{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:57:47Z","timestamp":1790477867672,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073656"],"award-info":[{"award-number":["82073656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFA007"],"award-info":[{"award-number":["2023AFA007"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA0915101"],"award-info":[{"award-number":["2023YFA0915101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tox.2025.154264","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T21:21:13Z","timestamp":1755552073000},"page":"154264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Integration of vitro models with machine learning and epidemiological data reveals PCB-induced glucose metabolism disruption linked to mitochondrial dysfunction"],"prefix":"10.1016","volume":"518","author":[{"given":"Peiwen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoya","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2025.154264_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10020065","article-title":"The role of persistent organic pollutants in obesity: a review of laboratory and epidemiological studies","volume":"10","author":"Aaseth","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.tox.2025.154264_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/toxsci\/kfac044","article-title":"Exposure to 3,3\u2032,4,4\u2032,5-Pentachlorobiphenyl (PCB126) causes widespread DNA hypomethylation in adult zebrafish testis","volume":"188","author":"Aluru","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/toxsci\/kfx192","article-title":"Early life exposure to low levels of AHR agonist PCB126 (3,3\u2032,4,4\u2032,5-Pentachlorobiphenyl) reprograms gene expression in adult brain","volume":"160","author":"Aluru","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1165\/rcmb.2022-0111OC","article-title":"Intracellular chloride channels regulate endothelial metabolic reprogramming in pulmonary arterial hypertension","volume":"68","author":"Alzaydi","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tox.2025.154264_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114004","article-title":"Serum concentrations of persistent organic pollutants and the metabolic syndrome in akwesasne mohawks, a Native American community","volume":"260","author":"Aminov","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154264_bib6","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.jnutbio.2013.08.009","article-title":"Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes","volume":"24","author":"Baker","year":"2013","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.tox.2025.154264_bib7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/bcpt.12620","article-title":"Low-Chlorinated Non-Dioxin-like polychlorinated biphenyls present in blood and breast milk induce higher levels of reactive oxygen species in neutrophil granulocytes than High-Chlorinated congeners","volume":"119","author":"Berntsen","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib8","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1210\/jc.2005-1024","article-title":"Structural and functional consequences of mitochondrial biogenesis in human adipocytesin vitro","volume":"90","author":"Bogacka","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2025.154264_bib9","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tox.2025.154264_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kft106","article-title":"A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis","volume":"134","author":"Cai","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2015.00037","article-title":"Endocrine disrupters: the new players able to affect the epigenome","volume":"3","author":"Casati","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tox.2025.154264_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.envint.2016.06.033","article-title":"The influence of maternal dietary exposure to dioxins and PCBs during pregnancy on ADHD symptoms and cognitive functions in Norwegian preschool children","volume":"94","author":"Caspersen","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154264_bib13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/tx300510v","article-title":"Perinatal exposure to Purity-Controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months","volume":"26","author":"De Boever","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.envint.2019.04.001","article-title":"Linking past uses of legacy SVOCs with today's indoor levels and human exposure","volume":"127","author":"Demirtepe","year":"2019","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2025.154264_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052477","article-title":"Inhibition of inducible nitric oxide synthase prevents IL-1\u03b2-Induced mitochondrial dysfunction in human chondrocytes","volume":"22","author":"Eitner","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10061349","article-title":"Osteoarthritis-Induced metabolic alterations of human hip chondrocytes","volume":"10","author":"Eitner","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.tox.2025.154264_bib17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.bbadis.2017.02.017","article-title":"Mitochondrial DNA maintenance defects","volume":"1863","author":"El-Hattab","year":"2017","journal-title":"Biochim. Et. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"10.1016\/j.tox.2025.154264_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117764","article-title":"Estimating the dietary exposure and risk of persistent organic pollutants in China: a national analysis","volume":"288","author":"Fan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154264_bib19","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1021\/acs.est.3c10175","article-title":"Mitochondrial DNA Stress-Mediated health risk to dibutyl phthalate contamination on zebrafish (Danio rerio) at early life stage","volume":"58","author":"Fan","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154264_bib20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00204-012-0979-z","article-title":"AhR-mediated changes in global gene expression in rat liver progenitor cells","volume":"87","author":"Faust","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/joim.13242","article-title":"Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14176 individuals","volume":"290","author":"Fazzini","year":"2021","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.tox.2025.154264_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123032","article-title":"Assessment of legacy and alternative halogenated organic pollutants in outdoor dust and soil from e-waste sites in Nigeria: concentrations, patterns, and implications for human exposure","volume":"342","author":"Folarin","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154264_bib23","article-title":"Polychlorinated biphenyls' impact on comorbidity networks: unveiling epidemiological patterns and offsetting through dietary adjustments","author":"Gao","year":"2024","journal-title":"Res. Sq."},{"key":"10.1016\/j.tox.2025.154264_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165773","article-title":"Polychlorinated biphenyls and risk of metabolic syndrome and comparison with the risk of diabetes: a systematic review and meta-analysis","volume":"900","author":"Gao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154264_bib25","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1002\/tox.24083","article-title":"Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons","volume":"39","author":"Geng","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib26","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.envint.2010.06.010","article-title":"Polychlorinated biphenyls (PCB-153) and (PCB-77) absorption in human liver (HepG2) and kidney (HK2) cells in vitro: PCB levels and cell death","volume":"36","author":"Ghosh","year":"2010","journal-title":"Environ. Int"},{"key":"10.1016\/j.tox.2025.154264_bib27","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1080\/15592294.2018.1543506","article-title":"Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm","volume":"13","author":"Gillette","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.tox.2025.154264_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105396","article-title":"Transcriptome sequencing of 3,3\u2032,4,4\u2032,5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes","volume":"83","author":"Gourronc","year":"2022","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.tox.2025.154264_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00096","article-title":"Intracellular chloride channels: novel biomarkers in diseases","volume":"11","author":"Gururaja Rao","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tox.2025.154264_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.chemosphere.2019.05.109","article-title":"A review of organochlorine pesticides and polychlorinated biphenyls in Lebanon: environmental and human contaminants","volume":"231","author":"Helou","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154264_bib31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/bit.22799","article-title":"Effects of glucose and insulin on HepG2-C3A cell metabolism","volume":"107","author":"Iyer","year":"2010","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.tox.2025.154264_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab454","article-title":"A roadmap for multi-omics data integration using deep learning","volume":"23","author":"Kang","year":"2022","journal-title":"Brief. Bioinforma."},{"key":"10.1016\/j.tox.2025.154264_bib33","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1073\/pnas.1113987109","article-title":"Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy","volume":"109","author":"Ke","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.tox.2025.154264_bib34","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00204-016-1889-2","article-title":"Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27","volume":"91","author":"Kim","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib35","article-title":"Persistent organic Pollutant-Mediated insulin resistance","volume":"16","author":"Kim","year":"2019","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.tox.2025.154264_bib36","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1073\/pnas.1424353112","article-title":"Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I","volume":"112","author":"Kmita","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110442","article-title":"Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure","volume":"38","author":"Laufer","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.tox.2025.154264_bib38","doi-asserted-by":"crossref","first-page":"E448","DOI":"10.1152\/ajpendo.00156.2023","article-title":"Endoplasmic reticulum stress in pancreatic \u03b2 cells induces incretin desensitization and \u03b2-cell dysfunction via ATF4-mediated PDE4D expression","volume":"325","author":"Lee","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2025.154264_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152312","article-title":"Role of c-Myc\/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases","volume":"429","author":"Li","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154264_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115743","article-title":"Association between polychlorinated biphenyls exposure and incident type 2 diabetes mellitus: a nested case-control study","volume":"228","author":"Li","year":"2023","journal-title":"Environ. Res"},{"issue":"8","key":"10.1016\/j.tox.2025.154264_bib41","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1021\/es901871e","article-title":"Polychlorinated biphenyls in global air and surface soil: distributions, air-soil exchange, and fractionation effect","volume":"44","author":"Li","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154264_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/joim.13049","article-title":"Epigenetic regulation of insulin action and secretion \u2013 role in the pathogenesis of type 2 diabetes","volume":"288","author":"Ling","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.tox.2025.154264_bib43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41574-022-00671-w","article-title":"Epigenetics of type 2 diabetes mellitus and weight change \u2014 a tool for precision Medicine?","volume":"18","author":"Ling","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tox.2025.154264_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122030","article-title":"Multiomics reveals new biomarkers and mechanistic insights into the combined toxicity effects of 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl and atrazine exposures in MCF-7 cells","volume":"333","author":"Lu","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154264_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102075","article-title":"Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4\u03b1","volume":"91","author":"Luo","year":"2025","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tox.2025.154264_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165151","article-title":"Short-term exposure to multiple metals mixture and mitochondrial DNA copy number among children: a panel study","volume":"896","author":"Lv","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2025.154264_bib47","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/infdis\/jiz023","article-title":"DNA methylation markers of type 2 diabetes mellitus among Male veterans with or without human immunodeficiency virus infection","volume":"219","author":"Mathur","year":"2019","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tox.2025.154264_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-84132-w","article-title":"Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: a population-based follow-up study","volume":"11","author":"Memon","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tox.2025.154264_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128847","article-title":"The transcriptional effects of PCB118 and PCB153 on the liver, adipose tissue, muscle and colon of mice: highlighting of Glut4 and Lipin1 as main target genes for PCB induced metabolic disorders","volume":"10","author":"Mesnier","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tox.2025.154264_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111041","article-title":"Gut microbiota health closely associates with PCB153-derived risk of host diseases","volume":"203","author":"Min","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tox.2025.154264_bib51","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1096\/fj.13-231670","article-title":"Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice","volume":"27","author":"Naville","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2025.154264_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/nu15173693","article-title":"Novel Multi-Ingredient supplement facilitates weight loss and improves body composition in overweight and obese individuals: a randomized, Double-Blind, Placebo-Controlled clinical trial","volume":"15","author":"Nederveen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tox.2025.154264_bib53","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1021\/acschemneuro.4c00116","article-title":"Astrocyte mitochondria are a sensitive target of PCB52 and its Human-Relevant metabolites","volume":"15","author":"Paranjape","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tox.2025.154264_bib54","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s12276-023-00993-3","article-title":"Sex differences in the progression of glucose metabolism dysfunction in Alzheimer\u2019s disease","volume":"55","author":"Park","year":"2023","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.tox.2025.154264_bib55","doi-asserted-by":"crossref","first-page":"19383","DOI":"10.1021\/acs.est.3c06095","article-title":"Association between environmental exposure to multiclass organic pollutants and sex steroid hormone levels in women of reproductive age","volume":"57","author":"Peng","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154264_bib56","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1194\/jlr.M007575","article-title":"Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria","volume":"52","author":"Prasad","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tox.2025.154264_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127141","article-title":"Machine learning-based biomarkers identification from toxicogenomics \u2013 bridging to regulatory relevant phenotypic endpoints","volume":"423","author":"Rahman","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2025.154264_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1085958","article-title":"Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance","volume":"14","author":"Rice","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tox.2025.154264_bib59","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.redox.2017.01.013","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2025.154264_bib60","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.0901321","article-title":"Persistent organic pollutant exposure leads to insulin resistance syndrome","volume":"118","author":"Ruzzin","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2025.154264_bib61","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.chemosphere.2012.03.089","article-title":"Very high correlations between fresh weight and lipid-adjusted PCB-153 serum concentrations: irrespective of fasting status, age, body mass index, gender, or exposure distributions","volume":"88","author":"Rylander","year":"2012","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.tox.2025.154264_bib62","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/tox.24094","article-title":"Polychlorinated biphenyls exposure and type 2 diabetes: molecular mechanism that causes insulin resistance and islet damage","volume":"39","author":"Shan","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tox.2025.154264_bib63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jhazmat.2010.08.061","article-title":"PCB congeners induced mitochondrial dysfunction in vero cells","volume":"185","author":"Shen","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tox.2025.154264_bib64","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.immuni.2020.10.008","article-title":"Plasma proteomics identify biomarkers and pathogenesis of COVID-19","volume":"53","author":"Shu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.tox.2025.154264_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-33484-6","article-title":"Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion","volume":"13","author":"Strembitska","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tox.2025.154264_bib66","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envpol.2015.11.040","article-title":"Concentrations, distribution, sources and risk assessment of organohalogenated contaminants in soils from Kenya, Eastern Africa","volume":"209","author":"Sun","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2025.154264_bib67","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1021\/acs.est.3c00032","article-title":"Multi- and transgenerational developmental impairments are induced by decabromodiphenyl ethane (DBDPE) in zebrafish larvae","volume":"57","author":"Sun","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2025.154264_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152744","article-title":"Effect of exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) on mitochondrial DNA (mtDNA) copy number in rats","volume":"454","author":"VanEtten","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2025.154264_bib69","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cellsig.2018.06.005","article-title":"Role of cAMP and phosphodiesterase signaling in liver health and disease","volume":"49","author":"Wahlang","year":"2018","journal-title":"Cell Signal"},{"key":"10.1016\/j.tox.2025.154264_bib70","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/ije\/dys053","article-title":"Cohort profile: the Dongfeng-Tongji cohort study of retired workers","volume":"42","author":"Wang","year":"2013","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.tox.2025.154264_bib71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1001-0742(09)60221-7","article-title":"Inflammatory response and insulin signaling alteration induced by PCB77","volume":"22","author":"Wang","year":"2010","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.tox.2025.154264_bib72","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-023-05014-0","article-title":"GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation","volume":"80","author":"Wang","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tox.2025.154264_bib73","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00125-022-05759-6","article-title":"Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and mendelian randomisation study","volume":"65","author":"Wang","year":"2022","journal-title":"Diabetologia"},{"issue":"3-4","key":"10.1016\/j.tox.2025.154264_bib74","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF00377929","article-title":"Body burden of polychlorinated biphenyls among persons employed in capacitor manufacturing","volume":"49","author":"Wolff","year":"1982","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2025.154264_bib75","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.redox.2017.02.026","article-title":"Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS\/NF-kappaB signaling via downregulation of HNF1b","volume":"12","author":"Wu","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.tox.2025.154264_bib76","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.envpol.2019.03.101","article-title":"Exposure to aroclor 1254 persistently suppresses the functions of pancreatic \u03b2-cells and deteriorates glucose homeostasis in Male mice","volume":"249","author":"Xi","year":"2019","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"key":"10.1016\/j.tox.2025.154264_bib77","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.phrs.2017.12.026","article-title":"Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK\/NOX4\/PI3K\/AKT pathway","volume":"130","author":"Yan","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tox.2025.154264_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140532","article-title":"PCB126 impairs human sperm functions by affecting post-translational modifications and mitochondrial functions","volume":"346","author":"Yang","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2025.154264_bib79","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.jmb.2018.07.027","article-title":"Mechanisms orchestrating mitochondrial dynamics for energy homeostasis","volume":"430","author":"Yu","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tox.2025.154264_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108440","article-title":"Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study: matrix dependent partitioning differences compared to legacy POPs","volume":"183","author":"Yuan","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2025.154264_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-03289-w","article-title":"Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tox.2025.154264_bib82","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/15376516.2019.1584658","article-title":"Polychlorinated biphenyls promote cell survival through pyruvate kinase M2-dependent glycolysis in HeLa cells","volume":"29","author":"Zhang","year":"2019","journal-title":"Toxicol. Mech. Methods"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X25002239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:30:58Z","timestamp":1772803858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X25002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":82,"alternative-id":["S0300483X25002239"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2025.154264","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of vitro models with machine learning and epidemiological data reveals PCB-induced glucose metabolism disruption linked to mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2025.154264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154264"}}