{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:21:25Z","timestamp":1787163685088,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.tox.2023.153462","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T02:11:52Z","timestamp":1676686312000},"page":"153462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity"],"prefix":"10.1016","volume":"487","author":[{"given":"Shun","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuangen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanping","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2023.153462_bib1","doi-asserted-by":"crossref","first-page":"C583","DOI":"10.1152\/ajpcell.00301.2002","article-title":"A-type potassium currents in smooth muscle. American journal of physiology","volume":"284","author":"Amberg","year":"2003","journal-title":"Cell Physiol."},{"key":"10.1016\/j.tox.2023.153462_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116907","article-title":"Comparison of the chronic toxicities of graphene and graphene oxide toward adult zebrafish by using biochemical and phenomic approaches","volume":"278","author":"Audira","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2023.153462_bib3","first-page":"1587","article-title":". Ca(V)1.1: The atypical prototypical voltage-gated Ca(2)(+) channel","author":"Bannister","year":"2013","journal-title":"Biochim. Et. Biophys. Acta 1828"},{"key":"10.1016\/j.tox.2023.153462_bib4","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1523\/JNEUROSCI.1655-19.2020","article-title":"The relationship between glutamate dynamics and activity-dependent synaptic plasticity","volume":"40","author":"Barnes","year":"2020","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.tox.2023.153462_bib5","doi-asserted-by":"crossref","first-page":"a020453","DOI":"10.1101\/cshperspect.a020453","article-title":"Oligodendrocyte development and plasticity","volume":"8","author":"Bergles","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tox.2023.153462_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2009.11.009","article-title":"Behavioral measures of anxiety in zebrafish (Danio rerio)","volume":"208","author":"Blaser","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tox.2023.153462_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128611","article-title":"Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae","volume":"270","author":"Cao","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2023.153462_bib8","first-page":"42","article-title":"Specific nanotoxicity of graphene oxide during zebrafish embryogenesis","volume":"10","author":"Chen","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tox.2023.153462_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110608","article-title":"Toxic effects of different-sized graphene oxide particles on zebrafish embryonic development","volume":"197","author":"Chen","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2023.153462_bib10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1897\/06-272R.1","article-title":"Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos","volume":"26","author":"Cheng","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tox.2023.153462_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103426","article-title":"Induced toxicity in early-life stage zebrafish (Danio rerio) and its behavioral analysis after exposure to non-doped, nitrogen-doped and nitrogen, sulfur-co doped carbon quantum dots","volume":"79","author":"Chousidis","year":"2020","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2023.153462_bib12","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/ar300159f","article-title":"Biomedical applications of graphene and graphene oxide","volume":"46","author":"Chung","year":"2013","journal-title":"Acc. Chem. Res"},{"key":"10.1016\/j.tox.2023.153462_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biomaterials.2019.03.028","article-title":"Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish","volume":"206","author":"Deng","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.tox.2023.153462_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jhazmat.2018.05.063","article-title":"Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs)","volume":"357","author":"Deng","year":"2018","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2023.153462_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2022.05.006","article-title":"In vivo toxicity assessment of four types of graphene quantum dots (GQDs) using mRNA sequencing","volume":"363","author":"Deng","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153462_bib16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","article-title":"The AMPA Receptor Code of Synaptic Plasticity","volume":"100","author":"Diering","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.tox.2023.153462_bib17","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1021\/acsnano.8b04758","article-title":"Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment","volume":"12","author":"Fadeel","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.tox.2023.153462_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202102683","article-title":"Synthesis, applications, and prospects of graphene quantum dots: a comprehensive review","volume":"18","author":"Ghaffarkhah","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.tox.2023.153462_bib19","article-title":"Graphene quantum dots redefine nanobiomedicine. Materials science & engineering. C","volume":"110","author":"Henna","year":"2020","journal-title":"Mater. Biol. Appl."},{"key":"10.1016\/j.tox.2023.153462_bib20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ecoenv.2018.11.053","article-title":"Persistent DNA methylation changes in zebrafish following graphene quantum dots exposure in surface chemistry-dependent manner","volume":"169","author":"Hu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2023.153462_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2131\/fts.3.79","article-title":"Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs","volume":"3","author":"Inoue","year":"2016","journal-title":"Fundam. Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153462_bib22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.envpol.2019.01.072","article-title":"Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo","volume":"247","author":"Jia","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2023.153462_bib23","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/acs.nanolett.0c03741","article-title":"Graphene quantum dots alleviate impaired functions in niemann-pick disease type C in vivo","volume":"21","author":"Kang","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.tox.2023.153462_bib24","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/s41565-018-0179-y","article-title":"Graphene quantum dots prevent alpha-synucleinopathy in Parkinson's disease","volume":"13","author":"Kim","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tox.2023.153462_bib25","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1897\/05-460R.1","article-title":"A novel contact assay for testing genotoxicity of chemicals and whole sediments in zebrafish embryos","volume":"25","author":"Kosmehl","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tox.2023.153462_bib26","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1021\/acs.est.0c07359","article-title":"Graphene quantum dots disrupt embryonic stem cell differentiation by interfering with the methylation level of Sox2","volume":"55","author":"Ku","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2023.153462_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biomaterials.2016.12.022","article-title":"Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging","volume":"120","author":"Kuo","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.tox.2023.153462_bib28","doi-asserted-by":"crossref","first-page":"14438","DOI":"10.1021\/acsami.8b01429","article-title":"Antimicrobial amino-functionalized nitrogen-doped graphene quantum dots for eliminating multidrug-resistant species in dual-modality photodynamic therapy and bioimaging under two-photon excitation","volume":"10","author":"Kuo","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.tox.2023.153462_bib29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nrn1938","article-title":"The distribution and targeting of neuronal voltage-gated ion channels","volume":"7","author":"Lai","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tox.2023.153462_bib30","doi-asserted-by":"crossref","first-page":".","DOI":"10.1126\/sciadv.aaz2630","article-title":"Graphene quantum dots as anti-inflammatory therapy for colitis","volume":"6","author":"Lee","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tox.2023.153462_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/toxsci\/kfy235","article-title":"Systematic assessment of the toxicity and potential mechanism of graphene derivatives in vitro and in vivo","volume":"167","author":"Li","year":"2019","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.tox.2023.153462_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/kfy090","article-title":"Hydroxylated-graphene quantum dots induce DNA damage and disrupt microtubule structure in human esophageal epithelial cells","volume":"164","author":"Li","year":"2018","journal-title":"Toxicol. Sci.: Off. J. Soc. Toxicol."},{"key":"10.1016\/j.tox.2023.153462_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.colsurfb.2016.05.007","article-title":"Crossing the blood-brain-barrier with transferrin conjugated carbon dots: a zebrafish model study","volume":"145","author":"Li","year":"2016","journal-title":"Colloids Surf. B, Biointerfaces"},{"key":"10.1016\/j.tox.2023.153462_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900386","article-title":"Surface-engineered monocyte inhibits atherosclerotic plaque destabilization via graphene quantum dot-mediated MicroRNA delivery","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.tox.2023.153462_bib35","doi-asserted-by":"crossref","first-page":"19060","DOI":"10.1039\/C5NR06282A","article-title":"Graphene quantum dots for the inhibition of beta amyloid aggregation","volume":"7","author":"Liu","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.tox.2023.153462_bib36","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.neuropharm.2010.01.008","article-title":"Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum","volume":"58","author":"Lovinger","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tox.2023.153462_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2021.115624","article-title":"Sn(IV) porphyrin-biotin decorated nitrogen doped graphene quantum dots nanohybrids for photodynamic therapy","volume":"213","author":"Magaela","year":"2022","journal-title":"Polyhedron"},{"key":"10.1016\/j.tox.2023.153462_bib38","doi-asserted-by":"crossref","first-page":"12821","DOI":"10.1007\/s11356-018-1420-9","article-title":"In vivo toxicity evaluation of pristine graphene in developing zebrafish (Danio rerio) embryos","volume":"25","author":"Manjunatha","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2023.153462_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cga.12079","article-title":"Zebrafish as a systems toxicology model for developmental neurotoxicity testing","volume":"55","author":"Nishimura","year":"2015","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.tox.2023.153462_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0498-345","article-title":"Vertebrate genome evolution and the zebrafish gene map","volume":"18","author":"Postlethwait","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tox.2023.153462_bib41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2006.11.001","article-title":"Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants","volume":"168","author":"Pulskamp","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153462_bib42","doi-asserted-by":"crossref","first-page":"1700595","DOI":"10.1002\/advs.201700595","article-title":"Graphene oxide quantum dots reduce oxidative stress and inhibit neurotoxicity in vitro and in vivo through catalase-like activity and metabolic regulation","volume":"5","author":"Ren","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.tox.2023.153462_bib43","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1039\/D1NA00145K","article-title":"Crossing the blood-brain barrier with carbon dots: uptake mechanism and in vivo cargo delivery","volume":"3","author":"Seven","year":"2021","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.tox.2023.153462_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110596","article-title":"Biomedical application of graphene: from drug delivery, tumor therapy, to theranostics","volume":"185","author":"Song","year":"2020","journal-title":"Colloids Surf. B, Biointerfaces"},{"key":"10.1016\/j.tox.2023.153462_bib45","doi-asserted-by":"crossref","DOI":"10.3791\/51060","article-title":"Analysis of apoptosis in zebrafish embryos by whole-mount immunofluorescence to detect activated Caspase 3","author":"Sorrells","year":"2013","journal-title":"J. Vis. Exp. JoVE"},{"key":"10.1016\/j.tox.2023.153462_bib46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2018.11.030","article-title":"Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats","volume":"146","author":"Tosic","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tox.2023.153462_bib47","doi-asserted-by":"crossref","first-page":"12098","DOI":"10.1021\/nn502466z","article-title":"Large graphene quantum dots alleviate immune-mediated liver damage","volume":"8","author":"Volarevic","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.tox.2023.153462_bib48","doi-asserted-by":"crossref","first-page":"19995","DOI":"10.1039\/C8NR07180B","article-title":"Graphene quantum dots against human IAPP aggregation and toxicity in vivo","volume":"10","author":"Wang","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.tox.2023.153462_bib49","doi-asserted-by":"crossref","first-page":"89867","DOI":"10.1039\/C6RA16516H","article-title":"The toxicity of graphene quantum dots","volume":"6","author":"Wang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.tox.2023.153462_bib50","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12989-020-00363-1","article-title":"Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia","volume":"17","author":"Wu","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.tox.2023.153462_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12989-022-00464-z","article-title":"Nitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia","volume":"19","author":"Wu","year":"2022","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.tox.2023.153462_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12989-018-0279-8","article-title":"Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage","volume":"15","author":"Xu","year":"2018","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.tox.2023.153462_bib53","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jat.3944","article-title":"Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio)","volume":"40","author":"Yan","year":"2020","journal-title":"J. Appl. Toxicol.: JAT"},{"key":"10.1016\/j.tox.2023.153462_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201808283","article-title":"Recent advances on graphene quantum dots: from chemistry and physics to applications","volume":"31","author":"Yan","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.tox.2023.153462_bib55","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1021\/acschemneuro.7b00015","article-title":"Fluorine functionalized graphene quantum dots as inhibitor against hIAPP amyloid aggregation","volume":"8","author":"Yousaf","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tox.2023.153462_bib56","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1080\/17435390.2019.1668068","article-title":"Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells","volume":"13","author":"Yu","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tox.2023.153462_bib57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12951-021-00908-2","article-title":"The neuroprotective effect of pretreatment with carbon dots from Crinis Carbonisatus (carbonized human hair) against cerebral ischemia reperfusion injury","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.tox.2023.153462_bib58","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12951-022-01362-4","article-title":"Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3\/Periostin\/ERK signaling","volume":"20","author":"Zhao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.tox.2023.153462_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113896","article-title":"Neurotoxicity of nanoparticles: Insight from studies in zebrafish","volume":"242","author":"Zhao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2023.153462_bib60","doi-asserted-by":"crossref","first-page":"22387","DOI":"10.1039\/C9NR08194A","article-title":"Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of beta-amyloid","volume":"11","author":"Zhou","year":"2019","journal-title":"Nanoscale"}],"updated-by":[{"DOI":"10.1016\/j.tox.2023.153591","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000}}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23000483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23000483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T08:19:35Z","timestamp":1681719575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X23000483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":60,"alternative-id":["S0300483X23000483"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2023.153462","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Graphene quantum dots (GQDs) induce thigmotactic effect in zebrafish larvae via modulating key genes and metabolites related to synaptic plasticity","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2023.153462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153462"}}