{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:07:23Z","timestamp":1792512443217,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tox.2025.154243","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T06:30:54Z","timestamp":1753511454000},"page":"154243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Phthalate exposure and hepatocellular carcinoma: Unraveling mechanisms through network toxicology"],"prefix":"10.1016","volume":"518","author":[{"given":"Simin","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154243_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tox.2025.154243_bib2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1517\/17425255.2013.796929","article-title":"Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation","volume":"9","author":"Badenhorst","year":"2013","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.tox.2025.154243_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.tox.2025.154243_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.tox.2025.154243_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinforma."},{"issue":"23","key":"10.1016\/j.tox.2025.154243_bib6","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","article-title":"Analysis and visualization of longitudinal genomic and clinical data from the AACR project GENIE biopharma collaborative in cBioPortal","volume":"83","author":"de Bruijn","year":"2023","journal-title":"Cancer Res."},{"issue":"269","key":"10.1016\/j.tox.2025.154243_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tox.2025.154243_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70284","article-title":"Predictive prognostic model for hepatocellular carcinoma based on seven genes participating in arachidonic acid metabolism","volume":"13","author":"Gu","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.tox.2025.154243_bib9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/bph.16257","article-title":"Transcriptome-level discovery of survival-associated biomarkers and therapy targets in non-small-cell lung cancer","volume":"181","author":"Gy\u0151rffy","year":"2024","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.tox.2025.154243_bib10","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.tox.2025.154243_bib11","doi-asserted-by":"crossref","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","article-title":"TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment","volume":"51","author":"Han","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.tox.2025.154243_bib12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/oem.2004.017590","article-title":"Phthalates and human health","volume":"62","author":"Hauser","year":"2005","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.tox.2025.154243_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126277","article-title":"Occurrence and migration of phthalates in adhesive materials to fruits and vegetables","volume":"418","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2025.154243_bib14","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1007\/s00210-024-03598-3","article-title":"Mechanism of atorvastatin in treating hepatocellular carcinoma: a study based on network pharmacology, molecular docking, and bioinformatics analysis","volume":"398","author":"Hu","year":"2025","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.tox.2025.154243_bib15","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s10528-023-10527-1","article-title":"Mongolian HCC vs. Caucasian HCC: the metabolic reprogramming process in Mongolian HCC is an interesting difference","volume":"62","author":"Huang","year":"2024","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.tox.2025.154243_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/10408449609048302","article-title":"Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk","volume":"26","author":"Huber","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tox.2025.154243_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tox.2025.154243_bib18","doi-asserted-by":"crossref","first-page":"W561","DOI":"10.1093\/nar\/gkz445","article-title":"MEXPRESS update 2019","volume":"47","author":"Koch","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2025.154243_bib19","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2025.154243_bib20","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2025.154243_bib21","doi-asserted-by":"crossref","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","article-title":"TIMER2.0 for analysis of tumor-infiltrating immune cells","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2025.154243_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13059-016-1028-7","article-title":"Comprehensive analyses of tumor immunity: implications for cancer immunotherapy","volume":"17","author":"Li","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.tox.2025.154243_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14297","article-title":"When less is more: The association between the expression of polymorphic CYPs and AFB1-induced HCC","volume":"54","author":"Mohamed","year":"2024","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.tox.2025.154243_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020126","article-title":"Age-dependent effects of butyl benzyl phthalate exposure on lipid metabolism and hepatic fibrosis in mice","volume":"14","author":"Park","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.tox.2025.154243_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41597-024-03015-7","article-title":"A comprehensive database of exosome molecular biomarkers and disease-gene associations","volume":"11","author":"Qi","year":"2024","journal-title":"Sci. Data"},{"key":"10.1016\/j.tox.2025.154243_bib26","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor-immune system interactions","volume":"35","author":"Ru","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tox.2025.154243_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"issue":"1","key":"10.1016\/j.tox.2025.154243_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tox.2025.154243_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.tox.2025.154243_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.tox.2025.154243_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116161","article-title":"Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma","volume":"273","author":"Shih","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154243_bib32","doi-asserted-by":"crossref","first-page":"D1420","DOI":"10.1093\/nar\/gkaa1020","article-title":"TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment","volume":"49","author":"Sun","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tox.2025.154243_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142605","article-title":"Occurrence and ecological risk assessment of 16 plasticizers in the rivers and estuaries in Japan","volume":"362","author":"Uaciquete","year":"2024","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.tox.2025.154243_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/07482337241245453","article-title":"Gender associations between phthalate exposure and biomarkers of oxidative stress: a prospective cohort study","volume":"40","author":"Wang","year":"2024","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tox.2025.154243_bib35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.14715\/cmb\/2023.69.7.28","article-title":"Identification of key biomarkers in hepatocellular carcinoma induced by non-alcoholic steatohepatitis or metabolic syndrome via integrated bioinformatics analysis","volume":"69","author":"Wang","year":"2023","journal-title":"Cell Mol. Biol. (Noisylegrand)"},{"key":"10.1016\/j.tox.2025.154243_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.tox.2025.154243_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.20517\/2394-5079.2018.29","article-title":"Oxidative stress and hepatocarcinogenesis","volume":"4","author":"Ying","year":"2018","journal-title":"Hepatoma Res."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T05:09:27Z","timestamp":1760591367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25002021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"alternative-id":["S0300483X25002021"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154243","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phthalate exposure and hepatocellular carcinoma: Unraveling mechanisms through network toxicology","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154243"}}