lymphocytes in ozone-induced pulmonary lesions in the mouse","volume":"105","author":"Bleavins","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.tox.2021.152823_bib0045","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.imbio.2009.10.003","article-title":"Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells","volume":"215","author":"Boldizsar","year":"2010","journal-title":"Immunobiology."},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0050","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/toxsci\/kft155","article-title":"An autonomic link between inhaled diesel exhaust and impaired cardiac performance: insight from treadmill and dobutamine challenges in heart failure-prone rats","volume":"135","author":"Carll","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152823_bib0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2018.07.026","article-title":"Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids","volume":"286","author":"Chen","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.tox.2021.152823_bib0060","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1172\/JCI75157","article-title":"\u03b2\u2082-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis","volume":"124","author":"Chiarella","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0065","doi-asserted-by":"crossref","first-page":"18.1.1","DOI":"10.1002\/0471140856.tx1801s67","article-title":"Associating changes in the immune system with clinical diseases for interpretation in risk assessment","volume":"67","author":"DeWitt","year":"2016","journal-title":"Curr. Protoc. Toxicol."},{"issue":"2\u20133","key":"10.1016\/j.tox.2021.152823_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol. Res."},{"issue":"9","key":"10.1016\/j.tox.2021.152823_bib0075","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.psyneuen.2012.05.008","article-title":"Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner","volume":"37","author":"Dhabhar","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0080","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0013-9351(86)80154-2","article-title":"Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse","volume":"41","author":"Dziedzic","year":"1986","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.tox.2021.152823_bib0085","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/jcp.26135","article-title":"Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia","volume":"233","author":"Evangelisti","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.tox.2021.152823_bib0090","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.1508920113","article-title":"Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts","volume":"113","author":"Fay","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.tox.2021.152823_bib0095","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1080\/15287390500468696","article-title":"Ozone exposure impairs antigen-specific immunity but activates IL-7-induced proliferation of CD4-CD8- thymocytes in BALB\/c mice","volume":"69","author":"Feng","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0100","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/toxsci\/kfw226","article-title":"Editor\u2019s highlight: CCR2 regulates inflammatory cell accumulation in the lung and tissue injury following ozone exposure","volume":"155","author":"Francis","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.tox.2021.152823_bib0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0378-4274(90)90239-I","article-title":"Enhanced antibody production in W\/Wv mice exposed to ozone","volume":"53","author":"Fujimaki","year":"1990","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2021.152823_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000453397","article-title":"Cellular innate immunity: an old game with new players","volume":"9","author":"Gasteiger","year":"2017","journal-title":"J. Innate Immun."},{"issue":"5","key":"10.1016\/j.tox.2021.152823_bib0115","doi-asserted-by":"crossref","first-page":"57007","DOI":"10.1289\/EHP3286","article-title":"The association between long-term air pollution and urinary catecholamines: evidence from the multi-ethnic study of atherosclerosis","volume":"127","author":"Hajat","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152823_bib0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4137\/BMI.S11102","article-title":"Biomarkers of dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats","volume":"8","author":"Hatch","year":"2013","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.tox.2021.152823_bib0125","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.taap.2017.06.009","article-title":"Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation","volume":"329","author":"Henriquez","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152823_bib0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.taap.2017.12.006","article-title":"Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation","volume":"339","author":"Henriquez","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/toxsci\/kfy198","article-title":"Beta-2 adrenergic and glucocorticoid receptor agonists modulate ozone-induced pulmonary protein leakage and inflammation in healthy and adrenalectomized rats","volume":"166","author":"Henriquez","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2021.152823_bib0140","first-page":"kfz182","article-title":"Ozone-induced dysregulation of neuroendocrine axes requires adrenal-derived stress hormones [published online ahead of print, 2019a Aug 9]","author":"Henriquez","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0145","doi-asserted-by":"crossref","first-page":"17925","DOI":"10.1038\/s41598-019-54269-w","article-title":"Exacerbation of ozone-induced pulmonary and systemic effects by \u03b22-adrenergic and\/or glucocorticoid receptor agonist\/s","volume":"9","author":"Henriquez","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00018-005-5390-y","article-title":"Glucocorticoids in T cell apoptosis and function","volume":"63","author":"Herold","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.tox.2021.152823_bib0155","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s004200000216","article-title":"Flow cytometric analysis of lymphocyte subpopulations in bronchoalveolar lavage fluid after repeated ozone exposure","volume":"74","author":"Holz","year":"2001","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2021.152823_bib0160","article-title":"Glucocorticoids prime the inflammatory response of human hippocampal cells through up-regulation of inflammatory pathways [published online ahead of print, 2020 Mar 16]","author":"Horowitz","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"155","key":"10.1016\/j.tox.2021.152823_bib0165","doi-asserted-by":"crossref","first-page":"190102","DOI":"10.1183\/16000617.0102-2019","article-title":"Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target","volume":"29","author":"Hughes","year":"2020","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.tox.2021.152823_bib0170","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.3389\/fimmu.2018.03143","article-title":"Control of leukocyte trafficking by stress-associated hormones","volume":"9","author":"Ince","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0175","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00262-013-1477-8","article-title":"Non-genomic events determining the sensitivity of hemopoietic malignancies to glucocorticoid-induced apoptosis","volume":"63","author":"Kfir-Erenfeld","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0180","first-page":"103","article-title":"Cellular and molecular interactions of thymus with endocrine organs and nervous system","volume":"47","author":"Kinoshita","year":"2001","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"issue":"12","key":"10.1016\/j.tox.2021.152823_bib0185","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.bbagen.2016.05.010","article-title":"Stretching the stress boundary: linking air pollution health effects to a neurohormonal stress response","volume":"1860","author":"Kodavanti","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.tox.2021.152823_bib0190","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1177\/0192623319878402","article-title":"Susceptibility variations in air pollution health effects: incorporating neuroendocrine activation","volume":"47","author":"Kodavanti","year":"2019","journal-title":"Toxicol. Pathol."},{"issue":"Suppl 1","key":"10.1016\/j.tox.2021.152823_bib0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/08958378.2014.954169","article-title":"Variability in ozone-induced pulmonary injury and inflammation in healthy and cardiovascular-compromised rat models","volume":"27","author":"Kodavanti","year":"2015","journal-title":"Inhal. Toxicol."},{"issue":"5","key":"10.1016\/j.tox.2021.152823_bib0200","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.4049\/jimmunol.1090076","article-title":"Multiple roles of CD4 and CD8 in T cell activation","volume":"185","author":"Koretzky","year":"2010","journal-title":"J. Immunol."},{"issue":"7815","key":"10.1016\/j.tox.2021.152823_bib0205","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-020-2424-4","article-title":"Structural cells are key regulators of organ-specific immune responses","volume":"583","author":"Krausgruber","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tox.2021.152823_bib0210","first-page":"117","article-title":"Exercise-induced leukocyte apoptosis","volume":"20","author":"Kr\u00fcger","year":"2014","journal-title":"Exerc. Immunol. Rev."},{"issue":"10119","key":"10.1016\/j.tox.2021.152823_bib0215","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/00039896.1991.9937430","article-title":"Ambient level ozone effects on subpopulations of thymocytes and spleen T lymphocytes","volume":"46","author":"Li","year":"1991","journal-title":"Arch. Environ. Health"},{"issue":"7186","key":"10.1016\/j.tox.2021.152823_bib0225","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"M\u00e9ndez-Ferrer","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.tox.2021.152823_bib0230","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1210\/endo.135.5.7956914","article-title":"Effects of selective type I and II adrenal steroid agonists on immune cell distribution","volume":"135","author":"Miller","year":"1994","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0235","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2015.03.025","article-title":"Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats","volume":"286","author":"Miller","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.tox.2021.152823_bib0240","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.201508-1599OC","article-title":"Ozone exposure increases circulating stress hormones and lipid metabolites in humans","volume":"193","author":"Miller","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0245","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/kfv331","article-title":"Acute ozone-induced pulmonary and systemic metabolic effects are diminished in adrenalectomized rats","volume":"150","author":"Miller","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.tox.2021.152823_bib0250","first-page":"557","article-title":"Environmental stressors and cardio-metabolic disease: part II-mechanistic insights","volume":"38","author":"M\u00fcnzel","year":"2017","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.tox.2021.152823_bib0255","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/EBC20160017","article-title":"The immune system","volume":"60","author":"Nicholson","year":"2016","journal-title":"Essays Biochem."},{"key":"10.1016\/j.tox.2021.152823_bib0260","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.cdd.4402182","article-title":"Apoptosis in the development of the immune system","volume":"15","author":"Opferman","year":"2008","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.tox.2021.152823_bib0265","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.smim.2014.01.003","article-title":"Neuroendocrine regulation of inflammation","volume":"26","author":"Padro","year":"2014","journal-title":"Semin. Immunol."},{"issue":"5","key":"10.1016\/j.tox.2021.152823_bib0270","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000216183","article-title":"Neuroimmunomodulation in asthma: focus on the hypothalamic-pituitary-adrenal axis. Introduction","volume":"16","author":"Priftis","year":"2009","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.tox.2021.152823_bib0275","first-page":"248","article-title":"Studies on the morphology of peripheral blood in rats. I. Normal rats","volume":"3","author":"Reich","year":"1943","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2021.152823_bib0280","series-title":"\u201cOutdoor Air Pollution\u201d. Published Online at OurWorldInData.org","author":"Ritchie","year":"2020"},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0285","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1165\/rcmb.2017-0315LE","article-title":"\u03b22-agonists enhance asthma-relevant inflammatory mediators in human airway epithelial cells","volume":"58","author":"Ritchie","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tox.2021.152823_bib0290","series-title":"Psychoneuroimmunology","first-page":"161","article-title":"Neurotransmitter receptors on lymphocytes and other lymphoid cells","author":"Sanders","year":"2001"},{"issue":"2","key":"10.1016\/j.tox.2021.152823_bib0295","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrendo.2015.168","article-title":"Hormonal control of T-cell development in health and disease","volume":"12","author":"Savino","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"10.1016\/j.tox.2021.152823_bib0300","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/10408440701385622","article-title":"Short-term effects of particulate matter: an inflammatory mechanism?","volume":"37","author":"Scapellato","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"issue":"10","key":"10.1016\/j.tox.2021.152823_bib0305","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/15287390903578208","article-title":"Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease","volume":"73","author":"Shannahan","year":"2010","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0310","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/toxsci\/kfy129","article-title":"Neuroendocrine regulation of air pollution health effects: emerging insights","volume":"164","author":"Snow","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.tox.2021.152823_bib0315","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/08958378.2013.861884","article-title":"Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project","volume":"26","author":"Steenhof","year":"2014","journal-title":"Inhal. Toxicol."},{"issue":"24","key":"10.1016\/j.tox.2021.152823_bib0320","doi-asserted-by":"crossref","first-page":"18432","DOI":"10.1074\/jbc.M906304199","article-title":"Glucocorticoids suppress tumor necrosis factor-alpha expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-kappa B and c-Jun-activating transcription factor-2 binding sites in the promoter","volume":"275","author":"Steer","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2021.152823_bib0325","series-title":"Integrated Science Assessment (ISA) for Ozone and Related Photochemical Oxidants (Final Report)","author":"U.S. EPA","year":"2020"},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0330","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1513\/pats.200406-035MS","article-title":"Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease","volume":"2","author":"van Eeden","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"1","key":"10.1016\/j.tox.2021.152823_bib0335","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13148-019-0682-5","article-title":"Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus","volume":"11","author":"Wiechmann","year":"2019","journal-title":"Clin. Epigenetics"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21001463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21001463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:46:06Z","timestamp":1759535166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21001463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":67,"alternative-id":["S0300483X21001463"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152823","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152823","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"152823"}}