{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:48Z","timestamp":1787314188851,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773471"],"award-info":[{"award-number":["81773471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.tox.2021.152933","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:15:39Z","timestamp":1631146539000},"page":"152933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Improvement roles of zinc supplementation in low dose lead induced testicular damage and glycolytic inhibition in mice"],"prefix":"10.1016","volume":"462","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-3293","authenticated-orcid":false,"given":"Zhaoyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.152933_bib0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4161\/oxim.1.1.6843","article-title":"Antioxidant systems and oxidative stress in the testes","volume":"1","author":"Aitken","year":"2008","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tox.2021.152933_bib0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.reprotox.2013.03.005","article-title":"Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells","volume":"38","author":"Alves","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0015","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00018-012-1079-1","article-title":"Hormonal control of Sertoli cell metabolism regulates spermatogenesis","volume":"70","author":"Alves","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tox.2021.152933_bib0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0748233716637543","article-title":"The protective effects of zinc in lead-induced testicular and epididymal toxicity in Wistar rats","volume":"33","author":"Anjum","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tox.2021.152933_bib0025","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.fertnstert.2008.01.015","article-title":"Fragmentation of DNA in morphologically normal human spermatozoa","volume":"91","author":"Avendano","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2021.152933_bib0030","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jat.796","article-title":"Influence of lead and zinc on rat male reproduction at\u2019 biochemical and histopathological levels\u2019","volume":"21","author":"Batra","year":"2001","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0035","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4161\/spmg.22014","article-title":"New insights into germ cell migration and survival\/apoptosis in spermatogenesis: lessons from CD147","volume":"2","author":"Chen","year":"2012","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.tox.2021.152933_bib0040","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.fertnstert.2018.08.015","article-title":"Male infertility as a window to health","volume":"110","author":"Choy","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2021.152933_bib0045","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-arplant-043015-112301","article-title":"Toxic heavy metal and metalloid accumulation in crop plants and foods","volume":"67","author":"Clemens","year":"2016","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.tox.2021.152933_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114694","article-title":"Low concentrations of lead decrease the sperm fertilization ability by altering the acrosome reaction in mice","volume":"380","author":"Godinez-Solis","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152933_bib0055","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lfs.2019.04.020","article-title":"Protective effect of diallyl sulfide against lead-mediated oxidative damage, apoptosis and down-regulation of CYP19 gene expression in rat testes","volume":"226","author":"Hassan","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2021.152933_bib0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2019.04.015","article-title":"The protective effect of epigallocatechin-3-gallate on testicular oxidative stress in lead-induced toxicity mediated by Cyp19 gene \/ estradiol level","volume":"422","author":"Hassan","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2021.152933_bib0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.reprotox.2005.01.007","article-title":"Low lead environmental exposure alters semen quality and sperm chromatin condensation in northern Mexico","volume":"20","author":"Hernandez-Ochoa","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0070","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3168\/jds.S0022-0302(84)81416-2","article-title":"Zinc in mammalian sperm: a review","volume":"67","author":"Hidiroglou","year":"1984","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.tox.2021.152933_bib0075","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.tox.2021.152933_bib0080","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.fertnstert.2014.10.020","article-title":"Male infertility testing: reactive oxygen species and antioxidant capacity","volume":"102","author":"Ko","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2021.152933_bib0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-005-1097-5","article-title":"DNA damage to spermatozoa has impacts on fertilization and pregnancy","volume":"322","author":"Lewis","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tox.2021.152933_bib0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2016.05.016","article-title":"The role of PGC-1alpha and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells","volume":"355\u2013356","author":"Li","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2021.152933_bib0095","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12011-016-0799-8","article-title":"Protective effects of PGC-1alpha against lead-induced oxidative stress and energy metabolism dysfunction in testis sertoli cells","volume":"175","author":"Liu","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2021.152933_bib0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.envint.2014.12.010","article-title":"Impacts of soil and water pollution on food safety and health risks in China","volume":"77","author":"Lu","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152933_bib0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc requirements and the risks and benefits of zinc supplementation","volume":"20","author":"Maret","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tox.2021.152933_bib0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12011-010-8787-x","article-title":"Human exposure to arsenic, cadmium, mercury, and lead from foods in Catalonia, Spain: temporal trend","volume":"142","author":"Martorell","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2021.152933_bib0115","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1017\/S0007114508159037","article-title":"Relationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testes of growing rats","volume":"102","author":"Merrells","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tox.2021.152933_bib0120","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.etp.2009.04.004","article-title":"Reversal of cadmium-induced oxidative stress in rat erythrocytes by selenium, zinc or their combination","volume":"62","author":"Messaoudi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.tox.2021.152933_bib0125","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10408363.2017.1408562","article-title":"Clinical and molecular aspects of lead toxicity: an update","volume":"54","author":"Mitra","year":"2017","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.tox.2021.152933_bib0130","series-title":"Principles of Classification and Treatment of Hyperlead and Lead Poisoning in Children","author":"National Health Commission of the People\u2019s Republic of China","year":"2006"},{"key":"10.1016\/j.tox.2021.152933_bib0135","first-page":"BR325","article-title":"Short term lead exposure induces a stress-like response in adult mice","volume":"12","author":"Nieto-Fernandez","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.tox.2021.152933_bib0140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/med.21325","article-title":"The Warburg effect revisited--lesson from the Sertoli cell","volume":"35","author":"Oliveira","year":"2015","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.tox.2021.152933_bib0145","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2486\/indhealth.45.546","article-title":"Effects of zinc coadministration on lead toxicities in rats","volume":"45","author":"Piao","year":"2007","journal-title":"Ind. Health"},{"key":"10.1016\/j.tox.2021.152933_bib0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/tox.22072","article-title":"p,p\u2019-DDE damages spermatogenesis via phospholipid hydroperoxide glutathione peroxidase depletion and mitochondria apoptosis pathway","volume":"31","author":"Quan","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0155","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/tx000017v","article-title":"Lead interaction with human protamine (HP2) as a mechanism of male reproductive toxicity","volume":"13","author":"Quintanilla-Vega","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jbt.20247","article-title":"Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats","volume":"22","author":"Sadik","year":"2008","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/BTER:99:1-3:049","article-title":"Zinc deficiency and growth: current concepts in relationship to two important points: intellectual and sexual development","volume":"99","author":"Salgueiro","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2021.152933_bib0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ygcen.2015.11.009","article-title":"Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice","volume":"239","author":"Sarkar","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.tox.2021.152933_bib0175","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.03.007","article-title":"Regulation of spermatogenesis: an evolutionary biologist\u2019s perspective","volume":"29","author":"Schlatt","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.tox.2021.152933_bib0180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/0748233718770293","article-title":"Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats","volume":"34","author":"Soussi","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tox.2021.152933_bib0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0300-483X(95)03107-Q","article-title":"Lead affects steroidogenesis in rat Leydig cells in vivo and in vitro","volume":"103","author":"Thoreux-Manlay","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2021.152933_bib0190","first-page":"1068","article-title":"Environmental lead exposure: a public health problem of global dimensions","volume":"78","author":"Tong","year":"2000","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tox.2021.152933_bib0195","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-8223(01)00078-5","article-title":"Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","volume":"101","author":"Trumbo","year":"2001","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.tox.2021.152933_bib0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02783260","article-title":"Lead increases urinary zinc excretion in rats","volume":"4","author":"Victery","year":"1982","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2021.152933_bib0205","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.fertnstert.2014.10.021","article-title":"Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests","volume":"102","author":"Wang","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2021.152933_bib0210","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/jat.2795","article-title":"Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring","volume":"33","author":"Wang","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2021.152933_bib0215","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.envint.2018.04.027","article-title":"Genomic instability in adult men involved in processing electronic waste in Northern China","volume":"117","author":"Wang","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152933_bib0220","series-title":"Vitamin and Mineral Requirements in Human Nutrition","author":"World Health Organization","year":"2004"},{"key":"10.1016\/j.tox.2021.152933_bib0225","series-title":"Childhood Lead Poisoning","author":"World Health Organization","year":"2010"},{"key":"10.1016\/j.tox.2021.152933_bib0230","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1073\/pnas.72.11.4425","article-title":"Chemical induction of sperm abnormalities in mice","volume":"72","author":"Wyrobek","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2021.152933_bib0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114942","article-title":"Low dose lead exposure at the onset of puberty disrupts spermatogenesis-related gene expression and causes abnormal spermatogenesis in mouse","volume":"393","author":"Xie","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152933_bib0240","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12275-017-6642-x","article-title":"Potential use of lactic acid bacteria Leuconostoc mesenteroides as a probiotic for the removal of Pb(II) toxicity","volume":"55","author":"Yi","year":"2017","journal-title":"J. Microbiol."},{"key":"10.1016\/j.tox.2021.152933_bib0245","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tiv.2019.01.001","article-title":"Exposure to Pb and Cd alters MCT4\/CD147 expression and MCT4\/CD147-dependent lactate transport in mice Sertoli cells cultured in vitro","volume":"56","author":"Yu","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2021.152933_bib0250","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"Zegers-Hochschild","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tox.2021.152933_bib0255","doi-asserted-by":"crossref","first-page":"22386","DOI":"10.1038\/srep22386","article-title":"Zinc levels in seminal plasma and their correlation with male infertility: a systematic review and meta-analysis","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21002560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21002560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:46:37Z","timestamp":1759535197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21002560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":51,"alternative-id":["S0300483X21002560"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152933","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improvement roles of zinc supplementation in low dose lead induced testicular damage and glycolytic inhibition in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152933"}}