{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:45:48Z","timestamp":1785739548846,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002729","name":"Anhui University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.tox.2025.154222","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:31:36Z","timestamp":1749843096000},"page":"154222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Three typical organophosphorus flame retardants trigger thyroid hormone synthesis by inducing oxidative stress or inflammation reactions in Nthy-ori 3\u20111 cells"],"prefix":"10.1016","volume":"517","author":[{"given":"Xinyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-247X","authenticated-orcid":false,"given":"Tianrong","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-6986","authenticated-orcid":false,"given":"Yuanyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154222_bib1","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1021\/acs.est.0c01152","article-title":"In vitro immunotoxicity of organophosphate flame retardants in human THP-1-derived macrophages","volume":"54","author":"Li","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133404","article-title":"The influence of emerging atmospheric organophosphorus flame retardants from land source emissions on the East China Sea","volume":"465","author":"Ma","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2025.154222_bib3","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.4c06504","article-title":"Global gridded emission inventory of organophosphate flame retardants from 2010 to 2020","author":"Ma","year":"2024","journal-title":"Environ. Sci. Technol. 58 1707080"},{"key":"10.1016\/j.tox.2025.154222_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125886","article-title":"National urinary metabolites of organophosphate flame retardants in urban Chinese residents","volume":"370","author":"Meng","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125529","article-title":"Comparison of indoor and outdoor atmospheric organophosphorus flame retardants (OPFRs) from the petrochemical industrial area in North China: Occurrence, gas-PM(2.5) distribution, source appointment and health implications","volume":"367","author":"Gong","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib6","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1021\/acs.est.7b01294","article-title":"Current-use flame retardants in the water of Lake Michigan tributaries","volume":"51","author":"Guo","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envint.2017.11.028","article-title":"Presence of diphenyl phosphate and aryl-phosphate flame retardants in indoor dust from different microenvironments in Spain and the Netherlands and estimation of human exposure","volume":"112","author":"Bjornsdotter","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2025.154222_bib8","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.envpol.2018.07.077","article-title":"Trophic transfer of organophosphorus flame retardants in a lake food web","volume":"242","author":"Zhao","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138597","article-title":"Occurrence and risk of human exposure to organophosphate flame retardants in indoor air and dust in Hanoi, Vietnam","volume":"328","author":"Hoang","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154222_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12030195","article-title":"A review of the distribution and health effect of organophosphorus flame retardants in indoor environments","volume":"12","author":"Song","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.tox.2025.154222_bib11","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1021\/acs.est.2c01850","article-title":"Penetration of organophosphate triesters and diesters across the blood-cerebrospinal fluid barrier: efficiencies, impact factors, and mechanisms","volume":"56","author":"Hou","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115685","article-title":"Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice","volume":"268","author":"Peng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154222_bib13","doi-asserted-by":"crossref","DOI":"10.4209\/aaqr.220148","article-title":"An overview: organophosphate flame retardants in the atmosphere","volume":"22","author":"Kung","year":"2022","journal-title":"Aerosol Air Qual. Res."},{"key":"10.1016\/j.tox.2025.154222_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162107","article-title":"Exposure to novel brominated and organophosphate flame retardants and associations with type 2 diabetes in East China: a case-control study","volume":"871","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154222_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107503","article-title":"Exposure assessment of aryl-organophosphate esters based on specific urinary biomarkers and their associations with reproductive hormone homeostasis disruption in women of childbearing age","volume":"169","author":"Gao","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154222_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174772","article-title":"Organophosphate flame retardants tris (2-butoxyethyl) phosphate (TBEP) and tris (2-chloroethyl) phosphate (TCEP) disrupt human motor neuron development by differentially affecting their survival and differentiation","volume":"948","author":"Zheng","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154222_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126300","article-title":"Association of organophosphate flame retardants exposure with liver function and the contrasting mediating roles of inflammatory and oxidative stress pathways","volume":"375","author":"Dai","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.177756","article-title":"Organophosphate flame retardants associated with increased oxidative stress biomarkers and elevated FeNO levels in general population of children: the Hokkaido study","volume":"957","author":"Zeng","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154222_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.aquatox.2012.11.009","article-title":"Exposure of zebrafish embryos\/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis","volume":"126","author":"Wang","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2025.154222_bib20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.envpol.2019.05.110","article-title":"Early life exposure to triphenyl phosphate: Effects on thyroid function, growth, and resting metabolic rate of Japanese quail (Coturnix japonica) chicks","volume":"253","author":"Guigueno","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ecoenv.2018.11.058","article-title":"Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish","volume":"170","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154222_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ese.2022.100198","article-title":"Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain","volume":"12","author":"Yan","year":"2022","journal-title":"Environ. Sci. Ecotechnol."},{"key":"10.1016\/j.tox.2025.154222_bib23","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1021\/acs.est.5b00857","article-title":"Investigating endocrine and physiological parameters of captive American kestrels exposed by diet to selected organophosphate flame retardants","volume":"49","author":"Fernie","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/acs.est.1c05140","article-title":"Organophosphate and organohalogen flame-retardant exposure and thyroid hormone disruption in a cross-sectional study of female firefighters and office workers from San Francisco","volume":"56","author":"Trowbridge","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12885-018-4553-9","article-title":"A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women","volume":"18","author":"Deziel","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tox.2025.154222_bib26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envint.2017.01.020","article-title":"Associations between urinary diphenyl phosphate and thyroid function","volume":"101","author":"Preston","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154222_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.envint.2017.06.021","article-title":"Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: a case-control study","volume":"107","author":"Hoffman","year":"2017","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2025.154222_bib28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1039\/b921910b","article-title":"Organophosphorus flame retardants and plasticizers in marine and fresh water biota and in human milk","volume":"12","author":"Sundkvist","year":"2010","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.tox.2025.154222_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chemosphere.2015.10.087","article-title":"Organophosphorus flame retardants and phthalate esters in indoor dust from different microenvironments: Bioaccessibility and risk assessment","volume":"150","author":"He","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154222_bib30","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaa146","article-title":"Reevaluation of the effect of iodine on thyroid cell survival and function using PCCL3 and Nthy-ori 3-1 cells","volume":"4","author":"Kurashige","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.tox.2025.154222_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114926","article-title":"Drinking water disinfection byproduct iodoacetic acid affects thyroid hormone synthesis in Nthy-ori 3-1 cells","volume":"257","author":"Xiao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154222_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153407","article-title":"Multiple neurological effects associated with exposure to organophosphorus pesticides in man","volume":"484","author":"Jokanovi\u0107","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154222_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2013.09.004","article-title":"In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors","volume":"314","author":"Kojima","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154222_bib34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aquatox.2015.01.016","article-title":"Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos\/larvae, and in GH3 and FRTL-5 cell lines","volume":"160","author":"Kim","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tox.2025.154222_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103600","article-title":"Effects of environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) on early life stages of zebrafish (Danio rerio)","volume":"83","author":"Hu","year":"2021","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.tox.2025.154222_bib36","doi-asserted-by":"crossref","first-page":"9043","DOI":"10.1021\/acs.est.3c01631","article-title":"Tris (2-chloroethyl) phosphate exerts hepatotoxic impacts on zebrafish by disrupting hypothalamic\u2013pituitary\u2013thyroid and gut\u2013liver axes","volume":"57","author":"Tian","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib37","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/15376516.2020.1765060","article-title":"Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice","volume":"30","author":"Wang","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tox.2025.154222_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125911","article-title":"Identification of the associations between co-exposure to organophosphate flame retardants and thyroid dysfunction and exposure risk factors in residents of Shanghai, China","author":"Du","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/toxsci\/kfae034","article-title":"Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells","volume":"199","author":"Yu","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154222_bib40","unstructured":"Pirahanchi, Y.; Tariq, M.A.; Jialal, I., (2023). Physiology, thyroid. StatPearls [Internet]."},{"key":"10.1016\/j.tox.2025.154222_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/CCO.0000000000000335","article-title":"Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer?","volume":"29","author":"Hoffman","year":"2017","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.tox.2025.154222_bib42","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/etc.3395","article-title":"Long-term exposure to triphenylphosphate alters hormone balance and HPG, HPI, and HPT gene expression in zebrafish (Danio rerio)","volume":"35","author":"Liu","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tox.2025.154222_bib43","doi-asserted-by":"crossref","first-page":"17825","DOI":"10.1021\/acs.est.2c04759","article-title":"Exposure to novel brominated flame retardants and organophosphate esters and associations with thyroid cancer risk: a case-control study in Eastern China","volume":"56","author":"Liu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154222_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2025.154222_bib45","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/CM9.0000000000003126","article-title":"Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility","volume":"138","author":"Meng","year":"2025","journal-title":"Chin. Med J. (Engl. )"},{"key":"10.1016\/j.tox.2025.154222_bib46","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1210\/en.2007-0951","article-title":"Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content","volume":"149","author":"Poncin","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2025.154222_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2011.05.047","article-title":"Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines","volume":"343","author":"Massart","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tox.2025.154222_bib48","article-title":"Status of mitochondrial oxidative phosphorylation during the development of heart failure","volume":"12","author":"Bhullar","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tox.2025.154222_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6757154","article-title":"Thyroid hormones, oxidative stress, and inflammation","volume":"2016","author":"Mancini","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.tox.2025.154222_bib50","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1038\/s41598-025-90491-5","article-title":"Association between oxidative balance score and thyroid function and all-cause mortality in euthyroid adults","volume":"15","author":"Xiao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2025.154222_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105751","article-title":"Mediating role of oxidative\/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults","volume":"140","author":"Huang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154222_bib52","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12020-024-04005-w","article-title":"Polychlorinated Biphenyls (PCBS)-induced oxidative stress and inflammation in human thyrocytes: involvement of AhR and NRF-2\/HO-1 pathway","volume":"87","author":"Ruggeri","year":"2025","journal-title":"Endocrine"},{"key":"10.1016\/j.tox.2025.154222_bib53","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/antiox11020334","article-title":"Associations between oxidative\/nitrosative stress and thyroid hormones in pregnant women\u2014Tainan Birth Cohort Study (TBCS)","volume":"11","author":"Cheng","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.tox.2025.154222_bib54","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.tox.2025.154222_bib55","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109972118","article-title":"TNF plays a crucial role in inflammation by signaling via T cell TNFR2","volume":"118","author":"Alam","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tox.2025.154222_bib56","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1038\/jid.2013.237","article-title":"IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis","volume":"133","author":"Wang","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tox.2025.154222_bib57","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/rheumatology\/keac385","article-title":"IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via I\u03baB\u03b6-dependent induction of ELF3","volume":"62","author":"Kouri","year":"2023","journal-title":"Rheumatology"},{"key":"10.1016\/j.tox.2025.154222_bib58","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","article-title":"IL-17 signaling: the yin and the yang","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tox.2025.154222_bib59","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.HYP.33.1.183","article-title":"TNF-alpha-induced migration of vascular smooth muscle cells is MAPK dependent","volume":"33","author":"Goetze","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.tox.2025.154222_bib60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.tox.2025.154222_bib61","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1210\/clinem\/dgad723","article-title":"Increased Thyroid DPP4 Expression Is Associated With Inflammatory Process in Patients With Hashimoto Thyroiditis","volume":"109","author":"Wen","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2025.154222_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114474","article-title":"Triphenyl phosphate modulated saturation of phospholipids: induction of endoplasmic reticulum stress and inflammation","volume":"263","author":"Hu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154222_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115685","article-title":"Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice","volume":"268","author":"Peng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25001817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25001817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T05:11:32Z","timestamp":1760591492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25001817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":63,"alternative-id":["S0300483X25001817"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154222","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three typical organophosphorus flame retardants trigger thyroid hormone synthesis by inducing oxidative stress or inflammation reactions in Nthy-ori 3\u20111 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154222"}}