{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:41:41Z","timestamp":1789188101551,"version":"build-2803163510"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-02738"],"award-info":[{"award-number":["2022-02738"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.tox.2024.153950","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T10:27:09Z","timestamp":1726136829000},"page":"153950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Developmental neurotoxicity evaluation of acrylamide based on in vitro to in vivo extrapolation by pregnancy PBTK modelling"],"prefix":"10.1016","volume":"509","author":[{"given":"Ylva","family":"Johansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseline Ayowumi","family":"Awoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Forsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2024.153950_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1136174","article-title":"Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro\u2013in vivo extrapolation","volume":"14","author":"Algharably","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tox.2024.153950_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.885843","article-title":"In vitro\u2013in vivo extrapolation by physiologically based kinetic modeling: experience with three case studies and lessons learned","volume":"4","author":"Algharably","year":"2022","journal-title":"Front. Toxicol."},{"issue":"1-3","key":"10.1016\/j.tox.2024.153950_bib3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2008.08.006","article-title":"Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta","volume":"182","author":"Annola","year":"2008","journal-title":"Toxicol. Lett."},{"issue":"11","key":"10.1016\/j.tox.2024.153950_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/toxics9110315","article-title":"Update and evaluation of a high-throughput in vitro mass balance distribution model: IV-MBM EQP v2. 0","volume":"9","author":"Armitage","year":"2021","journal-title":"Toxics"},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73698-6","article-title":"Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line","volume":"10","author":"Attoff","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.153950_bib6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tiv.2016.05.014","article-title":"Acrylamide affects proliferation and differentiation of the neural progenitor cell line C17. 2 and the neuroblastoma cell line SH-SY5Y","volume":"35","author":"Attoff","year":"2016","journal-title":"Toxicol. Vitr."},{"issue":"11","key":"10.1016\/j.tox.2024.153950_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225449","article-title":"Beyond detoxification: pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile","volume":"14","author":"Behrens","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1021\/tx960113p","article-title":"Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers","volume":"10","author":"Bergmark","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib9","unstructured":"Billett, H.H. (1990). Hemoglobin and hematocrit. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition."},{"key":"10.1016\/j.tox.2024.153950_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137035","article-title":"Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals","volume":"311","author":"Blum","year":"2023","journal-title":"Chemosphere"},{"issue":"1-2","key":"10.1016\/j.tox.2024.153950_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrgentox.2004.11.010","article-title":"Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population","volume":"580","author":"Boettcher","year":"2005","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"issue":"8","key":"10.1016\/j.tox.2024.153950_bib12","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.fct.2008.05.020","article-title":"Exploration of different methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa","volume":"46","author":"Brantsaeter","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/taap.1994.1127","article-title":"Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide","volume":"126","author":"Calleman","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2024.153950_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fct.2015.04.030","article-title":"Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells","volume":"82","author":"Chen","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib15","first-page":"769","article-title":"Cytotoxic effects of acrylamide in nerve growth factor or fibroblast growth factor 1-induced neurite outgrowth in PC12 cells","volume":"88","author":"Chen","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1021\/acs.molpharmaceut.8b00941","article-title":"Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics","volume":"16","author":"Couto","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.tox.2024.153950_bib17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s40262-017-0539-z","article-title":"Gestationspecific changes in the anatomy and physiology of healthy pregnant women: an extended repository of model parameters for physiologically based pharmacokinetic modeling in pregnancy","volume":"56","author":"Dallmann","year":"2017","journal-title":"Clin. Pharmacokinet."},{"issue":"7","key":"10.1016\/j.tox.2024.153950_bib18","first-page":"419","article-title":"Applied concepts in PBPK modeling: how to extend an open systems pharmacology model to the special population of pregnant women","volume":"7","author":"Dallmann","year":"2018","journal-title":"CPT: Pharmacomet. Syst. Pharmacol."},{"key":"10.1016\/j.tox.2024.153950_bib19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40262-017-0594-5","article-title":"A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways","volume":"57","author":"Dallmann","year":"2018","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2478\/intox-2018-0007","article-title":"Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity","volume":"11","author":"Dasari","year":"2018","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135298","article-title":"Neuronal differentiation pathways and compoundinduced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq","volume":"304","author":"de Leeuw","year":"2022","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.tox.2024.153950_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/taap.1999.8670","article-title":"Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations","volume":"158","author":"DeJongh","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1158\/1055-9965.EPI-08-0832","article-title":"In vivo role of cytochrome P 450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans","volume":"18","author":"Doroshyenko","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/toxsci\/kfn269","article-title":"Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes","volume":"108","author":"Duale","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2024.153950_bib25","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.1205396","article-title":"Dietary acrylamide intake during pregnancy and fetal growth\u2014 results from the Norwegian mother and child cohort study (MoBa)","author":"Duarte-Salles","year":"2013","journal-title":"Environ. Health Perspect., 121(3), 374-379"},{"key":"10.1016\/j.tox.2024.153950_bib26","unstructured":"ECB (2002). ECB \u2013 European Chemicals Bureau. European risk assessment report: Acrylamide. 1st priority list, Vol. 24, European Commission, Joint Research Centre, Ispra, Italy (2002). \u3008http:\/\/echa.europa.eu\/documents\/10162\/50218bf9-ba0f-4254-a0d9-d577a5504ca7\u3009."},{"issue":"6","key":"10.1016\/j.tox.2024.153950_bib27","first-page":"4104","article-title":"EFSA Panel on Contaminants in the Food Chain (CONTAM).Scientific opinion on acrylamide in food","volume":"13","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.tox.2024.153950_bib28","unstructured":"EU Animals in science. (2024). Retrieved from \u3008https:\/\/environment.ec.europa.eu\/topics\/chemicals\/animals-science_en#the-three-rs\u3009. Accessed 2024-07-04."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/toxsci\/kfi069","article-title":"Metabolism and hemoglobin adduct formation of acrylamide in humans","volume":"85","author":"Fennell","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfl069","article-title":"Kinetics of elimination of urinary metabolites of acrylamide in humans","volume":"93","author":"Fennell","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib31","first-page":"311","article-title":"OECD\/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes","volume":"34","author":"Fritsche","year":"2017","journal-title":"ALTEX - Altern. Anim. Exp."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/1055-9965.EPI-05-0647","article-title":"Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity","volume":"15","author":"Fuhr","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tox.2024.153950_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cotox.2019.03.005","article-title":"Paradigm shift in safety assessment using new approach methods: the EUToxRisk strategy","volume":"15","author":"Graepel","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"issue":"3","key":"10.1016\/j.tox.2024.153950_bib34","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tox.2024.153950_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5271\/sjweh.608","article-title":"Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose","author":"Hagmar","year":"2001","journal-title":"Scand. J. Work, Environ. Health"},{"issue":"10","key":"10.1016\/j.tox.2024.153950_bib36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/10408444.2019.1692191","article-title":"The mercapturic acid pathway","volume":"49","author":"Hanna","year":"2019","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuro.2023.05.011","article-title":"Evaluation of mRNA markers in differentiating human SH-SY5Y cells for estimation of developmental neurotoxicity","volume":"97","author":"Hinojosa","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2024.153950_bib38","series-title":"Acrylamide. In Some Industrial Chemicals","article-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"1994"},{"issue":"5","key":"10.1016\/j.tox.2024.153950_bib39","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1002\/app.38966","article-title":"Studies on usage of acrylamide copolymers for textile effluent treatment","volume":"129","author":"Jain","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.tox.2024.153950_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114623","article-title":"Attenuated neuronal differentiation caused by acrylamide is not related to oxidative stress in differentiated human neuroblastoma SH-SY5Y cells","volume":"187","author":"Johansson","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.tox.2024.153950_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215906","article-title":"Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation","volume":"14","author":"Kapraun","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.tox.2024.153950_bib42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.reprotox.2022.09.004","article-title":"Evaluation of a rapid, generic human gestational dose model","volume":"113","author":"Kapraun","year":"2022","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.tox.2024.153950_bib43","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/tx3000939","article-title":"Update on EPA\u2019s ToxCast program: providing high throughput decision support tools for chemical risk management","volume":"25","author":"Kavlock","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jps.22255","article-title":"Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection","volume":"100","author":"Kawakami","year":"2011","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.tox.2024.153950_bib45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/15287390306368","article-title":"A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat","volume":"66","author":"Kirman","year":"2003","journal-title":"J. Toxicol. Environ. Health Part A"},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.taap.2008.12.001","article-title":"Toxicokinetics of acrylamide in rats and humans following single oral administration of low doses","volume":"235","author":"Kopp","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"10","key":"10.1016\/j.tox.2024.153950_bib47","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4103\/1673-5374.217345","article-title":"Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats","volume":"12","author":"Lai","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.tox.2024.153950_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuro.2022.07.001","article-title":"Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in concentrations relevant for human exposure","volume":"92","author":"Lauv\u00e5s","year":"2022","journal-title":"Neurotoxicology"},{"issue":"7","key":"10.1016\/j.tox.2024.153950_bib49","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.tiv.2010.08.004","article-title":"The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2\/Ikaros signaling pathway","volume":"24","author":"Lee","year":"2010","journal-title":"Toxicol. Vitr."},{"issue":"9","key":"10.1016\/j.tox.2024.153950_bib50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/15287394.2018.1440184","article-title":"Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide","volume":"81","author":"Lee","year":"2018","journal-title":"J. Toxicol. Environ. Health, Part A"},{"issue":"4","key":"10.1016\/j.tox.2024.153950_bib51","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1039\/C4AN02092H","article-title":"A new sample preparation method for the absolute quantitation of a target proteome using 18 O labeling combined with multiple reaction monitoring mass spectrometry","volume":"140","author":"Li","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.tox.2024.153950_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133458","article-title":"The construction and application of physiologically based toxicokinetic models for acrylamide, glycidamide and their biomarkers in rats and humans","volume":"292","author":"Li","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2024.153950_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107816","article-title":"Urinary metabolites of multiple volatile organic compounds among pregnant women across pregnancy: Variability, exposure characteristics, and associations with selected oxidative stress biomarkers","volume":"173","author":"Li","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2024.153950_bib54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2021.02.006","article-title":"Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps","volume":"101","author":"Lindeman","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib55","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00204-014-1289-4","article-title":"Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling","volume":"89","author":"Louisse","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"2-3","key":"10.1016\/j.tox.2024.153950_bib56","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/03602559108020132","article-title":"Applications of acrylamide polymers and copolymers: a review","volume":"30","author":"Myagchenkov","year":"1991","journal-title":"Polym. -Plast. Technol. Eng."},{"issue":"6906","key":"10.1016\/j.tox.2024.153950_bib57","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/419448a","article-title":"Acrylamide is formed in the Maillard reaction","volume":"419","author":"Mottram","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tox.2024.153950_bib58","unstructured":"OECD (2021), Guidance document on the characterisation, validation and reporting of Physiologically Based Kinetic (PBK) models for regulatory purposes, OECD Series on Testing and Assessment, No. 331, Environment, Health and Safety, Environment Directorate, OECD."},{"key":"10.1016\/j.tox.2024.153950_bib59","doi-asserted-by":"crossref","unstructured":"OECD (2023), Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery, OECD Series on Testing and Assessment, No. 377, OECD Publishing, Paris. https:\/\/doi.org\/10.1787\/91964ef3-en.","DOI":"10.1787\/91964ef3-en"},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1124\/dmd.111.042259","article-title":"Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities","volume":"40","author":"Ohtsuki","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2024.153950_bib61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tiv.2017.06.015","article-title":"From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling","volume":"45","author":"Paini","year":"2017","journal-title":"Toxicol. Vitr."},{"issue":"1-2","key":"10.1016\/j.tox.2024.153950_bib62","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1383-5718(02)00027-X","article-title":"Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment","volume":"516","author":"Paulsson","year":"2002","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"issue":"13","key":"10.1016\/j.tox.2024.153950_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137439","article-title":"Exploring the regulation of cytochrome P450 in SH-SY5Y cells: implications for the onset of neurodegenerative diseases","volume":"25","author":"Pifferi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2024.153950_bib64","unstructured":"PK-Sim sensitivity analysis. (2024). Retrieved from \u3008https:\/\/docs.open-systems-pharmacology.org\/shared-tools-and-example-workflows\/sensitivity-analysis\u3009. Accessed 2024-07-04."},{"key":"10.1016\/j.tox.2024.153950_bib65","unstructured":"PK-Sim Compounds: Definition and Work Flows (2024). Retrieved from \u3008https:\/\/docs.open-systems-pharmacology.org\/working-with-pk-sim\/pk-sim-documentation\/pk-sim-compounds-definition-and-work-flow\u3009."},{"key":"10.1016\/j.tox.2024.153950_bib66","unstructured":"PK-Sim Expression profile (2024). Retrieved from \u3008https:\/\/docs.open-systems-pharmacology.org\/working-with-pk-sim\/pk-sim-documentation\/pk-sim-expression-profile\u3009."},{"key":"10.1016\/j.tox.2024.153950_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-017-0151-8","article-title":"Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical-and toxininduced neurotoxicity","volume":"18","author":"Popova","year":"2017","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.tox.2024.153950_bib68","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/toxics10080443","article-title":"Trends of exposure to acrylamide as measured by urinary biomarkers levels within the HBM4EU biomonitoring aligned studies (2000\u20132021)","volume":"10","author":"Poteser","year":"2022","journal-title":"Toxics"},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib69","first-page":"105","article-title":"Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice","volume":"61","author":"Punt","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.tox.2024.153950_bib70","first-page":"465","article-title":"Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes","volume":"57","author":"Rodrigues","year":"1999","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.tox.2024.153950_bib71","doi-asserted-by":"crossref","DOI":"10.1021\/jf035238w","article-title":"Reduction of acrylamide uptake by dietary proteins in a Caco-2 gut model","volume":"52","author":"Schabacker","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2024.153950_bib72","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00204-016-1852-2","article-title":"Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro","volume":"91","author":"Schmuck","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"18","key":"10.1016\/j.tox.2024.153950_bib73","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1021\/acs.est.7b00650","article-title":"An intuitive approach for predicting potential human health risk with the Tox21 10k library","volume":"51","author":"Sipes","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib74","first-page":"152","article-title":"Revolutionizing developmental neurotoxicity testing\u2013a journey from animal models to advanced in vitro systems","volume":"41","author":"Smirnova","year":"2024","journal-title":"ALTEX-Altern. Anim. Exp."},{"issue":"6","key":"10.1016\/j.tox.2024.153950_bib75","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000069715","article-title":"Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans","volume":"48","author":"S\u00f6rgel","year":"2003","journal-title":"Chemotherapy"},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib76","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.fct.2009.11.049","article-title":"Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans","volume":"48","author":"Sweeney","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"17","key":"10.1016\/j.tox.2024.153950_bib77","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1021\/jf020302f","article-title":"Analysis of acrylamide, a carcinogen formed in heated foodstuffs","volume":"50","author":"Tareke","year":"2002","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib78","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cpt.382","article-title":"Pregnancy-related pharmacokinetic changes","volume":"100","author":"Tasnif","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.tox.2024.153950_bib79","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1021\/acs.jproteome.5b00334","article-title":"Comparative proteomic analysis of human liver tissue and isolated hepatocytes with a focus on proteins determining drug exposure","volume":"14","author":"Vildhede","year":"2015","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/toxsci\/kfq323","article-title":"In vivo doses of acrylamide and glycidamide in humans after intake of acrylamide-rich food","volume":"119","author":"Vikstr\u00f6m","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"11","key":"10.1016\/j.tox.2024.153950_bib81","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/tx200284u","article-title":"Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother\/cord blood samples from Denmark","volume":"24","author":"von Stedingk","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2024.153950_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114031","article-title":"Dietary intake of acrylamide in the Norwegian EuroMix biomonitoring study: comparing probabilistic dietary estimates with haemoglobin adduct measurements","volume":"180","author":"Vryonidis","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"14","key":"10.1016\/j.tox.2024.153950_bib83","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1039\/C5AY00664C","article-title":"A new calibration curve calculation method for absolute quantification of drug metabolizing enzymes in human liver microsomes by stable isotope dilution mass spectrometry","volume":"7","author":"Wang","year":"2015","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib84","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1124\/dmd.119.089235","article-title":"Comparative proteomics analysis of human liver microsomes and S9 fractions","volume":"48","author":"Wang","year":"2020","journal-title":"Drug Metab. Dispos."},{"issue":"24","key":"10.1016\/j.tox.2024.153950_bib85","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1080\/15287390701601202","article-title":"Approaches to acrylamide physiologically based toxicokinetic modeling for exploring child\u2013adult dosimetry differences","volume":"70","author":"Walker","year":"2007","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.tox.2024.153950_bib86","unstructured":"WHO (2007). Joint FAO\/WHO Expert Committee on Food Additives. Meeting, & World Health Organization. Evaluation of certain food additives and contaminants: sixty-eighth report of the Joint FAO\/WHO Expert Committee on Food Additives (Vol. 68). World Health Organization."},{"key":"10.1016\/j.tox.2024.153950_bib87","unstructured":"WHO (2010). Project H, No D. Characterization and Application of Physiologically Based Pharmacokinetic Models. IPCS -WHO. Available at: \u3008https:\/\/iris.who.int\/bitstream\/handle\/10665\/44495\/9789241500906_eng.pdf\u3009."},{"issue":"4","key":"10.1016\/j.tox.2024.153950_bib88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1478-5382(03)02342-4","article-title":"PKSim\u00ae: a physiologically based pharmacokinetic \u2018whole-body\u2019model","volume":"1","author":"Willmann","year":"2003","journal-title":"Biosilico"},{"issue":"2","key":"10.1016\/j.tox.2024.153950_bib89","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0892-0362(94)00071-K","article-title":"Developmental neurotoxicity evaluation of acrylamide in Sprague-Dawley rats","volume":"17","author":"Wise","year":"1995","journal-title":"Neurotoxicol. Teratol."},{"issue":"3","key":"10.1016\/j.tox.2024.153950_bib90","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/tx600287w","article-title":"Physiologically based pharmacokinetic\/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans","volume":"20","author":"Young","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib91","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1124\/jpet.116.233635","article-title":"Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes","volume":"358","author":"Zhang","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.tox.2024.153950_bib92","first-page":"421","article-title":"Dietary exposure of the Chinese population to acrylamide","volume":"26","author":"Zhou","year":"2013","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.tox.2024.153950_bib93","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41576-023-00626-5","article-title":"Genetics of human brain development","volume":"25","author":"Zhou","year":"2024","journal-title":"Nat. Rev. Genet."},{"issue":"1-2","key":"10.1016\/j.tox.2024.153950_bib94","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tox.2006.12.014","article-title":"Intestinal transport and metabolism of acrylamide","volume":"232","author":"Z\u00f6dl","year":"2007","journal-title":"Toxicology"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24002312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24002312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T11:26:38Z","timestamp":1732361198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X24002312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":94,"alternative-id":["S0300483X24002312"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2024.153950","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental neurotoxicity evaluation of acrylamide based on in vitro to in vivo extrapolation by pregnancy PBTK modelling","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2024.153950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"153950"}}