{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:04:04Z","timestamp":1794409444009,"version":"4.9.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070330"],"award-info":[{"award-number":["82070330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042021kf0119"],"award-info":[{"award-number":["2042021kf0119"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.tox.2021.153055","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T22:59:51Z","timestamp":1638485991000},"page":"153055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation"],"prefix":"10.1016","volume":"465","author":[{"given":"Chang","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyou","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-2733","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2021.153055_bib0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijcard.2021.01.067","article-title":"The alcohol-induced cardiomyopathy: a cardiovascular magnetic resonance characterization","volume":"331","author":"Artico","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0010","doi-asserted-by":"crossref","first-page":"18016","DOI":"10.1038\/nrdp.2018.16","article-title":"Haemochromatosis","volume":"4","author":"Brissot","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tox.2021.153055_bib0015","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1093\/eurheartj\/ehx156","article-title":"Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW)","volume":"38","author":"Brunner","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tox.2021.153055_bib0020","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.3843","article-title":"Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation","volume":"49","author":"Christophersen","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tox.2021.153055_bib0025","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/eurheartj\/ehz062","article-title":"Alcohol and atrial fibrillation","volume":"40","author":"Conen","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tox.2021.153055_bib0030","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/blood.V92.2.632","article-title":"The Iron Chelator l1 potentiates oxidative DNA damage in iron-loaded liver cells","volume":"92","author":"Cragg","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.tox.2021.153055_bib0035","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/eurheartj\/ehaa953","article-title":"Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes","volume":"42","author":"Csengeri","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tox.2021.153055_bib0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tox.2021.153055_bib0045","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2021.153055_bib0050","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","article-title":"Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-Mediated ferroptosis","volume":"127","author":"Fang","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.tox.2021.153055_bib0055","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(13)70174-8","article-title":"Effects of iron overload on chronic metabolic diseases","volume":"2","author":"Fernandez-Real","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.tox.2021.153055_bib0060","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tox.2021.153055_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: an intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.tox.2021.153055_bib0070","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tox.2021.153055_bib0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tox.2021.153055_bib0080","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"392","author":"Griswold","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2021.153055_bib0085","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jacc.2020.05.062","article-title":"Comparison of atrial remodeling caused by sustained atrial flutter versus atrial fibrillation","volume":"76","author":"Guichard","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0090","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1073\/pnas.1908137116","article-title":"Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking","volume":"116","author":"Guillot","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2021.153055_bib0095","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/hep.21895","article-title":"Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol","volume":"46","author":"Harrison-Findik","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2021.153055_bib0100","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.2834821","article-title":"Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro","volume":"240","author":"Imlay","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.tox.2021.153055_bib0105","first-page":"216","article-title":"Frequent drinking is a more important risk factor for new-onset atrial fibrillation than binge drinking: a nationwide population-based study","volume":"22","author":"Kim","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.tox.2021.153055_bib0110","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/eurheartj\/ehz039","article-title":"Are the cardiac effects of alcohol good, bad, or neither?","volume":"40","author":"Leong","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tox.2021.153055_bib0115","first-page":"10","article-title":"Targeting ferroptosis against Ischemia\/Reperfusion cardiac injury","author":"Lillo-Moya","year":"2021","journal-title":"Antioxidants Basel (Basel)"},{"key":"10.1016\/j.tox.2021.153055_bib0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41419-020-02948-2","article-title":"Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tox.2021.153055_bib0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tox.2021.153055_bib0130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tox.2021.153055_bib0135","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/hep.31328","article-title":"Iron chaperone poly rC binding protein 1 protects mouse liver from lipid peroxidation and steatosis","volume":"73","author":"Protchenko","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2021.153055_bib0140","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.jacc.2018.07.050","article-title":"Association between alcohol intake and cardiac remodeling","volume":"72","author":"Rodrigues","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0145","first-page":"208","article-title":"MD1 deficiency promotes inflammatory atrial remodelling induced by high-fat diets","volume":"35","author":"Shuai","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2021.7683","article-title":"Diagnosis and treatment of alcohol-associated liver disease: a review","volume":"326","author":"Singal","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.tox.2021.153055_bib0155","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tox.2021.153055_bib0160","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yjmcc.2020.07.007","article-title":"Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: insights from multiscale in silico analyses","volume":"146","author":"Sutanto","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0165","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.jacc.2017.10.014","article-title":"Eplerenone reduces atrial fibrillation burden without preventing atrial electrical remodeling","volume":"70","author":"Takemoto","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0170","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tox.2021.153055_bib0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.tox.2021.153055_bib0180","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tox.2021.153055_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.tox.2021.153055_bib0190","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2018.03.462","article-title":"Genetic etiology for alcohol-induced cardiac toxicity","volume":"71","author":"Ware","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tox.2021.153055_bib0195","series-title":"Global Status Report on Alcohol and Health 2018: Executive Summary","first-page":"1","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.tox.2021.153055_bib0200","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tox.2021.153055_bib0205","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tox.2021.153055_bib0210","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2017.11.001","article-title":"Alpha-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice","volume":"14","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2021.153055_bib0215","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1111\/jcmm.14206","article-title":"Role of mitochondrial calcium uniporter-mediated Ca(2+) and iron accumulation in traumatic brain injury","volume":"23","author":"Zhang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tox.2021.153055_bib0220","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.hrthm.2019.11.014","article-title":"Effect of acute and chronic ethanol on atrial fibrillation vulnerability in rats","volume":"17","author":"Zhang","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tox.2021.153055_bib0225","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1021\/acs.jafc.1c03751","article-title":"Autophagy inhibition plays a protective role in ferroptosis induced by alcohol via the p62-Keap1-Nrf2 pathway","volume":"69","author":"Zhao","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2021.153055_bib0230","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2021.05.009","article-title":"Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis","volume":"171","author":"Zhou","year":"2021","journal-title":"Free Radic. Biol. Med."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21003772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X21003772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:52:14Z","timestamp":1759535534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X21003772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":46,"alternative-id":["S0300483X21003772"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2021.153055","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2021.153055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153055"}}