{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:44:35Z","timestamp":1793130275963,"version":"4.5.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277420"],"award-info":[{"award-number":["42277420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30801156"],"award-info":[{"award-number":["30801156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42377421"],"award-info":[{"award-number":["42377421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41931291"],"award-info":[{"award-number":["41931291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.tox.2024.153792","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:39:03Z","timestamp":1711636743000},"page":"153792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications"],"prefix":"10.1016","volume":"504","author":[{"given":"Jingfan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2024.153792_bib1","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1038\/s41598-018-23410-6","article-title":"An advanced human in vitro co-culture model for translocation studies across the placental barrier","volume":"8","author":"Aengenheister","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.153792_bib2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/acs.estlett.2c00186","article-title":"Maternal exposure to polystyrene micro- and nanoplastics causes fetal growth restriction in mice","volume":"9","author":"Aghaei","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tox.2024.153792_bib3","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/acs.est.7b05559","article-title":"Microplastics and nanoplastics in aquatic environments: aggregation, deposition, and enhanced contaminant transport","volume":"52","author":"Alimi","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2024.153792_bib4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s11356-017-0528-7","article-title":"Quantifying shedding of synthetic fibers from textiles; a source of microplastics released into the environment","volume":"25","author":"Almroth","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.tox.2024.153792_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: from a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120174","article-title":"Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies","volume":"314","author":"Amereh","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2024.153792_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111517","article-title":"Surgical face masks as a potential source for microplastic pollution in the COVID-19 scenario","volume":"159","author":"Aragaw","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.tox.2024.153792_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114977","article-title":"Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor \u03b1 in MCF-7 breast cancer cells promoting cancer growth","volume":"395","author":"B\u00f6ckers","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2024.153792_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114995","article-title":"Indeno[1,2,3-cd]pyrene and picene mediate actions via estrogen receptor \u03b1 signaling pathway in in vitro cell systems, altering gene expression","volume":"396","author":"B\u00f6ckers","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2024.153792_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115030","article-title":"Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor \u03b1","volume":"399","author":"B\u00f6ckers","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2024.153792_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.128208","article-title":"Analysis of environmental nanoplastics: progress and challenges","volume":"410","author":"Cai","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.tox.2024.153792_bib13","doi-asserted-by":"crossref","unstructured":"Cartwright, Poulsen, Nielsen, Pojana, Knudsen, Saunders, Rytting, E., 2012. In vitro placental model optimization for nanoparticle transport studies. Int. J. Nanomedicine 497. https:\/\/doi.org\/10.2147\/IJN.S26601.","DOI":"10.2147\/IJN.S26601"},{"key":"10.1016\/j.tox.2024.153792_bib14","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2022.36.S1.R4754","article-title":"Uterine Microvascular dysfunction after plastic particle inhalation","volume":"36","author":"Cary","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2024.153792_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158666","article-title":"Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice","volume":"854","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104938","article-title":"Leaching of endocrine disrupting chemicals from marine microplastics and mesoplastics under common life stress conditions","volume":"130","author":"Chen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153792_bib17","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/17435390.2021.1996650","article-title":"In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice","volume":"15","author":"Choi","year":"2021","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tox.2024.153792_bib18","doi-asserted-by":"crossref","first-page":"26530","DOI":"10.1021\/acsami.5b07764","article-title":"pH-sensitive biocompatible nanoparticles of paclitaxel-conjugated poly(styrene-co-maleic acid) for anticancer drug delivery in solid tumors of syngeneic mice","volume":"7","author":"Dalela","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.tox.2024.153792_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117985","article-title":"Science-society-policy interface for microplastic and nanoplastic: environmental and biomedical aspects","volume":"290","author":"Das","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41467-018-03465-9","article-title":"Turning microplastics into nanoplastics through digestive fragmentation by Antarctic krill","volume":"9","author":"Dawson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2024.153792_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128980","article-title":"Microplastics released from food containers can suppress lysosomal activity in mouse macrophages","volume":"435","author":"Deng","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib22","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.153792_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116974","article-title":"Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells","volume":"280","author":"Ding","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.envpol.2016.12.013","article-title":"A first overview of textile fibers, including microplastics, in indoor and outdoor environments","volume":"221","author":"Dris","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160403","article-title":"Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics","volume":"860","author":"Dusza","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2013.01.046","article-title":"Trophic level transfer of microplastic: Mytilus edulis (L.) to Carcinus maenas (L.)","volume":"177","author":"Farrell","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-020-00385-9","article-title":"Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy","volume":"17","author":"Fournier","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.tox.2024.153792_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41565-021-00886-4","article-title":"Nanoplastics are neither microplastics nor engineered nanoparticles","volume":"16","author":"Gigault","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tox.2024.153792_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130138","article-title":"The landscape of micron-scale particles including microplastics in human enclosed body fluids","volume":"442","author":"Guan","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41598-023-50781-2","article-title":"Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice","volume":"14","author":"Hanrahan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.153792_bib31","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2024.153792_bib32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1039\/D2VA00227B","article-title":"Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring","volume":"2","author":"Harvey","year":"2023","journal-title":"Environ. Sci. Adv."},{"key":"10.1016\/j.tox.2024.153792_bib33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/acs.estlett.7b00187","article-title":"Are there nanoplastics in your personal care products?","volume":"4","author":"Hernandez","year":"2017","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tox.2024.153792_bib34","doi-asserted-by":"crossref","first-page":"12300","DOI":"10.1021\/acs.est.9b02540","article-title":"Plastic teabags release billions of microparticles and nanoparticles into tea","volume":"53","author":"Hernandez","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2024.153792_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104610","article-title":"Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro","volume":"61","author":"Hesler","year":"2019","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2024.153792_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2024.153792_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reprotox.2021.10.002","article-title":"Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice","volume":"106","author":"Hu","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2024.153792_bib39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.placenta.2015.10.007","article-title":"Nanoparticles can cross mouse placenta and induce trophoblast apoptosis","volume":"36","author":"Huang","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.tox.2024.153792_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112803","article-title":"Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring","volume":"160","author":"Huang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2024.153792_bib41","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.scitotenv.2017.12.144","article-title":"Decay of low-density polyethylene by bacteria extracted from earthworm\u2019s guts: a potential for soil restoration","volume":"624","author":"Huerta Lwanga","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102064","article-title":"Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: environmental challenge","volume":"34","author":"Ijaz","year":"2022","journal-title":"J. King Saud. Univ. - Sci."},{"key":"10.1016\/j.tox.2024.153792_bib43","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1021\/acs.chemrev.1c00178","article-title":"Chemical analysis of microplastics and nanoplastics: challenges, advanced methods, and perspectives","volume":"121","author":"Ivleva","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tox.2024.153792_bib44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2014.09.002","article-title":"Transgenerational inheritance of prenatal obesogen exposure","volume":"398","author":"Janesick","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tox.2024.153792_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127815","article-title":"Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny","volume":"426","author":"Jeong","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.724989","article-title":"A review of human exposure to microplastics and insights into microplastics as obesogens","volume":"12","author":"Kannan","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tox.2024.153792_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126779","article-title":"Are your shoes safe for the environment? \u2013 Toxicity screening of leachates from microplastic fragments of shoe soles using freshwater organisms","volume":"421","author":"Kim","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib48","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.tiv.2015.07.003","article-title":"Translocation of positively and negatively charged polystyrene nanoparticles in an in vitro placental model","volume":"29","author":"Kloet","year":"2015","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2024.153792_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136050","article-title":"Micro- and nanoplastic toxicity on aquatic life: determining factors","volume":"709","author":"K\u00f6gel","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib50","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3390\/ijerph14101265","article-title":"Wear and tear of tyres: a stealthy source of microplastics in the environment","volume":"14","author":"Kole","year":"2017","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.tox.2024.153792_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124034","article-title":"Microplastic digestion generates fragmented nanoplastics in soils and damages earthworm spermatogenesis and coelomocyte viability","volume":"402","author":"Kwak","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123991","article-title":"Eye-glass polishing wastewater as significant microplastic source: microplastic identification and quantification","volume":"403","author":"Lee","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib53","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153792_bib55","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s43016-020-00171-y","article-title":"Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation","volume":"1","author":"Li","year":"2020","journal-title":"Nat. Food"},{"key":"10.1016\/j.tox.2024.153792_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113520","article-title":"Polystyrene microplastics induce mitochondrial damage in mouse GC-2 cells","volume":"237","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2024.153792_bib57","doi-asserted-by":"crossref","first-page":"14093","DOI":"10.3390\/ijerph192114093","article-title":"Determination of biological and molecular attributes related to polystyrene microplastic-induced reproductive toxicity and its reversibility in male mice","volume":"19","author":"Liu","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.tox.2024.153792_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126770","article-title":"Size-dependent effects of polystyrene nanoplastics on autophagy response in human umbilical vein endothelial cells","volume":"421","author":"Lu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib59","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1021\/acs.est.9b03191","article-title":"Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring","volume":"53","author":"Luo","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2024.153792_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113122","article-title":"Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring","volume":"255","author":"Luo","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157686","article-title":"Raman imaging of microplastics and nanoplastics released from the printed toner powders burned by a mimicked bushfire","volume":"849","author":"Luo","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.636640","article-title":"Micro and nanoplastics identification: classic methods and innovative detection techniques","volume":"3","author":"Mariano","year":"2021","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.tox.2024.153792_bib63","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fchem.2018.00407","article-title":"Synthetic polymer contamination in bottled water","volume":"6","author":"Mason","year":"2018","journal-title":"Front. Chem."},{"key":"10.1016\/j.tox.2024.153792_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41565-021-00888-2","article-title":"Placing nanoplastics in the context of global plastic pollution","volume":"16","author":"Mitrano","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tox.2024.153792_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126507","article-title":"Uncovering the release of micro\/nanoplastics from disposable face masks at times of COVID-19","volume":"419","author":"Morgana","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113877","article-title":"Disentangling biological effects of primary nanoplastics from dispersion paints\u2019 additional compounds","volume":"242","author":"M\u00fcller","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2024.153792_bib67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.toxlet.2020.01.008","article-title":"Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation","volume":"324","author":"Park","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2024.153792_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: first evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153792_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115609","article-title":"3D printer waste, a new source of nanoplastic pollutants","volume":"267","author":"Rodr\u00edguez-Hern\u00e1ndez","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149374","article-title":"An analytical survey of benzotriazole UV stabilizers in plastic products and their endocrine-disrupting potential via human estrogen and androgen receptors","volume":"800","author":"Sakuragi","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib71","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trac.2018.12.014","article-title":"Methods for the analysis of submicrometer- and nanoplastic particles in the environment","volume":"112","author":"Schwaferts","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.tox.2024.153792_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124004","article-title":"Estimation of the mass of microplastics ingested - a pivotal first step towards human health risk assessment","volume":"404","author":"Senathirajah","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148384","article-title":"Smoked cigarette butts: Unignorable source for environmental microplastic fibers","volume":"791","author":"Shen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib74","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.envpol.2019.05.102","article-title":"Recent advances in toxicological research of nanoplastics in the environment: a review","volume":"252","author":"Shen","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128181","article-title":"Extraction of microplastics from commonly used sea salts in India and their toxicological evaluation","volume":"263","author":"Sivagami","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2024.153792_bib76","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4209\/aaqr.2018.03.0099","article-title":"Tire abrasion as a major source of microplastics in the environment","volume":"18","author":"Sommer","year":"2018","journal-title":"Aerosol Air Qual. Res."},{"key":"10.1016\/j.tox.2024.153792_bib77","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.atmosenv.2013.06.050","article-title":"Ultrafine particle emissions from desktop 3D printers","volume":"79","author":"Stephens","year":"2013","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.tox.2024.153792_bib78","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00204-019-02478-7","article-title":"Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo","volume":"93","author":"Stock","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153792_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/science.1094559","article-title":"Lost at Sea: Where Is All the Plastic?","volume":"304","author":"Thompson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tox.2024.153792_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110066","article-title":"Microplastics and seafood: lower trophic organisms at highest risk of contamination","volume":"190","author":"Walkinshaw","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2024.153792_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107200","article-title":"Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants","volume":"163","author":"Winkler","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153792_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155825","article-title":"Oxidative stress mediated by the TLR4\/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice","volume":"838","author":"Wu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib84","article-title":"Assessment of cancer-related signaling pathways in responses to polystyrene nanoplastics via a kidney-testis microfluidic platform (KTP)","volume":"857","author":"Xiao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2024.153792_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107362","article-title":"Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis","volume":"166","author":"Yang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153792_bib87","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jhazmat.2018.12.048","article-title":"Toxicity-based toxicokinetic\/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice","volume":"366","author":"Yang","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2024.153792_bib88","article-title":"Evidence on invasion of blood, adipose tissues, nervous system and reproductive system of mice after a single oral exposure: nanoplastics versus microplastics","volume":"35","author":"Yang","year":"2022","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.tox.2024.153792_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133643","article-title":"Adsorption behavior of organic pollutants and metals on micro\/nanoplastics in the aquatic environment","volume":"694","author":"Yu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib90","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/0975-7406.111820","article-title":"Recent trends and future of pharmaceutical packaging technology","volume":"5","author":"Zadbuke","year":"2013","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.tox.2024.153792_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121482","article-title":"Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress","volume":"327","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2024.153792_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162713","article-title":"Detection and characterization of microplastics in the human testis and semen","volume":"877","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2024.153792_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159060","article-title":"Identification of microplastics in human placenta using laser direct infrared spectroscopy","volume":"856","author":"Zhu","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T05:23:41Z","timestamp":1763789021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X24000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":93,"alternative-id":["S0300483X24000738"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2024.153792","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2024.153792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153792"}}