{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:44:11Z","timestamp":1784609051034,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.tox.2024.153801","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T04:12:16Z","timestamp":1712808736000},"page":"153801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products"],"prefix":"10.1016","volume":"504","author":[{"given":"Brian M.","family":"Keyser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Leverette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan","family":"McRae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wertman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Shutsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Szeliga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrudu","family":"Makena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2024.153801_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-publhealth-040617-013849","article-title":"Harm minimization and tobacco control: reframing societal views of nicotine use to rapidly save lives","volume":"39","author":"Abrams","year":"2018","journal-title":"Annu Rev. Public Health"},{"key":"10.1016\/j.tox.2024.153801_bib2","article-title":"An overview of the effects of tobacco ingredients on smoke chemistry and toxicity","volume":"42","author":"Baker","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib3","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1007\/s00216-020-02502-1","article-title":"Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening","volume":"412","author":"Bentley","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.tox.2024.153801_bib4","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1021\/acs.chemrestox.0c00088","article-title":"Free radical production and characterization of heat-not-burn cigarettes in comparison to conventional and electronic cigarettes","volume":"33","author":"Bitzer","year":"2020","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0278-6915(97)00108-7","article-title":"Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 1. Chemical composition of mainstream smoke","volume":"36","author":"Borgerding","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11626-020-00517-7","article-title":"Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives","volume":"57","author":"Cao","year":"2021","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"key":"10.1016\/j.tox.2024.153801_bib7","unstructured":"Centers for Diseases Control and Prevention. 2023. Heated Tobacco Products."},{"key":"10.1016\/j.tox.2024.153801_bib8","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/add.14365","article-title":"Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette","volume":"113","author":"Farsalinos","year":"2018","journal-title":"Addiction"},{"key":"10.1016\/j.tox.2024.153801_bib9","first-page":"144","article-title":"Development, qualification, validation and application of the neutral red uptake assay in Chinese Hamster Ovary (CHO) cells using a VITROCELL\u00ae VC10\u00ae smoke exposure system","volume":"40","author":"Fields","year":"2017","journal-title":"Toxicol. Vitr.\u00a0Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.tox.2024.153801_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/aivt.2016.0035","article-title":"Characterization and application of the VITROCELL VC1 smoke exposure system and 3D EpiAirway models for toxicological and e-Cigarette Evaluations","volume":"3","author":"Fields","year":"2017","journal-title":"Appl. Vitr. Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib11","unstructured":"Food and Drug Administration. 2012. Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established List. In: U.S. Department of Health and Human Services (Ed), Federal Register, pp. 20034-20037."},{"key":"10.1016\/j.tox.2024.153801_bib12","unstructured":"Food and Drug Administration. 2019. Guidance for Industry: Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems."},{"key":"10.1016\/j.tox.2024.153801_bib13","unstructured":"Food and Drug Administration. 2021. Premarket Tobacco Product Applications and Recordkeeping Requirements. In: Department of health and human services (Ed), Federal Register."},{"key":"10.1016\/j.tox.2024.153801_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yrtph.2017.10.006","article-title":"Assessment of novel tobacco heating product THP1.0. Part 3: comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions","volume":"93","author":"Forster","year":"2018","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2024.153801_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yrtph.2018.09.016","article-title":"Accurate measurement of main aerosol constituents from heated tobacco products (HTPs): implications for a fundamentally different aerosol","volume":"99","author":"Gasparyan","year":"2018","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2024.153801_bib16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.toxrep.2019.10.007","article-title":"In vitro mutagenicity of gas-vapour phase extracts from flavoured and unflavoured heated tobacco products","volume":"6","author":"Godec","year":"2019","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2024.153801_bib17","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.toxrep.2022.06.014","article-title":"Evaluation of behavioural, chemical, toxicological and clinical studies of a tobacco heated product glo\u2122 and the potential for bridging from a foundational dataset to new product iterations","volume":"9","author":"Goodall","year":"2022","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2024.153801_bib18","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1056\/NEJMp1707409","article-title":"A nicotine-focused framework for public health","volume":"377","author":"Gottlieb","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.tox.2024.153801_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.toxrep.2023.02.005","article-title":"Chemical and in vitro toxicological comparison of emissions from a heated tobacco product and the 1R6F reference cigarette","volume":"10","author":"Hashizume","year":"2023","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2024.153801_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxlet.2021.04.012","article-title":"The development of an in vitro 3D model of goblet cell hyperplasia using MUC5AC expression and repeated whole aerosol exposures","volume":"347","author":"Haswell","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2024.153801_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2020.106099","article-title":"Tobacco harm reduction: past history, current controversies and a proposed approach for the future","volume":"140","author":"Hatsukami","year":"2020","journal-title":"Prev. Med"},{"key":"10.1016\/j.tox.2024.153801_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ntr\/ntz013","article-title":"Reduction in Exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the menthol tobacco heating system 2.2 for 3 Months (Part 1)","volume":"22","author":"Haziza","year":"2020","journal-title":"Nicotine Tob. Res"},{"key":"10.1016\/j.tox.2024.153801_bib23","series-title":"Test Method T-115: Determination of Tar, Water, Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke","author":"Health Canada","year":"1999"},{"key":"10.1016\/j.tox.2024.153801_bib24","unstructured":"Health Canada. 1999a. Test Method T-104: Determination of Selected Carbonyls in Mainstream Tobacco Smoke."},{"key":"10.1016\/j.tox.2024.153801_bib25","series-title":"Neutral rEd Uptake Assay for Mainstream Tobacco Smoke","article-title":"Health Canada official method T-502","author":"Health Canada","year":"2017"},{"key":"10.1016\/j.tox.2024.153801_bib26","unstructured":"Health Canada. 2017a. Bacterial reverse mutation assay for mainstream tobacco smoke: T-501. In: H. Canada (Ed), Health Canada, Ottawa, Ontario, Canada."},{"key":"10.1016\/j.tox.2024.153801_bib27","unstructured":"Health Canada. 2017b. In Vitro Micronucleus Assay for Mainstream Tobacco Smoke. T-503."},{"key":"10.1016\/j.tox.2024.153801_bib28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jphs.2021.07.005","article-title":"Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells","volume":"147","author":"Horinouchi","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.tox.2024.153801_bib29","unstructured":"International Standards Organization. 2018. ISO 20778. Cigarettes \u2014 Routine analytical cigarette smoking machine \u2014 Definitions and standard conditions with an intense smoking regime. In: International Standards Organization (Ed), ISO20778:2018."},{"key":"10.1016\/j.tox.2024.153801_bib30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1039\/C7TX00152E","article-title":"Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach","volume":"6","author":"Iskandar","year":"2017","journal-title":"Toxicol. Res (Camb. )"},{"key":"10.1016\/j.tox.2024.153801_bib31","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.toxrep.2022.11.001","article-title":"Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell\u00ae Mammalian 6\/48 exposure module","volume":"9","author":"Keyser","year":"2022","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tox.2024.153801_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/toxics12020129","article-title":"Evaluation of cytotoxicity and oxidative stress of whole aerosol from Vuse Alto ENDS products","volume":"12","author":"Keyser","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.tox.2024.153801_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104684","article-title":"Nonanimal toxicology testing approaches for traditional and deemed tobacco products in a complex regulatory environment: limitations, possibilities, and future directions","volume":"62","author":"Lauterstein","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2024.153801_bib34","doi-asserted-by":"crossref","first-page":"s37","DOI":"10.1136\/tobaccocontrol-2018-054318","article-title":"Tobacco-specific nitrosamines (TSNA) in heated tobacco product IQOS","volume":"27","author":"Leigh","year":"2018","journal-title":"Tob. Control"},{"key":"10.1016\/j.tox.2024.153801_bib35","doi-asserted-by":"crossref","unstructured":"Lu, F., Yu, M., Chen, C., Liu, L., Zhao, P., Shen, B. and Sun, R. 2021. The Emission of VOCs and CO from Heated Tobacco Products, Electronic Cigarettes, and Conventional Cigarettes, and Their Health Risk. Toxics 10.","DOI":"10.3390\/toxics10010008"},{"key":"10.1016\/j.tox.2024.153801_bib36","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s00204-018-2215-y","article-title":"Levels of selected analytes in the emissions of \"heat not burn\" tobacco products that are relevant to assess human health risks","volume":"92","author":"Mallock","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fpubh.2019.00287","article-title":"Heated tobacco products: a review of current knowledge and initial assessments","volume":"7","author":"Mallock","year":"2019","journal-title":"Front Public Health"},{"key":"10.1016\/j.tox.2024.153801_bib38","doi-asserted-by":"crossref","unstructured":"Miller-Holt, J., Behrsing, H., Crooks, I., Curren, R., Demir, K., Gafner, J., Gillman, G., Hollings, M., Leverette, R., Oldham, M., Simms, L., Stankowski, L.F., Jr., Thorne, D., Wieczorek, R. and Moore, M.M. 2022. Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry. Drug Test Anal.","DOI":"10.1002\/dta.3344"},{"key":"10.1016\/j.tox.2024.153801_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/02611929221146536","article-title":"Key challenges and recommendations for in vitro testing of tobacco products for regulatory applications: consideration of test materials and exposure parameters","volume":"51","author":"Moore","year":"2023","journal-title":"Alter. Lab Anim."},{"key":"10.1016\/j.tox.2024.153801_bib40","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1038\/s41598-019-39011-w","article-title":"Designing a whole cell bioreporter to show antioxidant activities of agents that work by promotion of the KEAP1-NRF2 signaling pathway","volume":"9","author":"Mozaheb","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.153801_bib41","doi-asserted-by":"crossref","unstructured":"OECD. 2016. Test No. 487: In Vitro Mammalian Cell Micronucleus Test, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris. OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, https:\/\/doi.org\/10.1787\/9789264264861-en.","DOI":"10.1787\/9789264264861-en"},{"key":"10.1016\/j.tox.2024.153801_bib42","unstructured":"OECD. 2020. Test No. 471: Bacterial Reverse Mutation Test."},{"key":"10.1016\/j.tox.2024.153801_bib43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12920-022-01215-x","article-title":"Differential gene expression of 3D primary human airway cultures exposed to cigarette smoke and electronic nicotine delivery system (ENDS) preparations","volume":"15","author":"Rayner","year":"2022","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.tox.2024.153801_bib44","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00096.2019","article-title":"Cigarette and ENDS preparations differentially regulate ion channels and mucociliary clearance in primary normal human bronchial 3D cultures","volume":"317","author":"Rayner","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.tox.2024.153801_bib45","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00452.2020","article-title":"Cigarette smoke preparations, not electronic nicotine delivery system preparations, induce features of lung disease in a 3D lung repeat-dose model","volume":"320","author":"Rayner","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.tox.2024.153801_bib46","series-title":"The Chemical Components of Tobacco and Tobacco Smoke","author":"Rodgman","year":"2013"},{"key":"10.1016\/j.tox.2024.153801_bib47","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/ntr\/ntab014","article-title":"Differences in levels of biomarkers of potential harm among users of a heat-not-burn tobacco product, cigarette smokers, and never-smokers in japan: a post-marketing observational study","volume":"23","author":"Sakaguchi","year":"2021","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.tox.2024.153801_bib48","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1093\/ntr\/nty235","article-title":"Free-base and total nicotine, reactive oxygen species, and carbonyl emissions from IQOS, a heated tobacco product","volume":"21","author":"Salman","year":"2019","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.tox.2024.153801_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chroma.2018.10.035","article-title":"Comprehensive comparative compositional study of the vapour phase of cigarette mainstream tobacco smoke and tobacco heating product aerosol","volume":"1581-1582","author":"Savareear","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"Suppl 2","key":"10.1016\/j.tox.2024.153801_bib50","article-title":"Evaluation of the tobacco heating system 2.2. Part 2: chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol","volume":"RTP 81","author":"Schaller","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2024.153801_bib51","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1021\/acs.chemrestox.9b00085","article-title":"Comparison of free radical levels in the aerosol from conventional cigarettes, electronic cigarettes, and heat-not-burn tobacco products","volume":"32","author":"Shein","year":"2019","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxlet.2022.01.005","article-title":"Application of ToxTracker for the toxicological assessment of tobacco and nicotine delivery products","volume":"358","author":"Smart","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2024.153801_bib53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tiv.2017.04.003","article-title":"Studies on the contributions of smoke constituents, individually and in mixtures, in a range of in vitro bioactivity assays","volume":"42","author":"Stabbert","year":"2017","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2024.153801_bib54","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/add.16199","article-title":"Global prevalence of heated tobacco product use, 2015-22: a systematic review and meta-analysis","volume":"118","author":"Sun","year":"2023","journal-title":"Addiction"},{"key":"10.1016\/j.tox.2024.153801_bib55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.yrtph.2017.08.017","article-title":"Assessment of novel tobacco heating product THP1.0. Part 7: comparative in vitro toxicological evaluation","volume":"93","author":"Thorne","year":"2018","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2024.153801_bib56","article-title":"Genotoxicity evaluation of tobacco and nicotine delivery products: part two. In vitro micronucleus assay","volume":"132","author":"Thorne","year":"2019","journal-title":"Food Chem. Toxicol.\u00a0Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.tox.2024.153801_bib57","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.csbj.2020.04.011","article-title":"Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke","volume":"18","author":"Titz","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.tox.2024.153801_bib58","first-page":"111","article-title":"Family smoking prevention and tobacco control and federal retirement reform","volume":"2009","author":"United States Congress","year":"2009"},{"key":"10.1016\/j.tox.2024.153801_bib59","unstructured":"United States Public Health Service Office of the Surgeon, G., National Center for Chronic Disease, P., Health Promotion Office on, S. and Health. 2010. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease. A Report of the Surgeon General."},{"key":"10.1016\/j.tox.2024.153801_bib60","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0278-6915(00)00155-1","article-title":"Effect of pyrolysis temperature on the mutagenicity of tobacco smoke condensate","volume":"39","author":"White","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2024.153801_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11100847","article-title":"Impact of electronic cigarettes, heated tobacco products and conventional cigarettes on the generation of oxidative stress and genetic and epigenetic lesions in human bronchial epithelial BEAS-2B cells","volume":"11","author":"Zarcone","year":"2023","journal-title":"Toxics"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24000829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T05:24:02Z","timestamp":1763789042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X24000829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":61,"alternative-id":["S0300483X24000829"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2024.153801","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2024.153801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"153801"}}