{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:10:18Z","timestamp":1790971818727,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2018R1A6A1A03025159"],"award-info":[{"award-number":["NRF-2018R1A6A1A03025159"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.tox.2025.154182","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T16:58:10Z","timestamp":1746809890000},"page":"154182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Differential susceptibility of Leydig and Sertoli cells to bisphenol A"],"prefix":"10.1016","volume":"516","author":[{"given":"Do-Yeal","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ki","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Saidur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-3789","authenticated-orcid":false,"given":"Myung-Geol","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154182_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/adc.2005.088500","article-title":"Endocrine disrupting chemicals: a new and emerging public health problem?","volume":"91","author":"Acerini","year":"2006","journal-title":"Arch. Dis. Child"},{"key":"10.1016\/j.tox.2025.154182_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119067","article-title":"Bisphenol A damages testicular junctional proteins transgenerationally in mice","volume":"302","author":"Adegoke","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154182_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139277","article-title":"Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice","volume":"337","author":"Adegoke","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154182_bib4","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1074\/jbc.AAC120.012899","article-title":"Correction: Dynamin-related protein 1 inhibition mitigates bisphenol A-mediated alterations in mitochondrial dynamics and neural stem cell proliferation and differentiation","volume":"295","author":"Agarwal","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2025.154182_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/en.2002-220292","article-title":"Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell","volume":"144","author":"Akingbemi","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2025.154182_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1071\/RD09300","article-title":"Negative impact of endocrine-disrupting compounds on human reproductive health","volume":"23","author":"Balabanic","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.tox.2025.154182_bib7","article-title":"An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes","volume":"10","author":"Ben Maamar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2025.154182_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1289\/ehp.7534","article-title":"Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population","volume":"113","author":"Calafat","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2025.154182_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ygcen.2010.07.014","article-title":"T3 fails to restore mitochondrial thiol redox status altered by experimental hypothyroidism in rat testis","volume":"169","author":"Chattopadhyay","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.tox.2025.154182_bib10","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.tox.2025.154182_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0300-483X(02)00597-8","article-title":"Induction of oxidative stress by bisphenol A in the epididymal sperm of rats","volume":"185","author":"Chitra","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154182_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1933719111415547","article-title":"Bisphenol A induces oxidative stress and decreases levels of insulin receptor substrate 2 and glucose transporter 8 in rat testis","volume":"19","author":"D'Cruz","year":"2012","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tox.2025.154182_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.ph.50.030188.002411","article-title":"Endocrine regulation and communicating functions of the Leydig cell","volume":"50","author":"Dufau","year":"1988","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.tox.2025.154182_bib14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/0748233712446728","article-title":"Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats","volume":"29","author":"El-Beshbishy","year":"2013","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tox.2025.154182_bib15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.pedn.2009.05.006","article-title":"Bisphenol a exposure: human risk and health policy","volume":"25","author":"Erler","year":"2010","journal-title":"J. Pediatr. Nurs."},{"key":"10.1016\/j.tox.2025.154182_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ando.2013.04.002","article-title":"Bisphenol A: an endocrine and metabolic disruptor","volume":"74","author":"Fenichel","year":"2013","journal-title":"Ann. Endocrinol. (Paris)"},{"key":"10.1016\/j.tox.2025.154182_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.reprotox.2004.01.002","article-title":"Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants","volume":"18","author":"Fiorini","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib18","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1210\/jc.2003-030143","article-title":"The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway","volume":"88","author":"Fluck","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2025.154182_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhazmat.2014.12.012","article-title":"Why endocrine disrupting chemicals (EDCs) challenge traditional risk assessment and how to respond","volume":"286","author":"Futran Fuhrman","year":"2015","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2025.154182_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105328","article-title":"Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo mouse models","volume":"134","author":"Gao","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154182_bib21","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1517\/14728222.2015.1039513","article-title":"Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight","volume":"19","author":"Gao","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.tox.2025.154182_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0005-2728(84)90194-4","article-title":"The role of glucose, pyruvate and lactate in ATP production by rat spermatocytes and spermatids","volume":"767","author":"Grootegoed","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2025.154182_bib23","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.cub.2018.06.070","article-title":"Replacement bisphenols adversely affect mouse gametogenesis with consequences for subsequent generations","volume":"28","author":"Horan","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tox.2025.154182_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-4347(00)00351-0","article-title":"Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection","volume":"749","author":"Inoue","year":"2000","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.tox.2025.154182_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7555\/JBR.27.20120076","article-title":"Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats","volume":"27","author":"Jin","year":"2013","journal-title":"J. Biomed. Res"},{"key":"10.1016\/j.tox.2025.154182_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1530\/jrf.0.0620399","article-title":"Exogenous lactate is essential for metabolic activities in isolated rat spermatocytes and spermatids","volume":"62","author":"Jutte","year":"1981","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.tox.2025.154182_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1530\/jrf.0.0650431","article-title":"Regulation of survival of rat pachytene spermatocytes by lactate supply from Sertoli cells","volume":"65","author":"Jutte","year":"1982","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.tox.2025.154182_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1530\/jrf.0.0680219","article-title":"FSH stimulation of the production of pyruvate and lactate by rat Sertoli cells may be involved in hormonal regulation of spermatogenesis","volume":"68","author":"Jutte","year":"1983","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.tox.2025.154182_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2020.111485","article-title":"Endocrine-disruptive chemicals as contaminants of emerging concern in wastewater and surface water: a review","volume":"277","author":"Kasonga","year":"2021","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.tox.2025.154182_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbrc.2003.10.135","article-title":"Gender differences in the levels of bisphenol A metabolites in urine","volume":"312","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2025.154182_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2131\/jts.37.565","article-title":"Lack of effects for dietary exposure of bisphenol A during in utero and lactational periods on reproductive development in rat offspring","volume":"37","author":"Kobayashi","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154182_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/bdrb.20336","article-title":"Effects of in utero exposure to Bisphenol A or diethylstilbestrol on the adult male reproductive system","volume":"92","author":"LaRocca","year":"2011","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1095\/biolreprod.102.005793","article-title":"Is the cadherin\/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?","volume":"68","author":"Lee","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2025.154182_bib34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/humrep\/16.5.1037","article-title":"Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters","volume":"16","author":"Leffers","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tox.2025.154182_bib35","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1038\/onc.2011.167","article-title":"Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?","volume":"30","author":"Lemarie","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.tox.2025.154182_bib36","doi-asserted-by":"crossref","first-page":"17998","DOI":"10.1073\/pnas.1007047107","article-title":"Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tox.2025.154182_bib37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/toxsci\/kfp024","article-title":"Bisphenol A exposure induces apoptosis and upregulation of Fas\/FasL and caspase-3 expression in the testes of mice","volume":"108","author":"Li","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154182_bib38","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1021\/es202507f","article-title":"Widespread occurrence of bisphenol A in paper and paper products: implications for human exposure","volume":"45","author":"Liao","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154182_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tox.2025.154182_bib40","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/0265203031000109495","article-title":"Determination of bisphenol A in, and its migration from, PVC stretch film used for food packaging","volume":"20","author":"Lopez-Cervantes","year":"2003","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.tox.2025.154182_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055387","article-title":"Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations","volume":"8","author":"Manikkam","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2025.154182_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/tx0001833","article-title":"In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta","volume":"14","author":"Matthews","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib43","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1095\/biolreprod.110.087460","article-title":"ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor Leydig cells","volume":"84","author":"Midzak","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2025.154182_bib44","article-title":"Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function","volume":"7","author":"N'Tumba-Byn","year":"2012","journal-title":"PLoS One"},{"issue":"135","key":"10.1016\/j.tox.2025.154182_bib45","article-title":"The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells","volume":"86","author":"Nanjappa","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2025.154182_bib46","article-title":"Estrogenic compounds or adiponectin inhibit cyclic AMP response to human luteinizing hormone in mouse leydig tumor cells","volume":"8","author":"Nguyen","year":"2019","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.tox.2025.154182_bib47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/reprod\/118.1.195","article-title":"Ontogeny of oestrogen receptor alpha in gonads and sex ducts of fetal and newborn mice","volume":"118","author":"Nielsen","year":"2000","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.tox.2025.154182_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/rep.1.00136","article-title":"Differential hormonal regulation of estrogen receptors ERalpha and ERbeta and androgen receptor expression in rat efferent ductules","volume":"128","author":"Oliveira","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.tox.2025.154182_bib49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.1307728","article-title":"Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013","volume":"122","author":"Peretz","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2025.154182_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.cdd.4400453","article-title":"An elevated bax\/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis","volume":"6","author":"Perlman","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tox.2025.154182_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.epirev.a036102","article-title":"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk","volume":"15","author":"Pike","year":"1993","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.tox.2025.154182_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcell.2018.00013","article-title":"Subcellular localization and dynamics of the Bcl-2 family of proteins","volume":"6","author":"Popgeorgiev","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.tox.2025.154182_bib53","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/bcpt.13125","article-title":"CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems","volume":"125","author":"Prins","year":"2019","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.freeradbiomed.2013.11.025","article-title":"A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes","volume":"67","author":"Pun","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tox.2025.154182_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126076","article-title":"Drivers of owning more BPA","volume":"417","author":"Rahman","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2025.154182_bib56","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/humrep\/deaa139","article-title":"Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model","volume":"35","author":"Rahman","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tox.2025.154182_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125791","article-title":"Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice","volume":"416","author":"Rahman","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.tox.2025.154182_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12958-016-0224-3","article-title":"Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro","volume":"15","author":"Riccetti","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tox.2025.154182_bib59","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1210\/endo.139.6.6028","article-title":"Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice","volume":"139","author":"Rosenfeld","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2025.154182_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107617","article-title":"Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially","volume":"170","author":"Ryu","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154182_bib61","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoad044","article-title":"Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility","author":"Ryu","year":"2023","journal-title":"Hum. Reprod. Open 2023"},{"key":"10.1016\/j.tox.2025.154182_bib62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2009.09.012","article-title":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","volume":"265","author":"Salian","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154182_bib63","article-title":"Fighting bisphenol A-induced male infertility: the power of antioxidants","volume":"10","author":"Santiago","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tox.2025.154182_bib64","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1677\/joe.0.156r013","article-title":"Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis","volume":"156","author":"Saunders","year":"1998","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2025.154182_bib65","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfm070","article-title":"Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid","volume":"98","author":"Shi","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154182_bib66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2006.02.004","article-title":"Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis","volume":"22","author":"Sobarzo","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib67","doi-asserted-by":"crossref","first-page":"21635","DOI":"10.1007\/s11356-018-2229-2","article-title":"Alteration in apoptotic rate of testicular cells and sperms following administration of Bisphenol A (BPA) in Wistar albino rats","volume":"25","author":"Srivastava","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tox.2025.154182_bib68","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1210\/en.2008-1311","article-title":"Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells","volume":"150","author":"Strauss","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2025.154182_bib69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/101053950301500208","article-title":"Leaching of bisphenol A from new and old babies' bottles, and new babies' feeding teats","volume":"15","author":"Tan","year":"2003","journal-title":"Asia Pac. J. Public Health"},{"key":"10.1016\/j.tox.2025.154182_bib70","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/toxsci\/kfr160","article-title":"Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure","volume":"123","author":"Teeguarden","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154182_bib71","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jat.3480","article-title":"Effect of bisphenol A on reproductive processes: a review of in vitro, in vivo and epidemiological studies","volume":"38","author":"Tomza-Marciniak","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib72","first-page":"225","article-title":"Human health risk on environmental exposure to Bisphenol-A: a review","volume":"24","author":"Tsai","year":"2006","journal-title":"J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1016\/j.tox.2025.154182_bib73","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S1413-81232012000200015","article-title":"Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A","volume":"17","author":"Vandenberg","year":"2012","journal-title":"Cien Saude Colet."},{"key":"10.1016\/j.tox.2025.154182_bib74","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2025.154182_bib75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2025.154182_bib76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/19396368.2016.1182234","article-title":"Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage","volume":"62","author":"Wang","year":"2016","journal-title":"Syst. Biol. Reprod. Med"},{"key":"10.1016\/j.tox.2025.154182_bib77","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/1471-2407-14-379","article-title":"Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tox.2025.154182_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109182","article-title":"Bisphenol A induces apoptosis, oxidative stress and inflammatory response in colon and liver of mice in a mitochondria-dependent manner","volume":"117","author":"Wang","year":"2019","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.tox.2025.154182_bib79","first-page":"1343","article-title":"Connexin 43: its regulatory role in testicular junction dynamics and spermatogenesis","volume":"26","author":"Weider","year":"2011","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.tox.2025.154182_bib80","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.chemosphere.2019.01.195","article-title":"Effects of exogenous bisphenol A on the function of mitochondria in root cells of soybean (Glycine max L.) seedlings","volume":"222","author":"Xiao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154182_bib81","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.tiv.2015.04.020","article-title":"T-2 toxin inhibits gene expression and activity of key steroidogenesis enzymes in mouse Leydig cells","volume":"29","author":"Yang","year":"2015","journal-title":"Toxicol. Vitr."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25001398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25001398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:11:38Z","timestamp":1749017498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25001398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"alternative-id":["S0300483X25001398"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154182","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential susceptibility of Leydig and Sertoli cells to bisphenol A","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"154182"}}