{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:32:46Z","timestamp":1792726366937,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES013661"],"award-info":[{"award-number":["P42 ES013661"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.tox.2025.154120","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T15:36:07Z","timestamp":1742052967000},"page":"154120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Subacute exposure of male adolescent rats to 2,2\u2032,5,5\u2032-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum"],"prefix":"10.1016","volume":"514","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-0077","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Bullert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5841-6159","authenticated-orcid":false,"given":"Morgan J.","family":"Linahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-4661","authenticated-orcid":false,"given":"Michael E.","family":"Dailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-9871","authenticated-orcid":false,"given":"Jonathan A.","family":"Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-5046","authenticated-orcid":false,"given":"Aloysius J.","family":"Klingelhutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Ankrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-927X","authenticated-orcid":false,"given":"Hans-Joachim","family":"Lehmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154120_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/jne.12271","article-title":"The diversity of mechanisms influenced by transthyretin in neurobiology: development, disease and endocrine disruption","volume":"27","author":"Alshehri","year":"2015","journal-title":"J. Neuroendocr."},{"key":"10.1016\/j.tox.2025.154120_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108719","article-title":"Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration","volume":"196","author":"Andersen","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tox.2025.154120_bib3","first-page":"276","article-title":"Inflammation, apoptosis, and Alzheimer's disease","volume":"8","author":"Bamberger","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.tox.2025.154120_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12640-011-9253-z","article-title":"Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a critical role on cerebellar dopaminergic receptor expression: ameliorative role of quercetin","volume":"21","author":"Bavithra","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tox.2025.154120_bib5","first-page":"133","article-title":"Prenatal exposure to PCBs and neurological and sexual\/pubertal development from birth to adolescence","volume":"49","author":"Berghuis","year":"2019","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"10.1016\/j.tox.2025.154120_bib6","first-page":"137","article-title":"Environmental fate and global distribution of polychlorinated biphenyls","volume":"201","author":"Beyer","year":"2009","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"24","key":"10.1016\/j.tox.2025.154120_bib7","first-page":"0","article-title":"EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling","volume":"1","author":"Blighe","year":"2019","journal-title":"R. Package Version"},{"key":"10.1016\/j.tox.2025.154120_bib8","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/0020-711X(91)90286-V","article-title":"In vitro metabolism of [14C]4-chlorobiphenyl and [14C]2,2\u2032,5,5\u2032-tetrachlorobiphenyl by hepatic microsomes from rats and pigeons. Evidence against an obligatory arene oxide in aromatic hydroxylation reactions","volume":"23","author":"Borlakoglu","year":"1991","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.tox.2025.154120_bib9","doi-asserted-by":"crossref","unstructured":"Bullert,\u00a0A.,\u00a0Linahon,\u00a0M.,\u00a0Dailey,\u00a0M.,\u00a0Lehmler,\u00a0H.J.,\u00a02023. IHC analysis of brain regions from PCB exposed rats.\u00a0V.1. doi:10.17504\/protocols.io.kqdg3xbbeg25\/v1.","DOI":"10.17504\/protocols.io.kqdg3xbbeg25\/v1"},{"key":"10.1016\/j.tox.2025.154120_bib10","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/acs.chemrestox.1c00226","article-title":"The effects of polychlorinated biphenyl exposure during adolescence on the nervous system: a comprehensive review","volume":"34","author":"Bullert","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153965","article-title":"Effects of 28-day nose-only inhalation of PCB52 (2,2\u2032,5,5\u2032-Tetrachlorobiphenyl) on the brain transcriptome","volume":"509","author":"Bullert","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib12","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/acschemneuro.4c00367","article-title":"Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice","volume":"15","author":"Bullert","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tox.2025.154120_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/pharmrev.122.000618","article-title":"Dopamine, immunity, and disease","volume":"75","author":"Channer","year":"2023","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.tox.2025.154120_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/faat.1995.1099","article-title":"Toxicity of PCB 77 (3,3\u2032,4,4\u2032-tetrachlorobiphenyl) and PCB 118 (2,3\u2032,4,4\u20325-pentachlorobiphenyl) in the rat following subchronic dietary exposure","volume":"26","author":"Chu","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib15","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00204-011-0660-y","article-title":"Developmental exposure to methylmercury and 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl (PCB153) affects cerebral dopamine D1-like and D2-like receptors of weanling and pubertal rats","volume":"85","author":"Coccini","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/toxsci\/kfq229","article-title":"Polychlorinated biphenyls and polybrominated diphenyl ethers alter striatal dopamine neurochemistry in synaptosomes from developing rats in an additive manner","volume":"118","author":"Dreiem","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154120_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/10408444.2024.2311270","article-title":"Complex roles for sulfation in the toxicities of polychlorinated biphenyls","volume":"54","author":"Duffel","year":"2024","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tox.2017.12.003","article-title":"PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells","volume":"394","author":"Enayah","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15287394.2020.1863887","article-title":"Effects of an environmentally relevant PCB-mixture on immune function, clinical chemistry, and thyroid hormone levels in adult female B(6)C(3)F(1) mice","volume":"84","author":"Fair","year":"2021","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tox.2025.154120_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0009-2797(82)90103-X","article-title":"Identification of an arene oxide metabolite of 2,2\u2032,5-5\u2032-tetrachlorobiphenyl by gas chromatography-mass spectroscopy","volume":"40","author":"Forgue","year":"1982","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.tox.2025.154120_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165773","article-title":"Polychlorinated biphenyls and risk of metabolic syndrome and comparison with the risk of diabetes: A systematic review and meta-analysis","volume":"900","author":"Gao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154120_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1194\/jlr.P056002","article-title":"Biomarkers of NAFLD progression: a lipidomics approach to an epidemic","volume":"56","author":"Gorden","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tox.2025.154120_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105568","article-title":"Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes","volume":"89","author":"Gourronc","year":"2023","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tox.2025.154120_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10408444.2014.999365","article-title":"Metabolism and metabolites of polychlorinated biphenyls","volume":"45","author":"Grimm","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00128-021-03285-6","article-title":"Effects of polychlorinated biphenyls on animal reproductive systems and epigenetic modifications","volume":"107","author":"He","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib26","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1021\/es902413k","article-title":"Inadvertent polychlorinated biphenyls in commercial paint pigments","volume":"44","author":"Hu","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154120_bib27","unstructured":"IARC. 2016. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon, France."},{"key":"10.1016\/j.tox.2025.154120_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/tx800405v","article-title":"Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate","volume":"22","author":"Jinsmaa","year":"2009","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tox.2017.09.005","article-title":"Identification of lipidomic markers of chronic 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver","volume":"390","author":"Kania-Korwel","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.eurpsy.2017.02.479","article-title":"The lipidome in major depressive disorder: shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk","volume":"43","author":"Knowles","year":"2017","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.tox.2025.154120_bib31","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.18632\/aging.202753","article-title":"Calorie restriction prevents age-related changes in the intestinal microbiota","volume":"13","author":"Kurup","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tox.2025.154120_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-069X-14-13","article-title":"Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment","volume":"14","author":"Lagarde","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2025.154120_bib33","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0045-6535(01)00052-2","article-title":"Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling","volume":"45","author":"Lehmler","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154120_bib34","doi-asserted-by":"crossref","first-page":"16508","DOI":"10.1007\/s11356-017-1162-0","article-title":"Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example","volume":"25","author":"Li","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2025.154120_bib35","article-title":"Dataset for synthesis and authentication of 2, 2\u2032, 5, 5\u2032-tetrachlorobiphenyl-4-ol (4-OH-PCB 52)","author":"Li","year":"2022","journal-title":"Iowa Res. Online"},{"key":"10.1016\/j.tox.2025.154120_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153790","article-title":"Germ-free status but not subacute polychlorinated biphenyl (PCB) exposure altered hepatic phosphatidylcholine and ether-phosphatidylcholine levels in mice","volume":"504","author":"Li","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/toxsci\/kfm027","article-title":"Polychlorinated biphenyl-induced neurotoxicity in organotypic cocultures of developing rat ventral mesencephalon and striatum","volume":"97","author":"Lyng","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154120_bib38","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3389\/fgene.2020.00654","article-title":"Gene set analysis: Challenges, opportunities, and future research","volume":"11","author":"Maleki","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.tox.2025.154120_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu14050917","article-title":"Emerging evidence for the widespread role of glutamatergic dysfunction in neuropsychiatric diseases","volume":"14","author":"McGrath","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tox.2025.154120_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141097","article-title":"Metabolomic profiling for juvenile Chinook salmon exposed to contaminants of emerging concern","volume":"747","author":"Meador","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154120_bib41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1478-811X-11-34","article-title":"Complexity of dopamine metabolism","volume":"11","author":"Meiser","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.tox.2025.154120_bib42","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.1021\/acs.analchem.4c03719","article-title":"Discovery of hypoxanthine and inosine as robust biomarkers for predicting the preanalytical quality of human plasma and serum for metabolomics","volume":"96","author":"Nagana Gowda","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tox.2025.154120_bib43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.etap.2009.04.012","article-title":"Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead","volume":"28","author":"Niu","year":"2009","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2025.154120_bib44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/07853899509002590","article-title":"Nitric oxide in the central nervous system","volume":"27","author":"Paakkari","year":"1995","journal-title":"Ann. Med."},{"key":"10.1016\/j.tox.2025.154120_bib45","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2025.154120_bib46","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.3c00095","article-title":"Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity","author":"Paranjape","year":"2023","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2025.154120_bib47","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1021\/acschemneuro.4c00116","article-title":"Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its human-relevant metabolites","volume":"15","author":"Paranjape","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tox.2025.154120_bib48","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2009.10.009","article-title":"Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity","volume":"125","author":"Pessah","year":"2010","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.tox.2025.154120_bib49","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00401-019-01978-1","article-title":"Neurotoxicity of polychlorinated biphenyls and related organohalogens","volume":"138","author":"Pessah","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tox.2025.154120_bib50","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.1016\/S0021-9258(20)82065-1","article-title":"Non-arene oxide aromatic ring hydroxylation of 2,2\u2032,5,5\u2032-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbital-induced rat liver microsomes","volume":"258","author":"Preston","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2025.154120_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.etap.2018.06.010","article-title":"Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells","volume":"62","author":"Rodriguez","year":"2018","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2025.154120_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2008.04.023","article-title":"Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action","volume":"231","author":"Royland","year":"2008","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.tox.2025.154120_bib53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.taap.2008.04.022","article-title":"Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: developmental effects","volume":"231","author":"Royland","year":"2008","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.tox.2025.154120_bib54","first-page":"757","article-title":"Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12) cells","volume":"10","author":"Seegal","year":"1989","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2025.154120_bib55","first-page":"55","article-title":"Sub-chronic exposure of the adult rat to Aroclor 1254 yields regionally-specific changes in central dopaminergic function","volume":"12","author":"Seegal","year":"1991","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2025.154120_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0300-483X(94)90054-X","article-title":"Decreases in dopamine concentrations in adult, non-human primate brain persist following removal from polychlorinated biphenyls","volume":"86","author":"Seegal","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib57","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.tox.2025.154120_bib58","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1124\/dmd.116.072991","article-title":"Roles of human CYP2A6 and monkey CYP2A24 and 2A26 cytochrome P450 enzymes in the oxidation of 2,5,2\u2032,5\u2032-tetrachlorobiphenyl","volume":"44","author":"Shimada","year":"2016","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2025.154120_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ntt.2012.12.001","article-title":"Neuronal connectivity as a convergent target of gene x environment interactions that confer risk for Autism Spectrum Disorders","volume":"36","author":"Stamou","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.tox.2025.154120_bib60","doi-asserted-by":"crossref","first-page":"2748S","DOI":"10.1093\/jn\/134.10.2748S","article-title":"Enzymes of the L-arginine to nitric oxide pathway","volume":"134","author":"Stuehr","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2025.154120_bib61","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.scitotenv.2019.06.300","article-title":"Effects of PCB exposure on serum thyroid hormone levels in dogs and cats","volume":"688","author":"Takaguchi","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154120_bib62","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.3390\/ijms21249607","article-title":"The Regulation of astrocytic glutamate transporters in health and neurodegenerative diseases","volume":"21","author":"Todd","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tox.2025.154120_bib63","first-page":"332","article-title":"Dioxin cancer risk--example of hormesis?","volume":"3","author":"Tuomisto","year":"2006","journal-title":"Dose Response"},{"key":"10.1016\/j.tox.2025.154120_bib64","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/138920110790909632","article-title":"Heat shock proteins; an overview","volume":"11","author":"Tutar","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.tox.2025.154120_bib65","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/bioinformatics\/btx656","article-title":"xMWAS: a data-driven integration and differential network analysis tool","volume":"34","author":"Uppal","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tox.2025.154120_bib66","first-page":"160","article-title":"ggplot2: elegant graphics for data analysis","volume":"17","author":"Villanueva","year":"2019","journal-title":"Meas.-Interdiscip. Res."},{"key":"10.1016\/j.tox.2025.154120_bib67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuro.2024.07.009","article-title":"Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner","volume":"104","author":"Walker","year":"2024","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2025.154120_bib68","doi-asserted-by":"crossref","unstructured":"Wang, H., Bullert, A.J., Li, X., Stevens, H., Klingelhutz, A.J., Ankrum, J.A., Adamcakova-Dodd, A., Thorne, P.S., Lehmler, H.J., 2023. Dataset: Polymeric Implant to Assess the Neurotoxicity of Subacute Exposure to 2,2\u2032,5,5\u2032-Tetrachlorobiphenyl-4-ol in Male Rats. University of Iowa (dataset), https:\/\/doi.org\/10.25820\/data.006796.","DOI":"10.1016\/j.tox.2023.153677"},{"key":"10.1016\/j.tox.2025.154120_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153677","article-title":"Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2\u2032,5,5\u2032-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats","volume":"500","author":"Wang","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154120_bib70","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3354\/meps165247","article-title":"Induction of gene expression of the chaperones 14-3-3 and HSP70 by PCB 118 (2,3\u2032,4,4\u2032,5-pentachlorobiphenyl) in the marine sponge Geodia cydonium: novel biomarkers for polychlorinated biphenyls","volume":"165","author":"Wiens","year":"1998","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.tox.2025.154120_bib71","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov. (Camb. )"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25000769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25000769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:32:34Z","timestamp":1762284754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25000769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":71,"alternative-id":["S0300483X25000769"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154120","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subacute exposure of male adolescent rats to 2,2\u2032,5,5\u2032-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154120"}}