{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:59:40Z","timestamp":1791950380850,"version":"4.3.4"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES028206"],"award-info":[{"award-number":["ES028206"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES013508"],"award-info":[{"award-number":["ES013508"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018026","name":"Center of Excellence\u00a0in\u00a0Environmental Toxicology, University of Pennsylvania","doi-asserted-by":"publisher","award":["P30-CA016520"],"award-info":[{"award-number":["P30-CA016520"]}],"id":[{"id":"10.13039\/100018026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018026","name":"Center of Excellence\u00a0in\u00a0Environmental Toxicology, University of Pennsylvania","doi-asserted-by":"publisher","award":["T32-ES019851"],"award-info":[{"award-number":["T32-ES019851"]}],"id":[{"id":"10.13039\/100018026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018026","name":"Center of Excellence\u00a0in\u00a0Environmental Toxicology, University of Pennsylvania","doi-asserted-by":"publisher","award":["P30-ES013508"],"award-info":[{"award-number":["P30-ES013508"]}],"id":[{"id":"10.13039\/100018026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011969","name":"Cradle Coast NRM","doi-asserted-by":"publisher","award":["ES028206"],"award-info":[{"award-number":["ES028206"]}],"id":[{"id":"10.13039\/100011969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.tox.2023.153640","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:36:00Z","timestamp":1696624560000},"page":"153640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Preconception and developmental DEHP exposure alter liver metabolism in a sex-dependent manner in adult mouse offspring"],"prefix":"10.1016","volume":"499","author":[{"given":"Nicole","family":"Robles-Matos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Radaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa S.","family":"Bartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00217-019-03412-y","article-title":"Phthalate ester migration into food: effect of packaging material and time","volume":"246","author":"Alp","year":"2020","journal-title":"Eur. Food Res. Technol."},{"issue":"10","key":"10.1016\/j.tox.2023.153640_bib2","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1177\/09603271211003314","article-title":"Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1","volume":"40","author":"An","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib3","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1038\/s41598-020-62584-w","article-title":"Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations","volume":"10","author":"Barakat","year":"2020","journal-title":"Sci. Rep."},{"issue":"6761","key":"10.1016\/j.tox.2023.153640_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/bmj.301.6761.1111","article-title":"The fetal and infant origins of adult disease","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ"},{"issue":"sup6","key":"10.1016\/j.tox.2023.153640_bib5","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"issue":"8663","key":"10.1016\/j.tox.2023.153640_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"334","author":"Barker","year":"1989","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2337\/db17-1150","article-title":"Elevated medium-chain acylcarnitines are associated with gestational diabetes mellitus and early progression to type 2 diabetes and induce pancreatic \u03b2-cell dysfunction","volume":"67","author":"Batchuluun","year":"2018","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12986-018-0241-7","article-title":"Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice","volume":"15","author":"Bj\u00f8rndal","year":"2018","journal-title":"Nutr. Metab."},{"issue":"10","key":"10.1016\/j.tox.2023.153640_bib9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1289\/ehp.00108979","article-title":"Levels of seven urinary phthalate metabolites in a human reference population","volume":"108","author":"Blount","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1124\/jpet.110.168815","article-title":"Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet","volume":"334","author":"Boini","year":"2010","journal-title":"J. Pharm. Exp. Ther."},{"issue":"1\u20132","key":"10.1016\/j.tox.2023.153640_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tox.2006.03.015","article-title":"Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis","volume":"223","author":"Borch","year":"2006","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/toxsci\/53.1.2","article-title":"Paracelsus: herald of modern toxicology","volume":"53","author":"Borzelleca","year":"2000","journal-title":"Toxicol. Sci. J. Soc. Toxicol."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/0192623309332992","article-title":"Discovery of metabolomics biomarkers for early detection of nephrotoxicity","volume":"37","author":"Boudonck","year":"2009","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrendo.2016.186","article-title":"Early-life exposure to EDCs: role in childhood obesity and neurodevelopment","volume":"13","author":"Braun","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02316-6","article-title":"Exploring the evidence for epigenetic regulation of environmental influences on child health across generations","volume":"4","author":"Breton","year":"2021","journal-title":"Commun. Biol."},{"issue":"117","key":"10.1016\/j.tox.2023.153640_bib16","first-page":"358","article-title":"Wilson\u2019s principles--a base of modern teratology","volume":"20","author":"Burdan","year":"2006","journal-title":"Pol. Merkur Lek. Organ Pol. Tow. Lek."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib17","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/liv.14943","article-title":"Clinical impact of sexual dimorphism in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)","volume":"41","author":"Burra","year":"2021","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.tox.2023.153640_bib18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijheh.2014.02.005","article-title":"Age and sex differences in childhood and adulthood obesity association with phthalates: analyses of NHANES 2007-2010","volume":"217","author":"Buser","year":"2014","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.tox.2023.153640_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112665","article-title":"Phthalates exposure is associated with non-alcoholic fatty liver disease among US adults","volume":"224","author":"Cai","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.tox.2023.153640_bib20","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.3390\/ijms22094807","article-title":"Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review","volume":"22","author":"Cano","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.tox.2023.153640_bib21","doi-asserted-by":"crossref","first-page":"13018","DOI":"10.1073\/pnas.95.22.13018","article-title":"Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis","volume":"95","author":"Cases","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"42","key":"10.1016\/j.tox.2023.153640_bib22","doi-asserted-by":"crossref","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.tox.2023.153640_bib23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tem.2015.07.006","article-title":"Ceramides - lipotoxic inducers of metabolic disorders","volume":"26","author":"Chaurasia","year":"2015","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.1016\/j.tox.2023.153640_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.etap.2015.12.016","article-title":"Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms","volume":"42","author":"Chen","year":"2016","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2023.153640_bib25","doi-asserted-by":"crossref","first-page":"1059675","DOI":"10.3389\/fnut.2022.1059675","article-title":"Associations of phthalates with NAFLD and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2018","volume":"9","author":"Chen","year":"2022","journal-title":"Front Nutr."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0003-9861(03)00174-7","article-title":"Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues","volume":"414","author":"Choudhary","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.mehy.2004.08.028","article-title":"Swelling of hepatocytes injured by oxidative stress suggests pathological changes related to macromolecular crowding","volume":"64","author":"Del Monte","year":"2005","journal-title":"Med. Hypotheses"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3889\/oamjms.2019.086","article-title":"Phytoestrogens and their health effect","volume":"7","author":"Desmawati","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"issue":"Pt 2)(Pt 2","key":"10.1016\/j.tox.2023.153640_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj3200345","article-title":"Mammalian mitochondrial beta-oxidation","volume":"320","author":"Eaton","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2023.153640_bib30","unstructured":"Endocrine-Disrupting Chemicals (EDCs). Published January 24, 2022. Accessed April 30, 2023. \u3008https:\/\/www.endocrine.org\/patient-engagement\/endocrine-library\/edcs\u3009."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib31","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1038\/s41598-019-47216-2","article-title":"Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma","volume":"9","author":"Enooku","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2023.153640_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121534","article-title":"Prenatal low-dose DEHP exposure induces metabolic adaptation and obesity: Role of hepatic thiamine metabolism","volume":"385","author":"Fan","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2023.153640_bib33","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.foodcont.2016.10.050","article-title":"Migration of di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) from polypropylene food containers","volume":"73","author":"Fang","year":"2017","journal-title":"Food Control"},{"key":"10.1016\/j.tox.2023.153640_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/104132","article-title":"Does diacylglycerol accumulation in fatty liver disease cause hepatic insulin resistance","volume":"2015","author":"Finck","year":"2015","journal-title":"BioMed. Res. Int."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrendo.2017.42","article-title":"Endocrine-disrupting chemicals and fatty liver disease","volume":"13","author":"Foulds","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hep.29465","article-title":"Altered amino acid concentrations in NAFLD: impact of obesity and insulin resistance","volume":"67","author":"Gaggini","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.tox.2023.153640_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7827(98)00021-6","article-title":"Structure and functional properties of diacylglycerols in membranes1This work is dedicated to Professor Vittorio Luzzati on occasion of his 75th birthday.1","volume":"38","author":"Go\u00f1i","year":"1999","journal-title":"Prog. Lipid Res."},{"issue":"7","key":"10.1016\/j.tox.2023.153640_bib39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2362.2008.01963.x","article-title":"Severe liver steatosis correlates with nitrosative and oxidative stress in rats","volume":"38","author":"Grattagliano","year":"2008","journal-title":"Eur. J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tox.2023.153640_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-069X-7-27","article-title":"Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999\u20132002","volume":"7","author":"Hatch","year":"2008","journal-title":"Environ. Health"},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/17843286.1990.11718105","article-title":"Microvesicular steatosis of the liver","volume":"45","author":"Hautekeete","year":"1990","journal-title":"Acta Clin. Belg."},{"issue":"S3","key":"10.1016\/j.tox.2023.153640_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/bcpt.13118","article-title":"The developmental basis of disease: Update on environmental exposures and animal models","volume":"125","author":"Heindel","year":"2019","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818798282","article-title":"Nonmonotonic dose\u2013response curves occur in dose ranges that are relevant to regulatory decision-making","volume":"16","author":"Hill","year":"2018","journal-title":"Dose-Response"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1203\/PDR.0b013e31815b8e8f","article-title":"Factors predicting ante- and postnatal growth","volume":"63","author":"Hindmarsh","year":"2008","journal-title":"Pedia Res"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/ijerph16030356","article-title":"The increase of ROS caused by the interference of DEHP with JNK\/p38\/p53 pathway as the reason for hepatotoxicity","volume":"16","author":"Huang","year":"2019","journal-title":"Int J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5487\/TR.2011.27.3.185","article-title":"Effect of Di-(2-ethylhexyl)-phthalate on sphingolipid metabolic enzymes in rat liver","volume":"27","author":"Jo","year":"2011","journal-title":"Toxicol. Res"},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126910","article-title":"Ceramide as a mediator of non-alcoholic fatty liver disease and associated atherosclerosis","volume":"10","author":"Kasumov","year":"2015","journal-title":"PloS One"},{"issue":"Suppl 4(Suppl 4","key":"10.1016\/j.tox.2023.153640_bib49","first-page":"715","article-title":"Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop","volume":"104","author":"Kavlock","year":"1996","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0773.1983.tb01862.x","article-title":"Placental transfer of diethylhexyl phthalate in the guinea-pig placenta perfused in situ","volume":"53","author":"Kihlstr\u00f6m","year":"1983","journal-title":"Acta Pharm. Toxicol. (Copenh)"},{"issue":"6","key":"10.1016\/j.tox.2023.153640_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"issue":"13","key":"10.1016\/j.tox.2023.153640_bib52","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14171","article-title":"The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity","volume":"7","author":"Kim","year":"2019","journal-title":"Physiol. Rep."},{"issue":"9","key":"10.1016\/j.tox.2023.153640_bib53","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.3390\/nu12092665","article-title":"An increase in liver polyamine concentration contributes to the tryptophan-induced acute stimulation of rat hepatic protein synthesis","volume":"12","author":"Koike","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tox.2023.153640_bib54","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fcell.2016.00154","article-title":"Sphingolipid organization in the plasma membrane and the mechanisms that influence it","volume":"4","author":"Kraft","year":"2017","journal-title":"Front Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib55","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1586\/egh.11.8","article-title":"Hepatocellular ballooning in nonalcoholic steatohepatitis: the pathologist\u2019s perspective","volume":"5","author":"Lackner","year":"2011","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"42","key":"10.1016\/j.tox.2023.153640_bib56","doi-asserted-by":"crossref","first-page":"38862","DOI":"10.1074\/jbc.M106168200","article-title":"DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from mortierella Ramanniana with diacylglycerol acyltransferase activity","volume":"276","author":"Lardizabal","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.tox.2023.153640_bib57","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.2174\/092986710792064992","article-title":"Materials degradation in PVC medical devices, DEHP leaching and neonatal outcomes","volume":"17","author":"Latini","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tox.2023.153640_bib58","article-title":"Role of carnitine in non-alcoholic fatty liver disease and other related diseases: an update","author":"Li","year":"2021","journal-title":"Front Med."},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/metabo9020036","article-title":"Function, detection and alteration of acylcarnitine metabolism in hepatocellular carcinoma","volume":"9","author":"Li","year":"2019","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib60","doi-asserted-by":"crossref","first-page":"dvab004","DOI":"10.1093\/eep\/dvab004","article-title":"Perinatal DEHP exposure induces sex- and tissue-specific DNA methylation changes in both juvenile and adult mice","volume":"7","author":"Liu","year":"2021","journal-title":"Environ. Epigenetics"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/MPG.0b013e318164d933","article-title":"Extraction of diethylhexylphthalate by home total parenteral nutrition from polyvinyl chloride infusion lines commonly used in the home","volume":"47","author":"Loff","year":"2008","journal-title":"J. Pedia Gastroenterol. Nutr."},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib62","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cmet.2020.08.001","article-title":"A membrane-bound diacylglycerol species induces PKC\u03f5-mediated hepatic insulin resistance","volume":"32","author":"Lyu","year":"2020","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib63","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.reprotox.2010.03.002","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice","volume":"29","author":"Maranghi","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1242\/jeb.106971","article-title":"Influence of environmental exposure on human epigenetic regulation","volume":"218","author":"Marsit","year":"2015","journal-title":"J. Exp. Biol."},{"issue":"10","key":"10.1016\/j.tox.2023.153640_bib65","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines\u2014old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tox.2023.153640_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112658","article-title":"An introduction to the sources, fate, occurrence and effects of endocrine disrupting chemicals released into the environment","volume":"207","author":"Metcalfe","year":"2022","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.tox.2023.153640_bib67","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.20176","article-title":"Association of prenatal exposure to endocrine-disrupting chemicals with liver injury in children","volume":"5","author":"Midya","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib68","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s40618-022-01983-4","article-title":"Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship","volume":"46","author":"Modica","year":"2023","journal-title":"J. Endocrinol. Invest"},{"issue":"9","key":"10.1016\/j.tox.2023.153640_bib69","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1089\/ars.2021.0044","article-title":"Sex differences in nonalcoholic fatty liver disease: estrogen influence on the liver\u2013adipose tissue crosstalk","volume":"35","author":"Mor\u00e1n-Costoya","year":"2021","journal-title":"Antioxid. Redox Signal"},{"issue":"16","key":"10.1016\/j.tox.2023.153640_bib70","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1016\/j.scitotenv.2009.05.006","article-title":"Exposure to endocrine disrupting compounds via the food chain: Is packaging a relevant source","volume":"407","author":"Muncke","year":"2009","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.tox.2023.153640_bib71","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1210\/en.2019-00287","article-title":"Longitudinal metabolic impacts of perinatal exposure to phthalates and phthalate mixtures in mice","volume":"160","author":"Neier","year":"2019","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib72","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1017\/S2040174418000430","article-title":"Perinatal exposures to phthalates and phthalate mixtures result in sex-specific effects on body weight, organ weights and intracisternal A-particle (IAP) DNA methylation in weanling mice","volume":"10","author":"Neier","year":"2019","journal-title":"J. Dev. Orig. Health Dis."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib73","doi-asserted-by":"crossref","first-page":"dvaa017","DOI":"10.1093\/eep\/dvaa017","article-title":"Short- and long-term effects of perinatal phthalate exposures on metabolic pathways in the mouse liver","volume":"6","author":"Neier","year":"2020","journal-title":"Environ. Epigenetics"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib74","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.tox.2023.153640_bib75","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.envint.2019.01.078","article-title":"Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells","volume":"125","author":"Nowak","year":"2019","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib76","first-page":"790","article-title":"Paracelsus. Sixteenth-century physician-scientist-philosopher","volume":"77","author":"de Paracelsus","year":"1977","journal-title":"N. Y State J. Med."},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib77","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.3390\/ijms23041986","article-title":"Dysregulation of S-adenosylmethionine metabolism in nonalcoholic steatohepatitis leads to polyamine flux and oxidative stress","volume":"23","author":"Quinn","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib78","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0023","article-title":"Exposure to endocrine disruptors during adulthood: consequences for female fertility","volume":"233","author":"Rattan","year":"2017","journal-title":"J. Endocrinol."},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib79","doi-asserted-by":"crossref","first-page":"G852","DOI":"10.1152\/ajpgi.00521.2005","article-title":"Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation","volume":"290","author":"Reddy","year":"2006","journal-title":"Am. J. Physiol. - Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib80","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/tau.2018.05.17","article-title":"Endocrine disrupting chemicals and impact on male reproductive health","volume":"7","author":"Rehman","year":"2018","journal-title":"Transl. Androl. Urol."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib81","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1039\/c0em00009d","article-title":"Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception","volume":"12","author":"Rhind","year":"2010","journal-title":"J. Environ. Monit."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib82","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1039\/b902085c","article-title":"Accumulation of endocrine disrupting compounds in sheep fetal and maternal liver tissue following exposure to pastures treated with sewage sludge","volume":"11","author":"Rhind","year":"2009","journal-title":"J. Environ. Monit."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib83","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/genes12081153","article-title":"Environmental exposure to endocrine disrupting chemicals influences genomic imprinting, growth, and metabolism","volume":"12","author":"Robles-Matos","year":"2021","journal-title":"Genes"},{"issue":"7","key":"10.1016\/j.tox.2023.153640_bib84","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1289\/ehp.1003170","article-title":"Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention","volume":"119","author":"Rudel","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib85","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1289\/ehp.10448","article-title":"Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the \u201cfetal estrogenization syndrome\u201d and obesity in CD-1 mice","volume":"116","author":"Ruhlen","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.tox.2023.153640_bib86","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib87","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-014-3466-7","article-title":"Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice","volume":"58","author":"Sasson","year":"2015","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib88","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib89","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1289\/ehp.1104016","article-title":"Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H\/N mice","volume":"120","author":"Schmidt","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"Suppl 3","key":"10.1016\/j.tox.2023.153640_bib90","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1289\/ehp.00108s3451","article-title":"Identifying critical windows of exposure for children\u2019s health","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib91","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-0676.1995.tb00667.x","article-title":"Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis","volume":"15","author":"Shaw","year":"1995","journal-title":"Liver"},{"issue":"6","key":"10.1016\/j.tox.2023.153640_bib92","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s00128-004-0374-4","article-title":"Detection of phthalate metabolites in human amniotic fluid","volume":"72","author":"Silva","year":"2004","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib93","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.6723","article-title":"Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000","volume":"112","author":"Silva","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib94","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jps.2600640819","article-title":"Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats","volume":"64","author":"Singh","year":"1975","journal-title":"J. Pharm. Sci."},{"issue":"10132","key":"10.1016\/j.tox.2023.153640_bib95","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0140-6736(18)30311-8","article-title":"Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health","volume":"391","author":"Stephenson","year":"2018","journal-title":"Lancet Lond. Engl."},{"issue":"11","key":"10.1016\/j.tox.2023.153640_bib96","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.jnutbio.2015.05.012","article-title":"In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge","volume":"26","author":"Strakovsky","year":"2015","journal-title":"J. Nutr. Biochem"},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib97","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpgi.00358.2018","article-title":"Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals","volume":"316","author":"Suppli","year":"2019","journal-title":"Am. J. Physiol. - Gastrointest. Liver Physiol."},{"issue":"8","key":"10.1016\/j.tox.2023.153640_bib98","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1210\/en.2017-00046","article-title":"Bile acids and tryptophan metabolism are novel pathways involved in metabolic abnormalities in BPA-exposed pregnant mice and male offspring","volume":"158","author":"Susiarjo","year":"2017","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib99","first-page":"130","article-title":"The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol A studies","volume":"52","author":"Thigpen","year":"2013","journal-title":"J. Am. Assoc. Lab Anim. Sci. JAALAS"},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.24272\/j.issn.2095-8137.2021.420","article-title":"Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation","volume":"43","author":"Tian","year":"2022","journal-title":"Zool. Res."},{"issue":"1","key":"10.1016\/j.tox.2023.153640_bib101","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q","article-title":"Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review","volume":"39","author":"Tickner","year":"2001","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.tox.2023.153640_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2018.00327","article-title":"Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations","author":"Vafeiadi","year":"2018","journal-title":"Front Public Health"},{"issue":"3","key":"10.1016\/j.tox.2023.153640_bib103","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3390\/antiox10030364","article-title":"Changes in glutathione content in liver diseases: an update","volume":"10","author":"Vairetti","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.tox.2023.153640_bib104","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.chemosphere.2017.08.165","article-title":"Systematic review and meta-analysis of early life exposure to di(2-ethylhexyl) phthalate and obesity related outcomes in rodents","volume":"188","author":"Wassenaar","year":"2017","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.tox.2023.153640_bib105","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tox.2023.153640_bib106","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1749-6632.1965.tb12260.x","article-title":"Embryological considerations in teratology","volume":"123","author":"Wilson","year":"1965","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.tox.2023.153640_bib107","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.semcdb.2015.05.008","article-title":"Multigenerational and transgenerational effects of endocrine disrupting chemicals: a role for altered epigenetic regulation","volume":"43","author":"Xin","year":"2015","journal-title":"Semin Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.tox.2023.153640_bib108","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.placenta.2008.08.011","article-title":"Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta","volume":"29","author":"Xu","year":"2008","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.tox.2023.153640_bib109","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/abbi.2000.1829","article-title":"Mitochondrial adaptations to obesity-related oxidant stress","volume":"378","author":"Yang","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2023.153640_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1014243","article-title":"Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice","author":"Zhang","year":"2022","journal-title":"Front Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.tox.2023.153640_bib111","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1289\/ehp.1510803","article-title":"Recent fast food consumption and bisphenol A and phthalates exposures among the U.S. population in NHANES, 2003\u20132010","volume":"124","author":"Zota","year":"2016","journal-title":"Environ. Health Perspect."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23002275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X23002275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:49:56Z","timestamp":1777546196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X23002275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":111,"alternative-id":["S0300483X23002275"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2023.153640","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preconception and developmental DEHP exposure alter liver metabolism in a sex-dependent manner in adult mouse offspring","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2023.153640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153640"}}