{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:23:53Z","timestamp":1777717433640,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573189"],"award-info":[{"award-number":["81573189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730087"],"award-info":[{"award-number":["81730087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872645"],"award-info":[{"award-number":["81872645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.tox.2021.152990","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T11:19:06Z","timestamp":1634642346000},"page":"152990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Immunosuppression characterized by increased Treg cell and IL-10 levels in benzene-induced hematopoietic toxicity mouse model"],"prefix":"10.1016","volume":"464","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-4150","authenticated-orcid":false,"given":"Jiawei","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-1020","authenticated-orcid":false,"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqiu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuepu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.152990_bib0005","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human th17 cells","volume":"204","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2021.152990_bib0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2014.02.012","article-title":"Current understandings and perspectives on non-cancer health effects of benzene: a global concern","volume":"276","author":"Bahadar","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2021.152990_bib0015","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1182\/blood-2005-09-3671","article-title":"In vivo peripheral expansion of naive cd4(+)cd25(high) foxp3(+) regulatory t cells in patients with multiple myeloma","volume":"107","author":"Beyer","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tox.2021.152990_bib0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2005.03.007","article-title":"An overview of occupational benzene exposures and occupational exposure limits in Europe and North America","volume":"153","author":"Capleton","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2021.152990_bib0025","first-page":"20","article-title":"Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the treg\/th17 ratio in aplastic anemia","author":"Chen","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.tox.2021.152990_bib0030","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41590-019-0389-y","article-title":"T-reg cell il-10 and il-35 exhaust cd8(+) t cells in tumors","volume":"20","author":"Damo","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0035","series-title":"Control of th17\/t\u1d63\u2091g Balance by Hypoxia-Inducible Factor","first-page":"1","author":"Dang","year":"2011"},{"key":"10.1016\/j.tox.2021.152990_bib0040","first-page":"3","article-title":"Distinctive patterns of microrna expression associated with karyotype in acute myeloid leukaemia","author":"Dixon-McIver","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2021.152990_bib0045","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.envpol.2019.04.001","article-title":"Use of toxicant sensitivity distributions (tsd) for development of exposure guidelines for risk to human health from benzene","volume":"250","author":"Edokpolo","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2021.152990_bib0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/1110-1067.225090","article-title":"Phenotype analysis of lymphocytes in workers with chronic benzene exposure","volume":"42","author":"Fayed","year":"2017","journal-title":"Egypt. J. Haematol."},{"key":"10.1016\/j.tox.2021.152990_bib0055","first-page":"127","article-title":"Association between outdoor air pollution and childhood leukemia: A systematic review and dose response meta-analysis","author":"Filippini","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2021.152990_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106050","article-title":"Combined exposure to formaldehyde and pm2.5: hematopoietic toxicity and molecular mechanism in mice","volume":"144","author":"Ge","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2021.152990_bib0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10875-019-00684-7","article-title":"Regulatory t cells: the many faces of foxp3","volume":"39","author":"Georgiev","year":"2019","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0070","doi-asserted-by":"crossref","DOI":"10.1111\/imm.13256","article-title":"Pre-selection tcr repertoire predicts cd4+ and cd8+ t cell differentiation state","author":"Hou","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.tox.2021.152990_bib0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2018.10.022","article-title":"Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde","volume":"412","author":"Huang","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2021.152990_bib0080","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/10428190902803677","article-title":"Enhanced formation and survival of cd4+cd25hi foxp3+t-cells in chronic lymphocytic leukemia","volume":"50","author":"Jak","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.tox.2021.152990_bib0085","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.aller.2018.12.003","article-title":"Effect of ginger extract on expression of gata3, t-bet and ror-gamma t in peripheral blood mononuclear cells of patients with allergic asthma","volume":"47","author":"Kardan","year":"2019","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.tox.2021.152990_bib0090","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood-2007-01-067546","article-title":"Cd4(+)cd25(high) foxp3(+) regulatory t cells in myelodysplastic syndrome (mds)","volume":"110","author":"Kordasti","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tox.2021.152990_bib0095","first-page":"3","article-title":"Exposure to benzene and childhood leukaemia: a pilot case-control study","author":"Lagorio","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.tox.2021.152990_bib0100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.critrevonc.2009.12.001","article-title":"Abnormal immunity and stem\/progenitor cells in acquired aplastic anemia","volume":"75","author":"Li","year":"2010","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.tox.2021.152990_bib0105","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2741\/4052","article-title":"Th17 related cytokines in acute myeloid leukemia","volume":"17","author":"Li","year":"2012","journal-title":"Front. Biosci.-Landmark"},{"key":"10.1016\/j.tox.2021.152990_bib0110","article-title":"The expression of p2x7 receptor on th1, th17, and regulatory t cells in patients with systemic lupus erythematosus or rheumatoid arthritis and its correlations with active disease","author":"Li","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cca.2015.07.031","article-title":"Decreased circulating th22 and th17 cells in patients with aplastic anemia","volume":"450","author":"Lu","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tox.2021.152990_bib0120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/15287394.2016.1176616","article-title":"Involvement of hypoxia-inducible factor-1 alpha (hif-1 alpha) in inhibition of benzene on mouse hematopoietic system","volume":"79","author":"Meng","year":"2016","journal-title":"J. Toxicol. Environ. Health-Part A-Curr. Issues"},{"key":"10.1016\/j.tox.2021.152990_bib0125","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1182\/blood-2007-08-105395","article-title":"Local and systemic induction of cd4(+)cd25(+) regulatory t-cell population by non-hodgkin lymphoma","volume":"111","author":"Mittal","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.tox.2021.152990_bib0130","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cbi.2009.12.023","article-title":"Topoisomerase ii inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms","volume":"184","author":"Mondrala","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2021.152990_bib0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cbi.2005.03.025","article-title":"Benzene and the hemopoietic stem cell","volume":"153","author":"Morgan","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2021.152990_bib0140","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"2 types of murine helper t-cell clone .1. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cll.2014.10.004","article-title":"Clinical utility of reticulocyte parameters","volume":"35","author":"Piva","year":"2015","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.tox.2021.152990_bib0150","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.coem.2004.03.014","article-title":"Benzene and hematopoietic malignancies","volume":"4","author":"Pyatt","year":"2004","journal-title":"Clin. Occup. Environ. Med."},{"key":"10.1016\/j.tox.2021.152990_bib0155","first-page":"255","article-title":"Interaction effects of environmental response gene polymorphisms and benzene exposure on telomere length in shoe-making workers","author":"Ren","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2021.152990_bib0160","first-page":"2839","article-title":"Benzene poisoning, a risk factor for hematological malignancy, is associated with the nq01 c-609-&t mutation and rapid fractional excretion of chlorzoxazone","volume":"57","author":"Rothman","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2021.152990_bib0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cbi.2009.12.020","article-title":"Peripheral blood effects in benzene-exposed workers","volume":"184","author":"Schnatter","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2021.152990_bib0170","article-title":"A clandestine culprit with critical consequences: benzene and acute myeloid leukemia","author":"Shallis","year":"2020","journal-title":"Blood Rev."},{"key":"10.1016\/j.tox.2021.152990_bib0175","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12016-016-8590-3","article-title":"Epigenetic variability of cd4+cd25+tregs contributes to the pathogenesis of autoimmune diseases","volume":"52","author":"Shu","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0180","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1158\/1055-9965.EPI-06-1057","article-title":"Benzene exposure and risk of non-hodgkin lymphoma","volume":"16","author":"Smith","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2021.152990_bib0185","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.3390\/ijerph9082875","article-title":"Leukemia and benzene","volume":"9","author":"Snyder","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2021.152990_bib0190","first-page":"13","article-title":"Benzene exposure alters expression of enzymes involved in fatty acid beta-oxidation in male c3h\/he mice","author":"Sun","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2021.152990_bib0195","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.etap.2017.02.013","article-title":"Acetyl-l-carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in c3h\/he mice","volume":"51","author":"Sun","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2021.152990_bib0200","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.etap.2017.02.013","article-title":"Acetyl-l-carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in c3h\/he mice","volume":"51","author":"Sun","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2021.152990_bib0205","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/tox.22939","article-title":"L-carnitine protects against 1,4-benzoquinone-induced apoptosis and DNA damage by suppressing oxidative stress and promoting fatty acid oxidation in k562 cells","volume":"35","author":"Sun","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2021.152990_bib0210","first-page":"705","article-title":"Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice","author":"Sun","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2021.152990_bib0215","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/16078454.2019.1642548","article-title":"Pathogenesis of aplastic anemia","volume":"24","author":"Wang","year":"2019","journal-title":"Hematology"},{"key":"10.1016\/j.tox.2021.152990_bib0220","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1600-0609.2005.00537.x","article-title":"Increased population of cd4(+)cd25(high) regulatory t cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients","volume":"75","author":"Wang","year":"2005","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.tox.2021.152990_bib0225","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.yrtph.2006.06.009","article-title":"Benzene exposure in the shoemaking industry in china, a literature survey, 1978-2004","volume":"46","author":"Wang","year":"2006","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2021.152990_bib0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/0192623311431467","article-title":"Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias","volume":"40","author":"Ward","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2021.152990_bib0235","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ni.1818","article-title":"Regulatory t cells exert checks and balances on self tolerance and autoimmunity","volume":"11","author":"Wing","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tox.2021.152990_bib0240","first-page":"149","article-title":"Classification of risk occupation for benzene exposure by urine trans, trans-munconic acid level","volume":"7","author":"Wiwanitkit","year":"2006","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.tox.2021.152990_bib0245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/107602960401000113","article-title":"The urine trans, trans muconic acid biomarker and platelet count in a sample of subjects with benzene exposure","volume":"10","author":"Wiwanitkit","year":"2004","journal-title":"Clin. Appl. Thrombosis\/Hemostasis"},{"key":"10.1016\/j.tox.2021.152990_bib0250","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3892\/mmr.2012.1055","article-title":"Th1\/th2\/th17\/treg expression in cultured pbmcs with antiphospholipid antibodies","volume":"6","author":"Xiao","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tox.2021.152990_bib0255","article-title":"Involvement of hypoxia-inducible factor-1 \u03b1 (hif-1\u03b1) in inhibition of benzene on mouse hematopoietic system","author":"Xing","year":"2016","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.tox.2021.152990_bib0260","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/carcin\/bgq286","article-title":"Chromosome-wide aneuploidy study (cwas) in workers exposed to an established leukemogen, benzene","volume":"32","author":"Zhang","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tox.2021.152990_bib0265","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/ijc.25791","article-title":"Elevated frequencies of cd4(+)cd25(+)cd127(lo) regulatory t cells is associated to poor prognosis in patients with acute myeloid leukemia","volume":"129","author":"Zhang","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2021.152990_bib0270","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.envpol.2018.12.055","article-title":"Cardiovascular endothelial inflammation by chronic coexposure to lead (pb) and polycyclic aromatic hydrocarbons from preschool children in an e-waste recycling area","volume":"246","author":"Zheng","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21003127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21003127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:48:04Z","timestamp":1759535284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21003127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":54,"alternative-id":["S0300483X21003127"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.152990","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunosuppression characterized by increased Treg cell and IL-10 levels in benzene-induced hematopoietic toxicity mouse model","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.152990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152990"}}