{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:50:22Z","timestamp":1789343422670,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJ212410160036"],"award-info":[{"award-number":["LJ212410160036"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81674036"],"award-info":[{"award-number":["81674036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2002023"],"award-info":[{"award-number":["XLYC2002023"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.tox.2025.154229","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:18:49Z","timestamp":1751663929000},"page":"154229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Formyl peptide receptor 2 (FPR2) mediates cisplatin-induced cochlear inflammation and hair cell apoptosis"],"prefix":"10.1016","volume":"517","author":[{"given":"Jiaojiao","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154229_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/109374001301419737","article-title":"Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2\u2019-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene","volume":"4","author":"Abu-Qare","year":"2001","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.tox.2025.154229_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1125948","article-title":"Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity","volume":"14","author":"Al Aameri","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tox.2025.154229_bib3","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.3390\/ijms232415790","article-title":"Pericytes of stria vascularis are targets of cisplatin-induced ototoxicity: new insights into the molecular mechanisms involved in blood-labyrinth barrier breakdown","volume":"23","author":"Anfuso","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2025.154229_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2021.108378","article-title":"LCCL peptide cleavage after noise exposure exacerbates hearing loss and is associated with the monocyte infiltration in the cochlea","volume":"412","author":"Bae","year":"2021","journal-title":"Hear. Res."},{"key":"10.1016\/j.tox.2025.154229_bib5","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3390\/cells10071686","article-title":"IGF-1 haploinsufficiency causes age-related chronic cochlear inflammation and increases noise-induced hearing loss","volume":"10","author":"Celaya","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tox.2025.154229_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12974-022-02414-0","article-title":"Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis","volume":"19","author":"Chen","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tox.2025.154229_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.58.3.4","article-title":"The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo","volume":"58","author":"Chiang","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2025.154229_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2022.100737","article-title":"Clinical treatment of cholangiocarcinoma: an updated comprehensive review","volume":"27","author":"Elvevi","year":"2022","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.tox.2025.154229_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1470-2045(05)70168-6","article-title":"The MAPK signalling pathways and colorectal cancer","volume":"6","author":"Fang","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tox.2025.154229_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2352-4642(19)30336-0","article-title":"Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline","volume":"4","author":"Freyer","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"10.1016\/j.tox.2025.154229_bib11","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.molmed.2019.08.002","article-title":"Cisplatin-induced ototoxicity: updates on molecular targets","volume":"25","author":"Gentilin","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tox.2025.154229_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40265-023-01838-z","article-title":"A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammation","volume":"83","author":"Jayabalan","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.tox.2025.154229_bib13","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1523\/JNEUROSCI.3111-15.2016","article-title":"Adenosine A1 receptor protects against cisplatin ototoxicity by suppressing the NOX3\/STAT1 inflammatory pathway in the cochlea","volume":"36","author":"Kaur","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2025.154229_bib14","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1200\/JCO.23.00179","article-title":"Five-year overall survival analysis of the JIPANG study: pemetrexed or vinorelbine plus cisplatin for resected stage II-IIIA nonsquamous non-small-cell lung cancer","volume":"41","author":"Kenmotsu","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tox.2025.154229_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/biomedicines10020512","article-title":"Comparative study of the aftereffect of CO2 inhalation or tiletamine-zolazepam-xylazine anesthesia on laboratory outbred rats and mice","volume":"10","author":"Khokhlova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.tox.2025.154229_bib16","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/cr.2011.27","article-title":"Cisplatin ototoxicity involves cytokines and STAT6 signaling network","volume":"21","author":"Kim","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.tox.2025.154229_bib17","doi-asserted-by":"crossref","first-page":"a033548","DOI":"10.1101\/cshperspect.a033548","article-title":"Aminoglycoside- and cisplatin-induced ototoxicity: mechanisms and otoprotective strategies","volume":"9","author":"Kros","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.tox.2025.154229_bib18","article-title":"Annexin 1: more than an anti-phospholipase protein","volume":"53","author":"L","year":"2004","journal-title":"Inflamm. Res. Off. J. Eur. Histamine Res. Soc. \u2026 [Et. al.]"},{"key":"10.1016\/j.tox.2025.154229_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s12276-023-00941-1","article-title":"Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tox.2025.154229_bib20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.intimp.2016.08.021","article-title":"Cnidilide, an alkylphthalide isolated from the roots of Cnidium officinale, suppresses LPS-induced NO, PGE2, IL-1\u03b2, IL-6 and TNF-\u03b1 production by AP-1 and NF-\u03baB inactivation in RAW 264.7 macrophages","volume":"40","author":"Lee","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tox.2025.154229_bib21","article-title":"qPCRtools: an R package for qPCR data processing and visualization","volume":"13","author":"Li","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.tox.2025.154229_bib22","doi-asserted-by":"crossref","first-page":"C939","DOI":"10.1152\/ajpcell.00108.2022","article-title":"Structural and conformational studies of biased agonism through formyl peptide receptors","volume":"322","author":"Liao","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tox.2025.154229_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115962","article-title":"Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload","volume":"220","author":"Lin","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2025.154229_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-018-1247-9","article-title":"Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-\u03b1 mediated NF-\u03baB and HDAC-3 nuclear translocation","volume":"10","author":"Pooladanda","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tox.2025.154229_bib25","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.3390\/antiox10121919","article-title":"Oxidative stress and inflammation caused by cisplatin ototoxicity","volume":"10","author":"Ramkumar","year":"2021","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.tox.2025.154229_bib26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1470-2045(22)00739-2","article-title":"Cisplatin with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"24","author":"Rodler","year":"2023","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tox.2025.154229_bib27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.tox.2025.154229_bib28","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/ijms19041045","article-title":"Annexin A1: uncovering the many talents of an old protein","volume":"19","author":"Sheikh","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2025.154229_bib29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10162-007-0084-9","article-title":"Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB","volume":"8","author":"So","year":"2007","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.tox.2025.154229_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115447","article-title":"U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells","volume":"415","author":"Wang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2025.154229_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fphar.2020.00337","article-title":"A ganoderma-derived compound exerts inhibitory effect through formyl peptide receptor 2","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tox.2025.154229_bib32","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1042\/CS20190599","article-title":"RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.tox.2025.154229_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41401-022-00944-0","article-title":"Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease","volume":"44","author":"Yang","year":"2023","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X2500188X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X2500188X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:47:24Z","timestamp":1778510844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X2500188X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":33,"alternative-id":["S0300483X2500188X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154229","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formyl peptide receptor 2 (FPR2) mediates cisplatin-induced cochlear inflammation and hair cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154229"}}