{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:48:14Z","timestamp":1791913694417,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073508"],"award-info":[{"award-number":["82073508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.tox.2022.153103","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T12:12:52Z","timestamp":1643112772000},"page":"153103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Protection from benzene-induced immune dysfunction in mice"],"prefix":"10.1016","volume":"468","author":[{"given":"Yamei","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2022.153103_bib0005","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0707166","article-title":"HDAC inhibitors as anti-inflammatory agents","volume":"150","author":"Adcock","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tox.2022.153103_bib0010","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3177\/jnsv.56.77","article-title":"Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells","volume":"56","author":"Bessler","year":"2010","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.tox.2022.153103_bib0015","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1073\/pnas.70.2.390","article-title":"Effect of stimulation of the host defense system by coenzyme Q 10 on dibenzpyrene-induced tumors and infection with Friend leukemia virus in mice","volume":"70","author":"Bliznakov","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tox.2022.153103_bib0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11302-012-9305-8","article-title":"ATP synthesis and storage","volume":"8","author":"Bonora","year":"2012","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.tox.2022.153103_bib0025","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bies.20528","article-title":"Development and function of the mammalian spleen","volume":"29","author":"Brendolan","year":"2007","journal-title":"Bioessays"},{"key":"10.1016\/j.tox.2022.153103_bib0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chemosphere.2016.01.096","article-title":"Workers exposed to low levels of benzene present in urban air: assessment of peripheral blood count variations","volume":"152","author":"Casale","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2022.153103_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16122240","article-title":"Environmental assessment and evaluation of oxidative stress and genotoxicity biomarkers related to chronic occupational exposure to benzene","volume":"16","author":"Costa-Amaral","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2022.153103_bib0040","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1210\/jc.2018-01185","article-title":"Statin treatment decreases mitochondrial respiration but muscle coenzyme Q10 levels are unaltered: the LIFESTAT study","volume":"104","author":"Dohlmann","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2022.153103_bib0045","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1142\/S0192415X16500579","article-title":"Pinellia ternata attenuates mucus secretion and airway inflammation after inhaled corticosteroid withdrawal in COPD rats","volume":"44","author":"Du","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.tox.2022.153103_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/taap.1996.8071","article-title":"The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression","volume":"143","author":"Geiselhart","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2022.153103_bib0055","first-page":"1","article-title":"Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review","volume":"78","author":"Guo","year":"2020","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.tox.2022.153103_bib0060","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12031-018-1090-6","article-title":"Coenzyme Q10 influences on the levels of TNF-\u03b1 and IL-10 and the ratio of Bax\/Bcl2 in a menopausal rat model following lumbar spinal cord injury","volume":"65","author":"Hassanzadeh","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.tox.2022.153103_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109908","article-title":"Epimedium polysaccharides attenuates hematotoxicity by reducing oxidative stress and enhancing immune function in mice model of benzene-induced bone marrow failure","volume":"125","author":"He","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tox.2022.153103_bib0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12026-009-8150-5","article-title":"Cell type-specific regulation of IL-10 expression in inflammation and disease","volume":"47","author":"Hedrich","year":"2010","journal-title":"Immunol. Res."},{"key":"10.1016\/j.tox.2022.153103_bib0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-94-024-0921-5_3","article-title":"Regulation of IL-4 expression in immunity and diseases","volume":"941","author":"Ho","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tox.2022.153103_bib0080","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF01972993","article-title":"Subclinical effects of groundwater contaminants. III. Effects of repeated oral exposure to combinations of benzene and toluene on immunologic responses in mice","volume":"64","author":"Hsieh","year":"1990","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2022.153103_bib0085","doi-asserted-by":"crossref","first-page":"7897584","DOI":"10.1155\/2019\/7897584","article-title":"Antiepileptic effects of protein-rich extract from Bombyx batryticatus on mice and its protective effects against H2O2-induced oxidative damage in PC12 cells via regulating PI3K\/Akt signaling pathways","volume":"2019","author":"Hu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tox.2022.153103_bib0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.fct.2017.08.019","article-title":"Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: searching for biomarkers of oncogenesis","volume":"109","author":"Jim\u00e9nez-Garza","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2022.153103_bib0095","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1189\/jlb.0206096","article-title":"Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21","volume":"80","author":"Jin","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tox.2022.153103_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2017.04.006","article-title":"The immunotoxicological pattern of subchronic and chronic benzene exposure in rats","volume":"275","author":"Karaulov","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2022.153103_bib0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2015.03.001","article-title":"Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model","volume":"331","author":"Komulainen","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2022.153103_bib0110","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1102443","article-title":"Hematotoxicity in workers exposed to low levels of benzene","volume":"306","author":"Lan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tox.2022.153103_bib0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/08958370590929529","article-title":"DNA damage in T and B lymphocytes, bone marrow, spleens, and livers of rats exposed to benzene","volume":"17","author":"Lee","year":"2005","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.tox.2022.153103_bib0120","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/08923973.2013.770522","article-title":"Pinellia ternata Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma","volume":"35","author":"Lee","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.tox.2022.153103_bib0125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ijbiomac.2016.08.069","article-title":"A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR)","volume":"93","author":"Li","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.tox.2022.153103_bib0130","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/antiox8120574","article-title":"Batryticatus Bombyx protects dopaminergic neurons against MPTP-Induced neurotoxicity by inhibiting oxidative damage","volume":"8","author":"Lim","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tox.2022.153103_bib0135","doi-asserted-by":"crossref","first-page":"28656","DOI":"10.1074\/jbc.M112.356584","article-title":"The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis","volume":"287","author":"Lv","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2022.153103_bib0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.canlet.2015.07.009","article-title":"The paradoxical role of IL-10 in immunity and cancer","volume":"367","author":"Mannino","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tox.2022.153103_bib0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1196\/annals.1371.004","article-title":"Causal relationship between non-Hodgkin\u2019s lymphoma and exposure to benzene and benzene-containing solvents","volume":"1076","author":"Mehlman","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2022.153103_bib0150","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.tox.2022.153103_bib0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5271\/sjweh.426","article-title":"Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene","volume":"25","author":"Petralia","year":"1999","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.tox.2022.153103_bib0160","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1096\/fj.201900927RR","article-title":"Butyrate prevents valproate-induced liver injury: in vitro and in vivo evidence","volume":"34","author":"Pirozzi","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2022.153103_bib0165","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1096\/fj.09-152728","article-title":"Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency","volume":"24","author":"Quinzii","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2022.153103_bib0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/jnci\/djz169","article-title":"The IARC monographs: updated procedures for modern and transparent evidence synthesis in Cancer hazard identification","volume":"112","author":"Samet","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tox.2022.153103_bib0175","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3390\/antiox10050793","article-title":"L-carnosine stimulation of coenzyme Q10 biosynthesis promotes improved mitochondrial function and decreases hepatic steatosis in diabetic conditions","volume":"10","author":"Schwank-Xu","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tox.2022.153103_bib0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00109-018-1722-x","article-title":"Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva","volume":"97","author":"Seet","year":"2019","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.tox.2022.153103_bib0185","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3858\/emm.2011.43.6.041","article-title":"Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity","volume":"43","author":"Shen","year":"2011","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tox.2022.153103_bib0190","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1289\/ehp.93100293","article-title":"The toxicology of benzene","volume":"100","author":"Snyder","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2022.153103_bib0195","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.3390\/cancers13102392","article-title":"Epigenetic effects of benzene in hematologic neoplasms: the altered gene expression","volume":"13","author":"Spatari","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tox.2022.153103_bib0200","doi-asserted-by":"crossref","first-page":"34692","DOI":"10.1038\/srep34692","article-title":"Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing","volume":"6","author":"Su","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2022.153103_bib0205","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2017.07.010","article-title":"The mechanisms of T cell selection in the Thymus","volume":"38","author":"Takaba","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2022.153103_bib0210","first-page":"83","article-title":"HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction","volume":"39","author":"Tian","year":"2019","journal-title":"EBio Med."},{"key":"10.1016\/j.tox.2022.153103_bib0215","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijbiomac.2020.02.219","article-title":"Structural characterization of an acid polysaccharide from Pinellia ternata and its induction effect on apoptosis of Hep G2 cells","volume":"153","author":"Tian","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.tox.2022.153103_bib0220","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.etap.2016.05.007","article-title":"Effects of combined exposure to formaldehyde and benzene on immune cells in the blood and spleen in Balb\/c mice","volume":"45","author":"Wen","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2022.153103_bib0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2015.06.037","article-title":"Mitochondrial delivery of Coenzyme Q10 via systemic administration using a MITO-Porter prevents ischemia\/reperfusion injury in the mouse liver","volume":"213","author":"Yamada","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.tox.2022.153103_bib0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/08830185.2012.755176","article-title":"Reactive oxygen species in the immune system","volume":"32","author":"Yang","year":"2013","journal-title":"Int. Rev. Immunol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22000154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22000154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:03:54Z","timestamp":1791911034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X22000154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":46,"alternative-id":["S0300483X22000154"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2022.153103","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection from benzene-induced immune dysfunction in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2022.153103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153103"}}