{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:00:45Z","timestamp":1760623245462,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.tox.2022.153254","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T02:12:54Z","timestamp":1657159974000},"page":"153254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Safety evaluation of MA-T after ingestion in mice"],"prefix":"10.1016","volume":"477","author":[{"given":"Takahiro","family":"Noguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutake","family":"Tsujikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Fujio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Yamagishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kutsuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masuo","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2022.153254_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1289\/ehp.824647","article-title":"Subchronic toxicity of chlorine dioxide and related compounds in drinking water in the nonhuman primate","volume":"46","author":"Bercz","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.tox.2022.153254_bib2","first-page":"1487","article-title":"Oxidative damage to the erythrocyte induced by sodium chlorite, in vivo","volume":"2","author":"Heffernan","year":"1979","journal-title":"J. Environ. Pathol. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2022.153254_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.tox.2022.153254_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2020.05.042","article-title":"SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract","volume":"182","author":"Hou","year":"2020","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.tox.2022.153254_bib5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41591-021-01296-8","article-title":"SARS-CoV-2 infection of the oral cavity and saliva","volume":"27","author":"Huang","year":"2021","journal-title":"Nat. Med."},{"issue":"4\u20135","key":"10.1016\/j.tox.2022.153254_bib6","first-page":"215","article-title":"Effects of the acute rising dose administration of chlorine dioxide, chlorate and chlorite to normal healthy adult male volunteers","volume":"5","author":"Lubbers","year":"1984","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"4\u20135","key":"10.1016\/j.tox.2022.153254_bib7","first-page":"229","article-title":"The effects of chronic administration of chlorine dioxide, chlorite and chlorate to normal healthy adult male volunteers","volume":"5","author":"Lubbers","year":"1984","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"4\u20135","key":"10.1016\/j.tox.2022.153254_bib8","first-page":"239","article-title":"The effects of chronic administration of chlorite to glucose-6-phosphate dehydrogenase deficient healthy adult male volunteers","volume":"5","author":"Lubbers","year":"1984","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.tox.2022.153254_bib9","article-title":"Fresh produce safety and quality: chlorine dioxide\u2019s role","volume":"12","author":"Malka","year":"2021","journal-title":"Front Plant Sci."},{"issue":"2","key":"10.1016\/j.tox.2022.153254_bib10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/10408398.2016.1169157","article-title":"Aqueous chlorine dioxide treatment of horticultural produce: Effects on microbial safety and produce quality-A review","volume":"58","author":"Praeger","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"7","key":"10.1016\/j.tox.2022.153254_bib11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1590\/S0100-879X2005000700003","article-title":"Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses","volume":"38","author":"Scandalios","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.tox.2022.153254_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1248\/bpbreports.3.6_174","article-title":"The respiratory chain of bacteria is a target of the disinfectant MA-T","volume":"3","author":"Shibata","year":"2020","journal-title":"BPB Rep."},{"key":"10.1016\/j.tox.2022.153254_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1248\/bpbreports.4.3_78","article-title":"Verification of MA-T safety and efficacy against pathogens including SARS-CoV-2","volume":"4","author":"Shibata","year":"2021","journal-title":"BPB Rep."},{"issue":"21","key":"10.1016\/j.tox.2022.153254_bib14","doi-asserted-by":"crossref","first-page":"8252","DOI":"10.1021\/ac202053y","article-title":"Estimation of the distribution of intravenously injected adipose tissue-derived stem cells labeled with quantum dots in mice organs through the determination of their metallic components by ICPMS","volume":"83","author":"Takasaki","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2022.153254_bib15","first-page":"1","article-title":"The bactericidal effect of oral care using matching transformation system: A prospective clinical study","author":"Urakawa","year":"2022","journal-title":"Oral. Sci. Int."},{"issue":"47","key":"10.1016\/j.tox.2022.153254_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abc3582","article-title":"TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes","volume":"5","author":"Zang","year":"2020","journal-title":"Sci. Immunol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22001664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22001664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:51:24Z","timestamp":1759535484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X22001664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":16,"alternative-id":["S0300483X22001664"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2022.153254","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety evaluation of MA-T after ingestion in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2022.153254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153254"}}