{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:08:59Z","timestamp":1777867739079,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2021\/14980-3"],"award-info":[{"award-number":["2021\/14980-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.tox.2024.153761","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T06:06:11Z","timestamp":1708668371000},"page":"153761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Recreational MDMA doses do not elicit hepatotoxicity in HepG2 spheroids under normo- and hyperthermia"],"prefix":"10.1016","volume":"503","author":[{"given":"Arthur L.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul G.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Dorta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2024.153761_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/0885066612445982","article-title":"Multiple MDMA (Ecstasy) overdoses at a rave event: a case series","volume":"28","author":"Armenian","year":"2013","journal-title":"J. Intensive Care Med."},{"key":"10.1016\/j.tox.2024.153761_bib2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0022-3565(24)29607-5","article-title":"3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions","volume":"297","author":"Bankson","year":"2001","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.tox.2024.153761_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-0888-2_2","article-title":"Cell cycle regulation by checkpoints","volume":"1170","author":"Barnum","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.tox.2024.153761_bib4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/sj.bjp.0706688","article-title":"Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve alpha-adrenoceptors","volume":"147","author":"Bexis","year":"2006","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.tox.2024.153761_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2022.100075","article-title":"A review on the mitochondrial toxicity of \"ecstasy\" (3,4-methylenedioxymethamphetamine, MDMA)","volume":"3","author":"Capela","year":"2022","journal-title":"Curr. Res Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s002040000200","article-title":"Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes","volume":"74","author":"Carvalho","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","article-title":"Toxicity of amphetamines: an update","volume":"86","author":"Carvalho","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib8","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","article-title":"Bastos, M. d. L. Toxicity of amphetamines: an update","volume":"86","author":"Carvalho","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib9","doi-asserted-by":"crossref","unstructured":"Cocchi, V. et al. Novel psychoactive phenethylamines: Impact on genetic material. Int J Mol Sci 21, 1\u201317 (2020). 2020 Dec 17;21(24):9616. doi: 10.3390\/ijms21249616.","DOI":"10.3390\/ijms21249616"},{"issue":"3","key":"10.1016\/j.tox.2024.153761_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0163-7258(91)90029-L","article-title":"Glutathione metabolism and its role in hepatotoxicity","volume":"52","author":"DeLeve","year":"1991","journal-title":"Pharm. Ther."},{"issue":"12","key":"10.1016\/j.tox.2024.153761_bib11","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00204-013-1082-9","article-title":"An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis","volume":"87","author":"Dias da Silva","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.tox.2024.153761_bib12","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00204-013-1082-9","article-title":"An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis","volume":"87","author":"Dias da Silva","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib13","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00213-004-1789-7","article-title":"Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics","volume":"173","author":"Farr\u00e9","year":"2004","journal-title":"Psychopharmacology"},{"issue":"3-4","key":"10.1016\/j.tox.2024.153761_bib14","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00213-004-1789-7","article-title":"Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics","volume":"173","author":"Farr\u00e9","year":"2004","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.tox.2024.153761_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.taap.2009.09.008","article-title":"Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA)","volume":"241","author":"Fonsart","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"41","key":"10.1016\/j.tox.2024.153761_bib16","article-title":"Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report","volume":"99","author":"Ghaffari-Rafi","year":"2020","journal-title":"Med. (Baltim. )"},{"issue":"1","key":"10.1016\/j.tox.2024.153761_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.20689","article-title":"The p53 tumor suppressor participates in multiple cell cycle checkpoints","volume":"209","author":"Giono","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.tox.2024.153761_bib18","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0269881108094650","article-title":"Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA","volume":"23","author":"Hasler","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.tox.2024.153761_bib19","doi-asserted-by":"crossref","unstructured":"Heifets B.D., Salgado J.S., Taylor M.D., Hoerbelt P., Cardozo Pinto D.F., Steinberg E.E., et al. Distinct neural mechanisms for the prosocial and rewarding properties of MDMA. Sci Transl Med. (2019).","DOI":"10.1101\/659466"},{"issue":"1","key":"10.1016\/j.tox.2024.153761_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1742-7843.2007.00159.x","article-title":"The dark side of ecstasy: neuropsychiatric symptoms after exposure to 3,4-methylenedioxymethamphetamine","volume":"102","author":"Karlsen","year":"2008","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2024.153761_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00213-017-4699-1","article-title":"MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor","volume":"235","author":"Kuypers","year":"2018","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"22","key":"10.1016\/j.tox.2024.153761_bib22","doi-asserted-by":"crossref","first-page":"R966","DOI":"10.1016\/j.cub.2012.10.006","article-title":"The spindle assembly checkpoint","volume":"22","author":"Lara-Gonzalez","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tox.2024.153761_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pbb.2016.08.004","article-title":"Sex differences in abuse-related neurochemical and behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats","volume":"152","author":"Lazenka","year":"2017","journal-title":"Pharm. Biochem Behav."},{"issue":"3","key":"10.1016\/j.tox.2024.153761_bib24","first-page":"192","article-title":"Effects of MDMA on body temperature in humans","volume":"1","author":"Liechti","year":"2014","journal-title":"Temp. (Austin)"},{"issue":"2","key":"10.1016\/j.tox.2024.153761_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s002130000648","article-title":"Gender differences in the subjective effects of MDMA","volume":"154","author":"Liechti","year":"2001","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"1","key":"10.1016\/j.tox.2024.153761_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00204-016-1677-z","article-title":"Comparative analysis of 3D culture methods on human HepG2 cells","volume":"91","author":"Luckert","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.tox.2024.153761_bib27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/02698811211069124","article-title":"A randomized controlled trial of 3,4-methylenedioxymethamphetamine (MDMA) and fear extinction retention in healthy adults","volume":"36","author":"Maples-Keller","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.tox.2024.153761_bib28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11419-018-0444-7","article-title":"MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity","volume":"37","author":"Marti","year":"2019","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.tox.2024.153761_bib29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-0716-1091-6_14","article-title":"Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads","volume":"2240","author":"Miranda","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tox.2024.153761_bib30","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41591-021-01336-3","article-title":"MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study","volume":"27","author":"Mitchell","year":"2021","journal-title":"Nat. Med"},{"issue":"6","key":"10.1016\/j.tox.2024.153761_bib31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bcp.2003.10.020","article-title":"Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine (\"Ecstasy\") on hepatic stellate cells","volume":"67","author":"Montiel-Duarte","year":"2004","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.tox.2024.153761_bib32","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1002\/pmic.200800215","article-title":"Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver","volume":"8","author":"Moon","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.tox.2024.153761_bib33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2015.09.011","article-title":"Amphetamine-related drugs neurotoxicity in humans and in experimental animals: main mechanisms","volume":"155","author":"Moratalla","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.tox.2024.153761_bib34","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1360-0443.2011.03399.x","article-title":"Pill content, dose and resulting plasma concentrations of 3,4-methylendioxymethamphetamine (MDMA) in recreational \u2018ecstasy\u2019 users","volume":"106","author":"Morefield","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.tox.2024.153761_bib35","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1360-0443.2011.03399.x","article-title":"Pill content, dose and resulting plasma concentrations of 3,4-methylendioxymethamphetamine (MDMA) in recreational \u2018ecstasy\u2019 users","volume":"106","author":"Morefield","year":"2011","journal-title":"Addiction"},{"issue":"1-2","key":"10.1016\/j.tox.2024.153761_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"2","key":"10.1016\/j.tox.2024.153761_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/hup.1270","article-title":"The effects of 'ecstasy' (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses","volume":"27","author":"Murphy","year":"2012","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.tox.2024.153761_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.863088","article-title":"Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated","volume":"13","author":"Nichols","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.tox.2024.153761_bib39","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00213-022-06086-9","article-title":"MDMA and memory, addiction, and depression: dose-effect analysis","volume":"239","author":"Pantoni","year":"2022","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"7","key":"10.1016\/j.tox.2024.153761_bib40","article-title":"Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, \u2018Ecstasy\u2019): The Influence of Gender and Genetics (CYP2D6, COMT, 5-HTT)","author":"Pardo-Lozano","year":"2012","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1016\/j.tox.2024.153761_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2011.08.012","article-title":"MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans","volume":"121","author":"Parrott","year":"2012","journal-title":"Drug Alcohol Depend."},{"issue":"4","key":"10.1016\/j.tox.2024.153761_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hup.2318","article-title":"Human psychobiology of MDMA or 'Ecstasy': an overview of 25\u2009years of empirical research","volume":"28","author":"Parrott","year":"2013","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.tox.2024.153761_bib43","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.neubiorev.2013.04.016","article-title":"MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users","volume":"37","author":"Parrott","year":"2013","journal-title":"Neurosci. Biobehav Rev."},{"issue":"4","key":"10.1016\/j.tox.2024.153761_bib44","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00213-012-2894-7","article-title":"Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2h apart","volume":"225","author":"Peir\u00f3","year":"2013","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"4","key":"10.1016\/j.tox.2024.153761_bib45","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00213-012-2894-7","article-title":"Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2h apart","volume":"225","author":"Peir\u00f3","year":"2013","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib46","first-page":"1083","article-title":"A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies","volume":"88","author":"Ramaiahgari","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.tox.2024.153761_bib47","doi-asserted-by":"crossref","DOI":"10.3310\/hta13060","article-title":"The harmful health effects of recreational ecstasy: a systematic review of observational evidence","volume":"13","author":"Rogers","year":"2009","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.tox.2024.153761_bib48","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41420-022-01207-x","article-title":"Drug toxicity assessment: cell proliferation versus cell death","volume":"8","author":"Sazonova","year":"2022","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.tox.2024.153761_bib49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/FPC.0000000000000231","article-title":"CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals","volume":"26","author":"Schmid","year":"2016","journal-title":"Pharm. Genom."},{"issue":"4","key":"10.1016\/j.tox.2024.153761_bib50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/0269881121991792","article-title":"First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder","volume":"35","author":"Sessa","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.tox.2024.153761_bib51","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/jat.2889","article-title":"Combination effects of amphetamines under hyperthermia - the role played by oxidative stress","volume":"34","author":"da Silva","year":"2014","journal-title":"J. Appl. Toxicol."},{"issue":"6","key":"10.1016\/j.tox.2024.153761_bib52","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jat.2885","article-title":"Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations","volume":"34","author":"da Silva","year":"2014","journal-title":"J. Appl. Toxicol."},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib53","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/138920110791591436","article-title":"Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage","volume":"11","author":"Song","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib54","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/138920110791591436","article-title":"Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage","volume":"11","author":"Song","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.tox.2024.153761_bib55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13011-020-00295-1","article-title":"Patterns of ecstasy use amongst live music event attendees and their opinions on pill testing: a cross sectional study","volume":"15","author":"Southey","year":"2020","journal-title":"Subst. Abus. Treat. Prev. Policy"},{"issue":"3","key":"10.1016\/j.tox.2024.153761_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.acthis.2018.02.005","article-title":"Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives","volume":"120","author":"Stockert","year":"2018","journal-title":"Acta Histochem"},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib57","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1177\/0269881121998322","article-title":"Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies","volume":"35","author":"Studerus","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.tox.2024.153761_bib58","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2125.2000.00121.x","article-title":"Non-linear pharmacokinetics of MDMA ('ecstasy') in humans","volume":"49","author":"de la Torre","year":"2000","journal-title":"Br. J. Clin. Pharm."},{"key":"10.1016\/j.tox.2024.153761_bib59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fgene.2012.00235","article-title":"MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?","volume":"3","author":"de la Torre","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.tox.2024.153761_bib60","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/acschemneuro.6b00421","article-title":"Neurotoxicity of \u03b2-Keto Amphetamines: Deathly Mechanisms Elicited by Methylone and MDPV in Human Dopaminergic SH-SY5Y Cells","volume":"8","author":"Valente","year":"2017","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib61","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0269881117691569","article-title":"Safety pharmacology of acute MDMA administration in healthy subjects","volume":"31","author":"Vizeli","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.tox.2024.153761_bib62","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00213-006-0531-z","article-title":"Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats","volume":"189","author":"Walker","year":"2007","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.tox.2024.153761_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2011.04.039","article-title":"Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats","volume":"1398","author":"Wallinga","year":"2011","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.tox.2024.153761_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.990080101","article-title":"A pragmatic approach to the analysis of DNA histograms with a definable G1 peak","volume":"8","author":"Watson","year":"1987","journal-title":"Cytometry"},{"issue":"1","key":"10.1016\/j.tox.2024.153761_bib65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41386-019-0473-x","article-title":"MDMA enhances pleasantness of affective touch","volume":"45","author":"de Wit","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tox.2024.153761_bib66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.taap.2008.12.003","article-title":"The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences","volume":"235","author":"Wyeth","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.tox.2024.153761_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.138","article-title":"3,4-Methylenedioxymethamphetamine facilitates fear extinction learning","volume":"5","author":"Young","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.tox.2024.153761_bib68","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s00213-017-4684-8","article-title":"Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4- methylenedioxymethamphetamine (MDMA)","volume":"234","author":"Young","year":"2017","journal-title":"Psychopharmacology"},{"issue":"5","key":"10.1016\/j.tox.2024.153761_bib69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/11584550-000000000-00000","article-title":"Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans","volume":"50","author":"Yubero-Lahoz","year":"2011","journal-title":"Clin. Pharm."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:49:33Z","timestamp":1777546173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X24000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":69,"alternative-id":["S0300483X24000428"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2024.153761","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recreational MDMA doses do not elicit hepatotoxicity in HepG2 spheroids under normo- and hyperthermia","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2024.153761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153761"}}