{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:46:23Z","timestamp":1792284383910,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","award":["LIDER\/4\/0099\/L-7\/15\/NCBR\/2016"],"award-info":[{"award-number":["LIDER\/4\/0099\/L-7\/15\/NCBR\/2016"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.tox.2023.153510","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T04:56:06Z","timestamp":1681361766000},"page":"153510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Comparative evaluation of mutagenic, genotoxic, cytotoxic, and antimicrobial effects of flavour and fragrance aldehydes, ketones, oximes, and oxime ethers"],"prefix":"10.1016","volume":"490","author":[{"given":"Lucyna","family":"Balcerzak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja K.","family":"Surowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Groborz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Str\u00f3\u017cak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Piekarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Strub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2023.153510_bib1","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.3390\/molecules24234237","article-title":"Impact of Citral and Phloretin, Alone and in Combination, on Major Virulence Traits of Streptococcus pyogenes","volume":"24","author":"Adil","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2023.153510_bib2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1128\/jcm.32.5.1261-1267.1994","article-title":"Evaluation of Alamar colorimetric MIC method for antimicrobial susceptibility testing of gram-negative bacteria","volume":"32","author":"Baker","year":"1994","journal-title":"J. Clin. Microbiol"},{"key":"10.1016\/j.tox.2023.153510_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125283","article-title":"Minor constituents of essential oils and aromatic extracts. Oximes derived from natural flavor and fragrance raw materials \u2013 Sensory evaluation, spectral and gas chromatographic characteristics","volume":"301","author":"Balcerzak","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.tox.2023.153510_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jiec.2022.08.017","article-title":"Evaluation of small combinatorial libraries of nitrogenous low-molecular-weight compounds for new fragrance development","volume":"115","author":"Balcerzak","year":"2022","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.tox.2023.153510_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2006.10.014","article-title":"Genotoxic potential associated with low levels of the Fusarium mycotoxins nivalenol and fusarenon X in a human intestinal cell line","volume":"21","author":"Bony","year":"2007","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2023.153510_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fct.2016.10.020","article-title":"FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results","volume":"98","author":"Cohen","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153510_bib7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/AAC.41.5.1004","article-title":"Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium","volume":"41","author":"Collins","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tox.2023.153510_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0166-445X(83)90050-4","article-title":"The Microtox as an alternative assay in the acute toxicity assessment of water pollutants","volume":"4","author":"De Zwart","year":"1983","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2023.153510_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/ph15010066","article-title":"FDA-Approved Oximes and Their Significance in Medicinal Chemistry","volume":"15","author":"Dhuguru","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.tox.2023.153510_bib10","unstructured":"ECHA 2018. REACH 2018 registration statistics. European Chemicals Agency."},{"key":"10.1016\/j.tox.2023.153510_bib11","unstructured":"ECHA. 2021a. Toxiclogical information of p-tolualdehyde https:\/\/echa.europa.eu\/pl\/registration-dossier\/-\/registered-dossier\/22054\/7\/7\/2 05.02.2023."},{"key":"10.1016\/j.tox.2023.153510_bib12","unstructured":"ECHA. 2021b. Toxicological information of 1,5-dimethylbicyclo[3.2.1]octan-8-one oxime https:\/\/echa.europa.eu\/pl\/registration-dossier\/-\/registered-dossier\/18511\/7\/7\/2 05.02.2023."},{"key":"10.1016\/j.tox.2023.153510_bib13","unstructured":"ECHA. 2021c. Toxicological information of citral https:\/\/echa.europa.eu\/pl\/registration-dossier\/-\/registered-dossier\/13515\/7\/7\/2 05.02.2023."},{"key":"10.1016\/j.tox.2023.153510_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0378-4274(93)90048-3","article-title":"The possible role of \u03b1,\u03b2-unsaturated carbonyl compounds in mutagenesis and carcinogenesis","volume":"67","author":"Eder","year":"1993","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153510_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/molecules23010123","article-title":"Chemical Composition and Evaluation of the Biological Properties of the Essential Oil of the Dietary Phytochemical Lippia citriodora","volume":"23","author":"Fitsiou","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2023.153510_bib16","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1039\/c7pp00024c","article-title":"The SOS Chromotest applied for screening plant antigenotoxic agents against ultraviolet radiation","volume":"16","author":"Fuentes","year":"2017","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.tox.2023.153510_bib17","article-title":"Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes","volume":"2018","author":"Fuyuno","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tox.2023.153510_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1383-5718(98)00077-1","article-title":"Mutagenicity testing (+\/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella\/microsome assay","volume":"416","author":"Gomes-Carneiro","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2023.153510_bib19","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1128\/JCM.02321-09","article-title":"Rapid Antifungal Susceptibility Determination for Yeast Isolates by Use of Etest Performed Directly on Blood Samples from Patients with Fungemia","volume":"48","author":"Guinea","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tox.2023.153510_bib20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.fct.2016.08.029","article-title":"Genotoxicity assessment of the flavouring agent, perillaldehyde","volume":"97","author":"Hobbs","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153510_bib21","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1039\/D1NJ05171G","article-title":"Synthesis and biological evaluation of isatin oxime ether-tethered aryl 1H-1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis","volume":"46","author":"Kancharla","year":"2022","journal-title":"N. J. Chem."},{"key":"10.1016\/j.tox.2023.153510_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137862","article-title":"Alternative type of Ames test allows for dynamic mutagenicity detection by online monitoring of respiration activity","volume":"726","author":"Kauffmann","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2023.153510_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1590\/S1415-47572011005000030","article-title":"Chemical composition and antigenotoxic properties of Lippia alba essential oils","volume":"34","author":"L\u00f3pez","year":"2011","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.tox.2023.153510_bib24","first-page":"682","article-title":"Assay of 855 test chemicals in ten tester strains using a new modification of the Ames test for bacterial mutagens","volume":"39","author":"McMahon","year":"1979","journal-title":"Cancer Res"},{"key":"10.1016\/j.tox.2023.153510_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0027-5107(00)00064-6","article-title":"The Ames Salmonella\/microsome mutagenicity assay","volume":"455","author":"Mortelmans","year":"2000","journal-title":"Mutat. Res. - Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.tox.2023.153510_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-7992(86)90005-9","article-title":"Antimutagenic effects of 5-fluorouracil and 5-fluorodeoxyuridine on UV-induced mutagenesis in Escherichia coli","volume":"173","author":"Ohta","year":"1986","journal-title":"Mutat. Res. Lett."},{"key":"10.1016\/j.tox.2023.153510_bib27","unstructured":"OJEU. 2006. Regulation (EC) no 1907\/2006 of the Eeuropean Parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)."},{"key":"10.1016\/j.tox.2023.153510_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0165-1218(87)90057-7","article-title":"Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest","volume":"189","author":"Olivier","year":"1987","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2023.153510_bib29","first-page":"8","article-title":"Food-Associated Lactobacillus plantarum and Yeasts Inhibit the Genotoxic Effect of 4-Nitroquinoline-1-Oxide","author":"Prete","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tox.2023.153510_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00204-008-0298-6","article-title":"Antioxidant properties of oxime 3-(phenylhydrazono) butan-2-one","volume":"82","author":"Puntel","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153510_bib31","first-page":"79","article-title":"The SOS Chromotest, a colorimetric bacterial assay for genotoxins: validation study with 83 compounds. Mutat. res","volume":"147","author":"Quillardet","year":"1985","journal-title":"Sect. Environ. Mutagen. Relat. Subj."},{"key":"10.1016\/j.tox.2023.153510_bib32","doi-asserted-by":"crossref","unstructured":"Quillardet, P., Huisman, O., D'Ari, R. and Hofnung, M. 1982. SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity. Proc. Natl. Acad. Sci. U S A. 79, 5971\u20135975.","DOI":"10.1073\/pnas.79.19.5971"},{"key":"10.1016\/j.tox.2023.153510_bib33","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1021\/jm020980t","article-title":"Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole","volume":"45","author":"Rossello","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tox.2023.153510_bib34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0026-0495(98)90120-2","article-title":"Use of a soluble tetrazolium compound to assay metabolic activation of intact beta cells","volume":"47","author":"Segu","year":"1998","journal-title":"Metab.: Clin. Exp."},{"key":"10.1016\/j.tox.2023.153510_bib35","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0960-894X(02)00054-9","article-title":"Oxime derivatives of sordaricin as potent antifungal agents","volume":"12","author":"Serrano-Wu","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tox.2023.153510_bib36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/01480545.2019.1585445","article-title":"Citral presents cytotoxic and genotoxic effects in human cultured cells","volume":"43","author":"Souza","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153510_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-1218(88)90006-7","article-title":"Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans","volume":"205","author":"Sugimura","year":"1988","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2023.153510_bib38","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1038\/s41598-022-09210-z","article-title":"Cytotoxicity, early safety screening, and antimicrobial potential of minor oxime constituents of essential oils and aromatic extracts","volume":"12","author":"Surowiak","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2023.153510_bib39","unstructured":"VIGON. 2015. Safety Data Sheet of stemone https:\/\/shop.perfumersapprentice.com\/msds\/6224.pdf 05.02.2023."},{"key":"10.1016\/j.tox.2023.153510_bib40","unstructured":"WHO. 2002. Safety evaluation of certain food additives and contaminants, IPCS, Geneva."},{"issue":"Suppl 9","key":"10.1016\/j.tox.2023.153510_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2860090602","article-title":"Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals","volume":"9","author":"Zeiger","year":"1987","journal-title":"Environ. Mutagen."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23000963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23000963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:54:31Z","timestamp":1759535671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X23000963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":41,"alternative-id":["S0300483X23000963"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2023.153510","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative evaluation of mutagenic, genotoxic, cytotoxic, and antimicrobial effects of flavour and fragrance aldehydes, ketones, oximes, and oxime ethers","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2023.153510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"153510"}}