{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:27:56Z","timestamp":1792898876217,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H03035"],"award-info":[{"award-number":["18H03035"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H04843"],"award-info":[{"award-number":["21H04843"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.tox.2023.153577","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T10:39:43Z","timestamp":1686393583000},"page":"153577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays"],"prefix":"10.1016","volume":"494","author":[{"given":"Wataru","family":"Murase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Ikeda-Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Shizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Yoshinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2023.153577_bib1","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s00204-016-1888-3","article-title":"Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid","volume":"91","author":"Abe","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.14791\/btrt.2015.3.1.24","article-title":"Validation of housekeeping genes for gene expression analysis in glioblastoma using quantitative real-time polymerase chain reaction","volume":"3","author":"Aithal","year":"2015","journal-title":"Brain Tumor Res. Treat."},{"key":"10.1016\/j.tox.2023.153577_bib3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1289\/ehp.10334","article-title":"Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth","volume":"115","author":"Apelberg","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2023.153577_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101602","article-title":"Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice","volume":"66","author":"Attema","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tox.2023.153577_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104700","article-title":"Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)","volume":"62","author":"Behr","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2023.153577_bib6","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00204-020-02732-3","article-title":"Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells","volume":"94","author":"Behr","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","article-title":"Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes","volume":"288","author":"Bjork","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.tox.2023.153577_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166101","article-title":"The xenobiotic receptors PXR and CAR in liver physiology, an update","volume":"1867","author":"Cai","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.tox.2023.153577_bib10","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1158\/0008-5472.CAN-04-0322","article-title":"Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha","volume":"64","author":"Cheung","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.tox.2023.153577_bib11","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1289\/ehp.1510391","article-title":"Modeled perfluorooctanoic acid (PFOA) exposure and liver function in a Mid-Ohio Valley Community","volume":"124","author":"Darrow","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2023.153577_bib12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1289\/ehp.10896","article-title":"Perfluorooctanoic acid-induced immunomodulation in adult C57BL\/6J or C57BL\/6N female mice","volume":"116","author":"DeWitt","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2023.153577_bib13","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal \u03b2-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tox.2023.153577_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108648","article-title":"Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature","volume":"177","author":"Domingo","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2023.153577_bib15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tox.2023.153577_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113559","article-title":"New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs","volume":"172","author":"Fragki","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152339","article-title":"Altered expression and activity of phase I and II biotransformation enzymes in human liver cells by perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)","volume":"430","author":"Franco","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envres.2014.10.004","article-title":"Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007-2010","volume":"136","author":"Gleason","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.tox.2023.153577_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tox.2007.09.030","article-title":"PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators","volume":"246","author":"Gonzalez","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/mol.62.2.359","article-title":"Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor","volume":"62","author":"Goodwin","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2023.153577_bib21","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1073\/pnas.232137699","article-title":"Infection of a human hepatoma cell line by hepatitis B virus","volume":"99","author":"Gripon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.tox.2023.153577_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135061","article-title":"Estimated daily intake of per- and polyfluoroalkyl substances related to different particle size fractions of house dust","volume":"303","author":"Gustafsson","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2023.153577_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.apha.2015.03.003","article-title":"Involvement of cytochrome P450 in reactive oxygen species formation and cancer","volume":"74","author":"Hrycay","year":"2015","journal-title":"Adv. Pharm."},{"key":"10.1016\/j.tox.2023.153577_bib24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR\u03b1","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tox.2023.153577_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12199-021-00980-y","article-title":"Hokkaido birth cohort study on environment and children's health: cohort profile 2021","volume":"26","author":"Kishi","year":"2021","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.tox.2023.153577_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2010.11.008","article-title":"Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays","volume":"280","author":"Kojima","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2013.09.004","article-title":"In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors","volume":"314","author":"Kojima","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2018.12.001","article-title":"Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors","volume":"413","author":"Kojima","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2131\/jts.28.49","article-title":"Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals","volume":"28","author":"Kudo","year":"2003","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153577_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153577_bib31","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12885-016-2462-3","article-title":"Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma","volume":"16","author":"Lei","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tox.2023.153577_bib32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/es505075z","article-title":"In vivo bioavailability and in vitro bioaccessibility of perfluorooctanoic acid (PFOA) in food matrices: correlation analysis and method development","volume":"49","author":"Li","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2023.153577_bib33","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1124\/dmd.121.000477","article-title":"Perfluorinated carboxylic acids with increasing carbon chain lengths upregulate amino acid transporters and modulate compensatory response of xenobiotic transporters in HepaRG cells","volume":"50","author":"Lim","year":"2022","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.tox.2023.153577_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.envint.2010.03.004","article-title":"The occurrence of perfluorinated alkyl compounds in human milk from different regions of China","volume":"36","author":"Liu","year":"2010","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2023.153577_bib35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.envint.2010.04.016","article-title":"Infant exposure of perfluorinated compounds: levels in breast milk and commercial baby food","volume":"36","author":"Llorca","year":"2010","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2023.153577_bib36","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s00204-020-02808-0","article-title":"Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells","volume":"94","author":"Louisse","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib37","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00204-023-03450-2","article-title":"Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells","volume":"97","author":"Louisse","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/taap.1999.8809","article-title":"trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals","volume":"161","author":"Maloney","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2023.153577_bib40","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2013.11.126","article-title":"SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells","volume":"443","author":"Miyata","year":"2014","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tox.2023.153577_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5483\/BMBRep.2016.49.3.188","article-title":"Hypoxic repression of CYP7A1 through a HIF-1\u03b1- and SHP-independent mechanism","volume":"49","author":"Moon","year":"2016","journal-title":"BMB Rep."},{"key":"10.1016\/j.tox.2023.153577_bib42","doi-asserted-by":"crossref","first-page":"ra31","DOI":"10.1126\/scisignal.2003705","article-title":"Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling","volume":"6","author":"Mutoh","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tox.2023.153577_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153024","article-title":"Predicting the effects of pre- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro","volume":"465","author":"Nielsen","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1248\/yakushi.122.339","article-title":"Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR","volume":"122","author":"Nishimura","year":"2002","journal-title":"Yakugaku. Zasshi."},{"key":"10.1016\/j.tox.2023.153577_bib45","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2023.153577_bib46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/tox.23680","article-title":"Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells","volume":"38","author":"Qi","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib47","doi-asserted-by":"crossref","unstructured":"Robarts, D.R., Paine-Cabrera, D., Kotulkar, M., Venneman, K.K., Gunewardena, S., Corton, J.C., Lau, C., Foquet, L., Bial, G., Apte, U., 2023, Identifying human specific adverse outcome pathways of per- and polyfluoroalkyl substances using liver-chimeric humanized mice. bioRxiv 2023.02.01.526711. https:\/\/doi.org\/10.1101\/2023.02.01.526711.","DOI":"10.1101\/2023.02.01.526711"},{"key":"10.1016\/j.tox.2023.153577_bib48","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0192623308318208","article-title":"Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid","volume":"36","author":"Rosen","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2023.153577_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115204","article-title":"Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR\u03b1 mice fed an American diet","volume":"405","author":"Schlezinger","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2023.153577_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1289\/ehp.1002346","article-title":"Accumulation and clearance of perfluorooctanoic acid (PFOA) in current and former residents of an exposed community","volume":"119","author":"Seals","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2023.153577_bib51","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.3390\/ijms24043953","article-title":"PPAR\u03b1 induces the expression of CAR that works as a negative regulator of PPAR\u03b1 functions in mouse livers","volume":"24","author":"Shizu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2023.153577_bib52","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3389\/fmed.2020.00544","article-title":"Bile acids and FXR: Novel targets for liver diseases","volume":"7","author":"Stofan","year":"2020","journal-title":"Front. Med (Lausanne)"},{"key":"10.1016\/j.tox.2023.153577_bib53","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.tox.2023.153577_bib54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator\u2013activated receptors (\u03b1, \u03b2\/\u03b4, \u03b3) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153577_bib55","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1016\/j.watres.2011.04.052","article-title":"Fate of perfluorooctanesulfonate and perfluorooctanoate in drinking water treatment processes","volume":"45","author":"Takagi","year":"2011","journal-title":"Water Res"},{"key":"10.1016\/j.tox.2023.153577_bib56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tox.2005.02.002","article-title":"Differential effects of phthalate esters on transcriptional activities via human estrogen receptors \u03b1 and \u03b2, and androgen receptor","volume":"210","author":"Takeuchi","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153577_bib57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jbt.2570060202","article-title":"Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats","volume":"6","author":"Vanden Heuvel","year":"1991","journal-title":"J. Biochem. Toxicol."},{"key":"10.1016\/j.tox.2023.153577_bib58","first-page":"117","article-title":"Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response","volume":"2","author":"Wei","year":"2002","journal-title":"Pharm. J."},{"key":"10.1016\/j.tox.2023.153577_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfm206","article-title":"The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha","volume":"101","author":"Yang","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153577_bib60","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1248\/bpb.b17-00913","volume":"41","author":"Yokoyama","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tox.2023.153577_bib61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.taap.2004.01.018","article-title":"Mechanisms that regulate production of reactive oxygen species by cytochrome P450","volume":"199","author":"Zangar","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2023.153577_bib62","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug. Metab. Rev."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23001634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23001634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:55:39Z","timestamp":1759535739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X23001634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":62,"alternative-id":["S0300483X23001634"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2023.153577","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2023.153577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153577"}}