{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:00:23Z","timestamp":1792814423097,"version":"4.5.0"},"reference-count":148,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.841810\/2023-00"],"award-info":[{"award-number":["88887.841810\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020812","name":"Instituto de Astrof\u00edsica de Andaluc\u00eda","doi-asserted-by":"publisher","award":["88887.568833\/2020-00"],"award-info":[{"award-number":["88887.568833\/2020-00"]}],"id":[{"id":"10.13039\/501100020812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.tox.2023.153630","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:11:37Z","timestamp":1694553097000},"page":"153630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies"],"prefix":"10.1016","volume":"497-498","author":[{"given":"Blessing A.","family":"Obafemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac A.","family":"Adedara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao B.T.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2023.153630_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/19440049.2013.793823","article-title":"Effect of quercetin on the toxicokinetics of ochratoxin A in rats","volume":"30","author":"Abbas","year":"2013","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.tox.2023.153630_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/07315724.2019.1683379","article-title":"Alzheimer's disease and Parkinson's disease: A nutritional toxicology perspective of the impact of oxidative stress, mitochondrial dysfunction, nutrigenomics and environmental chemicals","volume":"39","author":"Agnihotri","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12550-020-00407-7","article-title":"Biological monitoring for ochratoxin A and citrinin and their metabolites in urine samples of infants and children in Bangladesh","volume":"36","author":"Ali","year":"2020","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.tox.2023.153630_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12550-017-0299-5","article-title":"Blood plasma biomarkers of citrinin and ochratoxin A exposure in young adults in Bangladesh","volume":"34","author":"Ali","year":"2018","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.tox.2023.153630_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxlet.2017.04.013","article-title":"Ochratoxin A and its metabolites in urines of German adults-An assessment of variables in biomarker analysis","volume":"5","author":"Ali","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153630_bib6","first-page":"173","article-title":"The role of pumpkin pulp extract carotenoids against mycotoxin damage in the blood brain barrier in vitro","volume":"72","author":"Alonso-Garrido","year":"2021","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.tox.2023.153630_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/toxins13070477","article-title":"Biomonitoring of mycotoxins in plasma of patients with Alzheimer's and Parkinson's disease","volume":"13","author":"Arce-L\u00f3pez","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib8","article-title":"Neurotoxicity of furan in juvenile Wistar rats involves behavioral defects, microgliosis, astrogliosis and oxidative stress","volume":"7","author":"Awogbindin","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12550-019-00370-y","article-title":"Ochratoxin A induces global DNA hypomethylation and oxidative stress in neuronal cells in vitro","volume":"36","author":"Babayan","year":"2020","journal-title":"Mycotoxin Res."},{"issue":"5","key":"10.1016\/j.tox.2023.153630_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/toxins13050327","article-title":"Efflux at the blood-brain barrier reduces the cerebral exposure to ochratoxin a, ochratoxin \u03b1, citrinin and dihydrocitrinone","volume":"13","author":"Behrens","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s002040050557","article-title":"Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain","volume":"72","author":"Belmadani","year":"1998","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0378-4274(03)00043-2","article-title":"Interaction of Ochratoxin A with human intestinal Caco-2 cells: Possible implication of a multidrug resistance-associated protein (MRP2)","volume":"140\u2013141","author":"Berger","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153630_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuint.2018.04.003","article-title":"Restorative effect of l-Dopa treatment against Ochratoxin A induced neurotoxicity","volume":"18","author":"Bhat","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1016\/j.tox.2023.153630_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00394-010-0130-y","article-title":"The presence of ochratoxin A in cord serum and in human milk and its correspondence with maternal dietary habits","volume":"50","author":"Biasucci","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112247","article-title":"A one-generation reproductive toxicity study of the mycotoxin ochratoxin A in Fischer rats","volume":"153","author":"Bondy","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib16","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1080\/10408398.2012.724480","article-title":"Ochratoxin A and human health risk: a review of the evidence","volume":"55","author":"Bui-Klimke","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib17","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/toxins2051111","article-title":"Ochratoxin A producing species in the genus Penicillium","volume":"2","author":"Caba\u00f1es","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib18","first-page":"4","article-title":"Betalains and their applications in food: the current state of processing, stability and future opportunities in the industry","volume":"21","author":"Calva-Estrada","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib19","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1007\/s11064-022-03760-4","article-title":"Molecular mechanism of the protective effects of M2 microglia on neurons: a review focused on exosomes and secretory proteins","volume":"47","author":"Chai","year":"2022","journal-title":"Neurochem Res."},{"key":"10.1016\/j.tox.2023.153630_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1515\/bmc-2022-0017","article-title":"Corticosterone potentiates ochratoxin A-induced microglial activation","volume":"19","author":"Chansawhang","year":"2022","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.tox.2023.153630_bib21","first-page":"124","article-title":"Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases","volume":"10","author":"Chin-Chan","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tox.2023.153630_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"26","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tox.2023.153630_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1082013209353359","article-title":"Review. Ochratoxin A: presence in human plasma and intake estimation","volume":"16","author":"Coronel","year":"2010","journal-title":"Food Sci. Technol. Int"},{"key":"10.1016\/j.tox.2023.153630_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-pharmtox-051921-020812","article-title":"Air pollution-related neurotoxicity across the life span","volume":"20","author":"Cory-Slechta","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib25","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4315\/0362-028X.JFP-16-160","article-title":"Heat stability of Ochratoxin A in an aqueous buffered model system","volume":"79","author":"Dahal","year":"2016","journal-title":"J. Food Prot."},{"key":"10.1016\/j.tox.2023.153630_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3565(24)37570-6","article-title":"Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms","volume":"286","author":"Dahlmann","year":"1998","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.tox.2023.153630_bib27","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tox.2023.153630_bib28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1191\/0960327103ht357oa","article-title":"Ochratoxin A reduces NMDA receptor subunits 2A and 2B concentrations in rat hippocampus: partial protective effect of melatonin","volume":"22","author":"Delibas","year":"2003","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/157015906778520782","article-title":"Molecular mechanisms, biological actions, and neuropharmacology of the growth-associated protein GAP-43","volume":"4","author":"Denny","year":"2006","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.tox.2023.153630_bib30","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.3390\/ijms12085213","article-title":"Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways","volume":"12","author":"Doi","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/10408444.2010.529103","article-title":"Human ochratoxin a biomarkers--from exposure to effect","volume":"41","author":"Duarte","year":"2011","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib32","first-page":"6113","article-title":"Risk assessment of ochratoxin A in food","volume":"18","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2020","journal-title":"EFSA J."},{"key":"10.1016\/j.tox.2023.153630_bib33","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1039\/D1FO02059E","article-title":"Bioaccessibility and bioavailability of bioactive compounds from yellow mustard flour and milk whey fermented with lactic acid bacteria","volume":"12","author":"Escriv\u00e1","year":"2021","journal-title":"Food Funct"},{"key":"10.1016\/j.tox.2023.153630_bib34","first-page":"324","article-title":"Commission Regulation (EC) No 1881\/2006. Setting maximum levels for certain contaminants in foodstuffs","volume":"364","author":"European Commission","year":"2006","journal-title":". J. EU"},{"key":"10.1016\/j.tox.2023.153630_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113011","article-title":"Pumpkin extract and fermented whey individually and in combination alleviated AFB1- and OTA-induced alterations on neuronal differentiation in vitro","volume":"164","author":"Frangiamone","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib36","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1021\/jf060460x","article-title":"Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: correlation with antioxidant activity","volume":"9","author":"Fujioka","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aninu.2020.06.006","article-title":"Ochratoxin A: Carryover from animal feed into livestock and the mitigation strategies","volume":"7","author":"Ganesan","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2021.131978","article-title":"Distribution, toxicity, interactive effects, and detection of ochratoxin and deoxynivalenol in food: a review","volume":"378","author":"Ganesan","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib39","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1021\/jf0111817","article-title":"Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes","volume":"13","author":"Gross-Steinmeyer","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/(SICI)1522-7189(199802)6:1<43::AID-NT12>3.0.CO;2-4","article-title":"Placental and lactational transfer of ochratoxin A in rats","volume":"6","author":"Hall\u00e9n","year":"1998","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jchromb.2013.02.028","article-title":"Combinatorial approach of LC\u2013MS\/MS and LC\u2013TOF\u2013MS for uncovering in vivo kinetics and biotransformation of ochratoxin A in rat","volume":"925","author":"Han","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tox.2023.153630_bib42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0031-9422(01)00316-8","article-title":"Biosynthesis of ochratoxins by Aspergillus ochraceus","volume":"558","author":"Harris","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tox.2023.153630_bib43","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/asj.12466","article-title":"Influence of repeated ochratoxin A ingestion on milk production and its carry-over into the milk, blood and tissues of lactating cows","volume":"87","author":"Hashimoto","year":"2016","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.tox.2023.153630_bib44","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00204-022-03361-8","article-title":"Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity","volume":"96","author":"Hassan","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib45","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1007\/s00204-022-03395-y","article-title":"Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A","volume":"96","author":"Hassan","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib46","first-page":"185","article-title":"Ochratoxin A and beta2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of Ochratoxin A exposure","volume":"199","author":"Hassen","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153630_bib47","series-title":"Fifth Report on Human Biomonitoring of Environmental Chemicals in Canada: Results of the Canadian Health Measures Survey Cycle 5 (2016\u20132017)","author":"Health Canada","year":"2019"},{"key":"10.1016\/j.tox.2023.153630_bib48","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s12035-014-8913-4","article-title":"A\u03b2 Influences cytoskeletal signaling cascades with consequences to Alzheimer's disease","volume":"52","author":"Henriques","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tox.2023.153630_bib49","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.3390\/toxins7104253","article-title":"Comparative ochratoxin toxicity: a review of the available data","volume":"7","author":"Heussner","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2131\/jts.38.57","article-title":"Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression","volume":"38","author":"Hibi","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib51","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/ijms10041465","article-title":"Mycotoxin detection in human samples from patients exposed to environmental molds","volume":"10","author":"Hooper","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib52","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4315\/0362-028X-42.10.815","article-title":"Mycotoxins-their biosynthesis in fungi: ochratoxins-metabolites of combined pathways","volume":"42","author":"Huff","year":"1979","journal-title":"J. Food Prot."},{"key":"10.1016\/j.tox.2023.153630_bib53","first-page":"489","article-title":"Ochratoxin A","volume":"56","author":"IARC","year":"1993","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.tox.2023.153630_bib54","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/jp012315m","article-title":"Interaction of Ochratoxin A with human serum albumin. A common binding site of Ochratoxin A and warfarin in subdomain IIA","volume":"106","author":"Il\u2019ichev","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.tox.2023.153630_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112164","article-title":"Oral subchronic exposure to the mycotoxin ochratoxin A induces key pathological features of Parkinson's disease in mice six months after the end of the treatment","volume":"152","author":"Izco","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib56","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1124\/dmd.121.000451","article-title":"Attenuated ochratoxin A transporter expression in a mouse model of nonalcoholic steatohepatitis protects against proximal convoluted tubule toxicity","volume":"50","author":"Jilek","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2023.153630_bib57","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/10408390500436185","article-title":"Strategies to prevent mycotoxin contamination of food and animal feed: a review","volume":"46","author":"Kabak","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tox.2023.153630_bib59","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s11064-019-02881-7","article-title":"Role of Astrocytes in manganese neurotoxicity revisited","volume":"44","author":"Ke","year":"2019","journal-title":"Neurochem Res"},{"key":"10.1016\/j.tox.2023.153630_bib60","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4315\/0362-028X-62.12.1461","article-title":"Cholestyramine protection against ochratoxin A toxicity: role of ochratoxin A sorption by the resin and bile acid enterohepatic circulation","volume":"62","author":"Kerkadi","year":"1999","journal-title":"J. Food Prot."},{"key":"10.1016\/j.tox.2023.153630_bib61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/1547691X.2012.686533","article-title":"Amelioration of Ochratoxin A-induced immunotoxic effects by silymarin and Vitamin E in White Leghorn cockerels","volume":"10","author":"Khatoon","year":"2013","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.tox.2023.153630_bib62","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/toxins8040111","article-title":"Ochratoxin A: Molecular interactions, mechanisms of toxicity and prevention at the molecular level","volume":"8","author":"K\u0151szegi","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib63","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0278-6915(85)90112-7","article-title":"Ochratoxin A: Plasma concentration and excretion into bile and urine in albumin-deficient rats","volume":"23","author":"Kumagai","year":"1985","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.toxicon.2020.08.031","article-title":"Ochratoxins in food and feed: occurrence and its impact on human health and management strategies","volume":"187","author":"Kumar","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.tox.2023.153630_bib65","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/mutage\/get054","article-title":"Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats","volume":"29","author":"Kuroda","year":"2014","journal-title":"Mutagenesis"},{"key":"10.1016\/j.tox.2023.153630_bib66","article-title":"Diverse mycotoxin threats to safe food and feed cereals","volume":"14","author":"Latham","year":"2023","journal-title":"Essays Biochem."},{"key":"10.1016\/j.tox.2023.153630_bib67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuro.2022.07.001","article-title":"Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in concentrations relevant for human exposure","volume":"92","author":"Lauv\u00e5s","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2023.153630_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.114265","article-title":"Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations","volume":"175","author":"LIczbi\u0144ski","year":"2022","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.tox.2023.153630_bib69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2022.04.012","article-title":"Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis","volume":"213","author":"Liu","year":"2022","journal-title":"Toxicon"},{"key":"10.1016\/j.tox.2023.153630_bib70","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/1873-3468.14074","article-title":"Extracellular vesicles and intercellular communication in the central nervous system","volume":"595","author":"Lizarraga-Valderrama","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2023.153630_bib71","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3390\/toxins12100664","article-title":"Toxin degradation by rumen microorganisms: a review","volume":"12","author":"Loh","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib72","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ijheh.2019.05.009","article-title":"Human biomonitoring in health risk assessment in Europe: current practices and recommendations for the future","volume":"222","author":"Louro","year":"2019","journal-title":"Int J. Hyg. Environ. Health"},{"key":"10.1016\/j.tox.2023.153630_bib73","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/1354750X.2013.845609","article-title":"Ochratoxin A levels in blood serum of Czech women in the first trimester of pregnancy and its correspondence with dietary intake of the mycotoxin contaminant","volume":"18","author":"Malir","year":"2013","journal-title":"Biomarkers"},{"key":"10.1016\/j.tox.2023.153630_bib74","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3390\/toxins14090624","article-title":"The neurotoxic effect of ochratoxin-a on the hippocampal neurogenic niche of adult mouse brain","volume":"14","author":"Mateo","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib75","first-page":"1","article-title":"Recent advances in nanomaterial-based optical biosensors for food safety applications: ochratoxin-A detection, as case study","volume":"23","author":"Meira","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib76","article-title":"Food processing contaminants: dietary exposure to 3-MCPD and glycidol and associated burden of disease for Italian consumers","volume":"5","author":"Mihalache","year":"2023","journal-title":"Environ. Res"},{"key":"10.1016\/j.tox.2023.153630_bib77","first-page":"1745","article-title":"Stability of ochratoxin A during bread making process","author":"Milani","year":"2017","journal-title":"J. Food Saf."},{"key":"10.1016\/j.tox.2023.153630_bib78","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3390\/toxins204809","article-title":"Ochratoxin A in ruminants\u2212A review on its degradation by gut microbes and effects on animals","volume":"2","author":"Mobashar","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.tox.2023.153630_bib79","first-page":"837","article-title":"Exposure of infants to ochratoxin A with breast milk","volume":"88","author":"Mu\u00f1oz","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib80","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12550-016-0261-y","article-title":"Evidence of ochratoxin A conjugates in urine samples from infants and adults","volume":"33","author":"Mu\u00f1oz","year":"2017","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.tox.2023.153630_bib81","article-title":"Role of environmental toxicants on neurodegenerative disorders","volume":"11","author":"Nabi","year":"2022","journal-title":"Front Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib82","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11064-016-2030-x","article-title":"Solute carriers in the blood-brain barrier: safety in abundance","volume":"42","author":"Na\u0142\u0119cz","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.tox.2023.153630_bib83","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): A pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tox.2023.153630_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8884511","article-title":"The regenerative potential of facial nerve motoneurons following chronic axotomy in rats","volume":"2020","author":"Ni","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.tox.2023.153630_bib85","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxrep.2019.11.015","article-title":"Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A","volume":"15","author":"Nogaim","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2023.153630_bib86","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.3390\/ijms23147726","article-title":"The role of neurotrophin signaling in age-related cognitive decline and cognitive diseases","volume":"23","author":"Numakawa","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib87","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/ijc.30405","article-title":"Japan public health center-based prospective study group. coffee and green tea consumption in relation to brain tumor risk in a Japanese population","volume":"139","author":"Ogawa","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2023.153630_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111701","article-title":"Prevalence, level and health risk assessment of mycotoxins in the fried poultry eggs from Jordan","volume":"200","author":"Omar","year":"2021","journal-title":"Environ. Res"},{"key":"10.1016\/j.tox.2023.153630_bib89","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1124\/dmd.109.029454","article-title":"Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier","volume":"38","author":"Ose","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2023.153630_bib90","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12640-020-00308-8","article-title":"Neurodegenerative implications of neuronal cytoplasmic protein dysfunction in response to environmental contaminants","volume":"39","author":"Osemwegie","year":"2021","journal-title":"Neurotox. Res"},{"key":"10.1016\/j.tox.2023.153630_bib91","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/jat.3061","article-title":"Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain","volume":"35","author":"Paradells","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib92","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxlet.2019.05.021","article-title":"Ochratoxin A exerts neurotoxicity in human astrocytes through mitochondria-dependent apoptosis and intracellular calcium overload","volume":"313","author":"Park","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153630_bib93","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/BST20220830","article-title":"The role of the blood-brain barrier during neurological disease and infection","volume":"51","author":"Patabendige","year":"2023","journal-title":"Biochem Soc. Trans."},{"key":"10.1016\/j.tox.2023.153630_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113164","article-title":"Effectiveness of beetroot extract in SH-SY5Y neuronal cell protection against Fumonisin B1, Ochratoxin A and its combination","volume":"165","author":"Penalva-Olcina","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib95","article-title":"Microglial tissue surveillance: the never-resting gardener in the developing and adult CNS","volume":"12","author":"Petry","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.tox.2023.153630_bib96","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2885.2000.00244.x","article-title":"Ochratoxin A from a toxicological perspective","volume":"23","author":"Petzinger","year":"2000","journal-title":"J. Vet. Pharm. Ther."},{"key":"10.1016\/j.tox.2023.153630_bib97","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1051\/medsci\/2013292009","article-title":"Cellular communication between neurons and glial cells: an overview","volume":"29","author":"Pfrieger","year":"2013","journal-title":"Med. Sci. (Paris)"},{"key":"10.1016\/j.tox.2023.153630_bib98","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijbiomac.2012.05.019","article-title":"Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: a new possible mode of action","volume":"51","author":"Po\u00f3r","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.tox.2023.153630_bib99","first-page":"23","article-title":"Ochratoxin a in maternal and foetal blood and in maternal milk","volume":"57","author":"Postupolski","year":"2006","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"10.1016\/j.tox.2023.153630_bib100","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-3-030-73234-9_21","article-title":"The effect of green coffee bean extract on cardiovascular risk factors: a systematic review and meta-analysis","volume":"1328","author":"Pourmasoumi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tox.2023.153630_bib101","article-title":"Glutamate transport and preterm brain injury","volume":"24","author":"Pregnolato","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tox.2023.153630_bib102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/0-306-46830-1_27","article-title":"Exposition to and health effects of residues in human milk","volume":"478","author":"Przyrembel","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tox.2023.153630_bib103","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2017.05.022","article-title":"Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1","volume":"329","author":"Qi","year":"2017","journal-title":"Toxicol. Appl. Pharmaco."},{"key":"10.1016\/j.tox.2023.153630_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2018.12.014","article-title":"Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders","volume":"98","author":"Rankovic","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tox.2023.153630_bib105","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuro.2010.06.003","article-title":"The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1","volume":"31","author":"Razafimanjato","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2023.153630_bib106","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2005.10.106","article-title":"Toxicokinetics and toxicodynamics of ochratoxin A, an update","volume":"159","author":"Ringot","year":"2006","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.tox.2023.153630_bib107","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ejmg.2018.07.012","article-title":"Tubulin genes and malformations of cortical development","volume":"61","author":"Romaniello","year":"2018","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tox.2023.153630_bib108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0300-483X(88)90110-2","article-title":"Evidence for an enterohepatic circulation of ochratoxin A in mice","volume":"48","author":"Roth","year":"1988","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153630_bib109","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1021\/acs.jafc.1c05994","article-title":"Detection, contamination, toxicity, and prevention methods of ochratoxins: an update review","volume":"69","author":"Samuel","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuro.2005.07.004","article-title":"Acute neurotoxic effects of the fungal metabolite ochratoxin-A","volume":"27","author":"Sava","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2023.153630_bib111","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfm093","article-title":"Adult hippocampal neural stem\/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A","volume":"98","author":"Sava","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113921","article-title":"The prevalence and concentration of ochratoxin A in meat and edible offal: A global systematic review and meta-analysis","volume":"178","author":"Sharafi","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"483","key":"10.1016\/j.tox.2023.153630_bib113","article-title":"In vitro study of ochratoxin A in the expression of genes associated with neuron survival and viability","volume":"1","author":"Sharma","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2023.153630_bib114","doi-asserted-by":"crossref","first-page":"44906","DOI":"10.1007\/s11356-020-10950-6","article-title":"Effect of environmental toxicants on neuronal functions","volume":"27","author":"Sharma","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2023.153630_bib115","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1074\/jbc.M110314200","article-title":"15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes","volume":"277","author":"Shibata","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2023.153630_bib116","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1021\/acs.jafc.6b04208","article-title":"Chemical and antioxidant properties of betalains","volume":"65","author":"Slimen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110595","article-title":"Transport of mycotoxins across human gastric NCI-N87 and intestinal Caco-2\u00a0cell models","author":"Sobral","year":"2019","journal-title":"Food Chem. Toxicol. 131"},{"key":"10.1016\/j.tox.2023.153630_bib118","first-page":"313","article-title":"Blood, breast milk and urine: potential biomarkers of exposure and estimated daily intake of ochratoxin A: a review","volume":"33","author":"Soto","year":"2016","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess."},{"key":"10.1016\/j.tox.2023.153630_bib119","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s002040000157","article-title":"Kinetic parameters and intraindividual fluctuations of Ochratoxin A plasma levels in human","volume":"74","author":"Studer-Rohr","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-brain barrier: from physiology to disease and back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2023.153630_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109464","article-title":"Exposure assessment to ochratoxin A through the intake of three cereal derivatives from the Moroccan market","volume":"137","author":"Tabarani","year":"2020","journal-title":"Food Res Int"},{"key":"10.1016\/j.tox.2023.153630_bib122","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00394-017-1379-1","article-title":"The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature","volume":"56","author":"Tajik","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib123","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1007\/s00018-015-1937-8","article-title":"Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease","volume":"72","author":"Takahashi","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tox.2023.153630_bib124","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.reprotox.2016.06.018","article-title":"Maternal exposure to ochratoxin A targets intermediate progenitor cells of hippocampal neurogenesis in rat offspring via cholinergic signal downregulation and oxidative stress responses","volume":"65","author":"Tanaka","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib125","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential roles of M1 and M2 microglia in neurodegenerative diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tox.2023.153630_bib126","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fct.2018.01.002","article-title":"Ochratoxin A: Toxicity, oxidative stress and metabolism","volume":"112","author":"Tao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib127","doi-asserted-by":"crossref","first-page":"10077","DOI":"10.3390\/ijms221810077","article-title":"Molecular mechanism of arsenic-induced neurotoxicity including neuronal dysfunctions","volume":"22","author":"Thakur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib128","first-page":"1","article-title":"A comprehensive review of beetroot (Beta vulgaris L.) bioactive components in the food and pharmaceutical industries","volume":"16","author":"Thiruvengadam","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112661","article-title":"Multi-mycotoxin occurrence in feed, metabolism and carry-over to animal-derived food products: a review","volume":"158","author":"Tolosa","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ijmm.2012.1167","article-title":"Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells","volume":"31","author":"Tu","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.tox.2023.153630_bib131","doi-asserted-by":"crossref","first-page":"21144","DOI":"10.1007\/s11356-022-23692-4","article-title":"Ochratoxin A induces locomotor impairment and oxidative imbalance in adult zebrafish","volume":"30","author":"Valadas","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2023.153630_bib132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.fct.2014.07.020","article-title":"Ochratoxin A kinetics: a review of analytical methods and studies in rat model","volume":"72","author":"Vettorazzi","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib133","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.fct.2009.05.003","article-title":"A different kinetic profile of ochratoxin A in mature male rats","volume":"47","author":"Vettorazzi","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2023.153630_bib134","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuro.2014.04.005","article-title":"Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype","volume":"44","author":"von Tobel","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2023.153630_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115072","article-title":"Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A\/1B affect liver accumulation of Ochratoxin A in mice","volume":"401","author":"Wang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2023.153630_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138920011794520026","article-title":"Metabolic pathways of ochratoxin A","volume":"12","author":"Wu","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.tox.2023.153630_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125143","article-title":"Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor","volume":"242","author":"Wu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2023.153630_bib138","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s12035-017-0435-4","article-title":"Physiological and pathological roles of 15-Deoxy-\u039412,14-Prostaglandin J2 in the central nervous system and neurological diseases","volume":"55","author":"Yagami","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tox.2023.153630_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.711710","article-title":"The role of sonic hedgehog pathway in the development of the central nervous system and aging-related neurodegenerative diseases","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.tox.2023.153630_bib140","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1080\/10408398.2021.1957767","article-title":"Acids in coffee: A review of sensory measurements and meta-analysis of chemical composition","volume":"63","author":"Yeager","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tox.2023.153630_bib141","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.neuro.2009.04.013","article-title":"Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells","volume":"30","author":"Yoon","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2023.153630_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338515","article-title":"Smartphone biosensor for point-of-need chemiluminescence detection of ochratoxin A in wine and coffee","volume":"1163","author":"Zangheri","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.tox.2023.153630_bib143","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0041-008X(03)00261-8","article-title":"Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration","volume":"192","author":"Zepnik","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2023.153630_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101037","article-title":"Ochratoxin A: its impact on poultry gut health and microbiota, an overview","volume":"100","author":"Zhai","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.tox.2023.153630_bib145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.foodchem.2021.131592","article-title":"Assessment of traditional clarifiers on the adsorption of ochratoxin A in Cabernet Sauvignon red wine and their kinetics","volume":"373","author":"Zhang","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib146","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1021\/acs.jafc.7b00770","article-title":"Broad-specificity immunoassay for simultaneous detection of ochratoxins a, b, and c in millet and maize","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2023.153630_bib147","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.toxlet.2011.06.007","article-title":"Ochratoxin A at nanomolar concentration perturbs the homeostasis of neural stem cells in highly differentiated but not in immature three-dimensional brain cell cultures","volume":"28","author":"Zurich","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2023.153630_bib148","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuroscience.2005.04.030","article-title":"Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures","volume":"134","author":"Zurich","year":"2005","journal-title":"Neuroscience"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23002172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23002172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:55:00Z","timestamp":1759535700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X23002172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":148,"alternative-id":["S0300483X23002172"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2023.153630","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2023.153630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153630"}}