{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:57:52Z","timestamp":1793051872344,"version":"4.5.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.tox.2022.153350","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T10:54:26Z","timestamp":1665226466000},"page":"153350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Zinc and selenium mitigated heavy metals mixture (Pb, Al, Hg and Mn) mediated hepatic-nephropathy via modulation of oxido-inflammatory status and NF\u2011kB signaling in female albino rats"],"prefix":"10.1016","volume":"481","author":[{"given":"Boma F.","family":"Eddie-Amadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonet N.","family":"Ezejiofor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinna N.","family":"Orish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orish E.","family":"Orisakwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2022.153350_bib1","first-page":"401","article-title":"Effects of lead exposure on DNA damage and apoptosis in reproductive and vital organs in female rabbits","volume":"9","author":"Ahmed","year":"2012","journal-title":"Glob. Vet."},{"issue":"3","key":"10.1016\/j.tox.2022.153350_bib2","article-title":"Synergism in aluminum and mercury neurotoxicity","volume":"5","author":"Alexandrov","year":"2018","journal-title":"Integr. Food Nutr. Metab."},{"issue":"3","key":"10.1016\/j.tox.2022.153350_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818800153","article-title":"Amelioration of the protein expression of Cox2, NF \u03ba B, and STAT-3 by some antioxidants in the liver of sodium fluoride-intoxicated rats","volume":"16","author":"Alhusaini","year":"2018","journal-title":"Dose Response"},{"key":"10.1016\/j.tox.2022.153350_bib4","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.biopha.2018.07.089","article-title":"The potential hepatoprotective effect of royal jelly against cadmium chloride-induced hepatotoxicity in mice is mediated by suppression of oxidative stress and upregulation of Nrf2 expression","volume":"106","author":"Almeer","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tox.2022.153350_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.dci.2018.03.017","article-title":"Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1\u03b2 release","volume":"85","author":"Angosto","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.tox.2022.153350_bib6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/0960327119829521","article-title":"Roflumilast, a phosphodiesterase 4 inhibitor, attenuates cadmium-induced renal toxicity via modulation of NF-\u03baB activation and induction of NQO1 in rats","volume":"38","author":"Ansari","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.tox.2022.153350_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/toxics6040065","article-title":"Heavy metal mixture exposure and effects in developing nations: an update","volume":"6","author":"Anyanwu","year":"2018","journal-title":"Toxics"},{"issue":"2020","key":"10.1016\/j.tox.2022.153350_bib8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.toxrep.2020.08.008","article-title":"Neuroprotective effect of Costus afer on low dose heavy metal mixture (lead, cadmium, and mercury) induced neurotoxicity via antioxidant, anti-inflammatory activities","volume":"7","author":"Anyanwu","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2022.153350_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/764754","article-title":"Preventative effects of caffeic acid phenyl ester on cadmiumintoxication induced hematological and blood coagulation disturbances andhepatorenal damage in rats","volume":"764754","author":"Ashour","year":"2014","journal-title":"ISRN Hematol."},{"key":"10.1016\/j.tox.2022.153350_bib10","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry), 2008. Toxicological Profile for Aluminum. Atlanta: U.S. Department of Health and Human Services, Public Health Service."},{"key":"10.1016\/j.tox.2022.153350_bib11","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR), 2017. Toxicological Profiles | ATSDR (cdc.gov). accessed 10th June 2022."},{"issue":"5","key":"10.1016\/j.tox.2022.153350_bib12","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s12011-021-02827-7","article-title":"Protective role of the essential trace elements in the obviation of cadmium toxicity: glimpses of mechanisms","volume":"200","author":"Bhattacharya","year":"2022","journal-title":"Biological Trace Element Research"},{"key":"10.1016\/j.tox.2022.153350_bib13","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tox.2022.153350_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3732687","article-title":"Costus afer: a systematic review of evidence-based data in support of its medicinal relevance","volume":"2019","author":"Boison","year":"2019","journal-title":"Scientifica"},{"key":"10.1016\/j.tox.2022.153350_bib15","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/antiox10050630","article-title":"The role of toxic metals and metalloids in Nrf2 signaling","volume":"10","author":"Buha","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.tox.2022.153350_bib16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fsi.2017.03.007","article-title":"Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acid on CCl4-induced damagein precision-cut liver slices from Jian carp (Cyprinus carpio var. jian) through inhibition of the nf-\u03ba\u0181 pathway","volume":"64","author":"Cao","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.tox.2022.153350_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/1566524033479582","article-title":"Role of nitric oxide in liver injury","volume":"3","author":"Chen","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.tox.2022.153350_bib18","series-title":"Handbook of Methods for Oxygen Radical Research","first-page":"237","article-title":"Catalase activity","author":"Clairborne","year":"1995"},{"key":"10.1016\/j.tox.2022.153350_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.med.48.1.489","article-title":"Nitric oxide synthase: role in the genesis of vascular disease","volume":"48","author":"Cooke","year":"1997","journal-title":"Annu. Rev. Med."},{"issue":"4","key":"10.1016\/j.tox.2022.153350_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuro.2004.12.007","article-title":"Studying toxicants as single chemicals: does this strategyadequately identify neurotoxic risk","volume":"26","author":"Cory-Slechta","year":"2005","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.tox.2022.153350_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.etap.2013.11.026","article-title":"Differential effects of cadmium administration on peripheral blood granulocytes in rats","volume":"37","author":"Djokic","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2022.153350_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jtemb.2014.05.009","article-title":"Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats","volume":"29","author":"El-Boshy","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.tox.2022.153350_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jtemb.2013.10.001","article-title":"Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon","volume":"28","author":"El-Demerdash","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"6","key":"10.1016\/j.tox.2022.153350_bib24","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.7314\/APJCP.2013.14.6.3393","article-title":"Heavy metal pollution in sub-Saharan Africa and possible implications in cancer epidemiology","volume":"14","author":"Fasinu","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.tox.2022.153350_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2478\/v10102-012-0009-2","article-title":"Toxicity of lead: a review with recent updates","volume":"5","author":"Flora","year":"2012","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib26","series-title":"Arsenic, Cadmium, and Lead","author":"Flora","year":"2017"},{"key":"10.1016\/j.tox.2022.153350_bib27","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3389\/fphar.2019.01667","article-title":"Molecular biomarkers in drug-induced liver injury: challenges and future perspectives","volume":"10","author":"Fu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tox.2022.153350_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aquatox.2013.07.017","article-title":"Molecular cloning, immunohistochemical localization, characterization, and expression analysis of caspase-9 from the purse red common carp (Cyprinus carpio) exposed to cadmium","volume":"142\u2013143","author":"Gao","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.tox.2022.153350_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0041-008X(86)90384-4","article-title":"Disposition of metals in rats: a comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals","volume":"85","author":"Gregus","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.tox.2022.153350_bib31","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1111\/pde.13732","article-title":"Aluminum granuloma in a child secondary to DT aP\u2010 IPV vaccination: a case report","volume":"36","author":"Haag","year":"2019","journal-title":"Pediatr. Dermatol."},{"key":"10.1016\/j.tox.2022.153350_bib32","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2174\/1389200216666151015114515","article-title":"Application of glutathione as anti-oxidative and anti-aging drugs","volume":"16","author":"Homma","year":"2015","journal-title":"Curr. Drug Metab."},{"issue":"2","key":"10.1016\/j.tox.2022.153350_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2478\/intox-2019-0007","article-title":"Aluminium toxicosis: a review of toxic actions and effects","volume":"12","author":"Igbokwe","year":"2019","journal-title":"Interdiscip. Toxicol."},{"issue":"5","key":"10.1016\/j.tox.2022.153350_bib34","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ecoenv.2008.12.006","article-title":"Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress","volume":"72","author":"Imed","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.tox.2022.153350_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1556\/ABiol.57.2006.4.5","article-title":"Immunotoxicological Investigation of subacute combind exposure with low doses of Pb, Hg and Cd in rats","volume":"57","author":"Institoris","year":"2006","journal-title":"Acta Biol. Hunh."},{"issue":"2","key":"10.1016\/j.tox.2022.153350_bib36","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s12011-015-0375-7","article-title":"Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus","volume":"168","author":"Jangra","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tox.2022.153350_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacol."},{"key":"10.1016\/j.tox.2022.153350_bib38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.taap.2009.01.011","article-title":"Mechanisms of cadmium carcinogenesis","volume":"238","author":"Joseph","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2022.153350_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2017.00010","article-title":"C5a regulates IL-1\u03b2 production and leukocyte recruitment in a murine model of monosodium urate crystal-induced peritonitis","volume":"8","author":"Khameneh","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.tox.2022.153350_bib40","doi-asserted-by":"crossref","first-page":"16727","DOI":"10.1007\/s11356-019-04886-9","article-title":"Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits","volume":"26","author":"Khan","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"7","key":"10.1016\/j.tox.2022.153350_bib41","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3390\/molecules24071298","article-title":"Selenium\u2013fascinating microelement, properties and sources in food","volume":"24","author":"Kieliszek","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2022.153350_bib42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2121-14-4","article-title":"Cadmium induces neuronal cell death through reactive oxygen species activated by GADD153","volume":"14","author":"Kim","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.tox.2022.153350_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/03602537609029977","article-title":"Biliary excretion of metals","volume":"5","author":"Klaassen","year":"1976","journal-title":"Drzf,Y Metab. Rev."},{"key":"10.1016\/j.tox.2022.153350_bib44","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.fct.2010.07.003","article-title":"Influence of combinedtreatment with zinc and selenium on cadmium induced testicular pathophys-iology in rat","volume":"48","author":"Lamia","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib45","article-title":"Oxidative stress in hemodialysis patients: a review of the literature","volume":"2017","author":"Liakopoulos","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tox.2022.153350_bib46","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tox.2022.153350_bib47","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1080\/01480545.2020.1808670","article-title":"Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats","volume":"45","author":"Lim","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib48","doi-asserted-by":"crossref","first-page":"258e267","DOI":"10.1016\/j.cellsig.2007.10.017","article-title":"Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin","volume":"20","author":"Lin","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tox.2022.153350_bib49","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1021\/jf021066b","article-title":"Factors affecting the levels of tea polyphenols and caffeine in tea leaves","volume":"51","author":"Lin","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.tox.2022.153350_bib50","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.etp.2010.08.002","article-title":"Hepatoprotective role and antioxidant capacity of selenium on arsenic-induced liver injury in rats","volume":"64","author":"Messarah","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.tox.2022.153350_bib51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2478\/10004-1254-62-2011-2075","article-title":"Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium","volume":"62","author":"Matovic\u00b4","year":"2011","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.tox.2022.153350_bib52","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.fct.2015.02.011","article-title":"Insight into the oxidative stress induced by lead and\/or cadmium in blood, liver and kidneys","volume":"78","author":"Matovic\u00b4","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib53","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.biochi.2006.05.013","article-title":"Cadmium toxicity in animal cells by interference with essential metals","volume":"88","author":"Martelli","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.tox.2022.153350_bib54","doi-asserted-by":"crossref","first-page":"17161","DOI":"10.1073\/pnas.0134112100","article-title":"Distribution of nitric oxide synthase in normal and cirrhotic human Liver","volume":"99","author":"McNaughton","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tox.2022.153350_bib55","doi-asserted-by":"crossref","first-page":"16042","DOI":"10.1074\/jbc.M606781200","article-title":"Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance","volume":"282","author":"Medvedev","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2022.153350_bib56","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.bbagen.2012.10.012","article-title":"Glutathione and infection","volume":"1830","author":"Morris","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2022.153350_bib57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10534-010-9336-y","article-title":"Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals","volume":"23","author":"Moulis","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.tox.2022.153350_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtemb.2014.04.008","article-title":"Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke","volume":"29","author":"Milnerowicz","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tox.2022.153350_bib59","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.tox.2022.153350_bib60","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.fct.2009.01.032","article-title":"Propolis alleviates aluminum-induced lipid peroxidation and biochemical parameters in male rats","volume":"47","author":"Newairy","year":"2009","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"4","key":"10.1016\/j.tox.2022.153350_bib61","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1159\/000313492","article-title":"Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure-possible harmful effects after long-term exposure","volume":"115","author":"Nikolov","year":"2010","journal-title":"Nephron Exp. Nephrol."},{"issue":"2","key":"10.1016\/j.tox.2022.153350_bib62","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2022.153350_bib63","doi-asserted-by":"crossref","unstructured":"Okoye, E.A., Bocca, B., Ruggieri, F., Ezejiofor, A.N., Nwaogazie, I.L., Domingo, J.L., Rovira, J., Frazzoli, C., Orisakwe, O.E., 2021. Metal pollution of soil, plants, feed and food in the Niger Delta, Nigeria: health risk assessment through meat and fish consumption. Environ. Res. 198, 111273.","DOI":"10.1016\/j.envres.2021.111273"},{"key":"10.1016\/j.tox.2022.153350_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128350","article-title":"Heavy metal associated health hazards: an interplay of oxidative stress and signal transduction","volume":"262","author":"Paithankar","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2022.153350_bib65","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"6","key":"10.1016\/j.tox.2022.153350_bib66","article-title":"Systemic inflammation in C57BL\/6J mice receiving dietary aluminum sulfate; up-regulation of the pro-inflammatory cytokines IL-6 and TNF\u03b1, C-reactive protein (CRP) and miRNA-146a in blood serum","volume":"7","author":"Pogue","year":"2017","journal-title":"J. Alzheimer's Dis. Park."},{"issue":"1","key":"10.1016\/j.tox.2022.153350_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bionut.2010.12.003","article-title":"Quercetin in combination with vitamins (C and E) improve oxidative stress and hepatic injury in cadmium intoxicated rats","volume":"1","author":"Prabu","year":"2011","journal-title":"Biomed. Prevent. Nutr."},{"key":"10.1016\/j.tox.2022.153350_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/2277-8632.158577","article-title":"A review on role of essential trace elements in health and disease","volume":"4","author":"Prashanth","year":"2015","journal-title":"J. NTR Univ. Health Sci."},{"key":"10.1016\/j.tox.2022.153350_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6173893","article-title":"Comparison of two ginkgo biloba L. extracts on oxidative stress and inflammation markers in human endothelial cells","author":"Piazza","year":"2019","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.tox.2022.153350_bib70","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.2008.2263","article-title":"Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death","volume":"11","author":"Pivtoraiko","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.tox.2022.153350_bib71","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s001289900458","article-title":"Protective effects of GSH, a-tocopherol, and selenium onlipid-peroxidation in liver and kidney of copper fed rats","volume":"59","author":"Rana","year":"1997","journal-title":"Bull. Environ. Contam."},{"key":"10.1016\/j.tox.2022.153350_bib72","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.envres.2004.02.013","article-title":"Marginal nutritional status of zinc, iron, and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets","volume":"96","author":"Reeves","year":"2004","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2022.153350_bib73","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.tox.2022.153350_bib74","first-page":"1","article-title":"Inflammation in anxiety","volume":"88","author":"Salim","year":"2012"},{"key":"10.1016\/j.tox.2022.153350_bib75","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tox.2022.153350_bib76","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijdevneu.2013.07.003","article-title":"Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA)for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain","volume":"31","author":"Sannadia","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"issue":"9","key":"10.1016\/j.tox.2022.153350_bib77","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/nu11092112","article-title":"Crosstalk of Nrf2 with the trace elements selenium, iron, zinc, and copper","volume":"11","author":"Schwarz","year":"2019","journal-title":"Nutrients"},{"issue":"1\u20133","key":"10.1016\/j.tox.2022.153350_bib78","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tox.2004.06.012","article-title":"Strain differences of cadmium-induced hepatotoxicity in Wistar\u2013Imamichi and Fischer 344 rats: involvement of cadmium accumulation","volume":"203","author":"Shimada","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2022.153350_bib79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1432-1033.1993.tb18025.x","article-title":"Strategies of antioxidant defence","volume":"215","author":"Sies","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tox.2022.153350_bib80","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3390\/ijerph14101164","article-title":"Joint toxicity of different heavy metal mixtures after a short-term oral repeated-administration in rats","volume":"14","author":"Su","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tox.2022.153350_bib81","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"key":"10.1016\/j.tox.2022.153350_bib82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0300-483X(03)00305-6","article-title":"Molecular and cellular mechanisms of cadmium carcinogenesis","volume":"192","author":"Waisberg","year":"2003","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tox.2022.153350_bib83","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s12011-018-1318-x","article-title":"Effect of aluminum exposure on glucose metabolism and its mechanism in rats","volume":"186","author":"Wei","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"issue":"sup4","key":"10.1016\/j.tox.2022.153350_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2014.934439","article-title":"Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts","volume":"44","author":"Willhite","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2022.153350_bib85","unstructured":"World Health Organization (WHO), Health risks of heavy metals from long range trans boundary air polution, Jt. WHO l Conv. Task Force Heal. Asp. Air Pollut (2007) 2\u2013144."},{"key":"10.1016\/j.tox.2022.153350_bib86","unstructured":"World Health Organization, Ten Chemicals of Major Public Health Concern, World Health Organization, 2010, pp. 1\u20134."},{"issue":"6","key":"10.1016\/j.tox.2022.153350_bib87","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.3390\/ijms13067174","article-title":"Pu-erh tea reduces nitric oxide levels in rats by inhibiting inducible nitric oxide synthase expression through toll-like receptor 4","volume":"13","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2022.153350_bib88","doi-asserted-by":"crossref","unstructured":"Yermilov, V., Rubio, J., Becchi, M., Friesen, M.D., Pignatelli, B., Ohshima, H., 1996. Formation of Carcinogenesis, 16, 2045\u20132050.","DOI":"10.1093\/carcin\/16.9.2045"},{"issue":"51","key":"10.1016\/j.tox.2022.153350_bib89","article-title":"Aluminum overload increases\u00a0oxidative\u00a0stress in four functional brain areas of neonatal rats","volume":"19","author":"Yuan","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tox.2022.153350_bib90","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3390\/ijms9101977","article-title":"Elevation of inducible nitric oxide synthase and cyclooxygenase-2 expression in the mouse brain after chronic nonylphenol exposure","volume":"9","author":"Zhang","year":"2008","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2022.153350_bib91","doi-asserted-by":"crossref","first-page":"25939","DOI":"10.1074\/jbc.M001185200","article-title":"p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide","volume":"275","author":"Zhuang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2022.153350_bib92","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","article-title":"The essential metals for humans: a brief overvie w","volume":"195","author":"Zoroddu","year":"2019","journal-title":"J. Inorg. Biochem."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22002621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X22002621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:53:40Z","timestamp":1759535620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X22002621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":92,"alternative-id":["S0300483X22002621"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2022.153350","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc and selenium mitigated heavy metals mixture (Pb, Al, Hg and Mn) mediated hepatic-nephropathy via modulation of oxido-inflammatory status and NF\u2011kB signaling in female albino rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2022.153350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153350"}}