{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:39:17Z","timestamp":1778279957375,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tox.2024.154028","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T02:26:50Z","timestamp":1733365610000},"page":"154028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Disruption of serotonin homeostasis in intestinal organoids provides insights into drug-induced gastrointestinal toxicity"],"prefix":"10.1016","volume":"511","author":[{"given":"Georgia M.","family":"Rouseti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Rathfelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Grimes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Waldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Cuttat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Schuierer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Jivkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Dubost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko S.","family":"Schadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Vicart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2024.154028_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/flgastro-2013-100316","article-title":"Drug-induced gastrointestinal disorders","volume":"5","author":"Philpott","year":"2014","journal-title":"Frontline Gastroenterol."},{"key":"10.1016\/j.tox.2024.154028_bib2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/adt.2016.742","article-title":"Big data mining and adverse event pattern analysis in clinical drug trials","volume":"14","author":"Federer","year":"2016","journal-title":"Assay. Drug Dev. Technol."},{"key":"10.1016\/j.tox.2024.154028_bib3","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1039\/C9LC01107B","article-title":"Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems","volume":"20","author":"Peters","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.tox.2024.154028_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.taap.2017.09.006","article-title":"Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: the IQ consortium nonclinical to clinical translational database","volume":"334","author":"Monticello","year":"2017","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.tox.2024.154028_bib5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1476-5381.2009.00176.x","article-title":"Opportunities for the replacement of animals in the study of nausea and vomiting","volume":"157","author":"Holmes","year":"2009","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.tox.2024.154028_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2017.01.002","article-title":"Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury","volume":"172","author":"Carr","year":"2017","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.tox.2024.154028_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/toxsci\/kfad012","article-title":"A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment","volume":"192","author":"Magurany","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41573-022-00633-x","article-title":"The evolving role of investigative toxicology in the pharmaceutical industry","volume":"22","author":"Pognan","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tox.2024.154028_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.767621","article-title":"Human organoids for predictive toxicology research and drug development","volume":"12","author":"Matsui","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.tox.2024.154028_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tox.2024.154028_bib11","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2024.154028_bib12","doi-asserted-by":"crossref","DOI":"10.3791\/65343","article-title":"Generation and manipulation of rat intestinal organoids","author":"Zagoren","year":"2023","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tox.2024.154028_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12915-019-0652-6","article-title":"Derivation of adult canine intestinal organoids for translational research in gastroenterology","volume":"17","author":"Chandra","year":"2019","journal-title":"BMC Biol."},{"key":"10.1016\/j.tox.2024.154028_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13619-021-00094-4","article-title":"Establishment of porcine and monkey colonic organoids for drug toxicity study","volume":"10","author":"Li","year":"2021","journal-title":"Cell Regen."},{"key":"10.1016\/j.tox.2024.154028_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106481","article-title":"Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules","volume":"188","author":"Kourula","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104928","article-title":"Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs","volume":"68","author":"Belair","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2024.154028_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfy268","article-title":"Human 3D gastrointestinal microtissue barrier function as a predictor of drug-induced diarrhea","volume":"168","author":"Peters","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115797","article-title":"Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems","volume":"22","author":"Zhong","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/j.gastro.2005.09.031","article-title":"Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome","volume":"130","author":"Atkinson","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2024.154028_bib20","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/TCRM.S363404","article-title":"Risks of digestive system side-effects of selective serotonin reuptake inhibitors in patients with depression: a network meta-analysis","volume":"18","author":"Wang","year":"2022","journal-title":"Ther. Clin. Risk Manag"},{"key":"10.1016\/j.tox.2024.154028_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tox.2024.154028_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179487","article-title":"The multifaceted role of serotonin in intestinal homeostasis","volume":"22","author":"Koopman","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.autneu.2009.08.002","article-title":"Serotonin release and uptake in the gastrointestinal tract","volume":"153","author":"Bertrand","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.tox.2024.154028_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040822","article-title":"Generation of differentiating and long-living intestinal organoids reflecting the cellular diversity of canine intestine","volume":"9","author":"Kramer","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tox.2024.154028_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tox.2024.154028_bib26","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41586-023-05915-x","article-title":"Organization of the human intestine at single-cell resolution","volume":"619","author":"Hickey","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tox.2024.154028_bib27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41586-021-03852-1","article-title":"Cells of the human intestinal tract mapped across space and time","volume":"597","author":"Elmentaite","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tox.2024.154028_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41556-023-01337-z","article-title":"Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains","volume":"26","author":"Zwick","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tox.2024.154028_bib29","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s00216-010-3466-5","article-title":"Automated mass spectrometric analysis of urinary and plasma serotonin","volume":"396","author":"de Jong","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.tox.2024.154028_bib30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/bjc.1992.242","article-title":"Changes in serotonin metabolism in cancer patients: its relationship to nausea and vomiting induced by chemotherapeutic drugs","volume":"66","author":"Cubeddu","year":"1992","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tox.2024.154028_bib31","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/1097-0142(19931001)72:7<2239::AID-CNCR2820720729>3.0.CO;2-5","article-title":"Urinary serotonin metabolite excretion during cisplatin chemotherapy","volume":"72","author":"Wilder-Smith","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.tox.2024.154028_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2016.03.165","article-title":"Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium","volume":"474","author":"Tsuruta","year":"2016","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.tox.2024.154028_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jcmgh.2019.04.010","article-title":"Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion","volume":"8","author":"Chang-Graham","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tox.2024.154028_bib34","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1210\/me.2015-1106","article-title":"Research resource: a chromogranin a reporter for serotonin and histamine secreting enteroendocrine cells","volume":"29","author":"Engelstoft","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tox.2024.154028_bib35","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1073\/pnas.0805323106","article-title":"TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells","volume":"106","author":"Nozawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tox.2024.154028_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-023-01469-6","article-title":"Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management","volume":"8","author":"Shyam Sunder","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.tox.2024.154028_bib37","article-title":"Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.tox.2024.154028_bib38","unstructured":"FDA Label-Afatinib, \u3008https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/201292s014lbl.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib39","unstructured":"FDA Label-Crizotinib, \u3008https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/202570s033lbl.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib40","unstructured":"FDA Label-Vandetanib, \u3008https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/202570s033lbl.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib41","unstructured":"CHMP assessment report-crizotinib, \u3008https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/xalkori-epar-public-assessment-report_en.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib42","unstructured":"CHMP assessment report-vandetanib, \u3008https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/caprelsa-epar-public-assessment-report_en.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib43","unstructured":"CHMP assessment report-afatinib, \u3008https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/giotrif-epar-public-assessment-report_en.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib44","unstructured":"AUSPAR report-vandetanib, \u3008https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-vandetanib-130807.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib45","article-title":"Localization of the serotonin transporter in the dog intestine and comparison to the rat and human intestines","volume":"8","author":"Chiocchetti","year":"2021","journal-title":"Front Vet. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib46","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0024-3205(74)80012-3","article-title":"Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140)","volume":"15","author":"Fuller","year":"1974","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2024.154028_bib47","first-page":"143","article-title":"Canine separation anxiety: strategies for treatment and management","volume":"5","author":"Sargisson","year":"2014","journal-title":"Vet. Med."},{"key":"10.1016\/j.tox.2024.154028_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107059","article-title":"Properties of FDA-approved small molecule protein kinase inhibitors: a 2024 update","volume":"200","author":"Roskoski","year":"2024","journal-title":"Pharm. Res"},{"key":"10.1016\/j.tox.2024.154028_bib49","unstructured":"FDA Label Database, \u3008https:\/\/nctr-crs.fda.gov\/fdalabel\/ui\/search\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib50","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/s41467-023-40064-9","article-title":"A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs","volume":"14","author":"Sutherland","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2024.154028_bib51","unstructured":"Dextromethorphan EMA evaluation, \u3008https:\/\/www.ema.europa.eu\/en\/documents\/psusa\/dextromethorphan-cmdh-scientific-conclusions-and-grounds-variation-amendments-product-information-and-timetable-implementation-psusa00001009201811_en.pdf\u3009 (."},{"key":"10.1016\/j.tox.2024.154028_bib52","doi-asserted-by":"crossref","first-page":"C405","DOI":"10.1152\/ajpcell.00300.2017","article-title":"Gut organoids: mini-tissues in culture to study intestinal physiology and disease","volume":"317","author":"Almeqdadi","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tox.2024.154028_bib53","article-title":"Unravelling mechanisms of doxorubicin-induced toxicity in 3D human intestinal organoids","volume":"23","author":"Rodrigues","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib54","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s00204-021-03092-2","article-title":"New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids","volume":"95","author":"Rodrigues","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2024.154028_bib55","article-title":"A transcriptomic approach to elucidate the mechanisms of gefitinib-induced toxicity in healthy human intestinal organoids","volume":"23","author":"Rodrigues","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2024.154028_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.863","article-title":"Strategies to apply 3Rs in preclinical testing","volume":"9","author":"Gorzalczany","year":"2021","journal-title":"Pharm. Res Perspect."},{"key":"10.1016\/j.tox.2024.154028_bib57","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00280-014-2519-4","article-title":"Determining the mechanisms of lapatinib-induced diarrhoea using a rat model","volume":"74","author":"Bowen","year":"2014","journal-title":"Cancer Chemother. Pharm."},{"key":"10.1016\/j.tox.2024.154028_bib58","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ctrv.2015.05.011","article-title":"ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: chloride secretion as a mechanistic hypothesis","volume":"41","author":"Van Sebille","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tox.2024.154028_bib59","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejcsup.2013.07.016","article-title":"Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors","volume":"11","author":"Schmidinger","year":"2013","journal-title":"EJC Suppl."},{"key":"10.1016\/j.tox.2024.154028_bib60","doi-asserted-by":"crossref","DOI":"10.1177\/1534735420928493","article-title":"Diarrhea induced by small molecule tyrosine kinase inhibitors compared with chemotherapy: potential role of the microbiome","volume":"19","author":"Secombe","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.tox.2024.154028_bib61","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1038\/s41598-020-65350-0","article-title":"Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients","volume":"10","author":"Davies","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2024.154028_bib62","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41573-024-00942-3","article-title":"The state of the art in secondary pharmacology and its impact on the safety of new medicines","volume":"23","author":"Brennan","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tox.2024.154028_bib63","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1016\/j.apsb.2021.07.013","article-title":"The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity","volume":"11","author":"He","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.tox.2024.154028_bib64","doi-asserted-by":"crossref","DOI":"10.1063\/5.0206271","article-title":"Microfluidic gut-axis-on-a-chip models for pharmacokinetic-based disease models","volume":"18","author":"Kim","year":"2024","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.tox.2024.154028_bib65","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.3737","article-title":"An in vivo model of human small intestine using pluripotent stem cells","volume":"20","author":"Watson","year":"2014","journal-title":"Nat. Med"},{"key":"10.1016\/j.tox.2024.154028_bib66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nm.4233","article-title":"Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system","volume":"23","author":"Workman","year":"2017","journal-title":"Nat. Med"},{"key":"10.1016\/j.tox.2024.154028_bib67","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/s41596-021-00589-z","article-title":"Intestinal organoid cocultures with microbes","volume":"16","author":"Puschhof","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tox.2024.154028_bib68","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41587-022-01558-x","article-title":"In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice","volume":"41","author":"Bouffi","year":"2023","journal-title":"Nat. Biotechnol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24003093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X24003093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T19:22:21Z","timestamp":1739215341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X24003093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":68,"alternative-id":["S0300483X24003093"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2024.154028","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of serotonin homeostasis in intestinal organoids provides insights into drug-induced gastrointestinal toxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2024.154028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"154028"}}